What is Azilsartan CAS 147403-03-0?

Azilsartan is a benzimidazole-derived angiotensin II receptor blocker supplied as an antihypertensive pharmaceutical API. Its molecular formula is C₂₅H₂₀N₄O₅ and its molecular weight is about 456.46 g/mol.

How does Azilsartan lower blood pressure?

Azilsartan selectively blocks angiotensin II from binding to the AT1 receptor, which reduces vasoconstriction and aldosterone effects. This lowers peripheral vascular resistance and helps control hypertension.

Is Azilsartan the same as azilsartan medoxomil?

No. Azilsartan is the free acid active form, while azilsartan medoxomil is a prodrug that is converted to azilsartan after oral absorption. The CAS 147403-03-0 product is therefore the API acid or an intermediate for medoxomil manufacture.

What is Azilsartan API used to manufacture?

It is used to manufacture oral antihypertensive products and as the active acid intermediate for azilsartan medoxomil. The API is relevant to hypertension treatment and cardiovascular research or formulation development.

Azilsartan CAS 147403-03-0

Azilsartan (CAS 147403-03-0) is a benzimidazole-derived angiotensin II receptor blocker supplied as an antihypertensive Active Pharmaceutical Ingredient (API). Confirm the required grade, then request a quotation with COA/TDS/SDS for bulk supply.

CAS: 147403-03-0
Synonyms: TAK-536, Azilsartan free acid, Azilsartan acid, 2-ethoxy-1-[[2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylic acid
Einecs: 808-058-6
Molecular Formula: C₂₅H₂₀N₄O₅
Grade: Pharmaceutical Grade
Package: 25 kg/drum

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Product Description

Azilsartan, CAS 147403-03-0, is a benzimidazole-derived angiotensin II receptor blocker (ARB) supplied as an antihypertensive Active Pharmaceutical Ingredient (API); the EC/EINECS number is 808-058-6.

Synonyms: TAK-536; Azilsartan free acid; Azilsartan acid; 2-ethoxy-1-[[2′-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylic acid.

CAS: 147403-03-0.

Molecular formula: C₂₅H₂₀N₄O₅.

Molecular weight: 456.46.

EC number: 808-058-6.

It is a white to off-white powder with a melting point of about 188 °C (decomposition).

It is soluble in organic solvents such as DMSO and methanol and practically insoluble in water.

It selectively blocks angiotensin II binding to the AT1 receptor, reducing vasoconstriction and aldosterone effects.

It is used as an API in oral antihypertensive products for the treatment of hypertension.

It also serves as the active acid intermediate for the manufacture of azilsartan medoxomil.

Azilsartan is the free acid active form; azilsartan medoxomil is a prodrug converted to azilsartan after oral absorption, so confirm the intended CAS and salt/ester form.

Confirm identity, assay, related substances, residual solvents, water content, particle size and polymorphic form for the intended formulation.

Store in tightly closed containers in a cool, dry, light-protected area; many supplier specifications recommend 2–8 °C and protection from moisture. Handle with qualified procedures and suitable PPE.

Confirm the current product-specific specification.

Confirm packaging with the requested quantity and destination requirements.

Document requirements should be confirmed from the current specification, SDS, COA or other product-specific files.

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For an RFQ, state the intended use, required specification, quantity, packaging, destination and document needs.

FAQ - Technical & Supply Chain

Q:
What is Azilsartan CAS 147403-03-0?

A: Azilsartan is a benzimidazole-derived angiotensin II receptor blocker supplied as an antihypertensive pharmaceutical API. Its molecular formula is C₂₅H₂₀N₄O₅ and its molecular weight is about 456.46 g/mol.
Q:
How does Azilsartan lower blood pressure?

A: Azilsartan selectively blocks angiotensin II from binding to the AT1 receptor, which reduces vasoconstriction and aldosterone effects. This lowers peripheral vascular resistance and helps control hypertension.
Q:
Is Azilsartan the same as azilsartan medoxomil?

A: No. Azilsartan is the free acid active form, while azilsartan medoxomil is a prodrug that is converted to azilsartan after oral absorption. The CAS 147403-03-0 product is therefore the API acid or an intermediate for medoxomil manufacture.
Q:
What is Azilsartan API used to manufacture?

A: It is used to manufacture oral antihypertensive products and as the active acid intermediate for azilsartan medoxomil. The API is relevant to hypertension treatment and cardiovascular research or formulation development.
Q:
How should Azilsartan API be stored and handled?

A: Store in tightly closed containers in a cool, dry, light-protected area; many supplier specifications recommend 2–8 °C and protection from moisture. Handle as a potent pharmaceutical material using qualified procedures and appropriate PPE.

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