What is Artemisinin CAS 63968-64-9?

CAS 63968-64-9 is artemisinin, a sesquiterpene lactone originally isolated from Artemisia annua. It is also known as qinghaosu or arteannuin and has the molecular formula C15H22O5 with a molecular weight of about 282.33.

How does artemisinin differ from artesunate and artemether?

Artemisinin CAS 63968-64-9 is the parent natural product, while artesunate and artemether are semi-synthetic derivatives with different CAS numbers, solubility, and formulation profiles. Artemisinin is usually the starting material that is converted into those derivative APIs.

What are the main pharmaceutical applications?

It is used as an antimalarial API and as the precursor for artemisinin-based combination therapies, dihydroartemisinin, artesunate, and artemether. It is also studied in oncology research for endoperoxide-mediated activity and used in selected veterinary antiparasitic formulations.

What are the key specifications of the pharmaceutical grade?

The pharmaceutical grade is a white needle-like crystalline powder with an HPLC assay of 99.0-101.0%, specific rotation of about +75 to +78 degrees, and melting point around 150-153 C. Related substances, loss on drying, and heavy metals are controlled to pharmacopoeial limits.

What is the solubility profile of Artemisinin CAS 63968-64-9?

Artemisinin is practically insoluble in water and soluble in organic solvents such as chloroform, acetone, ethyl acetate, methanol, and DMSO. This low aqueous solubility is one reason it is commonly converted to more soluble derivatives for finished pharmaceutical formulations.

Artemisinin CAS 63968-64-9

Artemisinin CAS 63968-64-9 is a naturally occurring sesquiterpene lactone that serves as a high-purity API & Intermediates component for global pharmaceutical manufacturing. Within industrial medicinal chemistry, this qinghaosu functions as the foundational raw material for the semi-synthesis of critical derivatives such as dihydroartemisinin and artemether. This arteannuin is characterized by its unique endoperoxide bridge, which is the core structural element responsible for its reactive oxygen species (ROS) generation during metabolic activation, while huanghuahaosu is refined through standardized extraction and crystallization processes to ensure consistent potency for large-scale antimalarial production. The industrial theanine-like crystalline structure of artemisinine facilitates stable handling in dry-formulations and capsule manufacturing environments. We provide bulk supply with competitive factory pricing to pharmaceutical partners worldwide, ensuring all shipments are validated with MSDS, TDS, COA and we offer customized specifications regarding purity levels and particle size to meet global pharmacopeia standards.

CAS: 63968-64-9
Synonyms: Qinghaosu, Arteannuin, Artemisinine, Huanghuahaosu, Octahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10(3H)-one
Einecs: 1308068-626-2
Molecular Formula: C15H22O5
Grade: Pharmaceutical Grade / USP / EP / CP
Package: 25kg/drum, 1kg/bag, or customized bulk supply

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Product Description

1 Technical Data (Physicochemical Properties)

2 Applications

3 Storage & Safety

4 Quality Assurance

Technical Data (Physicochemical Properties)

Property Category	Parameter	Specification (Pharma Grade)
Physical State	Appearance	White needle-like crystalline powder
	Odor	Practically odorless
Purity Analysis	Assay (HPLC)	99.0% – 101.0%
	Specific Rotation	+75° to +78°
	Melting Point	150°C – 153°C
Purity Control	Loss on Drying	<= 0.5%
	Residue on Ignition	<= 0.1%
	Related Substances	Individual <= 0.2%; Total <= 0.5%
Contaminants	Heavy Metals	<= 10 ppm
	Arsenic (As)	<= 2 ppm
Solubility	Water Solubility	Practically insoluble
	Organic Solubility	Soluble in chloroform, acetone, ethyl acetate

Applications

Antimalarial API: Used as the primary therapeutic agent and raw material for the production of ACTs (Artemisinin-based Combination Therapies).
Pharmaceutical Intermediates: Acts as the starting material for the synthesis of dihydroartemisinin (DHA), artesunate, and artemether.
Oncology Research: Utilized as an industrial research chemical for exploring endoperoxide-mediated cytotoxicity in specific cancer cell lines.
Veterinary Medicine: Applied in the formulation of anti-parasitic treatments for specialized livestock and companion animal health.

Storage & Safety

Storage: Store in a cool, dry, and well-ventilated warehouse. Keep containers tightly closed and protected from light, as the endoperoxide bridge is sensitive to degradation. Recommended storage temperature is 2°C – 8°C for long-term stability.
Safety Operations (PPE): Wear standard laboratory protective gear, including chemical-resistant gloves, safety goggles, and a dust-filtering mask.
Handling: Avoid generating dust during bulk transfer. Ensure the work area is equipped with appropriate local exhaust ventilation to maintain exposure below recommended industrial limits.

Quality Assurance

Our extraction and purification facility operates under strict GMP-aligned protocols to ensure the highest pharmaceutical integrity. We utilize High-Performance Liquid Chromatography (HPLC) for precise assay determination and Gas Chromatography (GC) for residual solvent monitoring. Each batch of Artemisinin is subjected to full spectrum analysis, including IR and NMR, to confirm molecular identity and chiral purity, providing a transparent traceability chain for international pharmaceutical procurement and regulatory audits.

FAQ - Technical & Supply Chain

Q:
What is Artemisinin CAS 63968-64-9?

A: CAS 63968-64-9 is artemisinin, a sesquiterpene lactone originally isolated from Artemisia annua. It is also known as qinghaosu or arteannuin and has the molecular formula C15H22O5 with a molecular weight of about 282.33.
Q:
How does artemisinin differ from artesunate and artemether?

A: Artemisinin CAS 63968-64-9 is the parent natural product, while artesunate and artemether are semi-synthetic derivatives with different CAS numbers, solubility, and formulation profiles. Artemisinin is usually the starting material that is converted into those derivative APIs.
Q:
What are the main pharmaceutical applications?

A: It is used as an antimalarial API and as the precursor for artemisinin-based combination therapies, dihydroartemisinin, artesunate, and artemether. It is also studied in oncology research for endoperoxide-mediated activity and used in selected veterinary antiparasitic formulations.
Q:
What are the key specifications of the pharmaceutical grade?

A: The pharmaceutical grade is a white needle-like crystalline powder with an HPLC assay of 99.0-101.0%, specific rotation of about +75 to +78 degrees, and melting point around 150-153 C. Related substances, loss on drying, and heavy metals are controlled to pharmacopoeial limits.
Q:
What is the solubility profile of Artemisinin CAS 63968-64-9?

A: Artemisinin is practically insoluble in water and soluble in organic solvents such as chloroform, acetone, ethyl acetate, methanol, and DMSO. This low aqueous solubility is one reason it is commonly converted to more soluble derivatives for finished pharmaceutical formulations.

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