Is Piperazine Anhydrous interchangeable with piperazine hydrate or aqueous piperazine?

No. Piperazine Anhydrous is supplied without added water, whereas hydrate and solution grades carry water into the process. They cannot be substituted by equal weight. The charge should be recalculated on the actual active material and water balance required by the formulation or reaction.

Which controls should be agreed for Piperazine Anhydrous used as a chemical intermediate?

Confirm identity, assay, water, colour, insoluble matter and any process-relevant impurity limits, together with the test methods. The acceptance specification should reflect the intended chemistry; matching the CAS number or assay alone does not establish interchangeability with another supplied grade.

Does use of Piperazine Anhydrous in pharmaceutical synthesis make it pharmaceutical grade?

No. A synthesis application does not establish pharmaceutical grade, compendial compliance, GMP status or suitability for a regulated route. State the required grade, impurity limits, documentation and destination-market requirements before comparing an offer.

Piperazine Anhydrous CAS 110-85-0

Piperazine Anhydrous (CAS 110-85-0, EC 203-808-3) is a cyclic diamine intermediate used in pharmaceutical synthesis, polyamide and polyol chemistry, urethane and epoxy systems, and specialty chemical production. It must be distinguished from piperazine hydrates and aqueous solutions, and a synthesis application does not establish pharmaceutical-grade or compendial status. Confirm assay, water, appearance, process-relevant impurities, packaging and required documents for the selected grade.

CAS: 110-85-0
Synonyms: Piperazine, Anhydrous piperazine, 1,4-Diazacyclohexane, Hexahydropyrazine
Einecs: 203-808-3
Molecular Formula: C₄H₁₀N₂
Grade: Confirm assay, water, color, insoluble matter and process-specific impurities
Package: Confirm current packaging and transport requirements for the selected grade

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Product Description

1 Product Overview

2 Product Information / Specifications

3 Physical & Chemical Properties

Product Overview

Piperazine Anhydrous is a cyclic diamine intermediate used in pharmaceutical synthesis, polyamide and polyol chemistry, urethane and epoxy systems, and other specialty chemical routes that require piperazine functionality.

This is an industrial chemical intermediate, not a finished formulation. Use in a pharmaceutical synthesis route does not establish pharmaceutical grade, compendial compliance, GMP status or suitability for a regulated process. Confirm identity, assay, water and process-relevant impurities for the intended route.

Product Information / Specifications

Product Name	Piperazine Anhydrous
Synonyms	Diethylenediamine; 1,4-Diazacyclohexane
CAS Number	110-85-0
EINECS Number	203-808-3
Molecular Formula	C4H10N2
Molecular Weight	86.14 g/mol
Typical Grade	Confirm assay, water, color, insoluble matter and process-specific impurities
Standard Packaging	Confirm current packaging and transport requirements for the selected grade
Product Identity	Industrial chemical / cyclic diamine intermediate

Physical & Chemical Properties

Appearance	Colorless to white hygroscopic crystals or flakes; confirm physical form and color for the offered grade
Density	Approximately 1.1 g/cm³ at 20°C as a reference value; confirm the current technical documentation
Melting Point	Approximately 106°C as a reference value; confirm the method and grade-specific range
Boiling Point	Approximately 146°C at 760 mmHg as a reference value; use the current SDS/TDS for handling decisions
Flash Point	Published values vary with the test method; use the current SDS for classification and handling
Solubility	Soluble in water; confirm quantitative solubility and solvent compatibility for the intended process
pH	Confirm solution concentration, temperature and test method in the current technical data
Vapor Pressure	Approximately 0.16 mmHg at 20°C as a reference value; use the current SDS for handling
Stability Note	Hygroscopic; keep the package closed and follow the current SDS for light protection, storage and incompatibilities

Applications

Selected pharmaceutical synthesis routes only after grade, impurity and regulatory requirements are agreed
Polyamide, polyol and other polymer-related synthesis routes
Rubber-related chemical applications
Urethane, epoxy and specialty reaction systems requiring cyclic diamine functionality
Specialty chemical synthesis where cyclic diamine functionality is required

Packaging

Confirm current packaging and transport requirements for the selected grade

Packaging information may vary by grade, destination, and transport arrangement.

Storage Conditions

Store in a dry, ventilated, and cool warehouse away from direct sunlight.
Confirm the grade-specific storage temperature and retest period in the current product documentation.
Store separately from oxidants, acids, and incompatible chemicals.
Avoid contact with humid air and prolonged light exposure during storage.

Safety Precautions

Handle with protective gloves, goggles, and suitable respiratory protection where required.
Avoid skin and eye contact and reduce exposure to dust or vapors during handling.
Use suitable ventilation and sealed handling procedures where possible.
Keep away from strong acids, oxidizing agents, and other incompatible reactive substances.
Refer to the latest SDS before storage, transport, and industrial use.

FAQ - Technical & Supply Chain

Q:
Is Piperazine Anhydrous interchangeable with piperazine hydrate or aqueous piperazine?

A: No. Piperazine Anhydrous is supplied without added water, whereas hydrate and solution grades carry water into the process. They cannot be substituted by equal weight. The charge should be recalculated on the actual active material and water balance required by the formulation or reaction.
Q:
Which controls should be agreed for Piperazine Anhydrous used as a chemical intermediate?

A: Confirm identity, assay, water, colour, insoluble matter and any process-relevant impurity limits, together with the test methods. The acceptance specification should reflect the intended chemistry; matching the CAS number or assay alone does not establish interchangeability with another supplied grade.
Q:
Does use of Piperazine Anhydrous in pharmaceutical synthesis make it pharmaceutical grade?

A: No. A synthesis application does not establish pharmaceutical grade, compendial compliance, GMP status or suitability for a regulated route. State the required grade, impurity limits, documentation and destination-market requirements before comparing an offer.

Ordering & Documentation

Key information for document requests, quotations, and supply planning.

Documents

COA, TDS, SDS/MSDS and packing details are available on request.

Quotation

Send the CAS number, grade, quantity, packing preference and destination.

Sample & Supply

Support is available for samples, trial orders, bulk and repeat supply.

Storage & Shipping

Product-specific conditions are confirmed before order.

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