What is Agomelatine CAS 138112-76-2?

Agomelatine is a naphthalene-based melatonin analogue supplied as a pharmaceutical API. Its molecular formula is C₁₅H₁₇NO₂ and its molecular weight is about 243.30 g/mol.

How does Agomelatine work?

Agomelatine acts as an agonist at melatonin MT1 and MT2 receptors and as an antagonist at the 5-HT2C receptor. This dual action helps regulate circadian rhythm and supports antidepressant activity.

What is Agomelatine used for?

It is used in the manufacture of oral medicines for major depressive disorder. The API is also relevant to formulations intended to improve sleep-wake rhythm and mood regulation.

Is S-20098 the same as Agomelatine?

Yes. S-20098 is the developmental code name for agomelatine, so it refers to the same compound under CAS 138112-76-2. It should not be confused with agomelatine hydrochloride or other salt forms.

How should Agomelatine API be stored and handled?

Store tightly closed at 2–8 °C in a cool, dry, light-protected area as recommended by most pharmaceutical supplier data. Handle with qualified procedures and protect from moisture and contamination.

Agomelatine CAS 138112-76-2

Agomelatine (CAS 138112-76-2) is a naphthalene-based melatonin analogue supplied as an Active Pharmaceutical Ingredient (API) for antidepressant formulations. Confirm the required grade, then request a quotation with COA/TDS/SDS for bulk supply.

CAS: 138112-76-2
Synonyms: Agomelatina, S-20098, N-[2-(7-methoxy-1-naphthyl)ethyl]acetamide, N-[2-(7-methoxynaphthalen-1-yl)ethyl]acetamide
Einecs: 629-727-7
Molecular Formula: C₁₅H₁₇NO₂
Grade: Pharmaceutical Grade
Package: 25 kg/drum

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Product Description

Agomelatine, CAS 138112-76-2, is a naphthalene-based melatonin analogue supplied as an Active Pharmaceutical Ingredient (API); the EC/EINECS number is 629-727-7.

Synonyms: Agomelatina; S-20098; N-[2-(7-methoxy-1-naphthyl)ethyl]acetamide; N-[2-(7-methoxynaphthalen-1-yl)ethyl]acetamide.

CAS: 138112-76-2.

Molecular formula: C₁₅H₁₇NO₂.

Molecular weight: 243.30.

EC number: 629-727-7.

It is a white to off-white crystalline powder with a melting point of about 107–109 °C.

It is soluble in methanol and ethanol and slightly soluble in water; the predicted density is about 1.109 g/cm³.

It acts as an agonist at melatonin MT1 and MT2 receptors and as an antagonist at the 5-HT2C receptor.

It is used as an API in oral formulations for major depressive disorder (MDD).

It is also relevant to formulations intended to improve sleep-wake rhythm and mood regulation.

Unlike SSRIs and SNRIs, its melatonergic and 5-HT2C profile is distinct; confirm the intended salt form and pharmacopoeial grade.

Confirm identity, assay, related substances, residual solvents, water content, particle size and polymorphic form for the intended formulation.

Store tightly closed at 2–8 °C in a cool, dry, light-protected area; handle with qualified procedures and protect from moisture and contamination.

Confirm the current product-specific specification.

Confirm packaging with the requested quantity and destination requirements.

Document requirements should be confirmed from the current specification, SDS, COA or other product-specific files.

The page is an RFQ entry point and does not state stock, price, MOQ or fixed lead time.

For an RFQ, state the intended use, required specification, quantity, packaging, destination and document needs.

FAQ - Technical & Supply Chain

Q:
What is Agomelatine CAS 138112-76-2?

A: Agomelatine is a naphthalene-based melatonin analogue supplied as a pharmaceutical API. Its molecular formula is C₁₅H₁₇NO₂ and its molecular weight is about 243.30 g/mol.
Q:
How does Agomelatine work?

A: Agomelatine acts as an agonist at melatonin MT1 and MT2 receptors and as an antagonist at the 5-HT2C receptor. This dual action helps regulate circadian rhythm and supports antidepressant activity.
Q:
What is Agomelatine used for?

A: It is used in the manufacture of oral medicines for major depressive disorder. The API is also relevant to formulations intended to improve sleep-wake rhythm and mood regulation.
Q:
Is S-20098 the same as Agomelatine?

A: Yes. S-20098 is the developmental code name for agomelatine, so it refers to the same compound under CAS 138112-76-2. It should not be confused with agomelatine hydrochloride or other salt forms.
Q:
How should Agomelatine API be stored and handled?

A: Store tightly closed at 2–8 °C in a cool, dry, light-protected area as recommended by most pharmaceutical supplier data. Handle with qualified procedures and protect from moisture and contamination.

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