What is Atracurium Besylate CAS 64228-81-5?

Atracurium besylate is the bis-benzenesulfonate salt of atracurium, an active pharmaceutical ingredient used as a non-depolarizing neuromuscular blocker. Its molecular formula is C₆₅H₈₂N₂O₁₈S₂ and its molecular weight is about 1243.48.

How does Atracurium Besylate differ from Cisatracurium Besylate?

Atracurium besylate is a mixture of stereoisomers, while cisatracurium besylate is the purified 1R-cis,1R'-cis isomer. They have different CAS numbers and clinical profiles; atracurium besylate is identified by CAS 64228-81-5.

What are key physical properties of Atracurium Besylate API?

It is a white to off-white, slightly hygroscopic powder with a melting point around 85-90 °C and water solubility around 27 mg/mL. Store at 2-8 °C and protect from moisture.

Why is Atracurium Besylate stored at 2-8 C and protected from moisture?

Atracurium besylate is slightly hygroscopic and can degrade if exposed to moisture or warmer temperatures. Refrigerated storage at 2–8 °C with tightly closed containers helps preserve API assay, related-substance profile and injectable-formulation quality.

Atracurium Besylate CAS 64228-81-5

Atracurium Besylate (CAS 64228-81-5) is a bis-benzylisoquinolinium diester supplied as an Active Pharmaceutical Ingredient (API) for non-depolarizing neuromuscular blocking formulations. Confirm the required grade, then request a quotation with COA/TDS/SDS for bulk supply.

CAS: 64228-81-5
Synonyms: Atracurium besilate, Atracurium API
Einecs: 264-743-4
Molecular Formula: C₆₅H₈₂N₂O₁₈S₂
Grade: Pharmaceutical Grade
Package: 25 kg/drum

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Product Description

Atracurium Besylate, CAS 64228-81-5, is a bis-benzylisoquinolinium diester neuromuscular blocker supplied as an Active Pharmaceutical Ingredient (API); the EC/EINECS number is 264-743-4.

Synonyms: Atracurium besilate; Atracurium API.

CAS: 64228-81-5.

Molecular formula: C₆₅H₈₂N₂O₁₈S₂.

Molecular weight: 1243.48.

EC number: 264-743-4.

It is a white to off-white, slightly hygroscopic powder; the melting point is about 85–90 °C and the water solubility about 27 mg/mL.

It is a mixture of stereoisomers of a non-depolarizing neuromuscular blocking agent; cisatracurium besylate is the purified 1R-cis,1R′-cis isomer.

It is used as an API in injectable formulations for skeletal muscle relaxation during general anesthesia, mechanical ventilation and endotracheal intubation.

It acts as a nicotinic acetylcholine receptor antagonist and undergoes Hofmann elimination under physiological conditions.

It is handled within controlled pharmaceutical environments as an intermediate for anesthesia adjunct formulations.

Confirm identity, assay, related substances, residual solvents, water content, pH and endotoxin profile for the intended formulation.

Store at 2–8 °C in tightly closed containers, protected from light and moisture.

Handle under controlled conditions with suitable PPE; follow the current SDS for spill, disposal and first aid.

Confirm the current product-specific specification.

Confirm packaging with the requested quantity and destination requirements.

Document requirements should be confirmed from the current specification, SDS, COA or other product-specific files.

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FAQ - Technical & Supply Chain

Q:
What is Atracurium Besylate CAS 64228-81-5?

A: Atracurium besylate is the bis-benzenesulfonate salt of atracurium, an active pharmaceutical ingredient used as a non-depolarizing neuromuscular blocker. Its molecular formula is C₆₅H₈₂N₂O₁₈S₂ and its molecular weight is about 1243.48.
Q:
What is Atracurium Besylate used for?

A: It is used in injectable pharmaceutical formulations to provide skeletal muscle relaxation during general anesthesia, mechanical ventilation, and endotracheal intubation. It acts as a nicotinic acetylcholine receptor antagonist.
Q:
How does Atracurium Besylate differ from Cisatracurium Besylate?

A: Atracurium besylate is a mixture of stereoisomers, while cisatracurium besylate is the purified 1R-cis,1R'-cis isomer. They have different CAS numbers and clinical profiles; atracurium besylate is identified by CAS 64228-81-5.
Q:
What are key physical properties of Atracurium Besylate API?

A: It is a white to off-white, slightly hygroscopic powder with a melting point around 85-90 °C and water solubility around 27 mg/mL. Store at 2-8 °C and protect from moisture.
Q:
Why is Atracurium Besylate stored at 2-8 C and protected from moisture?

A: Atracurium besylate is slightly hygroscopic and can degrade if exposed to moisture or warmer temperatures. Refrigerated storage at 2–8 °C with tightly closed containers helps preserve API assay, related-substance profile and injectable-formulation quality.

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