Does CAS 19490-92-7 establish a single enantiomeric form of alpha-methyl-alpha-phenyl-pyridine-2-methanol?

No. The structure has a stereogenic center, and the CAS reference does not by itself define enantiomeric composition. When stereochemical composition affects the downstream process, confirm the required form, optical specification, analytical method and acceptance basis rather than relying on total assay alone.

Is material sold under CAS 19490-92-7 automatically equivalent to a doxylamine impurity reference standard?

No. A process intermediate and a certified or compendial impurity standard can share chemical identity but differ in intended use, characterization, metrological traceability, assigned content and documentation. State whether the requirement is a manufacturing intermediate or an analytical reference, then request the corresponding certificate and analytical package.

Alpha-methyl-alpha-phenyl-pyridine-2-methanol CAS 19490-92-7

1-Phenyl-1-(pyridin-2-yl)ethanol (CAS 19490-92-7), also called Alpha-methyl-alpha-phenyl-pyridine-2-methanol or Doxylamine Alcohol, is a pyridyl tertiary alcohol used as an intermediate in pharmaceutical and fine-chemical synthesis. Analytical use as Doxylamine EP Impurity B requires an appropriately characterized analytical reference grade. Identity, assay, related substances, residual solvents, physical form and storage conditions are key specification points. COA, TDS and SDS are available for specification review and safe handling.

CAS: 19490-92-7
Synonyms: Alpha-methyl-alpha-phenyl-pyridine-2-methanol, 1-Phenyl-1-(pyridin-2-yl)ethanol, Doxylamine Alcohol, Doxylamine EP Impurity B
Einecs: 243-110-6
Molecular Formula: C₁₃H₁₃NO
Grade: Specified by identity, HPLC assay, related substances, water, residual solvents and physical form; see the current COA.
Package: Confirm container, light or moisture protection, net weight, storage and transport against the current COA and SDS.

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Product Description

1 Identity and physicochemical profile

2 Applications and grade selection

3 Storage and handling

4 Safety, documentation and procurement

Identity and physicochemical profile

Item	Technical guidance
Product identity	1-Phenyl-1-(pyridin-2-yl)ethanol; alpha-methyl-alpha-phenyl-pyridine-2-methanol
CAS number	19490-92-7
Formula / molecular weight	C₁₃H₁₃NO / 199.25 g/mol
Recognized context	Doxylamine alcohol and Doxylamine EP Impurity B
Grade boundary	A synthesis intermediate grade is not automatically an authenticated analytical reference standard
Key controls	Identity, HPLC assay, related substances, water, residual solvents, physical form and characterization scope

Applications and grade selection

This pyridyl tertiary alcohol is evaluated as an intermediate in doxylamine-related and other pharmaceutical or fine-chemical synthesis routes. A separately characterized grade may be used in analytical method development or impurity testing.

For synthesis, define assay, related substances, water, residual solvents and reaction-performance requirements.
For analytical use, define characterization, assigned value, uncertainty or traceability requirements instead of relying on a commercial purity label.
Confirm physical form, package size and storage conditions for the exact offered grade.

Storage and handling

Store tightly closed under the temperature, light and atmosphere conditions stated in the supplier’s current documentation.

Safety, documentation and procurement

Handle with gloves, eye protection and ventilation according to the current SDS. A purchase inquiry should state synthesis or analytical use, required methods and limits, quantity, package, destination, delivery schedule and documentation scope.

FAQ - Technical & Supply Chain

Q:
Does CAS 19490-92-7 establish a single enantiomeric form of alpha-methyl-alpha-phenyl-pyridine-2-methanol?

A: No. The structure has a stereogenic center, and the CAS reference does not by itself define enantiomeric composition. When stereochemical composition affects the downstream process, confirm the required form, optical specification, analytical method and acceptance basis rather than relying on total assay alone.
Q:
Is material sold under CAS 19490-92-7 automatically equivalent to a doxylamine impurity reference standard?

A: No. A process intermediate and a certified or compendial impurity standard can share chemical identity but differ in intended use, characterization, metrological traceability, assigned content and documentation. State whether the requirement is a manufacturing intermediate or an analytical reference, then request the corresponding certificate and analytical package.

Ordering & Documentation

Key information for document requests, quotations, and supply planning.

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Storage & Shipping

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