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    HomeProductsLife SciencePharmaceuticalAgomelatine CAS 138112-76-2
    • Agomelatine CAS 138112-76-2
    • Agomelatine CAS 138112-76-2

    Agomelatine CAS 138112-76-2

    Agomelatine (CAS 138112-76-2), chemically identified as N-[2-(7-methoxy-1-naphthyl)ethyl]acetamide, is a naphthalene analog of melatonin functioning as a potent melatonergic agonist (MT1/MT2) and 5-HT2C antagonist. Often referred to by its development code S-20098, this crystalline powder exhibits a unique pharmacological profile distinct from SSRIs and SNRIs. It is extensively utilized as the primary Active Pharmaceutical Ingredient (API) in the manufacturing of antidepressant formulations intended for the treatment of Major Depressive Disorder (MDD). We provide this industrial material with competitive factory pricing to support continuous manufacturing operations, alongside options for customized specifications. Essential technical documentation, including MSDS, TDS, COA, is readily available for all bulk supply orders.

    • CAS: 138112-76-2
    • Synonyms: Agomelatina, S-20098, N-[2-(7-methoxy-1-naphthyl)ethyl]acetamide, N-[2-(7-methoxynaphthalen-1-yl)ethyl]acetamide
    • Einecs: 611-111-9
    • Molecular Formula: C15H17N1O2
    • Grade: Pharmaceutical Grade
    • Package: 25 kg/drum
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    Product Description

    Agomelatine (CAS 138112-76-2) is an antidepressant used primarily for the treatment of major depressive disorder (MDD). It is known for its unique mechanism of action, which involves melatonin receptors and serotonin receptors, helping to regulate mood and improve sleep patterns in patients with depression.

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    1 Physicochemical Properties:
    2 Applications:
    3 Storage Conditions:
    4 Safety Precautions:

    Physicochemical Properties:

    PropertyValue
    AppearanceWhite to off-white crystalline powder
    Melting Point145–150°C
    SolubilitySoluble in methanol and ethanol, slightly soluble in water
    Density1.2–1.3 g/cm³
    Purity≥99%
    Boiling PointNot available
    pH (1% solution)4.0–5.0
    Storage Temperature2°C to 8°C (Refrigeration recommended)

    Applications:

    • Used as an antidepressant for the treatment of major depressive disorder (MDD)
    • Helps regulate sleep-wake cycles in patients with sleep disturbances
    • Effective in improving mood and reducing symptoms of depression
    • Can be used to improve quality of sleep and manage circadian rhythm disorders

    Storage Conditions:

    • Store in a cool, dry place, away from direct sunlight
    • Keep container tightly closed when not in use
    • Store at temperatures between 2°C and 8°C (Refrigeration recommended)

    Safety Precautions:

    • Handling: Handle with care and avoid exposure to moisture and light.
    • Personal Protective Equipment (PPE): Wear appropriate gloves and safety glasses when handling the product.
    • Storage: Ensure the product is stored in a tightly sealed container, away from incompatible materials, and avoid any exposure to heat or moisture.
    • Disposal: Follow local regulations for disposal of pharmaceutical chemicals.

    FAQ - Technical & Supply Chain

    • Q:

      Is the code S-20098 synonymous with Agomelatine CAS 138112-76-2?

      A: Yes, S-20098 is the original laboratory development code for Agomelatine, referring to the exact same chemical entity used in pharmaceutical production.
    • Q:

      Is this API grade suitable for tableting processes?

      A: Yes, this material is typically processed into solid oral dosage forms, utilized for its dual mechanism of action in resynchronizing circadian rhythms.
    Documents

    Documents and Product Support

    For product review and sourcing evaluation, supporting documents can be coordinated according to the product type, inquiry stage, and order requirements.

    • COA for batch-based quality reference
    • TDS for key physical and chemical information
    • SDS / MSDS for handling, storage, and safety reference
    • Packing information for sample, trial, and bulk orders
    • Technical communication based on application and specification requirements
    Quotation

    Information to Confirm Before Quotation

    Clear sourcing information helps reduce specification mismatch and allows a more accurate quotation before sample or bulk order discussion.

    • Product name and CAS number
    • Application or intended end use
    • Required purity, grade, or specification
    • Sample quantity, trial order, or bulk demand
    • Preferred packing form or net weight
    • Destination country or port
    • Required documents or compliance expectations
    Storage & Handling

    Packaging, Storage, and Handling Notes

    Packaging form, storage conditions, shelf life, and shipment arrangements should be confirmed according to the product characteristics, package size, and destination requirements.

    Before order confirmation, buyers are advised to review the corresponding product documents and confirm whether any special storage, labeling, or handling requirements apply.

    Supply Support

    Sample, Bulk Order and Repeat Supply Support

    Support can be arranged for sample discussion, bulk supply planning, packaging confirmation, and routine sourcing communication based on the actual product and order requirements.

    For repeat-use formulations or long-term procurement plans, buyers may discuss specification consistency, packaging preferences, delivery expectations, and document coordination in advance.

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    Tags:

    Aromatic Amide Life Science Chemical Melatonin Receptor Compound Pharmaceutical Ingredient

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