What is Nicotinamide Riboside Chloride CAS 23111-00-4?

Nicotinamide Riboside Chloride, often called NR chloride or NR-Cl, is the chloride salt of nicotinamide riboside, a pyridine-nucleoside form of vitamin B3. It has the molecular formula C11H15ClN2O5, molecular weight about 290.70 g/mol, CAS 23111-00-4 and EINECS 200-184-4.

Why is the chloride salt form used instead of the free base?

The chloride salt form gives nicotinamide riboside improved crystalline stability and easier handling compared with the free base. It is still moisture-sensitive, so sealed packaging and controlled storage remain important even though the salt form is more stable.

What is Nicotinamide Riboside Chloride used for?

NR chloride is used as a raw material for NAD+ precursor products, including dietary supplements, functional foods and research formulations. It can also serve as a pharmaceutical intermediate, but it is a raw ingredient and is not supplied as a finished therapeutic product.

What are the key specifications for food or pharmaceutical-grade NR chloride?

Typical checks include a white to light-yellow crystalline appearance, HPLC purity of at least 98%, water content by Karl Fischer, acidic aqueous pH, specific rotation, residual solvents and heavy-metal limits. Buyers should select the grade and specification that match the final product and destination requirements.

How should Nicotinamide Riboside Chloride be stored and shipped?

NR chloride should be kept sealed, protected from light and moisture, and stored under cool conditions; cold-chain transport is recommended for larger or long-distance orders. The current offer uses 1 kg aluminum tins, 5 kg cartons or 25 kg drums, with the package selected to protect the material during storage and shipment.

Nicotinamide Riboside Chloride CAS 23111-00-4

Nicotinamide Riboside Chloride, identified by CAS 23111-00-4, is a high-purity crystalline pyridinium salt characterized by its role as a pivotal precursor in the biosynthesis of essential metabolic cofactors. As a specialized nicotinamide riboside chloride, this technical-grade nicotinamide riboside chloride salt functions as a primary building block in various pharmaceutical intermediate synthesis processes. This crystalline nicotinamide beta-D-ribofuranoside chloride is valued for its superior stability and bio-available structure, which facilitates the production of advanced biochemical derivatives and health-related chemical compounds. Our facility provides competitive factory pricing and customized specifications regarding purity and assay levels to ensure precise integration into high-precision synthesis workflows. For procurement and technical validation, we offer comprehensive MSDS, TDS, COA documentation and maintain consistent bulk supply for professional laboratory and industrial-scale manufacturing.

CAS: 23111-00-4
Synonyms: NR-Cl, Nicotinamide riboside salt, 1-(beta-D-Ribofuranosyl)nicotinamide chloride, Nicotinamide beta-D-riboside chloride
Einecs: 200-184-4
Molecular Formula: C11H15ClN2O5
Grade: Food Grade / Pharmaceutical Intermediate
Package: 1kg/Alu-tin, 5kg/Carton, or 25kg/Drum (Cold Chain recommended).

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Product Description

Nicotinamide Riboside Chloride is a crystal form of Nicotinamide Riboside stabilized with chloride. It works by entering the cell and bypassing certain rate-limiting steps in the NAD+ salvage pathway.

Product Characteristics:

High Bioavailability: Studies suggest NR is one of the most efficient boosters of NAD+ levels in mammals, supporting mitochondrial function.
Crystal Form Stability: We supply the specific polymorph of NR Chloride that resists moisture absorption better than amorphous forms, though strict moisture control is still required.
Low Solvent Residue: Our manufacturing process strictly controls residual Ethanol and Methanol to meet global food safety standards.
Taste Profile: It has a naturally sour/bitter taste, which is normal for this chloride salt.

1 Physicochemical Properties

2 Applications

3 Storage Conditions (Critical)

4 Safety Precautions

Physicochemical Properties

The data below is based on typical export batch COAs (Certificate of Analysis).

Parameter	Specification
Appearance	White to light yellow crystalline powder
Purity (HPLC)	≥ 98.0%
Water Content (Karl Fischer)	≤ 1.0%
pH Value	2.0 – 4.0 (Acidic in solution)
Specific Rotation	+41° to +45°
Heavy Metals (Total)	≤ 10 ppm
Lead (Pb)	≤ 0.5 ppm
Arsenic (As)	≤ 0.5 ppm
Mercury (Hg)	≤ 0.1 ppm
Residual Solvents	Complies with USP/EP (Methanol < 3000ppm)
Microbiology	Total Plate Count < 1000 cfu/g

Applications

Dietary Supplements (Capsules):
- This is the primary use. Due to its hygroscopic nature and sour taste, it is almost exclusively encapsulated rather than sold as loose powder or tablets.
- It is often formulated as a standalone anti-aging product or blended with Pterostilbene or Resveratrol.
Cosmetics (Raw Material):
- Used in some high-end skincare formulations for cellular repair concepts, though stability in aqueous creams is a challenge.
Functional Research:
- Used in laboratory settings for researching metabolic disorders and neuroprotection.

For a related conventional vitamin B3 raw material, see Niacinamide.

Storage Conditions (Critical)

Temperature Sensitivity: NR-Cl is heat-sensitive.
- Short term: Can withstand room temperature during transit (with cold packs).
- Long term: Must be stored frozen (-20°C) or refrigerated (2-8°C) to prevent degradation into Nicotinamide.
Moisture Sensitivity: Highly hygroscopic. The product must be kept in double-lined pharmaceutical-grade polyethylene bags inside aluminum foil bags.
Handling: Open containers only in a dehumidified environment if possible. Reseal immediately.

Safety Precautions

Handling: The powder is acidic. Avoid direct contact with skin and eyes. Wear protective gloves and safety glasses.
Dust: Avoid breathing dust. Use in a well-ventilated area or use a dust extraction system.
Ingestion: Generally recognized as safe (GRAS in US for specific uses) in controlled doses, but pure raw material should not be consumed directly without weighing.
First Aid:
- Eyes: Rinse cautiously with water for several minutes.
- Skin: Wash with soap and water.

FAQ - Technical & Supply Chain

Q:
What is Nicotinamide Riboside Chloride CAS 23111-00-4?

A: Nicotinamide Riboside Chloride, often called NR chloride or NR-Cl, is the chloride salt of nicotinamide riboside, a pyridine-nucleoside form of vitamin B3. It has the molecular formula C11H15ClN2O5, molecular weight about 290.70 g/mol, CAS 23111-00-4 and EINECS 200-184-4.
Q:
Why is the chloride salt form used instead of the free base?

A: The chloride salt form gives nicotinamide riboside improved crystalline stability and easier handling compared with the free base. It is still moisture-sensitive, so sealed packaging and controlled storage remain important even though the salt form is more stable.
Q:
What is Nicotinamide Riboside Chloride used for?

A: NR chloride is used as a raw material for NAD+ precursor products, including dietary supplements, functional foods and research formulations. It can also serve as a pharmaceutical intermediate, but it is a raw ingredient and is not supplied as a finished therapeutic product.
Q:
What are the key specifications for food or pharmaceutical-grade NR chloride?

A: Typical checks include a white to light-yellow crystalline appearance, HPLC purity of at least 98%, water content by Karl Fischer, acidic aqueous pH, specific rotation, residual solvents and heavy-metal limits. Buyers should select the grade and specification that match the final product and destination requirements.
Q:
How should Nicotinamide Riboside Chloride be stored and shipped?

A: NR chloride should be kept sealed, protected from light and moisture, and stored under cool conditions; cold-chain transport is recommended for larger or long-distance orders. The current offer uses 1 kg aluminum tins, 5 kg cartons or 25 kg drums, with the package selected to protect the material during storage and shipment.

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