Is the 98% viscous liquid form of D-Panthenol (CAS 81-13-0) difficult to handle in cold manufacturing environments?

Yes. High-purity D-Panthenol is a highly viscous, sticky liquid (similar to honey) that becomes even more difficult to pour or pump at lower temperatures. Industrial formulators typically recommend pre-heating the container to 40-50°C to reduce viscosity before dispensing, or opting for the 75% Aqueous Solution grade if handling ease is a priority over concentration.

Does this ingredient provide actual structural repair to hair fibers, or does it just coat the surface?

It provides internal structural support. Unlike silicones that coat the surface, D-Panthenol (CAS 81-13-0) has a low molecular weight that allows it to penetrate the hair cuticle and enter the cortex. Once inside, it binds water to improve flexibility and tensile strength, effectively reducing breakage ("split ends") from the inside out.

D-panthenol CAS 81-13-0

D-Panthenol CAS 81-13-0 is a viscous, water-soluble liquid chemically defined as the alcohol analog of pantothenic acid , functioning primarily as a deep-penetrating moisturizer and wound-healing agent in personal care and pharmaceutical formulations. Widely recognized as Provitamin B5 or Dexpanthenol, this clear, colorless syrup converts to pantothenic acid (Vitamin B5) upon absorption into the skin or hair shaft, utilizing this pathway to stimulate cell regeneration and improve hydration elasticity. We provide professional access to this material with competitive factory pricing and the ability to meet customized specifications (typically 75% aqueous solution or 98% pure viscous liquid) for various manufacturing requirements. Our commitment to technical transparency ensures that every shipment is accompanied by comprehensive MSDS, TDS, COA documentation to support your quality assurance protocols, and we maintain capacity for consistent bulk supply to facilitate large-scale industrial operations.

CAS: 81-13-0
Synonyms: Dexpanthenol, Provitamin B5, D-Pantothenyl alcohol, (R)-Panthenol, 2,4-Dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutanamide
Einecs: 201-327-3
Molecular Formula: C9H19NO4
Grade: Industrial Detergent Material
Package: 200 kg drum / 1000 kg IBC (customizable)

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Product Description

1 Physical & Chemical Properties

2 Key Application Fields

3 Handling & Safety Precautions

4 Storage Conditions & Shelf Life

5 Why Partner With Us?

Physical & Chemical Properties

When sourcing raw materials, specs matter. You need to ensure the material will remain stable in your formulation. Here is the technical breakdown of our high-purity D-Panthenol:

Property	Specification
Product Name	D-Panthenol (Provitamin B5)
CAS Number	81-13-0
Appearance	Colorless to slightly yellowish, clear, viscous liquid
Odor	Slight, characteristic odor
Assay (Purity)	98.0% – 101.0%
Solubility	Highly soluble in water, ethanol, methanol, and propylene glycol
Specific Rotation	+29.0° to +31.5°
Refractive Index (20°C)	1.495 – 1.502
Heavy Metals	≤ 10 ppm
pH Value (5% solution)	Neutral to slightly alkaline (approx. 9-10.5 typically)

Key Application Fields

D-Panthenol isn’t a one-trick pony. Its versatility allows it to be used across a wide spectrum of personal care sectors:

1. Skincare (Creams, Lotions, Serums)

Deep Hydration: As a penetrating humectant, it improves the skin’s barrier function and elasticity.
Soothing Agent: It significantly reduces redness and inflammation, making it ideal for sensitive skin, acne treatments, or after-sun care.
Healing: It promotes the proliferation of fibroblasts, speeding up wound healing and skin regeneration.

2. Hair Care (Shampoos, Conditioners, Masks)

Long-lasting Moisture: It penetrates the hair shaft to moisturize from within, preventing dryness.
Damage Control: It coats the hair to lubricate the shaft, reducing split ends and making hair shinier and easier to comb.
Scalp Health: A healthy scalp grows healthy hair; D-Panthenol soothes itchy or irritated scalps.

3. Nail Care

It improves the flexibility of nails, preventing breakage and chipping.

4. Pharmaceutical Preparations

Used widely in ointments for burns, minor cuts, and diaper rash formulations due to its proven regenerative properties.

Handling & Safety Precautions

While D-Panthenol is widely considered safe and gentle in finished consumer products, handling the raw, concentrated chemical requires standard laboratory safety protocols.

Personal Protective Equipment (PPE): Always wear safety glasses, gloves, and a lab coat when handling the raw viscous liquid to avoid direct contact with eyes or prolonged contact with skin.
Eye Contact: In case of contact, rinse immediately with plenty of water. It can cause mild irritation in its concentrated form.
Viscosity Warning: D-Panthenol is very thick and sticky (like honey). It can be difficult to pour when cold. Heating it slightly in a water bath (approx. 40°C) makes it much easier to handle and incorporate into the water phase of your formulation.

Storage Conditions & Shelf Life

D-Panthenol is hygroscopic, meaning it loves to absorb moisture from the air. Proper storage is critical to maintaining the quality of your stock.

Keep it Airtight: Always seal the container tightly immediately after use. If left open, it will absorb water and potentially crystallize or lose potency.
Environment: Store in a cool, dry, and well-ventilated place. Avoid direct sunlight and high temperatures.
Shelf Life: Under proper storage conditions, the product typically remains stable for 24 to 36 months (check the COA for the specific batch expiry).

Why Partner With Us?

Sourcing raw ingredients is about more than just finding the lowest price—it’s about reliability, purity, and consistency.

We understand that a slight variance in raw material viscosity or color can throw off your entire production batch. That is why we provide:

Consistent Purity: Each batch is tested to ensure it meets USP/BP/EP standards.
Flexible Packaging: Whether you need small pails for R&D or large drums for mass production.
Documentation: Full COA (Certificate of Analysis), MSDS, and TDS are available upon request to help you breeze through regulatory compliance.

FAQ - Technical & Supply Chain

Q:
Is the 98% viscous liquid form of D-Panthenol (CAS 81-13-0) difficult to handle in cold manufacturing environments?

A: Yes. High-purity D-Panthenol is a highly viscous, sticky liquid (similar to honey) that becomes even more difficult to pour or pump at lower temperatures. Industrial formulators typically recommend pre-heating the container to 40-50°C to reduce viscosity before dispensing, or opting for the 75% Aqueous Solution grade if handling ease is a priority over concentration.
Q:
Does this ingredient provide actual structural repair to hair fibers, or does it just coat the surface?

A: It provides internal structural support. Unlike silicones that coat the surface, D-Panthenol (CAS 81-13-0) has a low molecular weight that allows it to penetrate the hair cuticle and enter the cortex. Once inside, it binds water to improve flexibility and tensile strength, effectively reducing breakage ("split ends") from the inside out.

Documents

Documents and Product Support

For product review and sourcing evaluation, supporting documents can be coordinated according to the product type, inquiry stage, and order requirements.

COA for batch-based quality reference
TDS for key physical and chemical information
SDS / MSDS for handling, storage, and safety reference
Packing information for sample, trial, and bulk orders
Technical communication based on application and specification requirements

Quotation

Information to Confirm Before Quotation

Clear sourcing information helps reduce specification mismatch and allows a more accurate quotation before sample or bulk order discussion.

Product name and CAS number
Application or intended end use
Required purity, grade, or specification
Sample quantity, trial order, or bulk demand
Preferred packing form or net weight
Destination country or port
Required documents or compliance expectations

Storage & Handling

Packaging, Storage, and Handling Notes

Packaging form, storage conditions, shelf life, and shipment arrangements should be confirmed according to the product characteristics, package size, and destination requirements.

Before order confirmation, buyers are advised to review the corresponding product documents and confirm whether any special storage, labeling, or handling requirements apply.

Supply Support

Sample, Bulk Order and Repeat Supply Support

Support can be arranged for sample discussion, bulk supply planning, packaging confirmation, and routine sourcing communication based on the actual product and order requirements.

For repeat-use formulations or long-term procurement plans, buyers may discuss specification consistency, packaging preferences, delivery expectations, and document coordination in advance.