What is Mannitol CAS 69-65-8?

Mannitol CAS 69-65-8 is D-mannitol, a six-carbon sugar alcohol with the formula C6H14O6 and molecular weight 182.17 g/mol. It is supplied as a white crystalline powder or granules for food and pharmaceutical use.

Why is Mannitol described as non-hygroscopic and cooling?

Mannitol absorbs very little moisture from the air, which helps prevent sticking in chewing gum and protects moisture-sensitive formulations. Its negative heat of solution also creates a noticeable cooling effect in mints and chewable products.

What is the difference between food grade and pharmaceutical grade Mannitol?

Food grade Mannitol is commonly used as E421 with a focus on sweetness, anti-caking, and stability, while pharmaceutical grade is controlled to USP, BP, or EP standards for excipient use. Pharmaceutical grade has stricter identity, purity, and microbial requirements.

What pharmaceutical and analytical roles does Mannitol serve?

In pharmaceuticals it is used as a tablet diluent, dusting powder, and osmotic agent in approved formulations. It is also used in analytical chemistry, for example in boron determinations, because of its predictable reactivity and solubility.

What stability and solubility properties matter in formulation?

Mannitol is chemically stable, does not readily undergo Maillard browning, and dissolves in water with a cooling effect. Typical USP-grade material has a melting range around 164-170 C and controlled moisture, reducing sugars, and rotation values.

Mannitol CAS 69-65-8

Mannitol, CAS 69-65-8, is a non-hygroscopic, low-calorie sugar alcohol supplied for chewing gum, mints, functional foods, pharmaceutical tablets, lyophilized drugs and personal care. Confirm the required grade and specification, then request a quotation with COA/TDS/SDS for bulk supply.

CAS: 69-65-8
Synonyms: D-Mannitol, Mannite, Osmitrol, 1,2,3,4,5,6-Hexanehexol, Cordycepic acid
Einecs: 200-711-8
Molecular Formula: C₆H₁₄O₆
Grade: Food Grade (E421) / Pharmaceutical Grade (USP/BP/EP)
Package: 25kg Multi-layer Craft Paper Bag or Fiber Drum with PE liner

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Product Description

Mannitol, CAS 69-65-8, also called D-mannitol, is a six-carbon sugar alcohol.

Synonyms: D-Mannitol; Mannite; Osmitrol; 1,2,3,4,5,6-Hexanehexol; Cordycepic acid.

CAS: 69-65-8.

It has a molecular weight of 182.17 g/mol and is supplied as a white crystalline powder or granules.

It is non-hygroscopic, absorbs very little moisture, and has a negative heat of solution that creates a cooling effect.

It is non-cariogenic, low in calories at about 1.6 kcal/g, and has a low glycemic response suitable for diabetic formulations.

It is chemically stable, does not readily undergo Maillard browning, and is stable against heat and acids.

It is used as a dusting and anti-caking agent in chewing gum, and as a sweetener base in mints and lozenges.

It is used in diabetic candies, low-calorie bakery products and functional foods.

It is used as a tablet diluent, binder and dusting powder in chewable and sublingual pharmaceuticals.

It is used as a bulking agent or cryoprotectant in freeze-dried injectable drugs.

It is used in toothpaste and mouthwash as a humectant and flavoring agent.

It is also used as an osmotic agent in approved formulations and in analytical chemistry.

Confirm appearance, assay, melting point, loss on drying, specific rotation, reducing sugars, acidity, chloride, sulfate, heavy metals, nickel, arsenic and solubility.

Store in a cool, dry, well-ventilated area at 15–30 °C, away from open flames and ignition sources.

Keep containers tightly closed to ensure purity and prevent dust contamination.

Confirm packaging with the requested quantity and destination requirements.

The page is an RFQ entry point and does not state stock, price, MOQ or fixed lead time.

For an RFQ, state the intended use, required grade and specification, quantity, packaging, destination and document needs.

FAQ - Technical & Supply Chain

Q:
What is Mannitol CAS 69-65-8?

A: Mannitol CAS 69-65-8 is D-mannitol, a six-carbon sugar alcohol with the formula C6H14O6 and molecular weight 182.17 g/mol. It is supplied as a white crystalline powder or granules for food and pharmaceutical use.
Q:
Why is Mannitol described as non-hygroscopic and cooling?

A: Mannitol absorbs very little moisture from the air, which helps prevent sticking in chewing gum and protects moisture-sensitive formulations. Its negative heat of solution also creates a noticeable cooling effect in mints and chewable products.
Q:
What is the difference between food grade and pharmaceutical grade Mannitol?

A: Food grade Mannitol is commonly used as E421 with a focus on sweetness, anti-caking, and stability, while pharmaceutical grade is controlled to USP, BP, or EP standards for excipient use. Pharmaceutical grade has stricter identity, purity, and microbial requirements.
Q:
What pharmaceutical and analytical roles does Mannitol serve?

A: In pharmaceuticals it is used as a tablet diluent, dusting powder, and osmotic agent in approved formulations. It is also used in analytical chemistry, for example in boron determinations, because of its predictable reactivity and solubility.
Q:
What stability and solubility properties matter in formulation?

A: Mannitol is chemically stable, does not readily undergo Maillard browning, and dissolves in water with a cooling effect. Typical USP-grade material has a melting range around 164-170 C and controlled moisture, reducing sugars, and rotation values.

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