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    Related: Nutritional Ingredient Calcium Phytate Magnesium Gluconate
    • Calcium Glycerophosphate CAS 27214-00-2

    Calcium Glycerophosphate CAS 27214-00-2

    Calcium Glycerophosphate CAS 27214-00-2 is a water-soluble organic mineral salt chemically defined as the calcium salt of glycerophosphoric acid , functioning primarily as a highly bioavailable source of calcium and phosphorus in nutritional supplements and an anti-caries agent in oral care formulations. Also known as Calcium glycerylphosphate or Glycerol phosphate calcium salt, this fine white powder is utilized to neutralize plaque acidity in toothpaste manufacturing and serves as a mineral fortification agent in food processing that does not precipitate as readily as inorganic calcium salts. We provide professional access to this material with competitive factory pricing and the ability to meet customized specifications for various manufacturing requirements. Our commitment to technical transparency ensures that every shipment is accompanied by comprehensive MSDS, TDS, COA documentation to support your quality assurance protocols, and we maintain capacity for consistent bulk supply to facilitate large-scale industrial operations.

    • CAS: 27214-00-2
    • Synonyms: Calcium glycerylphosphate, Glycerophosphoric acid calcium salt, Calcium glycerinophosphate, 1,2,3-Propanetriol mono(dihydrogen phosphate) calcium salt, Neurosin
    • Einecs: 248-328-5
    • Molecular Formula: C3H7CaO6P
    • Grade: Food/Pharma Grade
    • Package: 25kg/bag (Plastic woven bag with PE liner) or 500kg/1000kg Jumbo Bag.
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    Product Description

    1 Physical & Chemical Properties
    2 Key Application Fields
    2.1 1. Advanced Oral Care (Toothpaste & Mouthwash)
    2.2 2. Dietary Supplements & Infant Nutrition
    2.3 3. Food Fortification
    3 Safety and Precautionary Measures
    4 Storage and Handling Conditions

    Physical & Chemical Properties

    Calcium Glycerophosphate is a white or slightly yellowish crystalline powder. Its key advantage over other calcium salts is its solubility profile and amphoteric nature, making it versatile in various pH environments.

    PropertySpecification / Description
    Product NameCalcium Glycerophosphate
    CAS Number27214-00-2
    Molecular FormulaC3H7CaO6P
    Molecular Weight210.14 g/mol
    AppearanceWhite or slightly white crystalline powder
    OdorOdorless
    Assay (Dry Basis)98.0% – 102.0%
    SolubilitySlightly soluble in water; Soluble in dilute acids; Insoluble in alcohol
    pH ValueTypically alkaline (saturated solution)
    Loss on Drying≤ 12.0% (depending on hydration state)
    StabilityStable under normal temperature and pressure

    Key Application Fields

    1. Advanced Oral Care (Toothpaste & Mouthwash)

    This is the highest-value application for CAS 27214-00-2.

    • Plaque Fighter: It helps neutralize the acidic environment in the mouth, which is the primary cause of tooth decay.
    • Remineralization: It provides both Calcium and Phosphate ions—the building blocks of enamel. It acts synergistically with fluoride to strengthen teeth more effectively than fluoride alone.
    • Sensitivity: It is a key ingredient in “desensitizing” toothpastes.

    2. Dietary Supplements & Infant Nutrition

    • Bioavailability: Unlike Calcium Carbonate, which requires strong stomach acid to break down, Calcium Glycerophosphate is more easily absorbed by the body.
    • Digestive Comfort: It is less likely to cause gas, bloating, or constipation, making it ideal for premium supplement lines targeting sensitive consumers or infants (often used in formula fortification).

    3. Food Fortification

    Because it is odorless and has a relatively neutral taste profile compared to other calcium salts, it does not alter the flavor of fortified beverages, yogurts, or baked goods.

    Safety and Precautionary Measures

    Although Calcium Glycerophosphate is widely recognized as safe (GRAS in many jurisdictions) for consumption, handling the raw chemical requires standard industrial safety protocols.

    • Inhalation: The powder can be fine. Inhalation may cause respiratory tract irritation. Workers should use N95 dust masks during weighing and mixing.
    • Eye Contact: Mechanical irritation is possible. Safety goggles are mandatory in the blending area.
    • Ingestion: While safe in food dosages, accidental ingestion of large, concentrated quantities should be managed by drinking water and seeking medical advice.

    For another calcium-phosphate material used in nutritional and feed formulations, see Anhydrous Dicalcium Phosphate.

    Storage and Handling Conditions

    Proper storage is critical to maintaining the material’s flowability and preventing microbial growth.

    1. Moisture Sensitivity: The product is slightly hygroscopic (absorbs moisture from the air). If left open, it can clump, which causes issues in automated feeders.
    2. Environment: Store in a cool, dry, and well-ventilated warehouse. Temperature should ideally be below 25°C.
    3. Packaging: Standard export packaging from Chinese factories is usually 25kg fiber drums or kraft paper bags with double PE liners. The fiber drum is recommended for ocean transport to prevent compression and moisture ingress.
    4. Shelf Life: Typically 24 months when stored in original, unopened packaging.

    FAQ - Technical & Supply Chain

    • Q:

      What is Calcium Glycerophosphate CAS 27214-00-2?

      A: Calcium Glycerophosphate CAS 27214-00-2 is a calcium salt of glycerophosphoric acid, with molecular formula C3H7CaO6P, molecular weight about 210.14, and EINECS 248-328-5. It is also known as calcium glycerylphosphate or calcium glycerinophosphate.
    • Q:

      Why is Calcium Glycerophosphate used in toothpaste and mouthwash?

      A: It supplies calcium and phosphate ions that support enamel remineralization and can work together with fluoride. In oral-care products it also helps buffer plaque acids and reduce acid-driven enamel demineralization.
    • Q:

      How does Calcium Glycerophosphate compare with inorganic calcium salts such as calcium carbonate?

      A: Calcium Glycerophosphate is more compatible with liquid or semi-transparent oral-care systems than poorly soluble inorganic calcium salts. It is not used primarily as an abrasive filler; instead it functions as a soluble calcium and phosphate source and buffering ingredient.
    • Q:

      What food, supplement, and pharmaceutical roles does Calcium Glycerophosphate support?

      A: It is used as a mineral fortifier and nutrient source of calcium and phosphorus in foods, nutritional products, infant formulas, and dietary supplements. It can also be used as a food stabilizer or acidity-control ingredient in suitable formulations.
    • Q:

      How should Calcium Glycerophosphate be handled in aqueous formulation?

      A: It is sparingly soluble in water, soluble in dilute acids, and practically insoluble in alcohol. Formulators typically disperse or dissolve it according to pH and temperature, and may use food acids to improve solubility in aqueous systems.

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