Nicotinamide Riboside Chloride CAS 23111-00-4

Nicotinamide Riboside Chloride is a crystal form of Nicotinamide Riboside stabilized with chloride. It works by entering the cell and bypassing certain rate-limiting steps in the NAD+ salvage pathway.

Product Characteristics:

1. High Bioavailability: Studies suggest NR is one of the most efficient boosters of NAD+ levels in mammals, supporting mitochondrial function.
2. Crystal Form Stability: We supply the specific polymorph of NR Chloride that resists moisture absorption better than amorphous forms, though strict moisture control is still required.
3. Low Solvent Residue: Our manufacturing process strictly controls residual Ethanol and Methanol to meet global food safety standards.
4. Taste Profile: It has a naturally sour/bitter taste, which is normal for this chloride salt.

Physicochemical Properties

The data below is based on typical export batch COAs (Certificate of Analysis).

Applications

1. Dietary Supplements (Capsules):
   • This is the primary use. Due to its hygroscopic nature and sour taste, it is almost exclusively encapsulated rather than sold as loose powder or tablets.
   • It is often formulated as a standalone anti-aging product or blended with Pterostilbene or Resveratrol.
2. Cosmetics (Raw Material):
   • Used in some high-end skincare formulations for cellular repair concepts, though stability in aqueous creams is a challenge.
3. Functional Research:
   • Used in laboratory settings for researching metabolic disorders and neuroprotection.

Storage Conditions (Critical)

• Temperature Sensitivity: NR-Cl is heat-sensitive.
  • Short term: Can withstand room temperature during transit (with cold packs).
  • Long term: Must be stored frozen (-20°C) or refrigerated (2-8°C) to prevent degradation into Nicotinamide.
• Moisture Sensitivity: Highly hygroscopic. The product must be kept in double-lined pharmaceutical-grade polyethylene bags inside aluminum foil bags.
• Handling: Open containers only in a dehumidified environment if possible. Reseal immediately.

Safety Precautions

• Handling: The powder is acidic. Avoid direct contact with skin and eyes. Wear protective gloves and safety glasses.
• Dust: Avoid breathing dust. Use in a well-ventilated area or use a dust extraction system.
• Ingestion: Generally recognized as safe (GRAS in US for specific uses) in controlled doses, but pure raw material should not be consumed directly without weighing.
• First Aid:
  • Eyes: Rinse cautiously with water for several minutes.
  • Skin: Wash with soap and water.