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    Related: DETA TMEDA Imidazole
    • Piperazine Anhydrous CAS 110-85-0
    • Piperazine Anhydrous CAS 110-85-0
    • Piperazine Anhydrous CAS 110-85-0
    • Piperazine Anhydrous CAS 110-85-0

    Piperazine Anhydrous CAS 110-85-0

    Piperazine Anhydrous (CAS 110-85-0) is a hygroscopic cyclic diamine intermediate supplied for polyamide and polyol synthesis, selected pharmaceutical routes, and urethane or epoxy chemistry. Its water specification distinguishes it from piperazine hydrates and aqueous solutions.

    • CAS: 110-85-0
    • Synonyms: Piperazine, Anhydrous piperazine, 1,4-Diazacyclohexane, Hexahydropyrazine
    • Einecs: 203-808-3
    • Molecular Formula: C₄H₁₀N₂
    • Grade: Industrial anhydrous piperazine; assay, water, color and process-specific impurity limits agreed for the application
    • Package: Packaging and transport details specified with the quotation for the offered grade, quantity and destination
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    Product Description

    1 Product Overview
    2 Product Information / Specifications
    3 Physical & Chemical Properties
    4 Quality Controls and Documents
    5 Applications
    6 Packaging
    7 Storage Conditions
    8 Safety Precautions

    Product Overview

    Piperazine Anhydrous (CAS 110-85-0) is a hygroscopic cyclic diamine intermediate for polyamide and polyol synthesis, selected pharmaceutical routes, and urethane or epoxy chemistry. Its anhydrous form has a different water specification from piperazine hydrates and aqueous solutions.

    Assay, water content and process-specific impurities are the main grade-selection points. Use as a pharmaceutical intermediate does not by itself establish pharmacopoeial or GMP status.

    Product Information / Specifications

    Product Name Piperazine Anhydrous
    Synonyms Diethylenediamine; 1,4-Diazacyclohexane
    CAS Number 110-85-0
    EINECS Number 203-808-3
    Molecular Formula C4H10N2
    Molecular Weight 86.14 g/mol
    Typical Grade Industrial anhydrous piperazine; assay, water, color and process-specific impurity limits agreed for the application
    Standard Packaging Packaging and transport details specified with the quotation for the offered grade, quantity and destination
    Product Identity Industrial chemical / cyclic diamine intermediate

    Physical & Chemical Properties

    Appearance Colorless to white hygroscopic crystals or flakes; physical form is stated for the offered grade
    Density Approximately 1.1 g/cm³ at 20°C (published reference for neat material)
    Melting Point Approximately 106°C (published reference for neat material)
    Boiling Point Approximately 146–147°C at 760 mmHg (published reference for neat material)
    Solubility Soluble in water; published reference is about 150 g/L at 20°C
    pH About 12 in a 150 g/L aqueous solution at 20°C (published reference, not a property of the dry solid)
    Vapor Pressure Approximately 0.16 mmHg at 20°C (published reference for neat material)
    Stability Note Hygroscopic; keep the package closed and dry, and follow the supplied SDS for storage and incompatibilities

    Quality Controls and Documents

    Gas chromatography (GC) can be used for piperazine assay, while Karl Fischer (KF) titration measures water content. Where color is a specification item, the solution concentration and APHA/Hazen test basis should be stated. These methods serve different measurements; a GC area percentage should not be treated as a mass percentage without the method basis.

    We can provide a Certificate of Analysis (COA), Technical Data Sheet (TDS) and Safety Data Sheet (SDS) for the offered grade. Include the required assay, water and any process-specific impurity limits in the inquiry so the quotation can address the relevant specification.

    Applications

    • Selected pharmaceutical synthesis routes where the agreed grade and impurity profile fit the process
    • Polyamide, polyol and other polymer-related synthesis
    • Urethane and epoxy systems requiring cyclic diamine functionality
    • Gas-treatment and other specialty chemical routes using piperazine chemistry

    For a route that calls for a linear diamine or triamine instead of cyclic piperazine, compare ethylenediamine (EDA) and diethylenetriamine (DETA) by amine functionality and water specification; neither is an equal-weight substitute. In epoxy systems, bisphenol A liquid epoxy resin is a related resin-side material, not another form of piperazine.

    Packaging

    State the required pack size and destination in the inquiry. The quotation will specify the offered packaging and transport details for the selected grade.

    Storage Conditions

    • Store in a dry, ventilated, and cool warehouse away from direct sunlight.
    • Use the supplied TDS/SDS for grade-specific storage conditions.
    • Store separately from oxidants, acids, and incompatible chemicals.
    • Avoid contact with humid air and prolonged light exposure during storage.

    Safety Precautions

    • Wear protective gloves and eye protection. Use respiratory protection where the SDS or exposure conditions require it.
    • Avoid skin and eye contact and reduce exposure to dust or vapors during handling.
    • Use suitable ventilation and sealed handling procedures where possible.
    • Keep away from ignition sources, strong acids, oxidizing agents, and other incompatible reactive substances.
    • Refer to the latest SDS before storage, transport, and industrial use.

    FAQ - Technical & Supply Chain

    • Q:

      Is Piperazine Anhydrous interchangeable with piperazine hydrate or aqueous piperazine?

      A: No. The anhydrous grade, hydrates and aqueous solutions have different water contents; anhydrous does not mean zero residual moisture. A change of form requires recalculating the piperazine charge and water contribution from the agreed specification.
    • Q:

      Which quality tests matter for Piperazine Anhydrous?

      A: Gas chromatography (GC) can measure piperazine assay, while Karl Fischer (KF) titration measures water. Color and route-specific impurities may also be relevant; an APHA/Hazen color result needs the stated test-solution concentration. The test method and reporting basis should be agreed with the offered grade.
    • Q:

      Does use of Piperazine Anhydrous in pharmaceutical synthesis make it pharmaceutical grade?

      A: No. Use as a synthesis intermediate does not itself establish pharmacopoeial or GMP status. Tell us the required monograph, impurity limits, documentation and destination-market requirements so we can quote an appropriate grade.

    Ordering & Documentation

    Key information for document requests, quotations, and supply planning.

    Documents

    Tell us which documents your procurement team needs. Before an order, we will check whether the quoted source can provide them for the offered lot.

    Quotation

    Send the CAS number, grade, quantity, packing preference and destination.

    Sample & Supply

    Ask whether samples, trial quantities or repeat orders are possible. We will check each request against the sourced product and current offer.

    Storage & Shipping

    Product-specific conditions are confirmed before order.

    Contact Form

    Use our contact form to send us your questions, suggestions or comments. We will respond as soon as possible.
    For a quotation, please include the product name or CAS number, quantity, grade or application, and destination country or port. Tell us if you need a sample, COA, TDS or SDS.

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