Relugolix (CAS 737789-87-6) is a non-peptide small molecule gonadotropin-releasing hormone (GnRH) receptor antagonist used strictly as an Active Pharmaceutical Ingredient (API) in the industrial manufacturing of therapeutic formulations. This organic urea derivative functions by competitively blocking GnRH receptors in the pituitary gland, serving as the foundational chemical agent in the synthesis of oral medications for hormone-dependent indications. Unlike peptide-based analogs, this small molecule structure allows for specific oral bioavailability profiles in finished dosage forms. We provide this pharmaceutical raw material with competitive factory pricing to support downstream formulation and process development. Our facility ensures bulk supply capabilities for commercial-scale production requirements, offering customized specifications for purity and particle size control. Every batch is rigorously tested and accompanied by comprehensive MSDS, TDS, COA documentation for regulatory compliance.
Relugolix CAS 737789-87-6
- CAS: 737789-87-6
- Synonyms: TAK-385, RVT-601, Relugolix API
- Molecular Formula: C22H27Cl2N5O2
- Grade: Pharmaceutical Grade
- Package: 25 kg/drum
Product Description
Relugolix (CAS 737789-87-6) is a potent gonadotropin-releasing hormone (GnRH) receptor antagonist used in the treatment of various hormone-related conditions, including prostate cancer and endometriosis. It works by inhibiting the release of sex hormones, providing effective control over conditions such as prostate cancer and uterine fibroids.
Physicochemical Properties:
| Property | Value |
|---|---|
| Appearance | White to off-white powder |
| Molecular Weight | 428.4 g/mol |
| Melting Point | 212–214°C |
| Solubility | Soluble in DMSO, methanol; slightly soluble in water |
| Purity | ≥99% |
| pH (1% solution) | 4.0–6.0 |
| Density | 1.2–1.3 g/cm³ |
| Boiling Point | 491.9°C at 760 mmHg |
Applications:
- Used in the treatment of prostate cancer, endometriosis, and uterine fibroids
- Effective in lowering testosterone and estrogen levels for certain cancers
- Often prescribed for hormone-related disorders in both men and women
Storage Conditions:
- Store in a cool, dry place, away from direct sunlight
- Keep container tightly closed when not in use
- Store at temperatures between 2°C and 8°C (Refrigeration recommended)
Safety Precautions:
- Handling: Wear appropriate protective equipment (e.g., gloves, safety goggles) when handling the substance.
- Storage: Ensure proper ventilation in storage areas. Avoid exposure to moisture.
- Ingestion/Contact: Avoid ingestion and contact with skin and eyes. In case of contact, rinse thoroughly with water.
- Disposal: Dispose of according to local regulations for pharmaceutical chemicals.
FAQ - Technical & Supply Chain
-
Q:
Does the identifier CAS 737789-87-6 correspond exclusively to Relugolix?
A: Yes, CAS 737789-87-6 is the definitive registry number for Relugolix (also known experimentally as TAK-385), identifying the specific non-peptide chemical structure . -
Q:
Is this material intended for clinical administration or industrial processing?
A: This product is supplied solely as a raw chemical material for industrial pharmaceutical manufacturing and research synthesis, not for direct clinical administration.
Documents and Product Support
For product review and sourcing evaluation, supporting documents can be coordinated according to the product type, inquiry stage, and order requirements.
- COA for batch-based quality reference
- TDS for key physical and chemical information
- SDS / MSDS for handling, storage, and safety reference
- Packing information for sample, trial, and bulk orders
- Technical communication based on application and specification requirements
Information to Confirm Before Quotation
Clear sourcing information helps reduce specification mismatch and allows a more accurate quotation before sample or bulk order discussion.
- Product name and CAS number
- Application or intended end use
- Required purity, grade, or specification
- Sample quantity, trial order, or bulk demand
- Preferred packing form or net weight
- Destination country or port
- Required documents or compliance expectations
Packaging, Storage, and Handling Notes
Packaging form, storage conditions, shelf life, and shipment arrangements should be confirmed according to the product characteristics, package size, and destination requirements.
Before order confirmation, buyers are advised to review the corresponding product documents and confirm whether any special storage, labeling, or handling requirements apply.
Sample, Bulk Order and Repeat Supply Support
Support can be arranged for sample discussion, bulk supply planning, packaging confirmation, and routine sourcing communication based on the actual product and order requirements.
For repeat-use formulations or long-term procurement plans, buyers may discuss specification consistency, packaging preferences, delivery expectations, and document coordination in advance.
