What is Rivaroxaban CAS 366789-02-8?

Rivaroxaban is a direct, selective Factor Xa inhibitor supplied as an oral anticoagulant pharmaceutical API. Its molecular formula is C₁₉H₁₈ClN₃O₅S and its molecular weight is about 435.88 g/mol.

How does Rivaroxaban prevent blood clots?

It directly inhibits free and clot-bound Factor Xa, reducing thrombin generation without requiring antithrombin III as a cofactor. This interrupts the coagulation cascade and lowers the risk of venous and arterial thrombus formation.

What is Rivaroxaban API used to manufacture?

Rivaroxaban is used to manufacture oral anticoagulant solid-dosage medicines for DVT and PE treatment, stroke risk reduction in nonvalvular atrial fibrillation, and VTE prevention after hip or knee replacement surgery.

Why is the (S)-enantiomer important for Rivaroxaban?

Rivaroxaban is supplied as the pure (S)-enantiomer, which is the pharmacologically active form of the molecule. Enantiomeric purity and polymorphic form should be controlled because they can affect bioavailability, stability and consistency of the final dosage form.

How should Rivaroxaban API be stored and handled?

Store in tightly closed containers under cool, dry, light-protected conditions; many supplier specifications recommend 2–8 °C or an inert atmosphere. Handle as a potent pharmaceutical material using qualified procedures and appropriate personal protective equipment.

Rivaroxaban CAS 366789-02-8

Rivaroxaban (CAS 366789-02-8) is a direct, selective Factor Xa inhibitor supplied as an Active Pharmaceutical Ingredient (API) for oral anticoagulant formulations. Confirm the required grade, then request a quotation with COA/TDS/SDS for bulk supply.

CAS: 366789-02-8
Synonyms: Rivaroxabanum, BAY 59-7939, (S)-Rivaroxaban
Einecs: 685-132-2
Molecular Formula: C₁₉H₁₈ClN₃O₅S
Grade: Pharmaceutical Grade
Package: 25 kg/drum

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Product Description

Rivaroxaban, CAS 366789-02-8, is a direct, selective Factor Xa inhibitor supplied as an oral anticoagulant Active Pharmaceutical Ingredient (API); the EC/EINECS number is 685-132-2.

Synonyms: Rivaroxabanum; BAY 59-7939; (S)-Rivaroxaban.

CAS: 366789-02-8.

Molecular formula: C₁₉H₁₈ClN₃O₅S.

Molecular weight: 435.88.

EC number: 685-132-2.

It is a white to off-white crystalline powder with a melting point of about 228–232 °C.

It is soluble in dimethyl sulfoxide (DMSO) and slightly soluble in water; the predicted density is about 1.46 g/cm³.

It directly inhibits free and clot-bound Factor Xa, reducing thrombin generation without requiring antithrombin III as a cofactor.

It is used as an API in oral anticoagulant solid-dosage medicines for DVT and PE treatment and stroke risk reduction in nonvalvular atrial fibrillation.

It is also used for VTE prevention after hip or knee replacement surgery.

Rivaroxaban is supplied as the pure (S)-enantiomer; control enantiomeric purity and polymorphic form because they affect bioavailability, stability and dosage-form consistency.

Confirm identity, assay, related substances, residual solvents, water content, particle size and enantiomeric purity for the intended formulation.

Store in tightly closed containers under cool, dry, light-protected conditions; many supplier specifications recommend 2–8 °C or an inert atmosphere. Handle with qualified procedures and suitable PPE.

Confirm the current product-specific specification.

Confirm packaging with the requested quantity and destination requirements.

Document requirements should be confirmed from the current specification, SDS, COA or other product-specific files.

The page is an RFQ entry point and does not state stock, price, MOQ or fixed lead time.

For an RFQ, state the intended use, required specification, quantity, packaging, destination and document needs.

FAQ - Technical & Supply Chain

Q:
What is Rivaroxaban CAS 366789-02-8?

A: Rivaroxaban is a direct, selective Factor Xa inhibitor supplied as an oral anticoagulant pharmaceutical API. Its molecular formula is C₁₉H₁₈ClN₃O₅S and its molecular weight is about 435.88 g/mol.
Q:
How does Rivaroxaban prevent blood clots?

A: It directly inhibits free and clot-bound Factor Xa, reducing thrombin generation without requiring antithrombin III as a cofactor. This interrupts the coagulation cascade and lowers the risk of venous and arterial thrombus formation.
Q:
What is Rivaroxaban API used to manufacture?

A: Rivaroxaban is used to manufacture oral anticoagulant solid-dosage medicines for DVT and PE treatment, stroke risk reduction in nonvalvular atrial fibrillation, and VTE prevention after hip or knee replacement surgery.
Q:
Why is the (S)-enantiomer important for Rivaroxaban?

A: Rivaroxaban is supplied as the pure (S)-enantiomer, which is the pharmacologically active form of the molecule. Enantiomeric purity and polymorphic form should be controlled because they can affect bioavailability, stability and consistency of the final dosage form.
Q:
How should Rivaroxaban API be stored and handled?

A: Store in tightly closed containers under cool, dry, light-protected conditions; many supplier specifications recommend 2–8 °C or an inert atmosphere. Handle as a potent pharmaceutical material using qualified procedures and appropriate personal protective equipment.

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