What is Microcrystalline Cellulose CAS 9004-34-6?

Microcrystalline cellulose, or MCC, is a purified, partially depolymerized cellulose made by controlled hydrolysis of alpha-cellulose from fibrous plant material. Its general formula is (C6H10O5)n and it is supplied as a white to off-white, odorless powder.

What is Microcrystalline Cellulose used for in pharmaceuticals?

MCC is used as a direct-compression binder, filler, diluent, disintegrant and flow aid in tablets and capsules. It is especially valued for its compressibility, compactibility and compatibility with many active ingredients.

Is Microcrystalline Cellulose the same as cellulose powder?

Not exactly. Both are cellulose-based powders, but microcrystalline cellulose is more purified and partially depolymerized, with better tablet-compression and direct-compression performance than ordinary cellulose powder or powdered cellulose.

What MCC grades should be considered for formulation?

Common choices include finer PH-101, larger-particle PH-102 and free-flowing PH-200 type grades, plus co-processed or agglomerated grades. Confirm average particle size, bulk and tapped density, moisture, degree of polymerization and the required pharmacopoeial or food grade.

How should pharmaceutical-grade Microcrystalline Cellulose be stored and handled?

Store it tightly closed in a cool, dry area away from moisture, strong oxidizers and excessive heat. Use dust controls and suitable PPE because it is a combustible organic powder.

Microcrystalline Cellulose CAS 9004-34-6

Microcrystalline Cellulose (CAS 9004-34-6), commonly abbreviated as MCC, is a purified, partially depolymerized cellulose derived from fibrous plant material. Functioning as a non-reactive binder, diluent, and disintegration aid, this white, free-flowing powder is the gold standard excipient in the formulation of solid dosage forms. It is extensively utilized in pharmaceutical direct compression tableting, capsule filling, and as an anti-caking agent in industrial food processing. We provide this industrial material with competitive factory pricing to support continuous manufacturing operations, alongside options for customized specifications (such as particle size and bulk density). Essential technical documentation, including MSDS, TDS, COA, is readily available for all bulk supply orders.

CAS: 9004-34-6
Synonyms: MCC, Cellulose microcrystalline, Purified cellulose, Hydrolyzed cellulose, Cellulose powder
Einecs: 232-674-9
Molecular Formula: (C6H10O5)n
Grade: Pharmaceutical Grade
Package: 25 kg/drum

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Product Description

Microcrystalline Cellulose (CAS 9004-34-6) is a purified, partially depolymerized cellulose used as a binder, filler, and stabilizer in the pharmaceutical, food, and cosmetic industries. It is widely used in tablet formulation due to its excellent compressibility, flowability, and stability, making it a key excipient in various drug products.

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1 Physicochemical Properties:

2 Applications:

3 Storage Conditions:

4 Safety Precautions:

Physicochemical Properties:

Property	Value
Appearance	White, free-flowing, odorless powder
Bulk Density	0.26–0.35 g/cm³ (grade-dependent)
Solubility	Insoluble in water and most organic solvents
pH (1% suspension)	4.0–6.0
Particle Size	80% passes through a 100 mesh sieve
Moisture Content	≤5%
Loss on Drying	≤5%
Purity	≥99%

Applications:

Used as a binder and filler in tablet formulations
Commonly employed as a stabilizer in food and cosmetic products
Serves as an excipient for controlled release drug formulations
Frequently utilized in powdered foods, dietary supplements, and cosmetics

For related cellulose-based excipient and polymer raw materials, see Hydroxypropyl Methylcellulose and Sodium Carboxymethyl Cellulose.

Storage Conditions:

Store in a cool, dry place away from direct sunlight and moisture
Keep container tightly closed when not in use
Ideal storage temperature: 15°C to 30°C

Safety Precautions:

Handling: Wear appropriate personal protective equipment (PPE), including gloves, safety goggles, and a dust mask when handling the product to prevent inhalation and skin contact.
Storage: Store in a sealed, moisture-proof container to avoid contamination and maintain product integrity.
First Aid: In case of eye contact, rinse with plenty of water for 15 minutes. If irritation persists, seek medical attention. If inhaled, move to an area with fresh air. If ingestion occurs, seek immediate medical advice.

FAQ - Technical & Supply Chain

Q:
What is Microcrystalline Cellulose CAS 9004-34-6?

A: Microcrystalline cellulose, or MCC, is a purified, partially depolymerized cellulose made by controlled hydrolysis of alpha-cellulose from fibrous plant material. Its general formula is (C6H10O5)n and it is supplied as a white to off-white, odorless powder.
Q:
What is Microcrystalline Cellulose used for in pharmaceuticals?

A: MCC is used as a direct-compression binder, filler, diluent, disintegrant and flow aid in tablets and capsules. It is especially valued for its compressibility, compactibility and compatibility with many active ingredients.
Q:
Is Microcrystalline Cellulose the same as cellulose powder?

A: Not exactly. Both are cellulose-based powders, but microcrystalline cellulose is more purified and partially depolymerized, with better tablet-compression and direct-compression performance than ordinary cellulose powder or powdered cellulose.
Q:
What MCC grades should be considered for formulation?

A: Common choices include finer PH-101, larger-particle PH-102 and free-flowing PH-200 type grades, plus co-processed or agglomerated grades. Confirm average particle size, bulk and tapped density, moisture, degree of polymerization and the required pharmacopoeial or food grade.
Q:
How should pharmaceutical-grade Microcrystalline Cellulose be stored and handled?

A: Store it tightly closed in a cool, dry area away from moisture, strong oxidizers and excessive heat. Use dust controls and suitable PPE because it is a combustible organic powder.

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