What is Tranexamic Acid CAS 1197-18-8?

Tranexamic Acid, also called trans-4-(aminomethyl)cyclohexanecarboxylic acid or t-AMCHA, is a synthetic lysine analogue with the molecular formula C8H15NO2 and molecular weight about 157.21 g/mol. It is supplied as a white crystalline powder and is used in both pharmaceutical and cosmetic applications.

Why is Tranexamic Acid described as suitable for cold-process cosmetic manufacturing?

It is highly water-soluble and heat-stable, so formulators normally add it to the aqueous phase without requiring high-temperature melting. This allows use in cold-process or lower-temperature serums and lotions, but the final pH and electrolyte balance still need to be checked for formula stability.

What is the difference between cosmetic grade and pharmaceutical grade Tranexamic Acid?

Cosmetic grade is typically specified at around 99% HPLC purity for topical skin care, while pharmaceutical grade is controlled to compendial standards such as USP/EP/JP for drug use. The same CAS 1197-18-8 can serve both markets, but the selected grade should match the intended regulatory and formulation requirements.

Tranexamic Acid (TXA) CAS 1197-18-8

Tranexamic Acid, also called TXA or trans-4-(aminomethyl)cyclohexanecarboxylic acid, CAS 1197-18-8, is a synthetic lysine analogue supplied for skin brightening cosmetics and pharmaceutical antifibrinolytic use. Confirm the required grade and specification, then request a quotation with COA/TDS/SDS for bulk supply.

CAS: 1197-18-8
Synonyms: trans-4-(Aminomethyl)cyclohexanecarboxylic acid, t-AMCHA, Transamin, Amstat, Cyclokapron
Einecs: 214-818-2
Molecular Formula: C₈H₁₅NO₂
Grade: Cosmetic Grade / Pharmaceutical Grade (API)
Package: 25kg/drum or customized fiber drums

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Product Description

Tranexamic Acid (TXA) CAS 1197-18-8 is trans-4-(aminomethyl)cyclohexanecarboxylic acid, a synthetic lysine analogue with the formula C₈H₁₅NO₂ and EINECS 214-818-2.

Synonyms: trans-4-(Aminomethyl)cyclohexanecarboxylic acid; t-AMCHA; Transamin; Amstat; Cyclokapron.

CAS: 1197-18-8.

Molecular formula: C₈H₁₅NO₂.

It is supplied as a white crystalline powder.

In topical cosmetics it inhibits the plasminogen/plasmin pathway, reducing signals that increase melanocyte activity and pigment transfer.

This makes it useful in serums, creams and spot treatments targeting melasma, post-inflammatory hyperpigmentation, freckles and uneven skin tone.

It is highly water-soluble and heat-stable, so formulators normally add it to the aqueous phase without high-temperature melting.

It is also used as an antifibrinolytic active pharmaceutical ingredient (API) to control excessive bleeding.

The typical assay (HPLC) is about 99.0% or higher, with a melting point of about 232-237 °C.

It is freely soluble in water and glacial acetic acid.

Cosmetic grade is typically specified at about 99% HPLC purity, while pharmaceutical grade is controlled to compendial standards such as USP/EP/JP.

Store in a cool, dry, well-ventilated area away from direct sunlight, heat and moisture.

Protect from moisture and light, and keep containers tightly sealed when not in use.

Confirm appearance, assay, melting point, loss on drying, residue on ignition, solubility and grade as required.

Use suitable eye and skin protection during handling, and wash skin contact with soap and water.

Confirm packaging with the requested quantity and destination requirements.

The page is an RFQ entry point and does not state stock, price, MOQ or fixed lead time.

For an RFQ, state the intended application, required grade, quantity, packaging, destination and document needs.

FAQ - Technical & Supply Chain

Q:
What is Tranexamic Acid CAS 1197-18-8?

A: Tranexamic Acid, also called trans-4-(aminomethyl)cyclohexanecarboxylic acid or t-AMCHA, is a synthetic lysine analogue with the molecular formula C8H15NO2 and molecular weight about 157.21 g/mol. It is supplied as a white crystalline powder and is used in both pharmaceutical and cosmetic applications.
Q:
How does Tranexamic Acid help with skin brightening and uneven tone?

A: In topical cosmetics it inhibits the plasminogen/plasmin pathway, reducing signals that increase melanocyte activity and pigment transfer. This makes it useful in serums, creams, and spot treatments targeting melasma, post-inflammatory hyperpigmentation, freckles, and uneven skin tone.
Q:
Why is Tranexamic Acid described as suitable for cold-process cosmetic manufacturing?

A: It is highly water-soluble and heat-stable, so formulators normally add it to the aqueous phase without requiring high-temperature melting. This allows use in cold-process or lower-temperature serums and lotions, but the final pH and electrolyte balance still need to be checked for formula stability.
Q:
What is the difference between cosmetic grade and pharmaceutical grade Tranexamic Acid?

A: Cosmetic grade is typically specified at around 99% HPLC purity for topical skin care, while pharmaceutical grade is controlled to compendial standards such as USP/EP/JP for drug use. The same CAS 1197-18-8 can serve both markets, but the selected grade should match the intended regulatory and formulation requirements.

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