What is D-Panthenol CAS 81-13-0?

D-Panthenol CAS 81-13-0 is the biologically active form of panthenol, also called dexpanthenol or provitamin B5. It has the molecular formula C9H19NO4, molecular weight about 205.25 g/mol, and EINECS 201-327-3, and is supplied as a colorless to slightly yellowish viscous liquid.

Why is D-Panthenol called Provitamin B5 and how does it benefit skin?

D-Panthenol is converted in the body to pantothenic acid, which is part of coenzyme A, so it is often described as provitamin B5. In skincare it functions as a humectant and soothing agent, helping improve moisture retention, skin barrier support, and the appearance of stressed or sensitive skin.

How does D-Panthenol work in hair-care formulations?

D-Panthenol has a low molecular weight that allows it to penetrate the hair cuticle and help retain moisture within the fiber. Unlike surface-coating silicones, it provides internal conditioning benefits such as improved flexibility, reduced brittleness, and better wet or dry combing.

What are the key cosmetic-grade specifications for D-Panthenol?

Typical specifications include a colorless to slightly yellowish clear viscous liquid, assay of about 98-101%, specific rotation around +29.0 to +31.5 degrees, and refractive index of 1.495-1.502 at 20 C. It is highly soluble in water, ethanol, methanol, and propylene glycol.

How should high-viscosity D-Panthenol be handled in manufacturing?

High-purity D-Panthenol can become very thick and difficult to pump or pour in cold conditions. Gentle warming to around 40-50 C is commonly used to reduce viscosity and improve transfer before adding it to the batch.

In which personal-care products is D-Panthenol most commonly used?

D-Panthenol is used in creams, lotions, serums, after-sun products, sensitive-skin treatments, shampoos, conditioners, and hair masks. Its combination of humectancy, soothing properties, and conditioning performance makes it suitable for both skincare and haircare formulations.

D-Panthenol CAS 81-13-0

D-Panthenol, also called dexpanthenol or provitamin B5, CAS 81-13-0, is a colorless to slightly yellowish clear viscous liquid supplied in cosmetic or personal-care grade. Confirm the required grade and specification, then request a quotation with COA/TDS/SDS for bulk supply.

CAS: 81-13-0
Synonyms: Dexpanthenol, Provitamin B5, D-Pantothenyl alcohol, (R)-Panthenol, 2,4-Dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutanamide
Einecs: 201-327-3
Molecular Formula: C₉H₁₉NO₄
Grade: Cosmetic / Personal Care Grade
Package: 200 kg drum / 1000 kg IBC (customizable)

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Product Description

D-Panthenol CAS 81-13-0 is the biologically active form of panthenol, also known as dexpanthenol or provitamin B5, with molecular formula C9H19NO4, molecular weight about 205.25 and EINECS 201-327-3.

Synonyms: Dexpanthenol; Provitamin B5; D-Pantothenyl alcohol; (R)-Panthenol; 2,4-Dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutanamide.

CAS: 81-13-0.

It has the molecular formula C9H19NO4 and a molecular weight of about 205.25 g/mol.

It appears as a colorless to slightly yellowish clear viscous liquid.

A typical specification includes assay of about 98–101%, specific rotation of about +29.0 to +31.5 degrees and refractive index of 1.495–1.502 at 20 °C.

It is freely soluble in water, ethanol and propylene glycol.

In the body it is converted to pantothenic acid, a component of coenzyme A, so it is described as provitamin B5.

In skincare it acts as a humectant and soothing agent, helping to improve hydration and support skin barrier function.

In hair care its low molecular weight allows it to penetrate the hair cuticle and retain moisture, providing internal conditioning.

It is used in creams, lotions, serums, after-sun products, sensitive-skin treatments, shampoos, conditioners and hair masks.

High-purity D-Panthenol can become very thick and difficult to pump or pour in cold conditions.

Gentle warming to about 40–50 °C is commonly used to reduce viscosity and improve transfer before processing.

Store in a cool, dry, dark place in tightly sealed containers to protect the product from moisture and light.

Confirm appearance, assay, specific rotation, refractive index, water content, heavy metals and microbial limits as required.

Use suitable eye and skin protection during handling, and wash skin contact with soap and water.

Confirm packaging with the requested quantity and destination requirements.

The page is an RFQ entry point and does not state stock, price, MOQ or fixed lead time.

For an RFQ, state the intended use, required grade and specification, quantity, packaging, destination and document needs.

FAQ - Technical & Supply Chain

Q:
What is D-Panthenol CAS 81-13-0?

A: D-Panthenol CAS 81-13-0 is the biologically active form of panthenol, also called dexpanthenol or provitamin B5. It has the molecular formula C9H19NO4, molecular weight about 205.25 g/mol, and EINECS 201-327-3, and is supplied as a colorless to slightly yellowish viscous liquid.
Q:
Why is D-Panthenol called Provitamin B5 and how does it benefit skin?

A: D-Panthenol is converted in the body to pantothenic acid, which is part of coenzyme A, so it is often described as provitamin B5. In skincare it functions as a humectant and soothing agent, helping improve moisture retention, skin barrier support, and the appearance of stressed or sensitive skin.
Q:
How does D-Panthenol work in hair-care formulations?

A: D-Panthenol has a low molecular weight that allows it to penetrate the hair cuticle and help retain moisture within the fiber. Unlike surface-coating silicones, it provides internal conditioning benefits such as improved flexibility, reduced brittleness, and better wet or dry combing.
Q:
What are the key cosmetic-grade specifications for D-Panthenol?

A: Typical specifications include a colorless to slightly yellowish clear viscous liquid, assay of about 98-101%, specific rotation around +29.0 to +31.5 degrees, and refractive index of 1.495-1.502 at 20 C. It is highly soluble in water, ethanol, methanol, and propylene glycol.
Q:
How should high-viscosity D-Panthenol be handled in manufacturing?

A: High-purity D-Panthenol can become very thick and difficult to pump or pour in cold conditions. Gentle warming to around 40-50 C is commonly used to reduce viscosity and improve transfer before adding it to the batch.
Q:
In which personal-care products is D-Panthenol most commonly used?

A: D-Panthenol is used in creams, lotions, serums, after-sun products, sensitive-skin treatments, shampoos, conditioners, and hair masks. Its combination of humectancy, soothing properties, and conditioning performance makes it suitable for both skincare and haircare formulations.

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