• Rivaroxaban CAS 366789-02-8
  • Rivaroxaban CAS 366789-02-8

Rivaroxaban CAS 366789-02-8

Rivaroxaban (CAS 366789-02-8), chemically identified as an oxazolidinone derivative, is a potent, direct Factor Xa inhibitor utilized as an active pharmaceutical ingredient (API). Often referred to by its development code BAY 59-7939, this crystalline powder functions by interrupting the intrinsic and extrinsic pathways of the blood coagulation cascade, preventing thrombin generation. It is extensively utilized as the primary bioactive component in the industrial manufacturing of oral anticoagulant formulations for thrombosis prevention and stroke risk reduction. We provide this industrial material with competitive factory pricing to support continuous manufacturing operations, alongside options for customized specifications. Essential technical documentation, including MSDS, TDS, COA, is readily available for all bulk supply orders.

  • CAS: 366789-02-8
  • Synonyms: Rivaroxabanum, BAY 59-7939, (S)-Rivaroxaban
  • Einecs: 603-456-8
  • Molecular Formula: C19H18Cl3N3O4S
  • Grade: Pharmaceutical Grade
  • Package: 25 kg/drum
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Product Description

Rivaroxaban (CAS 366789-02-8) is an oral anticoagulant used to prevent and treat blood clots, particularly in conditions such as deep vein thrombosis (DVT), pulmonary embolism (PE), and to reduce the risk of stroke in patients with atrial fibrillation. It works by inhibiting factor Xa, a key component in the blood clotting process, helping to prevent the formation of harmful clots.

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Physicochemical Properties:

PropertyValue
AppearanceWhite to off-white crystalline powder
Melting Point180–182°C
SolubilitySoluble in dimethyl sulfoxide (DMSO), slightly soluble in water
Bulk Density1.2–1.3 g/cm³
Purity≥98%
Particle Size≥99% passes through 100 mesh sieve
Boiling Point499°C
pH5.5–7.5 (1% solution)

Applications:

  • Prevention and treatment of deep vein thrombosis (DVT)
  • Pulmonary embolism (PE) treatment
  • Stroke prevention in patients with atrial fibrillation
  • Used in the prevention of venous thromboembolism after orthopedic surgeries
  • Management of blood clotting disorders in certain patients

Storage Conditions:

  • Store in a cool, dry place, away from direct sunlight and moisture
  • Keep container tightly closed when not in use
  • Ideal storage temperature: 2°C to 8°C (Refrigeration recommended)

Safety Precautions:

  • Handling: Handle with care, use appropriate personal protective equipment (PPE) such as gloves and protective eyewear.
  • Inhalation and Skin Contact: Avoid inhaling dust or vapor. In case of skin contact, wash thoroughly with soap and water.
  • Disposal: Dispose of unused or expired material in accordance with local regulations.
  • Toxicity: Use under medical supervision; overuse can lead to bleeding complications.
  • Precaution: Always consult with a healthcare provider before use, especially in patients with liver or kidney disorders.

FAQ - Technical & Supply Chain

  • Q:

    Is CAS 366789-02-8 the correct registry number for the anticoagulant Rivaroxaban?

    A: Yes, CAS 366789-02-8 uniquely identifies Rivaroxaban, the direct Factor Xa inhibitor used as an Active Pharmaceutical Ingredient (API).
  • Q:

    Is this product intended for the formulation of oral solid dosage forms?

    A: Yes, this API grade is typically applied in the compounding and tableting processes for manufacturing finished oral anticoagulant medications.
Documents

Documents and Product Support

For product review and sourcing evaluation, supporting documents can be coordinated according to the product type, inquiry stage, and order requirements.

  • COA for batch-based quality reference
  • TDS for key physical and chemical information
  • SDS / MSDS for handling, storage, and safety reference
  • Packing information for sample, trial, and bulk orders
  • Technical communication based on application and specification requirements
Quotation

Information to Confirm Before Quotation

Clear sourcing information helps reduce specification mismatch and allows a more accurate quotation before sample or bulk order discussion.

  • Product name and CAS number
  • Application or intended end use
  • Required purity, grade, or specification
  • Sample quantity, trial order, or bulk demand
  • Preferred packing form or net weight
  • Destination country or port
  • Required documents or compliance expectations
Storage & Handling

Packaging, Storage, and Handling Notes

Packaging form, storage conditions, shelf life, and shipment arrangements should be confirmed according to the product characteristics, package size, and destination requirements.

Before order confirmation, buyers are advised to review the corresponding product documents and confirm whether any special storage, labeling, or handling requirements apply.

Supply Support

Sample, Bulk Order and Repeat Supply Support

Support can be arranged for sample discussion, bulk supply planning, packaging confirmation, and routine sourcing communication based on the actual product and order requirements.

For repeat-use formulations or long-term procurement plans, buyers may discuss specification consistency, packaging preferences, delivery expectations, and document coordination in advance.

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