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    • D-Mannose CAS 3458-28-4

    D-Mannose CAS 3458-28-4

    D-Mannose, also called carubinose or seminose, CAS 3458-28-4, is a white crystalline naturally occurring sugar supplied in food or pharma grade. Confirm the required grade and specification, then request a quotation with COA/TDS/SDS for bulk supply.

    • CAS: 3458-28-4
    • Synonyms: Carubinose, Seminose, D-Mannopyranose, (3S,4S,5S,6R)-6-(Hydroxymethyl)oxane-2,3,4,5-tetrol, D-Man
    • Einecs: 222-392-4
    • Molecular Formula: C₆H₁₂O₆
    • Grade: Food/Pharma Grade
    • Package: 25kg/bag (Plastic woven bag with PE liner) or 500kg/1000kg Jumbo Bag.
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    Product Description

    D-Mannose CAS 3458-28-4 is a naturally occurring aldose sugar, also known as carubinose or seminose, with molecular formula C6H12O6, molecular weight about 180.16 and EINECS 222-392-4.

    Synonyms: Carubinose; Seminose; D-Mannopyranose; (3S,4S,5S,6R)-6-(Hydroxymethyl)oxane-2,3,4,5-tetrol; D-Man.

    CAS: 3458-28-4.

    It has the molecular formula C6H12O6 and a molecular weight of about 180.16 g/mol.

    It appears as a white crystalline powder with a sweet taste about 0.6 times as sweet as sucrose and a slightly bitter aftertaste at high concentration.

    A typical specification includes assay of at least 98.0–100.0% by HPLC and a melting point of 133–140 °C.

    It has a specific rotation of about +13.3° to +14.3°, is freely soluble in water and sparingly soluble in ethanol.

    In urinary tract supplements, it binds to certain E. coli bacteria and helps prevent them from adhering to the bladder wall.

    It is used in capsules, tablets and powder sachets for urinary tract health management.

    It is suitable for low-sugar or diabetic-friendly functional foods and beverages because much of it is excreted unmetabolized.

    It can act as a mild prebiotic in drinks, yogurts and meal replacement shakes.

    It is also used in pet and animal feed supplements, often combined with cranberry extract.

    It is hygroscopic, so warehouse humidity and airtight packaging must be controlled to prevent caking.

    Store in a cool, dry place, typically below 25 °C, away from direct sunlight.

    Confirm appearance, assay, melting range, specific rotation, heavy metals, microbial limits, loss on drying and residue limits as required.

    Use dust masks and eye protection during handling, and keep the inner liners sealed after opening.

    Confirm packaging with the requested quantity and destination requirements.

    The page is an RFQ entry point and does not state stock, price, MOQ or fixed lead time.

    For an RFQ, state the intended use, required grade and specification, quantity, packaging, destination and document needs.

    FAQ - Technical & Supply Chain

    • Q:

      What is D-Mannose CAS 3458-28-4?

      A: D-Mannose CAS 3458-28-4 is a naturally occurring aldose sugar with the molecular formula C6H12O6, a molecular weight of about 180.16 g/mol, and EINECS 222-392-4. It is also known as carubinose, seminose, or D-mannopyranose, and is supplied as a white crystalline powder for food, supplement, and pharmaceutical applications.
    • Q:

      How does D-Mannose support urinary tract health?

      A: In urinary tract supplements, D-Mannose works mechanically by binding to certain E. coli bacteria and helping prevent them from adhering to the bladder wall, allowing them to be flushed out with urine. This mechanism makes it a popular ingredient in capsules, tablets, and powder sachet formats.
    • Q:

      Is D-Mannose suitable for low-glycemic or diabetic-friendly formulations?

      A: D-Mannose is often used in functional foods and beverages for low-sugar or diabetic-friendly concepts because a large portion is excreted unmetabolized and it does not significantly affect blood glucose like ordinary glucose. Formulators still evaluate the total carbohydrate contribution and sweetness profile for the finished product.
    • Q:

      What are the key food/pharma-grade specifications for D-Mannose?

      A: Typical D-Mannose specifications include a white crystalline appearance, assay of at least 98-99% by HPLC, melting point around 133-140 C, and specific rotation around +13.3 to +14.3 degrees. It is freely soluble in water and sparingly soluble in ethanol.
    • Q:

      How does D-Mannose differ from D-Glucose?

      A: Both D-Mannose and D-Glucose are C6H12O6 aldose sugars, but they have different stereochemistry at C2, giving D-Mannose different sweetness, metabolism, and biological behavior. D-Mannose is less commonly used as a conventional energy sweetener and is valued more for its urinary tract support function.
    • Q:

      How does D-Mannose differ from Mannitol?

      A: D-Mannose is a reducing aldose sugar, while mannitol is the corresponding sugar alcohol formed by reduction and is not a reducing sugar. Mannitol is primarily used as a polyol sweetener, bulking agent, or pharmaceutical excipient, whereas D-Mannose is selected for its specific biological activity and supplement applications.

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