What is Azilsartan CAS 147403-03-0?

Azilsartan is a benzimidazole-derived angiotensin II receptor blocker supplied as an antihypertensive pharmaceutical API. Its molecular formula is C25H20N4O5 and its molecular weight is about 456.46 g/mol.

How does Azilsartan lower blood pressure?

Azilsartan selectively blocks angiotensin II from binding to the AT1 receptor, which reduces vasoconstriction and aldosterone effects. This lowers peripheral vascular resistance and helps control hypertension.

Is Azilsartan the same as azilsartan medoxomil?

No. Azilsartan is the free acid active form, while azilsartan medoxomil is a prodrug that is converted to azilsartan after oral absorption. The CAS 147403-03-0 product is therefore the API acid or an intermediate for medoxomil manufacture.

What is Azilsartan API used to manufacture?

It is used to manufacture oral antihypertensive products and as the active acid intermediate for azilsartan medoxomil. The API is relevant to hypertension treatment and cardiovascular research or formulation development.

How should Azilsartan API be stored and handled?

Store in tightly closed containers in a cool, dry, light-protected area; many supplier specifications recommend 2-8 deg C and protection from moisture. Handle as a potent pharmaceutical material using qualified procedures and appropriate PPE.

Azilsartan CAS 147403-03-0

Azilsartan (CAS 147403-03-0), chemically designated as TAK-536 or Azilsartan free acid, is a benzimidazole-derived angiotensin II receptor antagonist (ARB). Functioning as a high-affinity blocker of the AT1 receptor subtype, this crystalline solid serves as the active pharmaceutical ingredient (API) and key precursor in the synthesis of the prodrug Azilsartan Medoxomil. It is extensively utilized in the industrial production of antihypertensive formulations and cardiovascular research reagents. We provide this industrial material with competitive factory pricing to support continuous manufacturing operations, alongside options for customized specifications. Essential technical documentation, including MSDS, TDS, COA, is readily available for all bulk supply orders.

CAS: 147403-03-0
Synonyms: TAK-536, Azilsartan free acid, Azilsartan acid, 2-ethoxy-1-[[2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylic acid
Einecs: 808-058-6
Molecular Formula: C25H20N4O5
Grade: Pharmaceutical Grade
Package: 25 kg/drum

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Product Description

1 Product Introduction

2 Physicochemical Properties

3 Applications

4 Storage Conditions

5 Safety Precautions

Product Introduction

Azilsartan is a potent antihypertensive drug used in the treatment of high blood pressure (hypertension). It belongs to the angiotensin II receptor antagonist class, which works by blocking the effects of a chemical that causes blood vessels to constrict, thereby reducing blood pressure.

Physicochemical Properties

Property	Value
Appearance	White to off-white powder
Melting Point	188°C (dec.)
Solubility	Soluble in organic solvents (e.g., DMSO, methanol), insoluble in water
Purity	≥ 98%
Molecular Weight	456.46 g/mol

Applications

Azilsartan is primarily used for:

Treatment of hypertension: Used to lower high blood pressure and improve cardiovascular health.
Management of heart failure: Often prescribed in combination with other drugs for heart failure management.

Storage Conditions

Storage Temperature: Store in a cool, dry place at a temperature between 15–30°C.
Shelf Life: Typically 2 years when stored under recommended conditions.
Packaging: Ensure the packaging is sealed to avoid exposure to moisture and direct sunlight.

Safety Precautions

Handling: Handle with care and avoid inhalation or skin contact.
Personal Protection: Wear appropriate PPE, including gloves, goggles, and lab coat.
Disposal: Dispose of any waste material in accordance with local environmental regulations.

FAQ - Technical & Supply Chain

Q:
What is Azilsartan CAS 147403-03-0?

A: Azilsartan is a benzimidazole-derived angiotensin II receptor blocker supplied as an antihypertensive pharmaceutical API. Its molecular formula is C25H20N4O5 and its molecular weight is about 456.46 g/mol.
Q:
How does Azilsartan lower blood pressure?

A: Azilsartan selectively blocks angiotensin II from binding to the AT1 receptor, which reduces vasoconstriction and aldosterone effects. This lowers peripheral vascular resistance and helps control hypertension.
Q:
Is Azilsartan the same as azilsartan medoxomil?

A: No. Azilsartan is the free acid active form, while azilsartan medoxomil is a prodrug that is converted to azilsartan after oral absorption. The CAS 147403-03-0 product is therefore the API acid or an intermediate for medoxomil manufacture.
Q:
What is Azilsartan API used to manufacture?

A: It is used to manufacture oral antihypertensive products and as the active acid intermediate for azilsartan medoxomil. The API is relevant to hypertension treatment and cardiovascular research or formulation development.
Q:
How should Azilsartan API be stored and handled?

A: Store in tightly closed containers in a cool, dry, light-protected area; many supplier specifications recommend 2-8 deg C and protection from moisture. Handle as a potent pharmaceutical material using qualified procedures and appropriate PPE.

Ordering & Documentation

Key information for document requests, quotations, and supply planning.

Documents

COA, TDS, SDS/MSDS and packing details are available on request.

Quotation

Send the CAS number, grade, quantity, packing preference and destination.

Sample & Supply

Support is available for samples, trial orders, bulk and repeat supply.

Storage & Shipping

Product-specific conditions are confirmed before order.

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