What is Agomelatine CAS 138112-76-2?

Agomelatine is a naphthalene-based melatonin analogue supplied as a pharmaceutical API. Its molecular formula is C15H17NO2 and its molecular weight is about 243.30 g/mol.

How does Agomelatine work?

Agomelatine acts as an agonist at melatonin MT1 and MT2 receptors and as an antagonist at the 5-HT2C receptor. This dual action helps regulate circadian rhythm and supports antidepressant activity.

What is Agomelatine used for?

It is used in the manufacture of oral medicines for major depressive disorder. The API is also relevant to formulations intended to improve sleep-wake rhythm and mood regulation.

Is S-20098 the same as Agomelatine?

Yes. S-20098 is the developmental code name for agomelatine, so it refers to the same compound under CAS 138112-76-2. It should not be confused with agomelatine hydrochloride or other salt forms.

How should Agomelatine API be stored and handled?

Store tightly closed at 2-8 deg C in a cool, dry, light-protected area as recommended by most pharmaceutical supplier data. Handle with qualified procedures and protect from moisture and contamination.

Agomelatine CAS 138112-76-2

Agomelatine (CAS 138112-76-2), chemically identified as N-[2-(7-methoxy-1-naphthyl)ethyl]acetamide, is a naphthalene analog of melatonin functioning as a potent melatonergic agonist (MT1/MT2) and 5-HT2C antagonist. Often referred to by its development code S-20098, this crystalline powder exhibits a unique pharmacological profile distinct from SSRIs and SNRIs. It is extensively utilized as the primary Active Pharmaceutical Ingredient (API) in the manufacturing of antidepressant formulations intended for the treatment of Major Depressive Disorder (MDD). We provide this industrial material with competitive factory pricing to support continuous manufacturing operations, alongside options for customized specifications. Essential technical documentation, including MSDS, TDS, COA, is readily available for all bulk supply orders.

CAS: 138112-76-2
Synonyms: Agomelatina, S-20098, N-[2-(7-methoxy-1-naphthyl)ethyl]acetamide, N-[2-(7-methoxynaphthalen-1-yl)ethyl]acetamide
Einecs: 629-727-7
Molecular Formula: C15H17NO2
Grade: Pharmaceutical Grade
Package: 25 kg/drum

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Product Description

Agomelatine (CAS 138112-76-2) is an antidepressant used primarily for the treatment of major depressive disorder (MDD). It is known for its unique mechanism of action, which involves melatonin receptors and serotonin receptors, helping to regulate mood and improve sleep patterns in patients with depression.

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1 Physicochemical Properties:

2 Applications:

3 Storage Conditions:

4 Safety Precautions:

Physicochemical Properties:

Property	Value
Appearance	White to off-white crystalline powder
Melting Point	107–109°C
Solubility	Soluble in methanol and ethanol, slightly soluble in water
Density	1.109 ± 0.06 g/cm³ (predicted)
Purity	≥99%
Boiling Point	Not available
pH (1% solution)	4.0–5.0
Storage Temperature	2°C to 8°C (Refrigeration recommended)

Applications:

Used as an antidepressant for the treatment of major depressive disorder (MDD)
Helps regulate sleep-wake cycles in patients with sleep disturbances
Effective in improving mood and reducing symptoms of depression
Can be used to improve quality of sleep and manage circadian rhythm disorders

Storage Conditions:

Store in a cool, dry place, away from direct sunlight
Keep container tightly closed when not in use
Store at temperatures between 2°C and 8°C (Refrigeration recommended)

Safety Precautions:

Handling: Handle with care and avoid exposure to moisture and light.
Personal Protective Equipment (PPE): Wear appropriate gloves and safety glasses when handling the product.
Storage: Ensure the product is stored in a tightly sealed container, away from incompatible materials, and avoid any exposure to heat or moisture.
Disposal: Follow local regulations for disposal of pharmaceutical chemicals.

FAQ - Technical & Supply Chain

Q:
What is Agomelatine CAS 138112-76-2?

A: Agomelatine is a naphthalene-based melatonin analogue supplied as a pharmaceutical API. Its molecular formula is C15H17NO2 and its molecular weight is about 243.30 g/mol.
Q:
How does Agomelatine work?

A: Agomelatine acts as an agonist at melatonin MT1 and MT2 receptors and as an antagonist at the 5-HT2C receptor. This dual action helps regulate circadian rhythm and supports antidepressant activity.
Q:
What is Agomelatine used for?

A: It is used in the manufacture of oral medicines for major depressive disorder. The API is also relevant to formulations intended to improve sleep-wake rhythm and mood regulation.
Q:
Is S-20098 the same as Agomelatine?

A: Yes. S-20098 is the developmental code name for agomelatine, so it refers to the same compound under CAS 138112-76-2. It should not be confused with agomelatine hydrochloride or other salt forms.
Q:
How should Agomelatine API be stored and handled?

A: Store tightly closed at 2-8 deg C in a cool, dry, light-protected area as recommended by most pharmaceutical supplier data. Handle with qualified procedures and protect from moisture and contamination.

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COA, TDS, SDS/MSDS and packing details are available on request.

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