What is Dipeptide-2 Powder CAS 24587-37-9?

Dipeptide-2 Powder is a synthetic cosmetic peptide made from L-valyl-L-tryptophan, commonly written as Val-Trp or H-Val-Trp-OH. It has the molecular formula C16H21N3O3 and a theoretical molecular weight of about 303.36 g/mol. The product is supplied as a white to off-white water-soluble powder for use in personal-care formulations.

How does Val-Trp help reduce the appearance of under-eye puffiness?

Dipeptide-2 acts as a low-molecular-weight angiotensin-converting enzyme inhibitor and supports periorbital microcirculation and lymphatic drainage. This mechanism is used in eye-care formulas to target the look of under-eye bags, puffiness, and fluid accumulation. It is often paired with acetyl tetrapeptide-5 for a dual drainage approach.

How should Dipeptide-2 Powder be added to an eye serum or cream?

Dipeptide-2 is water-soluble and can be dissolved into the aqueous phase of eye serums, gels, creams, or emulsions. Add it during the cool-down phase below 40 C to avoid heat damage to the peptide. Typical use levels are very low, generally in the range of about 0.001% to 0.1%, depending on the formulation concept.

What pH and processing conditions should be maintained?

Dipeptide-2 is generally stable in a mild pH range around 4.5 to 7.0, with many eye formulas targeting about 5.0 to 6.5. Keep processing below 40 C and avoid strongly oxidizing conditions or high-pH systems above about 8.0. These limits help preserve peptide activity and clarity in the finished formula.

What quality specifications should be checked for this cosmetic peptide?

Confirm the Val-Trp sequence rather than the reverse Trp-Val sequence, and check HPLC purity, typically 98% or higher for cosmetic peptide grades. Also review peptide content, appearance, water, residual solvents, and the salt or counter-ion form. For finished cosmetic manufacture, confirm the applicable microbial limits for the selected grade.

What are the storage and handling recommendations for Dipeptide-2 Powder?

Store Dipeptide-2 Powder in a tightly closed container under cool, dry, light-protected conditions, with refrigeration preferred for long-term storage. Avoid moisture uptake and direct sunlight, and use standard powder-handling controls when weighing or transferring the material. Equilibrate the closed package before opening if it has been kept cold.

Dipeptide-2 Powder CAS 24587-37-9

Dipeptide-2 (CAS 24587-37-9) is a synthetic low-molecular-weight peptide consisting of valine and tryptophan, utilized primarily as a functional active ingredient in cosmetic eye care formulations. This specific Valyl-Tryptophan sequence functions as a lymphatic circulation booster, inhibiting Angiotensin Converting Enzyme (ACE) to facilitate fluid drainage and reduce edema in the periorbital area. As a targeted H-Val-Trp-OH component, it is typically incorporated into anti-puffiness creams and serums to improve skin elasticity and reduce the appearance of under-eye bags. Unlike general hydrolyzed proteins, this precise VW peptide offers defined bioactivity for targeted localized application. We provide this cosmetic peptide with competitive factory pricing to support personal care manufacturing and ensure bulk supply availability for formulation scale-up. Our facility accommodates customized specifications for purity and peptide content, while every shipment is fully documented with MSDS, TDS, COA files to meet international cosmetic regulations.

CAS: 24587-37-9
Einecs: 246-324-8
Molecular Formula: C₁₆H₂₁N₃O₃
Grade: Cosmetic grade peptide, purity (HPLC) typically ≥98%
Package: 1–10 g R&D vials; 100 g / 500 g / 1 kg aluminum foil bags or fiber drums with double PE liners (custom packaging available)

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Product Description

Dipeptide-2 is a small synthetic peptide consisting of valine and tryptophan, widely used as a cosmetic active in eye-contour formulations to help reduce puffiness, under-eye bags and dark circles. With high peptide purity and stable quality, it is suitable for use in premium eye creams, serums, masks and other anti-aging products.

📧 Email: info@industrochem.com – Contact our technical sales team for latest prices, COA and formulation support.

1 Physicochemical Properties

2 Applications

3 Storage Conditions

4 Safety Precautions

Physicochemical Properties

Physicochemical Properties (Typical Values, Not for Specification)

Property	Value / Description
CAS No.	24587-37-9
Molecular formula	C₁₆H₂₁N₃O₃
Molecular weight	303.36 g/mol (theoretical)
Peptide sequence	Val-Trp (VW), H-Val-Trp-OH
Appearance	White to off-white crystalline / amorphous powder
Purity (HPLC)	≥98% (cosmetic / peptide grade, typical)
Peptide content	≥80% peptide content (typical cosmetic-grade specification)
Density	~1.27–1.30 g/cm³ (predicted)
Boiling point (predicted)	~604.8 ± 55.0 °C at 760 mmHg
LogP (predicted)	~1.3–1.5
pKa (predicted)	~3.1 (carboxyl group)
Solubility	Water-soluble; supplied as powder for aqueous systems (insoluble in oils)
Recommended formulation pH	~5.0–7.0 for optimal stability and skin compatibility
Form	Lyophilized / spray-dried peptide powder
Storage temperature (long term)	−20 °C (tightly sealed, protected from light and moisture)
Storage temperature (short term)	2–8 °C for opened packages to be used within a few months
Shelf life (unopened, proper storage)	Typically 24 months from manufacturing date

Applications

Dipeptide-2 is designed for cosmetic use only (not a drug, not for injection or internal use). It is especially popular in eye-care and anti-aging skincare lines.

Main Functional Claims

Helps improve lymphatic micro-circulation in the eye contour area
Assists in reducing under-eye puffiness and the appearance of eye bags
Contributes to reducing the look of dark circles under the eyes
Acts as a skin-conditioning and anti-aging peptide, supporting smoother and more elastic skin

Typical Application Areas

Eye creams and eye-contour serums (gel, emulsion or lotion formats)
Under-eye masks, hydrogel patches, sheet masks
Anti-aging facial serums and creams, especially for delicate areas
Premium cosmetic formulas targeting tired-looking eyes, morning puffiness and fine lines

Suggested Use Level in Finished Formulations

Typical dosage: 0.005–0.5%
Maximum level (for most systems): up to ~0.7%, subject to stability and safety testing in your own formulation
Add during the cool-down phase (≤40 °C) of emulsions or directly into serums/gels to avoid peptide degradation.

Storage Conditions

To maintain peptide activity and product quality:

Unopened original packaging
- Store at −20 °C in a freezer or deep-cool storage.
- Keep container tightly closed, protected from moisture and direct light.
- Avoid repeated temperature cycling (freeze–thaw).
Opened packaging
- Reseal inner liner and outer container immediately after use.
- For frequent lab use, keep at 2–8 °C and use within a few months; for longer-term storage, return to −20 °C when possible.
Formulated products
- Follow your finished product stability data, but in general store at room temperature away from direct sunlight.
- Recommended formulation pH: 5.0–7.0 to balance peptide stability and skin tolerance.

Safety Precautions

Based on available SDS and cosmetic ingredient data, Dipeptide-2 is not classified as a hazardous substance under most chemical regulations when handled as a raw material, but standard laboratory and factory hygiene must always be observed.

Handling

For industrial / laboratory use only, not for pharmaceutical, injection or direct consumer use.
Avoid direct contact with eyes and skin in raw form; avoid inhalation of dust.
Use suitable PPE: lab coat, gloves, safety glasses or goggles.
Handle in a well-ventilated area; avoid generating dust.

First Aid

Inhalation: Move to fresh air; seek medical attention if irritation or discomfort persists.
Skin contact: Wash with soap and plenty of water; remove contaminated clothing.
Eye contact: Rinse cautiously with clean water for several minutes; seek medical advice if irritation continues.
Ingestion: Rinse mouth with water; do not induce vomiting; seek medical help immediately.

Fire & Spill

Use standard extinguishing media (dry chemical, CO₂, foam) for surrounding fire.
In case of spill, avoid dust, collect mechanically into a suitable container for disposal according to local regulations.

FAQ - Technical & Supply Chain

Q:
What is Dipeptide-2 Powder CAS 24587-37-9?

A: Dipeptide-2 Powder is a synthetic cosmetic peptide made from L-valyl-L-tryptophan, commonly written as Val-Trp or H-Val-Trp-OH. It has the molecular formula C16H21N3O3 and a theoretical molecular weight of about 303.36 g/mol. The product is supplied as a white to off-white water-soluble powder for use in personal-care formulations.
Q:
How does Val-Trp help reduce the appearance of under-eye puffiness?

A: Dipeptide-2 acts as a low-molecular-weight angiotensin-converting enzyme inhibitor and supports periorbital microcirculation and lymphatic drainage. This mechanism is used in eye-care formulas to target the look of under-eye bags, puffiness, and fluid accumulation. It is often paired with acetyl tetrapeptide-5 for a dual drainage approach.
Q:
How should Dipeptide-2 Powder be added to an eye serum or cream?

A: Dipeptide-2 is water-soluble and can be dissolved into the aqueous phase of eye serums, gels, creams, or emulsions. Add it during the cool-down phase below 40 C to avoid heat damage to the peptide. Typical use levels are very low, generally in the range of about 0.001% to 0.1%, depending on the formulation concept.
Q:
What pH and processing conditions should be maintained?

A: Dipeptide-2 is generally stable in a mild pH range around 4.5 to 7.0, with many eye formulas targeting about 5.0 to 6.5. Keep processing below 40 C and avoid strongly oxidizing conditions or high-pH systems above about 8.0. These limits help preserve peptide activity and clarity in the finished formula.
Q:
What quality specifications should be checked for this cosmetic peptide?

A: Confirm the Val-Trp sequence rather than the reverse Trp-Val sequence, and check HPLC purity, typically 98% or higher for cosmetic peptide grades. Also review peptide content, appearance, water, residual solvents, and the salt or counter-ion form. For finished cosmetic manufacture, confirm the applicable microbial limits for the selected grade.
Q:
What are the storage and handling recommendations for Dipeptide-2 Powder?

A: Store Dipeptide-2 Powder in a tightly closed container under cool, dry, light-protected conditions, with refrigeration preferred for long-term storage. Avoid moisture uptake and direct sunlight, and use standard powder-handling controls when weighing or transferring the material. Equilibrate the closed package before opening if it has been kept cold.

Ordering & Documentation

Key information for document requests, quotations, and supply planning.

Documents

COA, TDS, SDS/MSDS and packing details are available on request.

Quotation

Send the CAS number, grade, quantity, packing preference and destination.

Sample & Supply

Support is available for samples, trial orders, bulk and repeat supply.

Storage & Shipping

Product-specific conditions are confirmed before order.

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