What is Azelaic Acid Powder CAS 123-99-9?

Azelaic Acid, also called Nonanedioic acid or 1,7-heptanedicarboxylic acid, is a naturally occurring C9 saturated dicarboxylic acid. It is supplied as a white to off-white crystalline powder or flakes and is used in topical dermatology, cosmetics and specialty chemical synthesis.

How does Azelaic Acid work in acne and rosacea products?

It combines antimicrobial, anti-inflammatory, keratolytic and tyrosinase-inhibiting activity in one molecule. These mechanisms help normalize keratinization, reduce acne-related bacteria and inflammation, and support a more even skin tone.

Why is micronized particle size important for Azelaic Acid formulations?

Azelaic Acid has limited water solubility, about 2.4 g/L. Micronized powder can be suspended more evenly in aqueous gels, creams and serums, reducing grittiness and improving distribution; a common micronized specification is D50 at or below 10 um.

What is the preferred pH and formulation approach for Azelaic Acid?

Acid-compatible formulations around pH 4.5-5.5 are commonly preferred for stability and activity. For clear systems, formulators may use glycols or solubilizers such as propanediol or pentylene glycol; for suspension formats, micronized powder is dispersed in a suitable gel or emulsion base.

What are the key specifications for cosmetic and pharmaceutical grades?

Typical checks include HPLC assay at or above 99%, melting range around 106-110 C, loss on drying, acid value, related dicarboxylic acids, particle size, heavy metals and microbial limits. Cosmetic products often use 5-10% in the finished formula, while prescription products may use 15-20%.

Azelaic Acid Powder CAS 123-99-9

Azelaic Acid (Nonanedioic acid), CAS 123-99-9, is a saturated C9 dicarboxylic acid supplied for topical dermatology, cosmetics and specialty chemical synthesis. Confirm the required grade, then request a quotation with COA/TDS/SDS for bulk supply.

CAS: 123-99-9
Synonyms: Nonanedioic acid, 1,7-heptanedicarboxylic acid, Lepargylic acid, Anchoic acid, Azelaic acid micronized
Einecs: 204-669-1
Molecular Formula: C₉H₁₆O₄
Grade: Cosmetic / Pharmaceutical / Industrial Grade
Package: 25 kg fiber drum with double PE liner; 1–5 kg aluminum foil bags for samples or small orders

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Product Description

Azelaic Acid, CAS 123-99-9, also known as nonanedioic acid, is a saturated C9 dicarboxylic acid; the EC/EINECS number is 204-669-1.

Synonyms: Nonanedioic acid; 1,7-Heptanedicarboxylic acid; Lepargylic acid; Anchoic acid; micronized azelaic acid.

CAS: 123-99-9.

Molecular formula: C₉H₁₆O₄.

Molecular weight: 188.22.

EC number: 204-669-1.

It is a white to off-white crystalline powder or flakes with a melting point of about 106–110 °C and an assay typically ≥99.0% by HPLC.

The boiling point is about 286 °C at 100 mmHg, the density about 1.03 g/cm³ and the water solubility about 2.4 g/L at 20 °C; it is soluble in ethanol, propylene glycol and many organic solvents.

The carboxyl pKa values are about 4.5 and 5.3 at 25 °C and the estimated log P (octanol/water) is about 1.6.

It is used as a topical dermatological active in creams, gels and foams for acne vulgaris and rosacea, and in serums, lotions and emulsions for brightening and tone-evening.

It combines antimicrobial, anti-inflammatory, keratolytic and tyrosinase-inhibiting activity to normalize keratinization, reduce acne-related bacteria and inflammation, and support a more even skin tone.

It is used as an intermediate for polyesters, plasticizers, synthetic lubricants and specialty polyamides such as nylon-6,9.

Confirm HPLC assay, melting range, loss on drying, acid value, related dicarboxylic acids, particle size (micronized D50 commonly ≤10 µm), heavy metals and microbial limits; cosmetic and pharmaceutical grades are available.

Store in tightly closed, light-protected containers in a cool, dry place, away from strong oxidizers; minimize dust generation during handling and use suitable PPE.

Confirm the current product-specific specification.

Confirm packaging with the requested quantity and destination requirements.

Document requirements should be confirmed from the current specification, SDS, COA or other product-specific files.

The page is an RFQ entry point and does not state stock, price, MOQ or fixed lead time.

For an RFQ, state the intended use, required specification, quantity, packaging, destination and document needs.

FAQ - Technical & Supply Chain

Q:
What is Azelaic Acid Powder CAS 123-99-9?

A: Azelaic Acid, also called Nonanedioic acid or 1,7-heptanedicarboxylic acid, is a naturally occurring C9 saturated dicarboxylic acid. It is supplied as a white to off-white crystalline powder or flakes and is used in topical dermatology, cosmetics and specialty chemical synthesis.
Q:
How does Azelaic Acid work in acne and rosacea products?

A: It combines antimicrobial, anti-inflammatory, keratolytic and tyrosinase-inhibiting activity in one molecule. These mechanisms help normalize keratinization, reduce acne-related bacteria and inflammation, and support a more even skin tone.
Q:
Why is micronized particle size important for Azelaic Acid formulations?

A: Azelaic Acid has limited water solubility, about 2.4 g/L. Micronized powder can be suspended more evenly in aqueous gels, creams and serums, reducing grittiness and improving distribution; a common micronized specification is D50 at or below 10 um.
Q:
What is the preferred pH and formulation approach for Azelaic Acid?

A: Acid-compatible formulations around pH 4.5-5.5 are commonly preferred for stability and activity. For clear systems, formulators may use glycols or solubilizers such as propanediol or pentylene glycol; for suspension formats, micronized powder is dispersed in a suitable gel or emulsion base.
Q:
What are the key specifications for cosmetic and pharmaceutical grades?

A: Typical checks include HPLC assay at or above 99%, melting range around 106-110 C, loss on drying, acid value, related dicarboxylic acids, particle size, heavy metals and microbial limits. Cosmetic products often use 5-10% in the finished formula, while prescription products may use 15-20%.
Q:
How should Azelaic Acid Powder CAS 123-99-9 be stored and handled?

A: Store in tightly closed, light-protected containers in a cool, dry place, away from strong oxidizers. Minimize dust generation during handling, use suitable PPE, and keep the material dry to preserve assay and flow properties.

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