Relugolix (CAS 737789-87-6) is a non-peptide small molecule gonadotropin-releasing hormone (GnRH) receptor antagonist used strictly as an Active Pharmaceutical Ingredient (API) in the industrial manufacturing of therapeutic formulations. This organic urea derivative functions by competitively blocking GnRH receptors in the pituitary gland, serving as the foundational chemical agent in the synthesis of oral medications for hormone-dependent indications. Unlike peptide-based analogs, this small molecule structure allows for specific oral bioavailability profiles in finished dosage forms. We provide this pharmaceutical raw material with competitive factory pricing to support downstream formulation and process development. Our facility ensures bulk supply capabilities for commercial-scale production requirements, offering customized specifications for purity and particle size control. Every batch is rigorously tested and accompanied by comprehensive MSDS, TDS, COA documentation for regulatory compliance.
Relugolix CAS 737789-87-6
- CAS: 737789-87-6
- Synonyms: TAK-385, RVT-601, Relugolix API
- Molecular Formula: C29H27F2N7O5S
- Grade: Pharmaceutical Grade
- Package: 25 kg/drum
Product Description
Relugolix (CAS 737789-87-6) is a potent gonadotropin-releasing hormone (GnRH) receptor antagonist used in the treatment of various hormone-related conditions, including prostate cancer and endometriosis. It works by inhibiting the release of sex hormones, providing effective control over conditions such as prostate cancer and uterine fibroids.
Physicochemical Properties:
| Property | Value |
|---|---|
| Appearance | White to off-white powder |
| Molecular Weight | 623.63 g/mol |
| Melting Point | 228°C |
| Solubility | DMSO: 20 mg/mL (max); ethanol: 1.0 mg/mL (max) |
| Purity | ≥99% |
| pH (1% solution) | 4.0–6.0 |
| Density | 1.442 ± 0.06 g/cm³ (predicted) |
| Boiling Point | 491.9°C at 760 mmHg |
Applications:
- Used in the treatment of prostate cancer, endometriosis, and uterine fibroids
- Effective in lowering testosterone and estrogen levels for certain cancers
- Often prescribed for hormone-related disorders in both men and women
Storage Conditions:
- Store in a cool, dry place, away from direct sunlight
- Keep container tightly closed when not in use
- Store at -20°C for long-term powder storage (supplier recommendation)
Safety Precautions:
- Handling: Wear appropriate protective equipment (e.g., gloves, safety goggles) when handling the substance.
- Storage: Ensure proper ventilation in storage areas. Avoid exposure to moisture.
- Ingestion/Contact: Avoid ingestion and contact with skin and eyes. In case of contact, rinse thoroughly with water.
- Disposal: Dispose of according to local regulations for pharmaceutical chemicals.
FAQ - Technical & Supply Chain
-
Q:
What is Relugolix CAS 737789-87-6?
A: Relugolix is a non-peptide, orally active gonadotropin-releasing hormone receptor antagonist supplied as a pharmaceutical API. Its molecular formula is C29H27F2N7O5S and its molecular weight is about 623.63 g/mol. -
Q:
What is Relugolix used for?
A: Relugolix is used in the manufacture of oral medicines for hormone-dependent conditions. Approved applications include advanced prostate cancer and symptomatic uterine fibroids, and it has been studied for endometriosis. -
Q:
Are TAK-385 and RVT-601 the same as Relugolix?
A: Yes. TAK-385 and RVT-601 are developmental code names for relugolix, so they refer to the same GnRH receptor antagonist under CAS 737789-87-6. Altropane is a different compound and should not be used to identify this API. -
Q:
What are the key physical properties of Relugolix API?
A: It is a white to off-white crystalline powder with a melting point around 228 deg C. Supplier data report DMSO solubility around 20 mg/mL and ethanol solubility around 1.0 mg/mL, with a predicted density of about 1.442 g/cm3. -
Q:
How should Relugolix API be stored and handled?
A: Use qualified pharmaceutical handling procedures and protect the material from moisture, light and contamination. Supplier datasheets commonly recommend long-term powder storage at -20 deg C; confirm the exact storage condition with the batch documentation.
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