D-Mannose CAS 3458-28-4

Physical & Chemical Properties

D-Mannose is a white, crystalline powder. It is sweet, roughly 0.6 times as sweet as sucrose (table sugar), but with a slightly bitter aftertaste if used in high concentrations.

Key Application Fields

1. Dietary Supplements (UTI Management)

This is the primary driver of demand. D-Mannose works mechanically rather than biologically. It binds to the E. coli bacteria, preventing them from adhering to the bladder walls (urothelium). The bacteria are then flushed out with urine.

• Formats: Capsules, tablets, and increasingly popular “stick packs” (powder sachets).

2. Functional Foods and Beverages

Because it is a naturally occurring sugar that does not significantly affect blood glucose levels (it is mostly excreted unmetabolized), it is popular in:

• Diabetic-friendly formulations.
• Prebiotic drinks (it acts as a mild prebiotic).
• Yogurts and meal replacement shakes.

3. Animal Feed and Pet Health

The mechanism that works in humans also works in pets. D-Mannose is widely used in supplements for cats and dogs to prevent urinary tract issues, often combined with cranberry extract.

Safety and Precautionary Measures

D-Mannose is generally recognized as safe (GRAS) and is a naturally occurring food substance. However, for factory workers and handlers:

• Dust Control: Like any fine organic powder, creating a dust cloud poses a theoretical risk of explosion in confined spaces. Use explosion-proof ventilation.
• Inhalation: Prolonged inhalation of high concentrations of dust may irritate the respiratory tract. Workers should use standard dust masks (N95 or equivalent).
• Ingestion: Safe for consumption. However, in an industrial setting, do not eat, drink, or smoke in the working area.
• Eye Contact: May cause mechanical irritation. Rinse with plenty of water if contact occurs.

Storage and Handling Conditions

One of the biggest challenges with D-Mannose is its hygroscopicity (ability to absorb moisture from the air). If not stored correctly, the powder will turn into a solid block, making it unusable for production.

1. Moisture Control: The warehouse humidity must be strictly controlled. The packaging must be airtight.
2. Temperature: Store in a cool, dry place, typically below 25°C. Avoid direct sunlight.
3. Packaging:
   • Standard: 25kg fiber drums with double PE liners inside. The inner liners must be tied or heat-sealed tightly to prevent moisture ingress.
   • Retail/Small Batch: Aluminum foil bags are recommended for smaller quantities to provide a total moisture barrier.
4. Shelf Life: typically 2 to 3 years if the seal remains unbroken. Once opened, it should be used quickly or resealed immediately.