Sodium Hyaluronate (CAS 9067-32-7), chemically identified as the sodium salt of hyaluronic acid, is a naturally occurring glycosaminoglycan functioning as a premier humectant and viscoelastic agent in cosmetic skin care formulation and biomedical applications. This white hygroscopic powder, also technically referred to as hyaluronan sodium or sodium hyaluronate polymer, serves as a structural hydrator capable of holding up to 1,000 times its weight in water, ensuring deep hydration in serums, creams, and ophthalmic solutions. We provide bulk supply of this high-purity ingredient with competitive factory pricing to support personal care and medical device manufacturers. Our manufacturing capabilities cover various molecular weights, making MSDS, TDS, COA available alongside customized specifications to target precise permeation or film-forming properties.
Sodium Hyaluronate CAS 9067-32-7
- CAS: 9067-32-7
- Synonyms: Hyaluronic acid sodium salt, Hyaluronan sodium, Sodium hyaluronate polymer, poly(sodium hyaluronate), sodium hyaluronate biopolymer
- Einecs: 618-620-0
- Molecular Formula: (C14H20NNaO11)n
- Grade: Cosmetic / Pharmaceutical grade
- Package: 1 kg aluminum foil bag; 5 kg & 10 kg fiber drum with double PE liner, or customized on request
Product Description
Sodium Hyaluronate is the sodium salt of hyaluronic acid, a naturally occurring glycosaminoglycan widely used in skin care, pharmaceuticals and medical devices for its excellent moisturizing, lubricating and biocompatible properties. Produced by microbial fermentation and purified to low-impurity levels, it is suitable for high-end cosmetic formulations and selected pharmaceutical applications.
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Physicochemical Properties
| Item | Specification (Typical) |
|---|---|
| Product name | Sodium Hyaluronate |
| CAS No. | 9067-32-7 |
| EINECS No. | 618-620-0 |
| Molecular formula | (C₁₄H₂₀NNaO₁₁)ₙ |
| Molecular weight (monomer unit) | approx. 401.30 g/mol |
| Appearance | White to off-white, free-flowing or fibrous powder |
| Odor | Practically odorless |
| Assay (on dry basis) | ≥ 98.0% |
| pH (0.1–1.0% solution, 25 °C) | 6.0 – 7.5 |
| Solubility | Freely soluble in water; practically insoluble in organic solvents |
| Melting point | > 200 °C (decomposition) |
| Viscosity (0.1–1.0% aq., 25 °C) | As per grade: low, medium or high MW (specified on COA) |
| Loss on drying | ≤ 10.0% |
| Residue on ignition | ≤ 20.0% |
| Heavy metals | ≤ 20 ppm |
| Origin | Microbial fermentation (non-animal) |
(Parameters can be adjusted to your in-house specification; final values are confirmed on COA for each batch.)
Applications
1. Cosmetics & Personal Care
- Moisturizing serums, essences and ampoules
- Lotions, creams, eye creams and masks
- Cleansers, toners, make-up bases and foundations
- Hair care products (leave-in treatments, conditioners)
Key benefits for formulators:
- Strong humectant effect; helps reduce TEWL (transepidermal water loss)
- Improves skin smoothness, elasticity and plumpness
- Enhances sensory profile and film-forming on skin surface
- Works synergistically with glycerin, panthenol, ceramides and other actives
2. Pharmaceutical & Medical Uses
- Ophthalmic preparations (eye drops, viscoelastic solutions – according to local regulations)
- Topical formulations for wound care and scar management
- Intra-articular or injectable products (where permitted, subject to GMP and registration)
3. Nutraceuticals & Functional Foods
- Joint health, skin beauty and anti-aging supplements (capsules, sachets, beverages)
- Combination formulas with collagen, chondroitin, vitamins and minerals
4. Other Industrial Uses
- Biomedicine, tissue engineering and cell culture media (R&D and specialty applications)
For related humectant raw materials used in hydration-focused formulations, see Pure Polyglutamic Acid and Saccharide Isomerate.
Storage Conditions
- Store in tightly closed original packaging.
- Keep in a cool, dry and well-ventilated area, recommended storage temperature 2–8 °C or below 25 °C away from heat sources.
- Protect from moisture, direct sunlight and strong oxidizing agents.
- Avoid long exposure of opened bags to air; reseal promptly after each use.
- Under recommended conditions, typical shelf life is 24 months from manufacturing date (see product label/COA).
Safety Precautions
Sodium Hyaluronate is generally regarded as safe and well tolerated when used as directed in cosmetic and pharmaceutical formulations.
Basic handling recommendations for factory and laboratory staff:
- Avoid generating dust; handle in areas with adequate ventilation.
- Wear appropriate PPE: dust mask or respirator, safety glasses and protective gloves.
- In case of eye contact: rinse immediately with plenty of water; seek medical advice if irritation persists.
- In case of skin contact: wash with soap and water.
- Avoid inhalation of fine powder; move to fresh air if discomfort occurs.
- Not intended for direct household use; always formulate before end-use and comply with local regulations for cosmetics, pharmaceuticals or foods.
- Dispose of spilled material and waste according to local environmental regulations.
For detailed safety information, please request our latest MSDS by email.
FAQ - Technical & Supply Chain
-
Q:
What is Sodium Hyaluronate CAS 9067-32-7, and how is it different from hyaluronic acid?
A: Sodium Hyaluronate is the sodium salt of hyaluronic acid and is supplied as a water-soluble white to off-white powder. Compared with the acid form, it is more soluble and more stable in aqueous formulations, which is why it is the common cosmetic and pharmaceutical form. -
Q:
What molecular weight grades are available, and how do they affect performance?
A: High molecular weight grades, usually about 1,000 kDa or above, provide surface film formation and strong moisture retention. Medium grades around 200-1,000 kDa balance hydration and protection, while low grades around 5-200 kDa are often selected for deeper penetration and plumping or anti-aging claims. -
Q:
Is Sodium Hyaluronate suitable for both cosmetic and pharmaceutical use?
A: Yes, but the appropriate grade must be selected. Cosmetic and pharmaceutical grades are available; pharmaceutical uses include ophthalmic preparations, topical wound care, and injectable or viscoelastic products where permitted. Purity, microbial limits, and local regulatory requirements should be confirmed for the intended application. -
Q:
How is Sodium Hyaluronate produced?
A: It is typically produced by microbial fermentation, commonly using selected bacterial strains, followed by purification and drying. This provides a non-animal-origin polymer with controlled molecular weight, purity, and batch-to-batch consistency for cosmetic and pharmaceutical formulation. -
Q:
What specifications should be checked before ordering?
A: Confirm appearance, assay, molecular weight range, pH in a dilute aqueous solution, loss on drying, residue on ignition, heavy metals, and microbial limits. For pharmaceutical applications, also check protein and endotoxin limits when they are relevant, and specify the required grade. -
Q:
How should Sodium Hyaluronate powder be stored and handled?
A: Keep it in tightly closed, moisture-protected containers in a cool, dry place away from direct sunlight and strong temperature changes. Use dust-control measures and suitable PPE when weighing or transferring the powder, and reseal opened packaging promptly after each use.
Ordering & Documentation
Key information for document requests, quotations, and supply planning.
Documents
COA, TDS, SDS/MSDS and packing details are available on request.
Quotation
Send the CAS number, grade, quantity, packing preference and destination.
Sample & Supply
Support is available for samples, trial orders, bulk and repeat supply.
Storage & Shipping
Product-specific conditions are confirmed before order.
