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    Related: Feed Additive Calcium Butyrate L-Lysine Hydrochloride
    • Sodium Butyrate CAS 156-54-7
    • Sodium Butyrate CAS 156-54-7

    Sodium Butyrate CAS 156-54-7

    Sodium Butyrate CAS 156-54-7 is a short-chain fatty acid salt chemically defined as Sodium butanoate , functioning primarily as a mucosal conditioning agent in animal feed formulations and an esterification intermediate in chemical synthesis. Also known as Butanoic acid sodium salt or Sodium n-butyrate, this hygroscopic crystalline powder is utilized to promote intestinal epithelial integrity in livestock nutrition and serves as a specialized reagent for histone deacetylase inhibition in biochemical applications. We provide professional access to this material with competitive factory pricing and the ability to meet customized specifications for various manufacturing requirements. Our commitment to technical transparency ensures that every shipment is accompanied by comprehensive MSDS, TDS, COA documentation to support your quality assurance protocols, and we maintain capacity for consistent bulk supply to facilitate large-scale industrial operations.

    • CAS: 156-54-7
    • Synonyms: Sodium butanoate, Butanoic acid sodium salt, Sodium n-butyrate, Butyric acid sodium salt, Na-butyrate
    • Einecs: 205-857-6
    • Molecular Formula: C4H7NaO2
    • Grade: Food/Pharma Grade
    • Package: 25kg/bag (Plastic woven bag with PE liner) or 500kg/1000kg Jumbo Bag.
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    Product Description

    1 Physical & Chemical Properties
    2 Key Application Fields
    2.1 1. Animal Nutrition (The Primary Market)
    2.2 2. Human Dietary Supplements
    3 Safety and Precautionary Measures
    4 Storage and Handling Conditions

    Physical & Chemical Properties

    Sodium Butyrate is a short-chain fatty acid (SCFA) salt. Its physical characteristics depend heavily on whether it is raw or coated. The table below refers to the standard raw chemical substance.

    PropertySpecification / Description
    Product NameSodium Butyrate
    CAS Number156-54-7
    Molecular FormulaC4H7NaO2
    Molecular Weight110.09 g/mol
    AppearanceWhite or off-white powder / crystalline granules
    OdorCharacteristic sour, rancid butter odor (Raw); Mild fatty odor (Coated)
    Assay (Dry Basis)≥ 98.0% (for Raw powder)
    SolubilityEasily soluble in water and ethanol
    pH ValueAlkaline (typically 7.0 – 9.0 in solution)
    Melting Point250°C – 253°C

    Key Application Fields

    1. Animal Nutrition (The Primary Market)

    This is the volume driver for CAS 156-54-7. It acts as a direct energy source for epithelial cells.

    • Swine (Piglet Weaning): This is the “killer app.” It helps repair intestinal damage caused by weaning stress, reduces diarrhea, and improves feed intake.
    • Poultry: Used to improve eggshell quality and strengthen the gut barrier against pathogens like Salmonella.
    • Aquaculture: Increasingly used in shrimp and fish feed to improve the Feed Conversion Ratio (FCR) and immunity.

    2. Human Dietary Supplements

    While less common than in agriculture, Sodium Butyrate is gaining traction in the “Postbiotic” market. It is used in formulations targeting IBS (Irritable Bowel Syndrome) and general microbiome balance.

    • Note: For human use, high-grade micro-encapsulation is non-negotiable to prevent the “burp” effect and bad taste.

    Safety and Precautionary Measures

    Sodium Butyrate is generally considered safe and non-toxic, but it presents a unique “social” hazard due to its smell.

    • Odor Management: The raw powder smells strongly of vomit/rancid milk. If spilled on clothing, the smell is extremely difficult to remove. Workers must wear dedicated protective clothing that stays in the facility.
    • Inhalation: The dust is irritating to the respiratory tract. N95 masks or respirators are mandatory.
    • Eye/Skin Contact: It can cause irritation. Wash immediately with soap and water if contact occurs.
    • Fire Safety: As a fine organic powder, standard precautions against dust explosions should be taken in the mixing area.

    For a calcium salt alternative in butyrate supply programs, see Calcium Butyrate.

    Storage and Handling Conditions

    Proper storage is vital not just for product stability, but to keep your warehouse habitable.

    1. Airtight Sealing: This is the most important rule. If a bag of raw Sodium Butyrate is punctured, the odor will permeate the entire warehouse and can cross-contaminate other porous packaging (like cardboard).
    2. Hygroscopicity: The product readily absorbs moisture from the air. Once it absorbs water, it clumps and the smell intensifies.
    3. Temperature: Store in a cool, dry, and well-ventilated place.
    4. Packaging:
      • Raw (98%): Usually 25kg bags with thick, double-layer PE liners.
      • Coated: Often comes in 25kg Kraft bags. The coating provides some protection against moisture and smell leakage.

    FAQ - Technical & Supply Chain

    • Q:

      What is Sodium Butyrate CAS 156-54-7?

      A: Sodium Butyrate CAS 156-54-7 is the sodium salt of butyric acid, with the molecular formula C4H7NaO2, molecular weight about 110.09 g/mol, and EINECS 205-857-6. It is supplied as a white to off-white powder or granules and is also known as sodium butanoate or butyric acid sodium salt.
    • Q:

      Why is Sodium Butyrate used in animal nutrition?

      A: Sodium Butyrate is a short-chain fatty acid source that supplies energy to intestinal epithelial cells. In pigs, poultry, and aquaculture it supports gut integrity, helps reduce weaning-related diarrhea, strengthens the gut barrier, and can improve feed intake and growth performance.
    • Q:

      What is the difference between raw Sodium Butyrate powder and coated Sodium Butyrate?

      A: Raw Sodium Butyrate has a characteristic butyric acid odor and releases rapidly, while coated or encapsulated grades reduce odor and slow release so more butyrate reaches the lower gut. Coated products are often chosen for feed processing stability, handling, and targeted intestinal delivery.
    • Q:

      What are the key specifications of Sodium Butyrate food/pharma grade?

      A: Typical specifications include a white to off-white powder or crystalline appearance, assay of at least 98% on a dry basis, easy solubility in water and ethanol, alkaline solution pH around 7-9, and melting point around 250-253 C.
    • Q:

      How does Sodium Butyrate differ from Butyric Acid?

      A: Sodium Butyrate is a solid salt, while butyric acid is a corrosive liquid with stronger volatility and odor. The salt form is easier to handle, dose, and incorporate into feed, food, supplement, and research formulations while providing butyrate activity.
    • Q:

      What health or research applications does Sodium Butyrate support?

      A: Beyond animal nutrition, Sodium Butyrate is used as a butyrate source in gut-health and metabolic-support supplements and in research as a histone deacetylase inhibitor. These applications rely on its ability to modulate gene expression and support intestinal barrier function.

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