What is Dipeptide-2 Powder CAS 24587-37-9?

Dipeptide-2 Powder is a synthetic cosmetic peptide made from L-valyl-L-tryptophan, commonly written as Val-Trp or H-Val-Trp-OH. It has the molecular formula C₁₆H₂₁N₃O₃ and a theoretical molecular weight of about 303.36 g/mol. The product is supplied as a white to off-white water-soluble powder for use in personal-care formulations.

How does Val-Trp help reduce the appearance of under-eye puffiness?

Dipeptide-2 acts as a low-molecular-weight angiotensin-converting enzyme inhibitor and supports periorbital microcirculation and lymphatic drainage. This mechanism is used in eye-care formulas to target the look of under-eye bags, puffiness, and fluid accumulation. It is often paired with acetyl tetrapeptide-5 for a dual drainage approach.

How should Dipeptide-2 Powder be added to an eye serum or cream?

Dipeptide-2 is water-soluble and can be dissolved into the aqueous phase of eye serums, gels, creams, or emulsions. Add it during the cool-down phase below 40 C to avoid heat damage to the peptide. Typical use levels are very low, generally in the range of about 0.001% to 0.1%, depending on the formulation concept.

What pH and processing conditions should be maintained?

Dipeptide-2 is generally stable in a mild pH range around 4.5 to 7.0, with many eye formulas targeting about 5.0 to 6.5. Keep processing below 40 C and avoid strongly oxidizing conditions or high-pH systems above about 8.0. These limits help preserve peptide activity and clarity in the finished formula.

What quality specifications should be checked for this cosmetic peptide?

Confirm the Val-Trp sequence rather than the reverse Trp-Val sequence, and check HPLC purity, typically 98% or higher for cosmetic peptide grades. Also review peptide content, appearance, water, residual solvents, and the salt or counter-ion form. For finished cosmetic manufacture, confirm the applicable microbial limits for the selected grade.

What are the storage and handling recommendations for Dipeptide-2 Powder?

Store Dipeptide-2 Powder in a tightly closed container under cool, dry, light-protected conditions, with refrigeration preferred for long-term storage. Avoid moisture uptake and direct sunlight, and use standard powder-handling controls when weighing or transferring the material. Equilibrate the closed package before opening if it has been kept cold.

Dipeptide-2 Powder CAS 24587-37-9

Dipeptide-2 (Val-Trp, Valyl-Tryptophan), CAS 24587-37-9, is a water-soluble cosmetic peptide supplied for eye-contour and anti-aging personal-care formulations. Confirm the required purity, then request a quotation with COA/TDS/SDS for bulk supply.

CAS: 24587-37-9
Synonyms: Valyl-Tryptophan, Val-Trp, H-Val-Trp-OH, Dipeptide-2
Einecs: 246-324-8
Molecular Formula: C₁₆H₂₁N₃O₃
Grade: Cosmetic grade peptide, purity (HPLC) typically ≥98%
Package: 1–10 g R&D vials; 100 g / 500 g / 1 kg aluminum foil bags or fiber drums with double PE liners (custom packaging available)

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Product Description

Dipeptide-2, CAS 24587-37-9, also known as valyl-tryptophan or Val-Trp, is a synthetic dipeptide of L-valine and L-tryptophan; the EC/EINECS number is 246-324-8.

Synonyms: Valyl-Tryptophan; Val-Trp; H-Val-Trp-OH; Dipeptide-2.

CAS: 24587-37-9.

Molecular formula: C₁₆H₂₁N₃O₃.

Molecular weight: 303.36 (theoretical).

EC number: 246-324-8.

It is a white to off-white crystalline or amorphous powder, water-soluble and supplied as a lyophilized or spray-dried peptide, with a typical HPLC purity of 98% or higher.

The peptide sequence is Val-Trp (VW, H-Val-Trp-OH); the predicted log P is about 1.3–1.5, the predicted pKa of the carboxyl group is about 3.1 and the recommended formulation pH is about 5.0–7.0.

It is designed for cosmetic use only (not a drug, injection or internal use) and is especially used in eye-care and anti-aging skin-care lines.

It helps improve lymphatic micro-circulation in the eye-contour area and reduce the appearance of under-eye puffiness, eye bags and dark circles.

It acts as a low-molecular-weight angiotensin-converting enzyme inhibitor and supports periorbital microcirculation and lymphatic drainage, often paired with acetyl tetrapeptide-5.

Typical use levels are about 0.001% to 0.1% in eye serums, gels, creams and emulsions; add it to the aqueous phase during the cool-down phase below 40 °C.

Confirm the Val-Trp sequence, HPLC purity, peptide content, appearance, water, residual solvents and the salt or counter-ion form; cosmetic peptide grades are typically specified at 98% or higher.

Store in a tightly closed container under cool, dry, light-protected conditions, preferably at −20 °C for long-term storage or 2–8 °C for opened packages; avoid moisture and use standard powder-handling controls and suitable PPE.

Confirm the current product-specific specification.

Confirm packaging with the requested quantity and destination requirements.

Document requirements should be confirmed from the current specification, SDS, COA or other product-specific files.

The page is an RFQ entry point and does not state stock, price, MOQ or fixed lead time.

For an RFQ, state the intended use, required specification, quantity, packaging, destination and document needs.

FAQ - Technical & Supply Chain

Q:
What is Dipeptide-2 Powder CAS 24587-37-9?

A: Dipeptide-2 Powder is a synthetic cosmetic peptide made from L-valyl-L-tryptophan, commonly written as Val-Trp or H-Val-Trp-OH. It has the molecular formula C₁₆H₂₁N₃O₃ and a theoretical molecular weight of about 303.36 g/mol. The product is supplied as a white to off-white water-soluble powder for use in personal-care formulations.
Q:
How does Val-Trp help reduce the appearance of under-eye puffiness?

A: Dipeptide-2 acts as a low-molecular-weight angiotensin-converting enzyme inhibitor and supports periorbital microcirculation and lymphatic drainage. This mechanism is used in eye-care formulas to target the look of under-eye bags, puffiness, and fluid accumulation. It is often paired with acetyl tetrapeptide-5 for a dual drainage approach.
Q:
How should Dipeptide-2 Powder be added to an eye serum or cream?

A: Dipeptide-2 is water-soluble and can be dissolved into the aqueous phase of eye serums, gels, creams, or emulsions. Add it during the cool-down phase below 40 C to avoid heat damage to the peptide. Typical use levels are very low, generally in the range of about 0.001% to 0.1%, depending on the formulation concept.
Q:
What pH and processing conditions should be maintained?

A: Dipeptide-2 is generally stable in a mild pH range around 4.5 to 7.0, with many eye formulas targeting about 5.0 to 6.5. Keep processing below 40 C and avoid strongly oxidizing conditions or high-pH systems above about 8.0. These limits help preserve peptide activity and clarity in the finished formula.
Q:
What quality specifications should be checked for this cosmetic peptide?

A: Confirm the Val-Trp sequence rather than the reverse Trp-Val sequence, and check HPLC purity, typically 98% or higher for cosmetic peptide grades. Also review peptide content, appearance, water, residual solvents, and the salt or counter-ion form. For finished cosmetic manufacture, confirm the applicable microbial limits for the selected grade.
Q:
What are the storage and handling recommendations for Dipeptide-2 Powder?

A: Store Dipeptide-2 Powder in a tightly closed container under cool, dry, light-protected conditions, with refrigeration preferred for long-term storage. Avoid moisture uptake and direct sunlight, and use standard powder-handling controls when weighing or transferring the material. Equilibrate the closed package before opening if it has been kept cold.

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