What is Piperazine Anhydrous (CAS 110-85-0) mainly used for as an industrial intermediate?

Piperazine Anhydrous (CAS 110-85-0) is a cyclic diamine intermediate used primarily in epoxy curing systems, pharmaceutical active ingredient synthesis, polymer additive production, and rubber-related chemical manufacturing. Its two secondary amine groups in a heterocyclic ring structure enable controlled crosslinking and building-block reactivity.

What purity level is available for Piperazine Anhydrous and how does it affect performance?

Piperazine Anhydrous is supplied at a minimum purity of 99.5% (Grade 99.5%). Higher purity minimizes unwanted side reactions in pharmaceutical synthesis and epoxy curing formulations where reactive diamine functionality is critical. Buyers should confirm if the 99.5% grade meets their process requirements before ordering.

How should Piperazine Anhydrous be stored to maintain its quality?

Piperazine Anhydrous should be stored in a dry, cool, ventilated warehouse below 30°C, away from sunlight, humid air, acids, and oxidizing agents. Because the product is hygroscopic, moisture control during storage and handling is important to maintain the specified purity level.

Is Piperazine Anhydrous a finished formulation ingredient or an intermediate?

Piperazine Anhydrous is positioned as an industrial cyclic diamine intermediate rather than a finished formulation ingredient. It is intended for use in downstream chemical synthesis and manufacturing processes. Product selection should be based on identity consistency, purity level, moisture control, and compatibility with the intended synthesis route.

What documentation is available for Piperazine Anhydrous orders?

COA, SDS, and TDS can be provided according to the supplied grade and shipment arrangement. Buyers may request these documents during the procurement process for quality review and regulatory reference.

What packaging options are available for Piperazine Anhydrous?

Standard packaging for Piperazine Anhydrous is 25 kg/drum. Packaging can be adjusted based on shipment requirements. Buyers are advised to confirm packaging preferences at the ordering stage.

Piperazine Anhydrous (CAS 110-85-0)

Piperazine Anhydrous (CAS 110-85-0), also referred to as anhydrous piperazine, 1,4-diazacyclohexane, or hexahydropyrazine, is a cyclic diamine widely used as an intermediate in epoxy resin curing systems and pharmaceutical synthesis. Its reactivity is based on two secondary amine groups within a heterocyclic structure, enabling controlled crosslinking reactions in resin formulations and serving as a building block in active ingredient manufacturing. COA, SDS, and TDS are available according to the supplied grade and shipment arrangement.

CAS: 110-85-0
Synonyms: Piperazine, Anhydrous piperazine, 1,4-Diazacyclohexane, Hexahydropyrazine
Einecs: 203-808-3
Molecular Formula: C₄H₁₀N₂
Grade: 99.5%
Package: 25kg/drum or as required

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Product Description

1 Product Overview

2 Product Information / Specifications

3 Physical & Chemical Properties

Product Overview

Piperazine Anhydrous is provided for industrial use as a cyclic amine intermediate in chemical manufacturing routes that require reactive diamine functionality. It is commonly selected for synthesis systems in pharmaceutical processing, polymer-related chemistry, and auxiliary chemical production.

This product is more appropriately positioned as an industrial chemical intermediate rather than a finished end-use formulation ingredient. Product selection is generally based on identity consistency, purity level, moisture control, and compatibility with the intended synthesis or processing route.

Product Information / Specifications

Product Name	Piperazine Anhydrous
Synonyms	Diethylenediamine; 1,4-Diazacyclohexane
CAS Number	110-85-0
EINECS Number	203-808-3
Molecular Formula	C4H10N2
Molecular Weight	86.14 g/mol
Typical Grade	99.5%
Standard Packaging	25 kg/drum or as required
Product Identity	Industrial chemical / cyclic diamine intermediate

Physical & Chemical Properties

Appearance	Colorless or white crystalline powder or needle-like crystals
Density	0.874 g/cm³
Melting Point	107–111°C
Boiling Point	146–148°C
Flash Point	49.7–65°C (closed cup)
Solubility	150 g/L in water at 20°C; soluble in ethanol; insoluble in ether
pH	10.8–11.8 (10% aqueous solution)
Vapor Pressure	4.049 mmHg at 25°C
Stability Note	Stable under normal conditions, hygroscopic, light sensitive, and incompatible with strong oxidizing agents, strong acids, acid anhydrides, and acid chlorides

Applications

Pharmaceutical intermediates for synthesis routes including anthelmintic and antibacterial-related production
Polymer additives and related material modification systems
Rubber-related chemical applications
Preservative, antioxidant, and gas purification related industrial uses
Specialty chemical synthesis where cyclic diamine functionality is required

Packaging

Standard packaging is commonly supplied in 25 kg drums or according to shipment requirement.

Packaging information may vary by grade, destination, and transport arrangement.

Storage Conditions

Store in a dry, ventilated, and cool warehouse away from direct sunlight.
Recommended storage temperature is below 30°C.
Store separately from oxidants, acids, and incompatible chemicals.
Avoid contact with humid air and prolonged light exposure during storage.

Safety Precautions

Handle with protective gloves, goggles, and suitable respiratory protection where required.
Avoid skin and eye contact and reduce exposure to dust or vapors during handling.
Use suitable ventilation and sealed handling procedures where possible.
Keep away from strong acids, oxidizing agents, and other incompatible reactive substances.
Refer to the latest SDS before storage, transport, and industrial use.

FAQ - Technical & Supply Chain

Q:
What is Piperazine Anhydrous (CAS 110-85-0) mainly used for as an industrial intermediate?

A: Piperazine Anhydrous (CAS 110-85-0) is a cyclic diamine intermediate used primarily in epoxy curing systems, pharmaceutical active ingredient synthesis, polymer additive production, and rubber-related chemical manufacturing. Its two secondary amine groups in a heterocyclic ring structure enable controlled crosslinking and building-block reactivity.
Q:
What purity level is available for Piperazine Anhydrous and how does it affect performance?

A: Piperazine Anhydrous is supplied at a minimum purity of 99.5% (Grade 99.5%). Higher purity minimizes unwanted side reactions in pharmaceutical synthesis and epoxy curing formulations where reactive diamine functionality is critical. Buyers should confirm if the 99.5% grade meets their process requirements before ordering.
Q:
How should Piperazine Anhydrous be stored to maintain its quality?

A: Piperazine Anhydrous should be stored in a dry, cool, ventilated warehouse below 30°C, away from sunlight, humid air, acids, and oxidizing agents. Because the product is hygroscopic, moisture control during storage and handling is important to maintain the specified purity level.
Q:
Is Piperazine Anhydrous a finished formulation ingredient or an intermediate?

A: Piperazine Anhydrous is positioned as an industrial cyclic diamine intermediate rather than a finished formulation ingredient. It is intended for use in downstream chemical synthesis and manufacturing processes. Product selection should be based on identity consistency, purity level, moisture control, and compatibility with the intended synthesis route.
Q:
What documentation is available for Piperazine Anhydrous orders?

A: COA, SDS, and TDS can be provided according to the supplied grade and shipment arrangement. Buyers may request these documents during the procurement process for quality review and regulatory reference.
Q:
What packaging options are available for Piperazine Anhydrous?

A: Standard packaging for Piperazine Anhydrous is 25 kg/drum. Packaging can be adjusted based on shipment requirements. Buyers are advised to confirm packaging preferences at the ordering stage.

Documents

Documents and Product Support

For product review and sourcing evaluation, supporting documents can be coordinated according to the product type, inquiry stage, and order requirements.

COA for batch-based quality reference
TDS for key physical and chemical information
SDS / MSDS for handling, storage, and safety reference
Packing information for sample, trial, and bulk orders
Technical communication based on application and specification requirements

Quotation

Information to Confirm Before Quotation

Clear sourcing information helps reduce specification mismatch and allows a more accurate quotation before sample or bulk order discussion.

Product name and CAS number
Application or intended end use
Required purity, grade, or specification
Sample quantity, trial order, or bulk demand
Preferred packing form or net weight
Destination country or port
Required documents or compliance expectations

Storage & Handling

Packaging, Storage, and Handling Notes

Packaging form, storage conditions, shelf life, and shipment arrangements should be confirmed according to the product characteristics, package size, and destination requirements.

Before order confirmation, buyers are advised to review the corresponding product documents and confirm whether any special storage, labeling, or handling requirements apply.

Supply Support

Sample, Bulk Order and Repeat Supply Support

Support can be arranged for sample discussion, bulk supply planning, packaging confirmation, and routine sourcing communication based on the actual product and order requirements.

For repeat-use formulations or long-term procurement plans, buyers may discuss specification consistency, packaging preferences, delivery expectations, and document coordination in advance.

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Product Categories

Tags:

Heterocyclic Amine Pharmaceutical Intermediate Polyamide Intermediate

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