Atracurium Besylate (CAS 64228-81-5) is a complex bis-benzylisoquinolinium diester utilized strictly as an Active Pharmaceutical Ingredient (API) in the sterile manufacturing of non-depolarizing neuromuscular blocking agents. This bis-quaternary ammonium salt functions as the fundamental chemical precursor for anesthesia adjunct formulations, engineered to undergo Hofmann elimination in physiological conditions. As a specialized intermediate chemical, it is processed within controlled pharmaceutical environments to produce injectable muscle relaxants, ensuring precise potency and degradation profiles. We provide this high-purity raw material with competitive factory pricing to support pharmaceutical formulation development and assure bulk supply continuity for commercial manufacturing. Our technical team accommodates customized specifications for handling and packaging, while all deliveries are fully supported by valid MSDS, TDS, COA documentation.
Atracurium Besylate CAS 64228-81-5
- CAS: 64228-81-5
- Synonyms: Atracurium besilate, 33A74, Atracurium API,
- Einecs: 264-436-2
- Molecular Formula: C22H30N2O4·C6H6O3S
- Grade: Pharmaceutical Grade
- Package: 25 kg/drum
Product Description
Atracurium Besylate (CAS 64228-81-5) is a non-depolarizing muscle relaxant used for general anesthesia. It is commonly utilized in surgical procedures to induce muscle relaxation. This pharmaceutical product is critical in clinical settings for assisting with anesthesia management, ensuring the patient’s muscles are relaxed during surgery without causing prolonged paralysis post-surgery.
Physicochemical Properties:
| Property | Value |
|---|---|
| Appearance | White to pale yellow crystalline powder |
| Molecular Weight | 494.66 g/mol |
| Melting Point | 120–125°C |
| Solubility | Soluble in water, methanol, and ethanol |
| Density | ~1.25 g/cm³ |
| pH (1% solution) | 4.5 – 5.5 |
| Stability | Stable under normal conditions, sensitive to light and moisture |
| Purity | ≥99% |
| Water Content | <5% |
Applications:
- Primarily used as a muscle relaxant during anesthesia
- Used in intensive care for muscle relaxation in intubated patients
- Facilitates endotracheal intubation during surgeries
Storage Conditions:
- Store in a cool, dry place, away from direct sunlight
- Keep the container tightly closed when not in use
- Store at a temperature between 2°C and 8°C (Refrigeration is recommended)
Safety Precautions:
- Handling: Wear appropriate personal protective equipment (PPE) such as gloves and goggles.
- Storage: Keep out of reach of children and pets. Ensure proper ventilation when handling in bulk quantities.
- Disposal: Dispose of any unused or expired product in accordance with local regulations, especially when handling hazardous materials.
FAQ - Technical & Supply Chain
-
Q:
Does CAS 64228-81-5 refer to the free base or the salt form?
A: CAS 64228-81-5 specifically identifies Atracurium Besylate, which is the benzenesulfonate salt form of the molecule, rather than the cationic free base or other salt variations. -
Q:
Is this product suitable for compounding or sterile filling lines?
A: This material is supplied as a raw Active Pharmaceutical Ingredient (API) intended for use in the industrial production of sterile injectable formulations, not as a finished dosage form.
Documents and Product Support
For product review and sourcing evaluation, supporting documents can be coordinated according to the product type, inquiry stage, and order requirements.
- COA for batch-based quality reference
- TDS for key physical and chemical information
- SDS / MSDS for handling, storage, and safety reference
- Packing information for sample, trial, and bulk orders
- Technical communication based on application and specification requirements
Information to Confirm Before Quotation
Clear sourcing information helps reduce specification mismatch and allows a more accurate quotation before sample or bulk order discussion.
- Product name and CAS number
- Application or intended end use
- Required purity, grade, or specification
- Sample quantity, trial order, or bulk demand
- Preferred packing form or net weight
- Destination country or port
- Required documents or compliance expectations
Packaging, Storage, and Handling Notes
Packaging form, storage conditions, shelf life, and shipment arrangements should be confirmed according to the product characteristics, package size, and destination requirements.
Before order confirmation, buyers are advised to review the corresponding product documents and confirm whether any special storage, labeling, or handling requirements apply.
Sample, Bulk Order and Repeat Supply Support
Support can be arranged for sample discussion, bulk supply planning, packaging confirmation, and routine sourcing communication based on the actual product and order requirements.
For repeat-use formulations or long-term procurement plans, buyers may discuss specification consistency, packaging preferences, delivery expectations, and document coordination in advance.
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