What is Indole CAS 120-72-9?

Indole CAS 120-72-9 is an aromatic nitrogen-containing fused-ring compound with the formula C8H7N and molecular weight 117.15 g/mol. It is a crystalline solid at room temperature and an important intermediate for fragrance and chemical synthesis.

Why does Indole smell different at high and low concentrations?

In concentrated form indole has a strong, pungent or animalic odor. At very low dilution it becomes a floral jasmine-like and orange-blossom note, which is why it is used in very small amounts in fine fragrance and personal-care compositions.

What are the main fragrance applications of Indole CAS 120-72-9?

It is used as a fragrance ingredient and fixative in accords such as jasmine, lilac, lotus and orchid. Typical perfumery use is at low levels, because the concentrated odor is intense and unpleasant.

Can Indole be used as a pharmaceutical or agrochemical intermediate?

Yes. Indole is a key building block for synthesizing indole-containing pharmaceuticals, plant-growth regulators and agrochemicals. Its bicyclic indole ring is found in many biologically active molecules.

What are the main specifications and storage precautions?

Typical export specifications are white to shiny flake crystals or powder, GC assay at least 99%, melting point 51-54 C, boiling point 253-254 C and low moisture. Store it sealed in a cool, dry place, protected from light and air because indole can discolor on prolonged exposure.

Indole CAS 120-72-9

Indole (CAS 120-72-9) is a fundamental heterocyclic aromatic compound utilizing its unique nitrogen-containing bicyclic structure as a core building block in pharmaceutical synthesis and fine perfumery. Chemically identified as 1H-Indole or 2,3-Benzopyrrole, this white to yellowish crystalline flake functions as a potent precursor for the biosynthesis of tryptophan and plant hormones like auxin. While possessing a distinct, heavy odor in high concentrations, it exhibits a pleasant, floral jasmine note when highly diluted, making it an indispensable fixative in the fragrance industry. It is extensively integrated into the production of synthetic Jasmine and Orange Blossom scents, as well as acting as a key intermediate in the manufacturing of anti-inflammatory drugs (e.g., Indomethacin). We ensure bulk supply capabilities for this material, providing access to competitive factory pricing and customized specifications to meet specific purity requirements (typically >99% for Perfumery Grade). Full technical documentation, including MSDS, TDS, COA, is available to support compliance and safety protocols.

CAS: 120-72-9
Synonyms: 1H-Indole, 1-Azaindene, 2,3-Benzopyrrole, Ketole, Benzopyrrole
Einecs: 204-420-7
Molecular Formula: C8H7N
Grade: Industrial Grade / Perfumery Grade
Package: 25kg/Fiber Drum, lined with plastic bag (or customized per request)

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Product Description

Indole is a solid crystalline substance at room temperature. It is well-known for its unique olfactory properties: in high concentrations, it has a strong, unpleasant odor, but in very low concentrations, it exhibits a pleasant, floral fragrance reminiscent of jasmine and orange blossoms.

As a versatile chemical intermediate, Indole is the precursor to many pharmaceuticals, dyes, and agricultural chemicals. It is produced synthetically to meet the high demands of the perfumery and pharmaceutical sectors.

1 Physicochemical Properties

2 Applications

3 Storage Conditions

4 Safety Precautions

Physicochemical Properties

Parameter	Specification (Standard)
Appearance	White to shiny flake crystals or powder
Assay (GC)	≥ 99.0%
Melting Point	51.0°C – 54.0°C
Boiling Point	253°C – 254°C
Moisture (Water Content)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Solubility	Soluble in hot water, ethanol, ether, and benzene; Almost insoluble in cold water.
Flash Point	> 121°C
Density	1.22 g/cm³

Applications

Indole is a multi-functional raw material with applications across several industries:

Fragrances & Flavors:
- Used as a fixative and fragrance ingredient.
- Essential for creating artificial Jasmine, Lilac, Lotus, and Orchid scents.
- Used in the formulation of daily chemical essences (soaps, detergents).
Pharmaceutical Intermediates:
- A critical precursor for the synthesis of Tryptophan (an essential amino acid).
- Used to manufacture anti-inflammatory drugs like Indomethacin.
Agriculture:
- Used to synthesize Indole-3-Acetic Acid (IAA) and Indole-3-Butyric Acid (IBA), which are important plant growth regulators.
Dyes:
- Used in the production of tryptophan-based dyes.

Storage Conditions

Light Sensitivity: Indole turns red when exposed to light and air (oxidation). Must be stored in light-resistant containers.
Temperature: Store in a cool, dry area (below 30°C is recommended) to prevent melting or caking.
Ventilation: Keep the container tightly closed in a well-ventilated place.
Incompatibility: Keep away from strong oxidizing agents, iron, and strong acids.

Safety Precautions

Handling: Do not breathe dust/fume/gas/mist/vapors/spray. Use only outdoors or in a well-ventilated area.
PPE: Wear protective gloves, protective clothing, and eye/face protection.
Health Hazards:
- Harmful if swallowed or in contact with skin.
- Causes severe eye irritation.
- Toxic to aquatic life with long-lasting effects.
First Aid:
- Eye Contact: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing.
- Skin Contact: Wash with plenty of soap and water.

FAQ - Technical & Supply Chain

Q:
What is Indole CAS 120-72-9?

A: Indole CAS 120-72-9 is an aromatic nitrogen-containing fused-ring compound with the formula C8H7N and molecular weight 117.15 g/mol. It is a crystalline solid at room temperature and an important intermediate for fragrance and chemical synthesis.
Q:
Why does Indole smell different at high and low concentrations?

A: In concentrated form indole has a strong, pungent or animalic odor. At very low dilution it becomes a floral jasmine-like and orange-blossom note, which is why it is used in very small amounts in fine fragrance and personal-care compositions.
Q:
What are the main fragrance applications of Indole CAS 120-72-9?

A: It is used as a fragrance ingredient and fixative in accords such as jasmine, lilac, lotus and orchid. Typical perfumery use is at low levels, because the concentrated odor is intense and unpleasant.
Q:
Can Indole be used as a pharmaceutical or agrochemical intermediate?

A: Yes. Indole is a key building block for synthesizing indole-containing pharmaceuticals, plant-growth regulators and agrochemicals. Its bicyclic indole ring is found in many biologically active molecules.
Q:
What are the main specifications and storage precautions?

A: Typical export specifications are white to shiny flake crystals or powder, GC assay at least 99%, melting point 51-54 C, boiling point 253-254 C and low moisture. Store it sealed in a cool, dry place, protected from light and air because indole can discolor on prolonged exposure.

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