N-Acetylneuraminic Acid (CAS 131-48-6), chemically identified as 5-acetamido-3,5-dideoxy-D-glycero-D-galacto-2-nonulosonic acid, is a functional monosaccharide derivative that acts as a critical raw material in nutritional supplement compounding and pharmaceutical synthesis. This carbohydrate compound, also technically referred to as Neu5Ac or sialic acid, functions as a biological recognition site in glycoprotein synthesis and is extensively utilized in the industrial production of infant formula and functional food additives. We provide bulk supply of this high-purity ingredient with competitive factory pricing to ensure cost-efficiency for large-scale processors. Our quality management system guarantees full traceability, making MSDS, TDS, COA available alongside customized specifications to comply with strict regulatory standards.
N-Acetylneuraminic Acid Powder CAS 131-48-6
- CAS: 131-48-6
- Synonyms: sialic acid, NANA, 5-acetamido-3,5-dideoxy-D-glycero-D-galacto-2-nonulosonic acid, lactaminic acid
- Einecs: 205-023-1
- Molecular Formula: C₁₁H₁₉NO₉
- Grade: Pharmaceutical / Nutraceutical grade, ≥98% (HPLC)
- Package: 1 kg aluminum foil bag (with inner PE liner) 25 kg fiber drum (lined with double PE bags) Customized packaging available upon request
Product Description
N-Acetylneuraminic Acid (NANA, Neu5Ac) is the predominant sialic acid found in human and mammalian tissues. It is widely used as a functional ingredient in nutraceuticals, infant formula, functional foods, cosmetics, and biochemical research. With high purity and stable quality, it is suitable for manufacturers who need reliable sialic acid raw material for formulation and further processing.
📧 Email: info@industrochem.com – Contact our team for specifications, COA, and the latest bulk price.
Physicochemical Properties
| Item | Specification / Typical Data* |
|---|---|
| Chemical Name | N-Acetylneuraminic Acid |
| Synonyms | NANA; Neu5Ac; Sialic Acid |
| CAS | 131-48-6 |
| EC No. | 205-023-1 |
| Molecular Formula | C₁₁H₁₉NO₉ |
| Molecular Weight | 309.27 g/mol |
| Appearance | White to off-white crystalline powder |
| Assay (HPLC) | ≥98.0% (dry basis) |
| Melting Point | 184–186 °C (decomposition) |
| Solubility in Water (20 °C) | ≥50 g/L; freely soluble |
| Solubility in Ethanol | Practically insoluble / very low solubility |
| pKa (carboxyl group) | Approx. 2.4 (predicted) |
| Optical Rotation | [α] ≈ −32° (c=1, H₂O) |
| Stability | Stable under recommended storage; sensitive to moisture and strong oxidizing agents |
*The above values are typical technical data for reference. Final specifications can be adjusted according to your order and COA.
Product Description
N-Acetylneuraminic Acid (NANA, Neu5Ac) is an acidic monosaccharide and the major representative of sialic acids. It naturally occurs at the terminal position of glycoproteins and glycolipids in human and animal tissues, especially in the brain and nervous system.
In industrial production, N-Acetylneuraminic Acid is usually obtained by enzymatic or chemical processes starting from suitable carbohydrate precursors, followed by refinement and crystallization to achieve high purity. The resulting white crystalline powder is freely soluble in water and suitable for use as:
- A functional ingredient in nutritional and health products
- A fortification component for formulas requiring sialic acid
- An intermediate for the synthesis of related derivatives
- A biochemical reagent in glycoscience and cell biology research
Our N-Acetylneuraminic Acid is designed for B2B customers who need consistent quality, stable supply, and clear documentation (COA, MSDS, regulatory support).
Applications
- Nutraceuticals & Dietary Supplements
- Used as a functional sugar to support brain and nervous system development.
- Often combined with other nutrients in cognitive-supporting formulations and “nootropic” blends (for research and product-development use in regulated markets).
- Infant Formula & Functional Foods
- Serves as a sialic acid source in R&D formulations targeted at mimicking human milk oligosaccharide profiles.
- Can be used in functional beverages, dairy products, and solid drinks as a value-added ingredient (actual use subject to local regulations and approvals).
- Cosmetics & Personal Care
- Applied as a skin-conditioning and moisturizing ingredient, contributing to smoother skin feel and barrier support.
- Suitable for use in serums, creams, masks, and premium skincare concepts focused on anti-aging or barrier care.
- Biochemical & Pharmaceutical Research
- Widely used as a standard and substrate in glycomics, cell signaling, and virology research.
- Intermediate for the synthesis of sialylated glycoconjugates and related derivatives.
Note: Final application and dosage must comply with local laws and regulations. End users should perform their own formulation and safety evaluations.
Storage Conditions
- Recommended Storage Temperature: −20 °C (freezer)
- Container: Tightly sealed in original packaging, with inner moisture-proof liner.
- Environment:
- Store in a cool, dry, and well-ventilated place.
- Protect from direct sunlight and strong UV exposure.
- Keep away from strong oxidizing agents and strong acids/alkalis.
- Shelf Life: Typically 24–36 months when stored under recommended conditions; refer to COA for exact lot-based expiry date.
After opening, reseal the inner bag promptly and minimize exposure to air and humidity.
Safety Precautions
Although N-Acetylneuraminic Acid is generally regarded as having low acute toxicity and is used in food/cosmetic contexts under regulatory control, it should still be handled as a fine chemical in an industrial setting:
- Avoid inhalation of dust and contact with eyes, skin, and clothing.
- Use appropriate PPE: lab coat, gloves, safety glasses, and dust mask/respirator if dust generation is possible.
- Use in a well-ventilated area or under local exhaust.
- In case of contact:
- Eye contact: Rinse immediately with plenty of water and seek medical advice if irritation persists.
- Skin contact: Wash with soap and water.
- Inhalation: Move person to fresh air and keep at rest; seek medical attention if symptoms occur.
- Ingestion: Rinse mouth and seek medical advice.
- Keep out of reach of children and non-professional users.
- For detailed information, refer to the Material Safety Data Sheet (MSDS) of this product.
FAQ - Technical & Supply Chain
-
Q:
How is N-Acetylneuraminic Acid (CAS 131-48-6) chemically characterized for industrial verification?
A: N-Acetylneuraminic Acid is characterized as the most predominant form of sialic acid found in mammalian cells, chemically distinct as an acetylated derivative of neuraminic acid with a nine-carbon backbone structure. -
Q:
Is this N-Acetylneuraminic Acid intended for direct consumer use or industrial formulation?
A: This material is intended for industrial formulation and compounding processes, serving as a bulk raw material for manufacturers of nutritional supplements and pharmaceutical intermediates rather than as a finished retail product.
Documents and Product Support
For product review and sourcing evaluation, supporting documents can be coordinated according to the product type, inquiry stage, and order requirements.
- COA for batch-based quality reference
- TDS for key physical and chemical information
- SDS / MSDS for handling, storage, and safety reference
- Packing information for sample, trial, and bulk orders
- Technical communication based on application and specification requirements
Information to Confirm Before Quotation
Clear sourcing information helps reduce specification mismatch and allows a more accurate quotation before sample or bulk order discussion.
- Product name and CAS number
- Application or intended end use
- Required purity, grade, or specification
- Sample quantity, trial order, or bulk demand
- Preferred packing form or net weight
- Destination country or port
- Required documents or compliance expectations
Packaging, Storage, and Handling Notes
Packaging form, storage conditions, shelf life, and shipment arrangements should be confirmed according to the product characteristics, package size, and destination requirements.
Before order confirmation, buyers are advised to review the corresponding product documents and confirm whether any special storage, labeling, or handling requirements apply.
Sample, Bulk Order and Repeat Supply Support
Support can be arranged for sample discussion, bulk supply planning, packaging confirmation, and routine sourcing communication based on the actual product and order requirements.
For repeat-use formulations or long-term procurement plans, buyers may discuss specification consistency, packaging preferences, delivery expectations, and document coordination in advance.





