Niacinamide CAS 98-92-0

FAQ - Technical & Supply Chain

• Q:

  What is the difference between Niacinamide and Niacin (Nicotinic Acid)?

  A: Niacinamide (CAS 98-92-0) is the amide form of Niacin (Nicotinic Acid, CAS 59-67-6). While both are forms of Vitamin B3, Niacinamide does not cause the skin flushing reaction commonly associated with Niacin, making it more suitable for cosmetic and personal care formulations where heat generation or vasodilation response must be avoided. Their reactivity and coenzyme roles also differ in pharmaceutical synthesis pathways.
• Q:

  What grade options are available for Niacinamide CAS 98-92-0?

  A: Niacinamide is commonly supplied in food grade, BP (British Pharmacopoeia), and USP (United States Pharmacopoeia) grades. The choice depends on the intended application — USP grade is typically required for pharmaceutical formulations, while food grade may be suitable for dietary supplements and cosmetic raw material systems. Always verify that the selected grade meets your formulation's regulatory requirements.
• Q:

  How should Niacinamide be stored to maintain stability?

  A: Niacinamide (CAS 98-92-0) should be stored in a cool, dry place in tightly sealed containers, protected from light and moisture. It is a stable compound under normal storage conditions, but prolonged exposure to high temperatures or humidity may cause gradual degradation or discoloration. Proper storage ensures consistent quality for cosmetic and pharmaceutical applications.
• Q:

  Is Niacinamide water-soluble and how does this affect formulation?

  A: Yes, Niacinamide is freely soluble in water at approximately 100 g/L at 20 °C. Its excellent water solubility makes it easy to incorporate into aqueous-based formulations such as serums, creams, lotions, and injectable preparations. For oil-based systems, it may require solubilization or encapsulation depending on the target concentration and formulation matrix.
• Q:

  What are the key specifications to verify when sourcing Niacinamide?

  A: When sourcing Niacinamide (Nicotinamide, CAS 98-92-0), key specifications to confirm include: assay (typically ≥99.0%), melting point range (128–131 °C), heavy metals limits, loss on drying, and pH of solution. For pharmaceutical or cosmetic applications, additional testing such as residual solvents, microbial limits, and identification by IR or HPLC should be reviewed in the provided COA.
• Q:

  Can Niacinamide be used alongside other active ingredients in formulations?

  A: Niacinamide is generally compatible with most formulation ingredients, including peptides, antioxidants, and humectants. It is stable across a typical pH range of 5.0–7.0. However, it should not be formulated with strong acids or reducing agents that could hydrolyze the amide group. Compatibility testing is recommended when combining Niacinamide with other active ingredients at significant concentrations.