What is Citicoline Sodium CAS 33818-15-4?

Citicoline Sodium CAS 33818-15-4 is the sodium salt of cytidine 5'-diphosphocholine, also known as CDP-Choline Sodium. It has molecular formula C14H25N4NaO11P2, molecular weight about 510.31, and EINECS number 251-689-1.

How does Citicoline Sodium differ from citicoline free base?

Citicoline Sodium is the sodium salt form registered as CAS 33818-15-4, while citicoline free base is commonly listed as CAS 987-78-0. The sodium salt form is used in many pharmaceutical and supplement applications because it is highly water-soluble and convenient for aqueous formulations.

What are the main applications of Citicoline Sodium?

Citicoline Sodium is used as a CDP-choline source in pharmaceutical, nutraceutical, and related research formulations. It supports phospholipid synthesis and supplies choline for acetylcholine metabolism, with common application directions in cognitive, neuroprotective, and ocular-health products.

What is the difference between the injection and oral/food grades?

The injection grade carries tighter microbiological control, with bacterial endotoxins below 0.5 EU/mg. The oral/food grade is controlled for oral-use contaminants such as total plate count at or below 1000 cfu/g, while both grades use the same citicoline sodium CAS 33818-15-4 base identity.

How soluble is Citicoline Sodium, and how should it be stored?

Citicoline Sodium is freely soluble in water, with reported laboratory solubility around 200 mg/mL. It is highly hygroscopic, so it should be kept tightly sealed and stored in a cool, dry area protected from moisture; the offered packaging uses low-permeability liners to reduce moisture pickup.

Citicoline Sodium CAS 33818-15-4

Citicoline Sodium is the sodium salt form of citicoline, also known as CDP-choline sodium. Based on currently available identity information, this product is more appropriately positioned as a pharmaceutical or nutraceutical raw material rather than a general industrial chemical. We supply this material according to product positioning, grade, and application requirements.

CAS: 33818-15-4
Synonyms: CDP-Choline Sodium, Cytidine 5'-diphosphocholine sodium salt, Citicoline sodium salt, Cytidine 5'-(trihydrogen diphosphate) P'-(2-(trimethylammonio)ethyl) ester sodium salt
Einecs: 251-689-1
Molecular Formula: C14H25N4NaO11P2
Grade: Pharmaceutical Grade (Injection/Oral) / Food Grade
Package: 1kg/Alu-tin, 5kg/Drum, or 25kg/Fiber Drum (with double low-permeability PE liners).

Request a quote

Share:

Product Description

1 Physicochemical Properties

2 Reference Information

3 Applications

4 Packaging and Storage

Physicochemical Properties

Parameter	Specification
Appearance	White or off-white crystalline powder
Assay (on dry basis)	98.0% – 102.0%
Identification (IR/HPLC)	Conforms to standard
pH Value (1% solution)	6.0 – 7.5
Specific Rotation	+10.0° to +12.0°
Loss on Drying (Water)	≤ 5.0% (Highly Hygroscopic)
Related Substances (5′-CMP)	≤ 0.3%
Total Other Impurities	≤ 1.0%
Heavy Metals	≤ 10 ppm
Arsenic (As)	≤ 1 ppm
Bacterial Endotoxins	< 0.5 EU/mg (For Injection Grade)
Total Plate Count	≤ 1000 cfu/g (For Oral/Food Grade)

Reference Information

Molecular formula: C14H25N4NaO11P2
Molecular weight: 510.31
Chemical identity note: sodium salt of citicoline / cytidine 5′-diphosphocholine sodium salt
General physical description: solid; exact appearance should be confirmed against the offered grade and batch documentation.

Applications

Citicoline Sodium is generally handled as a specialized raw material for pharmaceutical, nutraceutical, research, or related formulation programs. Actual application suitability depends on grade, purity standard, formulation system, regulatory framework, and end-use validation.

Typical application directions may include:

pharmaceutical raw material programs, subject to grade and regulatory confirmation
nutraceutical or health-related formulation development, depending on local compliance requirements
laboratory, analytical, or research use, depending on the offered grade
custom supply projects where identity, specification, and document scope are confirmed before order

Any specific formulation use should be evaluated according to application requirements and product validation standards.

Packaging and Storage

Standard packaging is available. The product may be packed in bags, drums, cartons, or other suitable containers as applicable to the offered grade and supply format. Customized packaging may be discussed upon request.

Store in a tightly closed container in a dry and clean environment. Protection from moisture, heat, and unsuitable storage conditions should be considered according to the offered grade and handling requirements. Exact storage conditions should be confirmed against the applicable product documentation.

FAQ - Technical & Supply Chain

Q:
What is Citicoline Sodium CAS 33818-15-4?

A: Citicoline Sodium CAS 33818-15-4 is the sodium salt of cytidine 5'-diphosphocholine, also known as CDP-Choline Sodium. It has molecular formula C14H25N4NaO11P2, molecular weight about 510.31, and EINECS number 251-689-1.
Q:
How does Citicoline Sodium differ from citicoline free base?

A: Citicoline Sodium is the sodium salt form registered as CAS 33818-15-4, while citicoline free base is commonly listed as CAS 987-78-0. The sodium salt form is used in many pharmaceutical and supplement applications because it is highly water-soluble and convenient for aqueous formulations.
Q:
What are the main applications of Citicoline Sodium?

A: Citicoline Sodium is used as a CDP-choline source in pharmaceutical, nutraceutical, and related research formulations. It supports phospholipid synthesis and supplies choline for acetylcholine metabolism, with common application directions in cognitive, neuroprotective, and ocular-health products.
Q:
What is the difference between the injection and oral/food grades?

A: The injection grade carries tighter microbiological control, with bacterial endotoxins below 0.5 EU/mg. The oral/food grade is controlled for oral-use contaminants such as total plate count at or below 1000 cfu/g, while both grades use the same citicoline sodium CAS 33818-15-4 base identity.
Q:
How soluble is Citicoline Sodium, and how should it be stored?

A: Citicoline Sodium is freely soluble in water, with reported laboratory solubility around 200 mg/mL. It is highly hygroscopic, so it should be kept tightly sealed and stored in a cool, dry area protected from moisture; the offered packaging uses low-permeability liners to reduce moisture pickup.

Ordering & Documentation

Key information for document requests, quotations, and supply planning.

Documents

COA, TDS, SDS/MSDS and packing details are available on request.

Quotation

Send the CAS number, grade, quantity, packing preference and destination.

Sample & Supply

Support is available for samples, trial orders, bulk and repeat supply.

Storage & Shipping

Product-specific conditions are confirmed before order.

Current Language

Change Language