D-Panthenol CAS 81-13-0 is a viscous, water-soluble liquid chemically defined as the alcohol analog of pantothenic acid , functioning primarily as a deep-penetrating moisturizer and wound-healing agent in personal care and pharmaceutical formulations. Widely recognized as Provitamin B5 or Dexpanthenol, this clear, colorless syrup converts to pantothenic acid (Vitamin B5) upon absorption into the skin or hair shaft, utilizing this pathway to stimulate cell regeneration and improve hydration elasticity. We provide professional access to this material with competitive factory pricing and the ability to meet customized specifications (typically 75% aqueous solution or 98% pure viscous liquid) for various manufacturing requirements. Our commitment to technical transparency ensures that every shipment is accompanied by comprehensive MSDS, TDS, COA documentation to support your quality assurance protocols, and we maintain capacity for consistent bulk supply to facilitate large-scale industrial operations.
D-panthenol CAS 81-13-0
- CAS: 81-13-0
- Synonyms: Dexpanthenol, Provitamin B5, D-Pantothenyl alcohol, (R)-Panthenol, 2,4-Dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutanamide
- Einecs: 201-327-3
- Molecular Formula: C9H19NO4
- Grade: Industrial Detergent Material
- Package: 200 kg drum / 1000 kg IBC (customizable)
Product Description
Physical & Chemical Properties
When sourcing raw materials, specs matter. You need to ensure the material will remain stable in your formulation. Here is the technical breakdown of our high-purity D-Panthenol:
| Property | Specification |
|---|---|
| Product Name | D-Panthenol (Provitamin B5) |
| CAS Number | 81-13-0 |
| Appearance | Colorless to slightly yellowish, clear, viscous liquid |
| Odor | Slight, characteristic odor |
| Assay (Purity) | 98.0% – 101.0% |
| Solubility | Highly soluble in water, ethanol, methanol, and propylene glycol |
| Specific Rotation | +29.0° to +31.5° |
| Refractive Index (20°C) | 1.495 – 1.502 |
| Heavy Metals | ≤ 10 ppm |
| pH Value (5% solution) | Neutral to slightly alkaline (approx. 9-10.5 typically) |
Key Application Fields
D-Panthenol isn’t a one-trick pony. Its versatility allows it to be used across a wide spectrum of personal care sectors:
1. Skincare (Creams, Lotions, Serums)
- Deep Hydration: As a penetrating humectant, it improves the skin’s barrier function and elasticity.
- Soothing Agent: It significantly reduces redness and inflammation, making it ideal for sensitive skin, acne treatments, or after-sun care.
- Healing: It promotes the proliferation of fibroblasts, speeding up wound healing and skin regeneration.
2. Hair Care (Shampoos, Conditioners, Masks)
- Long-lasting Moisture: It penetrates the hair shaft to moisturize from within, preventing dryness.
- Damage Control: It coats the hair to lubricate the shaft, reducing split ends and making hair shinier and easier to comb.
- Scalp Health: A healthy scalp grows healthy hair; D-Panthenol soothes itchy or irritated scalps.
3. Nail Care
- It improves the flexibility of nails, preventing breakage and chipping.
4. Pharmaceutical Preparations
- Used widely in ointments for burns, minor cuts, and diaper rash formulations due to its proven regenerative properties.
Handling & Safety Precautions
While D-Panthenol is widely considered safe and gentle in finished consumer products, handling the raw, concentrated chemical requires standard laboratory safety protocols.
- Personal Protective Equipment (PPE): Always wear safety glasses, gloves, and a lab coat when handling the raw viscous liquid to avoid direct contact with eyes or prolonged contact with skin.
- Eye Contact: In case of contact, rinse immediately with plenty of water. It can cause mild irritation in its concentrated form.
- Viscosity Warning: D-Panthenol is very thick and sticky (like honey). It can be difficult to pour when cold. Heating it slightly in a water bath (approx. 40°C) makes it much easier to handle and incorporate into the water phase of your formulation.
For a complementary skin- and hair-care functional ingredient, see Allantoin.
Storage Conditions & Shelf Life
D-Panthenol is hygroscopic, meaning it loves to absorb moisture from the air. Proper storage is critical to maintaining the quality of your stock.
- Keep it Airtight: Always seal the container tightly immediately after use. If left open, it will absorb water and potentially crystallize or lose potency.
- Environment: Store in a cool, dry, and well-ventilated place. Avoid direct sunlight and high temperatures.
- Shelf Life: Under proper storage conditions, the product typically remains stable for 24 to 36 months (check the COA for the specific batch expiry).
Why Partner With Us?
Sourcing raw ingredients is about more than just finding the lowest price—it’s about reliability, purity, and consistency.
We understand that a slight variance in raw material viscosity or color can throw off your entire production batch. That is why we provide:
- Consistent Purity: Each batch is tested to ensure it meets USP/BP/EP standards.
- Flexible Packaging: Whether you need small pails for R&D or large drums for mass production.
- Documentation: Full COA (Certificate of Analysis), MSDS, and TDS are available upon request to help you breeze through regulatory compliance.
FAQ - Technical & Supply Chain
-
Q:
Is the 98% viscous liquid form of D-Panthenol (CAS 81-13-0) difficult to handle in cold manufacturing environments?
A: Yes. High-purity D-Panthenol is a highly viscous, sticky liquid (similar to honey) that becomes even more difficult to pour or pump at lower temperatures. Industrial formulators typically recommend pre-heating the container to 40-50°C to reduce viscosity before dispensing, or opting for the 75% Aqueous Solution grade if handling ease is a priority over concentration. -
Q:
Does this ingredient provide actual structural repair to hair fibers, or does it just coat the surface?
A: It provides internal structural support. Unlike silicones that coat the surface, D-Panthenol (CAS 81-13-0) has a low molecular weight that allows it to penetrate the hair cuticle and enter the cortex. Once inside, it binds water to improve flexibility and tensile strength, effectively reducing breakage ("split ends") from the inside out.
Ordering & Documentation
Key information for document requests, quotations, and supply planning.
Documents
COA, TDS, SDS/MSDS and packing details are available on request.
Quotation
Send the CAS number, grade, quantity, packing preference and destination.
Sample & Supply
Support is available for samples, trial orders, bulk and repeat supply.
Storage & Shipping
Product-specific conditions are confirmed before order.



