What is Tranexamic Acid CAS 1197-18-8?

Tranexamic Acid, also called trans-4-(aminomethyl)cyclohexanecarboxylic acid or t-AMCHA, is a synthetic lysine analogue with the molecular formula C8H15NO2 and molecular weight about 157.21 g/mol. It is supplied as a white crystalline powder and is used in both pharmaceutical and cosmetic applications.

How does Tranexamic Acid help with skin brightening and uneven tone?

In topical cosmetics it inhibits the plasminogen/plasmin pathway, reducing signals that increase melanocyte activity and pigment transfer. This makes it useful in serums, creams, and spot treatments targeting melasma, post-inflammatory hyperpigmentation, freckles, and uneven skin tone.

Why is Tranexamic Acid described as suitable for cold-process cosmetic manufacturing?

It is highly water-soluble and heat-stable, so formulators normally add it to the aqueous phase without requiring high-temperature melting. This allows use in cold-process or lower-temperature serums and lotions, but the final pH and electrolyte balance still need to be checked for formula stability.

What is the difference between cosmetic grade and pharmaceutical grade Tranexamic Acid?

Cosmetic grade is typically specified at around 99% HPLC purity for topical skin care, while pharmaceutical grade is controlled to compendial standards such as USP/EP/JP for drug use. The same CAS 1197-18-8 can serve both markets, but the selected grade should match the intended regulatory and formulation requirements.

Tranexamic Acid CAS 1197-18-8

Tranexamic Acid CAS 1197-18-8 is a synthetic derivative of the amino acid lysine, functioning as a robust hydrophilic molecule extensively utilized within the Cosmetic Raw Materials sector for its ability to interfere with the catalytic mechanism of UV-induced pigmentation. As a white crystalline powder, this trans-4-(Aminomethyl)cyclohexanecarboxylic acid acts by inhibiting the plasminogen/plasmin pathway, thereby reducing the interaction between melanocytes and keratinocytes in various topical formulations. Beyond its role as a skin-conditioning t-AMCHA derivative, it serves as a critical Transamin intermediate in specialized chemical synthesis and pharmaceutical production processes requiring high-purity lysine analogs. Our infrastructure ensures competitive factory pricing for global distributors requiring customized specifications to meet diverse regional regulatory standards. Each batch is accompanied by comprehensive MSDS, TDS, COA documentation to facilitate seamless quality audits, supporting consistent bulk supply for large-scale manufacturing.

CAS: 1197-18-8
Synonyms: trans-4-(Aminomethyl)cyclohexanecarboxylic acid, t-AMCHA, Transamin, Amstat, Cyclokapron
Einecs: 214-818-2
Molecular Formula: C8H15NO2
Grade: Cosmetic Grade / Pharmaceutical Grade (API)
Package: 25kg/drum or customized fiber drums

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Product Description

Technical Data

Properties	Specifications
Appearance	White crystalline powder
Assay (HPLC)	≥ 99.0%
Melting Point	232°C – 237°C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Solubility	Freely soluble in water and glacial acetic acid
Heavy Metals (Pb)	≤ 10 ppm
Chlorides	≤ 0.014%

Applications

Cosmetic Formulations: Used as a primary brightening agent in serums, creams, and essences to target hyperpigmentation and UV-induced skin darkening.
Pharmaceutical Manufacturing: Acts as an active pharmaceutical ingredient (API) for antifibrinolytic medications used to control excessive bleeding.
Chemical Research: Utilized as a biochemical reagent in the study of protease inhibitors and lysine-binding sites.

For cosmetic brightening systems built around a stable vitamin C derivative, Ethyl Ascorbic Acid is a separate active with different formulation behavior.

Storage & Safety

Storage: Store in a cool, dry, and well-ventilated warehouse. Keep containers tightly sealed and away from direct sunlight, heat, and moisture.
Safety (PPE): Operators should wear chemical safety goggles, oil-resistant gloves, and protective clothing. Ensure adequate local exhaust ventilation to minimize dust inhalation. In case of contact, rinse eyes or skin immediately with plenty of water.

Quality Assurance

Our production facility adheres to rigorous quality management protocols, utilizing advanced analytical instrumentation including High-Performance Liquid Chromatography (HPLC) for purity verification and Nuclear Magnetic Resonance (NMR) for structural confirmation. Every batch undergoes stringent testing to ensure compliance with international pharmacopoeia and cosmetic safety standards, ensuring the physical and chemical stability of the material for complex industrial applications.

FAQ - Technical & Supply Chain

Q:
What is Tranexamic Acid CAS 1197-18-8?

A: Tranexamic Acid, also called trans-4-(aminomethyl)cyclohexanecarboxylic acid or t-AMCHA, is a synthetic lysine analogue with the molecular formula C8H15NO2 and molecular weight about 157.21 g/mol. It is supplied as a white crystalline powder and is used in both pharmaceutical and cosmetic applications.
Q:
How does Tranexamic Acid help with skin brightening and uneven tone?

A: In topical cosmetics it inhibits the plasminogen/plasmin pathway, reducing signals that increase melanocyte activity and pigment transfer. This makes it useful in serums, creams, and spot treatments targeting melasma, post-inflammatory hyperpigmentation, freckles, and uneven skin tone.
Q:
Why is Tranexamic Acid described as suitable for cold-process cosmetic manufacturing?

A: It is highly water-soluble and heat-stable, so formulators normally add it to the aqueous phase without requiring high-temperature melting. This allows use in cold-process or lower-temperature serums and lotions, but the final pH and electrolyte balance still need to be checked for formula stability.
Q:
What is the difference between cosmetic grade and pharmaceutical grade Tranexamic Acid?

A: Cosmetic grade is typically specified at around 99% HPLC purity for topical skin care, while pharmaceutical grade is controlled to compendial standards such as USP/EP/JP for drug use. The same CAS 1197-18-8 can serve both markets, but the selected grade should match the intended regulatory and formulation requirements.

Ordering & Documentation

Key information for document requests, quotations, and supply planning.

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COA, TDS, SDS/MSDS and packing details are available on request.

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