Citicoline Sodium is the sodium salt form of citicoline, also known as CDP-choline sodium. Based on currently available identity information, this product is more appropriately positioned as a pharmaceutical or nutraceutical raw material rather than a general industrial chemical. We supply this material according to product positioning, grade, and application requirements.
Citicoline Sodium CAS 33818-15-4
- CAS: 33818-15-4
- Synonyms: CDP-Choline Sodium, Cytidine 5'-diphosphocholine sodium salt, Citicoline sodium salt, Cytidine 5'-(trihydrogen diphosphate) P'-(2-(trimethylammonio)ethyl) ester sodium salt
- Einecs: 251-689-1
- Molecular Formula: C14H25N4NaO11P2
- Grade: Pharmaceutical Grade (Injection/Oral) / Food Grade
- Package: 1kg/Alu-tin, 5kg/Drum, or 25kg/Fiber Drum (with double low-permeability PE liners).
Product Description
Physicochemical Properties
| Parameter | Specification |
|---|---|
| Appearance | White or off-white crystalline powder |
| Assay (on dry basis) | 98.0% – 102.0% |
| Identification (IR/HPLC) | Conforms to standard |
| pH Value (1% solution) | 6.0 – 7.5 |
| Specific Rotation | +10.0° to +12.0° |
| Loss on Drying (Water) | ≤ 5.0% (Highly Hygroscopic) |
| Related Substances (5′-CMP) | ≤ 0.3% |
| Total Other Impurities | ≤ 1.0% |
| Heavy Metals | ≤ 10 ppm |
| Arsenic (As) | ≤ 1 ppm |
| Bacterial Endotoxins | < 0.5 EU/mg (For Injection Grade) |
| Total Plate Count | ≤ 1000 cfu/g (For Oral/Food Grade) |
Reference Information
Molecular formula: C14H25N4NaO11P2
Molecular weight: 510.31
Chemical identity note: sodium salt of citicoline / cytidine 5′-diphosphocholine sodium salt
General physical description: solid; exact appearance should be confirmed against the offered grade and batch documentation.
Applications
Citicoline Sodium is generally handled as a specialized raw material for pharmaceutical, nutraceutical, research, or related formulation programs. Actual application suitability depends on grade, purity standard, formulation system, regulatory framework, and end-use validation.
Typical application directions may include:
- pharmaceutical raw material programs, subject to grade and regulatory confirmation
- nutraceutical or health-related formulation development, depending on local compliance requirements
- laboratory, analytical, or research use, depending on the offered grade
- custom supply projects where identity, specification, and document scope are confirmed before order
Any specific formulation use should be evaluated according to application requirements and product validation standards.
Packaging and Storage
Standard packaging is available. The product may be packed in bags, drums, cartons, or other suitable containers as applicable to the offered grade and supply format. Customized packaging may be discussed upon request.
Store in a tightly closed container in a dry and clean environment. Protection from moisture, heat, and unsuitable storage conditions should be considered according to the offered grade and handling requirements. Exact storage conditions should be confirmed against the applicable product documentation.
FAQ
1. Does Citicoline Sodium match CAS 33818-15-4?
Yes. Based on current reference and supplier listings, Citicoline Sodium is consistent with CAS 33818-15-4. It is also commonly listed as Cytidine 5′-Diphosphocholine Sodium Salt or CDP-Choline Sodium Salt.
2. What is the most suitable product type for this material?
This product is more appropriately treated as a pharmaceutical or nutraceutical raw material, rather than a general-purpose industrial chemical. The final positioning should be confirmed according to the intended market and offered grade.
3. What should be confirmed before purchase?
Before purchase, buyers should confirm intended use, required grade, purity standard, document scope, formulation compatibility, and any applicable regulatory expectations.
4. Can technical documents such as COA, TDS, or SDS / MSDS be provided?
These documents may be provided upon request and are available depending on the offered grade, product positioning, and supply arrangement.
5. What packaging options are commonly discussed?
Standard packaging is available, and the final packing format can be discussed according to order quantity, grade, and transportation requirements.
FAQ - Technical & Supply Chain
-
Q:
How is Citicoline Sodium (CAS 33818-15-4) chemically distinguished from Citicoline Free Base?
A: Citicoline Sodium is identified by CAS 33818-15-4 and exists as a sodium salt, which typically offers enhanced solubility and stability in aqueous formulations compared to the free acid form. Industrial verification relies on sodium flame tests and HPLC analysis to confirm the presence of the specific salt structure required for designated formulation matrices. -
Q:
What is the primary industrial application of Citicoline Sodium in health product manufacturing?
A: In the nutraceutical and pharmaceutical industries, this material is intended for use as a bioactive raw material. It is incorporated into formulations designed to support phospholipid synthesis and cognitive function, serving as a stable source of choline and cytidine in solid dosage forms or liquid complexes.
Documents and Product Support
For product review and sourcing evaluation, supporting documents can be coordinated according to the product type, inquiry stage, and order requirements.
- COA for batch-based quality reference
- TDS for key physical and chemical information
- SDS / MSDS for handling, storage, and safety reference
- Packing information for sample, trial, and bulk orders
- Technical communication based on application and specification requirements
Information to Confirm Before Quotation
Clear sourcing information helps reduce specification mismatch and allows a more accurate quotation before sample or bulk order discussion.
- Product name and CAS number
- Application or intended end use
- Required purity, grade, or specification
- Sample quantity, trial order, or bulk demand
- Preferred packing form or net weight
- Destination country or port
- Required documents or compliance expectations
Packaging, Storage, and Handling Notes
Packaging form, storage conditions, shelf life, and shipment arrangements should be confirmed according to the product characteristics, package size, and destination requirements.
Before order confirmation, buyers are advised to review the corresponding product documents and confirm whether any special storage, labeling, or handling requirements apply.
Sample, Bulk Order and Repeat Supply Support
Support can be arranged for sample discussion, bulk supply planning, packaging confirmation, and routine sourcing communication based on the actual product and order requirements.
For repeat-use formulations or long-term procurement plans, buyers may discuss specification consistency, packaging preferences, delivery expectations, and document coordination in advance.




