What is Rivaroxaban CAS 366789-02-8?

Rivaroxaban is a direct, selective Factor Xa inhibitor supplied as an oral anticoagulant pharmaceutical API. Its molecular formula is C19H18ClN3O5S and its molecular weight is about 435.88 g/mol.

How does Rivaroxaban prevent blood clots?

It directly inhibits free and clot-bound Factor Xa, reducing thrombin generation without requiring antithrombin III as a cofactor. This interrupts the coagulation cascade and lowers the risk of venous and arterial thrombus formation.

What is Rivaroxaban API used to manufacture?

Rivaroxaban is used to manufacture oral anticoagulant solid-dosage medicines for DVT and PE treatment, stroke risk reduction in nonvalvular atrial fibrillation, and VTE prevention after hip or knee replacement surgery.

Why is the (S)-enantiomer important for Rivaroxaban?

Rivaroxaban is supplied as the pure (S)-enantiomer, which is the pharmacologically active form of the molecule. Enantiomeric purity and polymorphic form should be controlled because they can affect bioavailability, stability and consistency of the final dosage form.

How should Rivaroxaban API be stored and handled?

Store in tightly closed containers under cool, dry, light-protected conditions; many supplier specifications recommend 2-8 deg C or an inert atmosphere. Handle as a potent pharmaceutical material using qualified procedures and appropriate personal protective equipment.

Rivaroxaban CAS 366789-02-8

Rivaroxaban (CAS 366789-02-8), chemically identified as an oxazolidinone derivative, is a potent, direct Factor Xa inhibitor utilized as an active pharmaceutical ingredient (API). Often referred to by its development code BAY 59-7939, this crystalline powder functions by interrupting the intrinsic and extrinsic pathways of the blood coagulation cascade, preventing thrombin generation. It is extensively utilized as the primary bioactive component in the industrial manufacturing of oral anticoagulant formulations for thrombosis prevention and stroke risk reduction. We provide this industrial material with competitive factory pricing to support continuous manufacturing operations, alongside options for customized specifications. Essential technical documentation, including MSDS, TDS, COA, is readily available for all bulk supply orders.

CAS: 366789-02-8
Synonyms: Rivaroxabanum, BAY 59-7939, (S)-Rivaroxaban
Einecs: 685-132-2
Molecular Formula: C19H18ClN3O5S
Grade: Pharmaceutical Grade
Package: 25 kg/drum

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Product Description

Rivaroxaban (CAS 366789-02-8) is an oral anticoagulant used to prevent and treat blood clots, particularly in conditions such as deep vein thrombosis (DVT), pulmonary embolism (PE), and to reduce the risk of stroke in patients with atrial fibrillation. It works by inhibiting factor Xa, a key component in the blood clotting process, helping to prevent the formation of harmful clots.

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1 Physicochemical Properties:

2 Applications:

3 Storage Conditions:

4 Safety Precautions:

Physicochemical Properties:

Property	Value
Appearance	White to off-white crystalline powder
Melting Point	228–232°C
Solubility	Soluble in dimethyl sulfoxide (DMSO), slightly soluble in water
Bulk Density	1.46 ± 0.06 g/cm³ (predicted)
Purity	≥98%
Particle Size	≥99% passes through 100 mesh sieve
Boiling Point	732.6 ± 60.0°C (predicted)
pH	5.5–7.5 (1% solution)

Applications:

Prevention and treatment of deep vein thrombosis (DVT)
Pulmonary embolism (PE) treatment
Stroke prevention in patients with atrial fibrillation
Used in the prevention of venous thromboembolism after orthopedic surgeries
Management of blood clotting disorders in certain patients

Storage Conditions:

Store in a cool, dry place, away from direct sunlight and moisture
Keep container tightly closed when not in use
Ideal storage temperature: 2°C to 8°C (Refrigeration recommended)

Safety Precautions:

Handling: Handle with care, use appropriate personal protective equipment (PPE) such as gloves and protective eyewear.
Inhalation and Skin Contact: Avoid inhaling dust or vapor. In case of skin contact, wash thoroughly with soap and water.
Disposal: Dispose of unused or expired material in accordance with local regulations.
Toxicity: Use under medical supervision; overuse can lead to bleeding complications.
Precaution: Always consult with a healthcare provider before use, especially in patients with liver or kidney disorders.

FAQ - Technical & Supply Chain

Q:
What is Rivaroxaban CAS 366789-02-8?

A: Rivaroxaban is a direct, selective Factor Xa inhibitor supplied as an oral anticoagulant pharmaceutical API. Its molecular formula is C19H18ClN3O5S and its molecular weight is about 435.88 g/mol.
Q:
How does Rivaroxaban prevent blood clots?

A: It directly inhibits free and clot-bound Factor Xa, reducing thrombin generation without requiring antithrombin III as a cofactor. This interrupts the coagulation cascade and lowers the risk of venous and arterial thrombus formation.
Q:
What is Rivaroxaban API used to manufacture?

A: Rivaroxaban is used to manufacture oral anticoagulant solid-dosage medicines for DVT and PE treatment, stroke risk reduction in nonvalvular atrial fibrillation, and VTE prevention after hip or knee replacement surgery.
Q:
Why is the (S)-enantiomer important for Rivaroxaban?

A: Rivaroxaban is supplied as the pure (S)-enantiomer, which is the pharmacologically active form of the molecule. Enantiomeric purity and polymorphic form should be controlled because they can affect bioavailability, stability and consistency of the final dosage form.
Q:
How should Rivaroxaban API be stored and handled?

A: Store in tightly closed containers under cool, dry, light-protected conditions; many supplier specifications recommend 2-8 deg C or an inert atmosphere. Handle as a potent pharmaceutical material using qualified procedures and appropriate personal protective equipment.

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