Imidazole, identifiable by CAS 288‑32‑4, functions as a five-membered heterocyclic aromatic compound used primarily as a versatile building block in pharmaceutical synthesis and as a hardening agent in epoxy resin systems. Chemically defined as 1,3-Diazole, this white to pale yellow crystalline solid serves as a proton donor-acceptor in buffer solutions and a corrosion inhibitor for transition metals. The substance, often referred to as Glyoxaline in older technical literature, acts as a pivotal intermediate for antifungal drugs and agricultural fungicides due to its unique ring structure. We facilitate bulk supply of this organic heterocycle with competitive factory pricing, capable of meeting customized specifications for assay purity, backed by comprehensive MSDS, TDS, COA documentation.
Imidazole CAS 288‑32‑4
- CAS: 288-32-4
- Synonyms: 1H-Imidazole, Glyoxaline, Imidazol, Imidazole base
- Einecs: 206-019-2
- Molecular Formula: C3H4N2
- Grade: Industrial grade 99%
- Package: 200kg iron drum or 50kg plastic drum packaging
Product Description
Physicochemical Properties
| Parameter | Specification | Test Method |
|---|---|---|
| Appearance | White to pale yellow crystalline flakes | Visual Inspection |
| Purity (Assay) | ≥ 99.5% | Gas Chromatography |
| Melting Point | 88°C – 91°C | Melting Point Apparatus |
| Water Content | ≤ 0.30% | Karl Fischer |
| Ash (Residue on Ignition) | ≤ 0.10% | Gravimetric |
| Iron (Fe) | ≤ 5 ppm | ICP-MS |
| Solubility (10% in Water) | Clear and colorless | Visual |
Applications
Pharmaceutical Synthesis
- Antifungal APIs: The primary intermediate for the synthesis of azole antifungals, including Clotrimazole, Miconazole, Ketoconazole, and Econazole.
- Cardiovascular Drugs: Used in the production of thromboxane synthase inhibitors.
Epoxy Resin Curing
- Curing Agent & Accelerator: Acts as a latent curing agent for epoxy resins in copper-clad laminates (CCL) and semiconductor encapsulation. It significantly enhances heat resistance and electrical properties.
Agrochemicals
- Pesticides: Key intermediate for synthesizing fungicides like Imazalil and Prochloraz used in fruit preservation and crop protection.
Industrial Applications
- Corrosion Inhibitor: Used in circulating cooling water systems to prevent corrosion of copper and brass.
Quality Assurance (QA/QC)
Our Imidazole is manufactured in a GMP-compliant environment to ensure suitability for high-end pharmaceutical and electronic applications.
- Purity Guarantee: We maintain a purity level of $\ge$ 99.5% to ensure optimal reaction yields in API synthesis.
- Moisture Control: Strictly controlled water content ($\le$ 0.3%) prevents defects in moisture-sensitive epoxy curing processes.
- Trace Metal Analysis: Regular ICP-MS testing limits iron content to <5 ppm, critical for electronic-grade resin applications.
Storage & Safety
Storage Guidelines
- Hygroscopic: Imidazole readily absorbs moisture. Store in a cool, dry place in tightly sealed containers.
- Light Sensitive: Protect from direct sunlight to prevent discoloration.
- Compatibility: Incompatible with strong oxidizing agents and acids.
Safety & PPE Recommendations
- Hazard Class: Corrosive (Class 8). Causes severe skin burns and eye damage.
- Reproductive Toxicity: Suspected of damaging the unborn child (Category 1B).
- PPE: Wear full protective clothing, chemical-resistant gloves, and face shields. Handle in a well-ventilated area or fume hood.
- First Aid: In case of contact, immediately rinse skin/eyes with plenty of water for at least 15 minutes.
FAQ - Technical & Supply Chain
-
Q:
What is the typical role of imidazole in epoxy systems?
A: It is typically used as a curing accelerator to influence reaction kinetics during epoxy resin processing. -
Q:
Is Imidazole chemically synonymous with 1,3-Diazole?
A: Yes, Imidazole and 1,3-Diazole refer to the same planar heterocyclic compound identified by CAS 288‑32‑4, characterized by the formula C3H4N2. -
Q:
What is the primary function of Imidazole in epoxy resin formulations?
A: Imidazole is typically applied as an accelerator or curing agent in epoxy resin systems, where it catalyzes the cross-linking reaction to improve thermal stability and mechanical properties.
Documents and Product Support
For product review and sourcing evaluation, supporting documents can be coordinated according to the product type, inquiry stage, and order requirements.
- COA for batch-based quality reference
- TDS for key physical and chemical information
- SDS / MSDS for handling, storage, and safety reference
- Packing information for sample, trial, and bulk orders
- Technical communication based on application and specification requirements
Information to Confirm Before Quotation
Clear sourcing information helps reduce specification mismatch and allows a more accurate quotation before sample or bulk order discussion.
- Product name and CAS number
- Application or intended end use
- Required purity, grade, or specification
- Sample quantity, trial order, or bulk demand
- Preferred packing form or net weight
- Destination country or port
- Required documents or compliance expectations
Packaging, Storage, and Handling Notes
Packaging form, storage conditions, shelf life, and shipment arrangements should be confirmed according to the product characteristics, package size, and destination requirements.
Before order confirmation, buyers are advised to review the corresponding product documents and confirm whether any special storage, labeling, or handling requirements apply.
Sample, Bulk Order and Repeat Supply Support
Support can be arranged for sample discussion, bulk supply planning, packaging confirmation, and routine sourcing communication based on the actual product and order requirements.
For repeat-use formulations or long-term procurement plans, buyers may discuss specification consistency, packaging preferences, delivery expectations, and document coordination in advance.
