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    HomeProductsLife SciencePharmaceuticalIsotretinoin CAS 4759-48-2
    • Isotretinoin CAS 4759-48-2

    Isotretinoin CAS 4759-48-2

    Isotretinoin, chemically designated as 13-cis-Retinoic Acid, is a retinoid chemical utilized as a potent active pharmaceutical ingredient (API). It functions by suppressing sebaceous gland activity and normalizing follicular keratinization, making it the primary agent in pharmaceutical formulation for severe dermatological conditions.This yellow to orange crystalline powder is often processed into micronized forms to enhance bioavailability in oral softgel manufacturing.We provide competitive factory pricing and ensure customized specifications regarding particle size distribution (PSD). Each batch is supported by full documentation including MSDS, TDS, COA, and is available for bulk supply to global industrial partners.

    • CAS: 4759-48-2
    • Synonyms: 13-cis-Retinoic Acid, Isoretinoin, 13-cis-Vitamin A acid, Neovitamin A acid
    • Einecs: 225-296-0
    • Molecular Formula: C20H28O2
    • Grade: Industrial grade 99%
    • Package: 200kg iron drum or 50kg plastic drum packaging
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    Product Description

    Isotretinoin

    Synonyms: Tretinoin Impurity 1 (Tretinoin EP Impurity A)

    CAS Number: 4759-48-2

    Formula: C20H28O2

    Molecular weight: 300.44

    EINECS Number: 225-296-0

    Properties: Yellow or orange-red crystalline powder or crystals, insoluble in water, slightly soluble in ethanol

    Specification: 25kg/cardboard drum or 1kg/foil bag

    Uses: 1. Isotretinoin is the drug of choice for refractory acne, especially for patients with severe nodular, cystic, and inflammatory acne that is ineffective from traditional treatment. 2. Generalized flat warts or warruous epidermal dysplasia; 3. Dyskeratotic skin disease; 4. Cutaneous lupus erythematosus; 5. Lichen planus, lichen sclerosus atrophic lichen.

    FAQ - Technical & Supply Chain

    • Q:

      What is the difference between standard and micronized grades for industrial application?

      A: Micronized Isotretinoin undergoes a particle size reduction process to significantly increase its specific surface area. This grade is typically selected for formulations requiring enhanced dissolution rates and bioavailability compared to the standard crystalline grade.
    • Q:

      Is this product supplied as a finished dosage form?

      A: No, this product is supplied as a raw API chemical intended for industrial processing and manufacturing. It is not a finished capsule or softgel and is meant for professional use in a controlled pharmaceutical environment.
    Documents

    Documents and Product Support

    For product review and sourcing evaluation, supporting documents can be coordinated according to the product type, inquiry stage, and order requirements.

    • COA for batch-based quality reference
    • TDS for key physical and chemical information
    • SDS / MSDS for handling, storage, and safety reference
    • Packing information for sample, trial, and bulk orders
    • Technical communication based on application and specification requirements
    Quotation

    Information to Confirm Before Quotation

    Clear sourcing information helps reduce specification mismatch and allows a more accurate quotation before sample or bulk order discussion.

    • Product name and CAS number
    • Application or intended end use
    • Required purity, grade, or specification
    • Sample quantity, trial order, or bulk demand
    • Preferred packing form or net weight
    • Destination country or port
    • Required documents or compliance expectations
    Storage & Handling

    Packaging, Storage, and Handling Notes

    Packaging form, storage conditions, shelf life, and shipment arrangements should be confirmed according to the product characteristics, package size, and destination requirements.

    Before order confirmation, buyers are advised to review the corresponding product documents and confirm whether any special storage, labeling, or handling requirements apply.

    Supply Support

    Sample, Bulk Order and Repeat Supply Support

    Support can be arranged for sample discussion, bulk supply planning, packaging confirmation, and routine sourcing communication based on the actual product and order requirements.

    For repeat-use formulations or long-term procurement plans, buyers may discuss specification consistency, packaging preferences, delivery expectations, and document coordination in advance.

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    Tags:

    Pharmaceutical Ingredient Retinoid Compound Vitamin A Derivative

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