Atracurium Besylate (CAS 64228-81-5) is a complex bis-benzylisoquinolinium diester utilized strictly as an Active Pharmaceutical Ingredient (API) in the sterile manufacturing of non-depolarizing neuromuscular blocking agents. This bis-quaternary ammonium salt functions as the fundamental chemical precursor for anesthesia adjunct formulations, engineered to undergo Hofmann elimination in physiological conditions. As a specialized intermediate chemical, it is processed within controlled pharmaceutical environments to produce injectable muscle relaxants, ensuring precise potency and degradation profiles. We provide this high-purity raw material with competitive factory pricing to support pharmaceutical formulation development and assure bulk supply continuity for commercial manufacturing. Our technical team accommodates customized specifications for handling and packaging, while all deliveries are fully supported by valid MSDS, TDS, COA documentation.
Atracurium Besylate CAS 64228-81-5
- CAS: 64228-81-5
- Synonyms: Atracurium besilate, Atracurium API
- Einecs: 264-743-4
- Molecular Formula: C65H82N2O18S2
- Grade: Pharmaceutical Grade
- Package: 25 kg/drum
Product Description
Atracurium Besylate (CAS 64228-81-5) is a non-depolarizing muscle relaxant used for general anesthesia. It is commonly utilized in surgical procedures to induce muscle relaxation. This pharmaceutical product is critical in clinical settings for assisting with anesthesia management, ensuring the patient’s muscles are relaxed during surgery without causing prolonged paralysis post-surgery.
Physicochemical Properties:
| Property | Value |
|---|---|
| Appearance | White to pale yellow crystalline powder |
| Molecular Weight | 1243.48 g/mol |
| Melting Point | 85–90°C |
| Solubility | About 27 mg/mL in water; DMSO >100 mg/mL |
| Density | ~1.25 g/cm³ |
| pH (1% solution) | 4.5 – 5.5 |
| Stability | Stable under normal conditions, sensitive to light and moisture |
| Purity | ≥99% |
| Water Content | <5% |
Applications:
- Primarily used as a muscle relaxant during anesthesia
- Used in intensive care for muscle relaxation in intubated patients
- Facilitates endotracheal intubation during surgeries
Storage Conditions:
- Store in a cool, dry place, away from direct sunlight
- Keep the container tightly closed when not in use
- Store at a temperature between 2°C and 8°C (Refrigeration is recommended)
Safety Precautions:
- Handling: Wear appropriate personal protective equipment (PPE) such as gloves and goggles.
- Storage: Keep out of reach of children and pets. Ensure proper ventilation when handling in bulk quantities.
- Disposal: Dispose of any unused or expired product in accordance with local regulations, especially when handling hazardous materials.
FAQ - Technical & Supply Chain
-
Q:
What is Atracurium Besylate CAS 64228-81-5?
A: Atracurium besylate is the bis-benzenesulfonate salt of atracurium, an active pharmaceutical ingredient used as a non-depolarizing neuromuscular blocker. Its molecular formula is C65H82N2O18S2 and its molecular weight is about 1243.48. -
Q:
What is Atracurium Besylate used for?
A: It is used in injectable pharmaceutical formulations to provide skeletal muscle relaxation during general anesthesia, mechanical ventilation, and endotracheal intubation. It acts as a nicotinic acetylcholine receptor antagonist. -
Q:
How does Atracurium Besylate differ from Cisatracurium Besylate?
A: Atracurium besylate is a mixture of stereoisomers, while cisatracurium besylate is the purified 1R-cis,1R'-cis isomer. They have different CAS numbers and clinical profiles; atracurium besylate is identified by CAS 64228-81-5. -
Q:
What are key physical properties of Atracurium Besylate API?
A: It is a white to off-white, slightly hygroscopic powder with a melting point around 85-90 deg C and water solubility around 27 mg/mL. Store at 2-8 deg C and protect from moisture. -
Q:
Why is Atracurium Besylate stored at 2-8 C and protected from moisture?
A: Atracurium besylate is slightly hygroscopic and can degrade if exposed to moisture or warmer temperatures. Refrigerated storage at 2-8 C with tightly closed containers helps preserve API assay, related-substance profile and injectable-formulation quality.
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