Azelaic Acid Powder CAS 123-99-9

Azelaic acid (nonanedioic acid) is a saturated C9 dicarboxylic acid widely used in dermatology formulations and specialty chemical applications. Our azelaic acid powder is produced in China with controlled impurity profile and stable batch-to-batch quality, suitable for pharmaceutical intermediates, topical creams, gels, serums and industrial synthesis.

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Physicochemical Properties

Product Introduction

Azelaic acid is an aliphatic dicarboxylic acid obtained industrially by oxidative cleavage of unsaturated fatty acids. It combines mild lipophilicity with good stability, making it a versatile ingredient in both personal care and industrial applications.

In dermatology and cosmetics, azelaic acid is valued for its keratolytic, anti-bacterial and anti-inflammatory properties, and for its ability to help regulate sebum and melanin production. These features make it a popular active in formulations targeting acne, rosacea, post-inflammatory hyperpigmentation and uneven skin tone.

In industrial fields, azelaic acid is also an important intermediate for polyesters, plasticizers, synthetic lubricants and specialty polyamides (e.g. Nylon-6,9).

Applications

1. Pharmaceutical & Dermatology (Topical Use)
   • Active ingredient in creams, gels and foams for mild to moderate acne vulgaris and rosacea.
   • Used in leave-on treatments (10–20% formulations are common in finished products) targeting comedones, inflammatory papules and pustules.
   • Helps normalize keratinization, reduce growth of acne-related bacteria and modulate skin inflammation.
   • Often combined with niacinamide, salicylic acid or soothing plant extracts in multi-functional formulations.
2. Cosmetic & Personal Care
   • Brightening and tone-evening active for serums, lotions and emulsions.
   • Used in products designed to reduce appearance of dark spots, melasma and post-acne marks.
   • Suitable for formulations marketed as “non-photosensitizing” alternatives to stronger peeling agents, when formulated correctly.
3. Polymer & Industrial Chemicals
   • Monomer for polyesters and copolyamides (e.g. Nylon-6,9) with good flexibility and chemical resistance.
   • Raw material for azelate esters used as plasticizers in PVC and other polymers.
   • Component of synthetic ester-based lubricants and greases, especially where low volatility and good low-temperature performance are required.
4. Research & Laboratory Use
   • Reference standard and building block in organic synthesis, dermatology research and formulation screening.

Storage Conditions

• Store in a cool, dry, well-ventilated warehouse, away from direct sunlight and heat sources.
• Recommended storage temperature: below 30 °C, with container tightly closed to avoid moisture uptake and caking.
• Keep away from strong bases, strong oxidizing or reducing agents.
• Use only corrosion-resistant, well-sealed packaging (fiber drums / HDPE containers with inner liner).

Under normal storage conditions azelaic acid is chemically stable for the stated shelf life (typically 24 months from manufacturing, depending on factory specification).

Safety Precautions

According to typical Safety Data Sheets for azelaic acid, the material is classified as an irritant:

• Hazards
  • Harmful if swallowed in large amounts.
  • Causes skin irritation and serious eye irritation.
  • Dust may cause respiratory tract irritation.
  • Harmful to aquatic life with long-lasting effects (handle and dispose responsibly).
• Personal Protection
  • Wear appropriate protective gloves, long sleeves and closed footwear when handling bulk powder.
  • Use safety goggles or face shield to protect eyes from dust.
  • In case of dust generation, wear a dust mask or respirator (e.g. NIOSH-approved) and use local exhaust ventilation.
• Handling Advice
  • Avoid breathing dust; avoid contact with eyes, skin and clothing.
  • Do not eat, drink or smoke while handling the product; wash hands thoroughly after work.
  • Prevent release to the environment; follow local regulations for waste and spill disposal.
• First Aid (summary)
  • Eye contact: Rinse cautiously with water for several minutes; remove contact lenses if present and easy to do; seek medical attention if irritation persists.
  • Skin contact: Wash with soap and plenty of water; remove contaminated clothing.
  • Inhalation: Move person to fresh air; keep comfortable for breathing; seek medical advice if respiratory irritation continues.