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    Related: Humectant D-Sorbitol Erythritol
    • Mannitol CAS 69-65-8

    Mannitol CAS 69-65-8

    Mannitol (CAS 69-65-8) is a hexahydric sugar alcohol utilized as a premium low-calorie sweetener in the food industry and a critical excipient in pharmaceutical tablet manufacturing. Chemically identified as D-Mannitol or Mannite, this white crystalline powder functions to provide a unique cooling sensation in the mouth and acts as a non-hygroscopic bulking agent. As a stable isomer of sorbitol, it is extensively integrated into sugar-free chewing gums, mints, and chewable medication formulations to ensure stability and palatability. We ensure bulk supply capabilities for this material, providing access to competitive factory pricing and customized specifications to meet specific mesh sizes and pharmacopoeial standards (e.g., USP/EP/BP). Full technical documentation, including MSDS, TDS, COA, is available to support compliance and safety protocols.

    • CAS: 69-65-8
    • Synonyms: D-Mannitol, Mannite, Osmitrol, 1,2,3,4,5,6-Hexanehexol, Cordycepic acid
    • Einecs: 200-711-8
    • Molecular Formula: C6H14O6
    • Grade: Food Grade (E421) / Pharmaceutical Grade (USP/BP/EP)
    • Package: 25kg Multi-layer Craft Paper Bag or Fiber Drum with PE liner
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    Product Description

    Our Mannitol is manufactured in a GMP-certified facility, ensuring high purity and safety. It serves dual roles in various industries:

    Key Features & Benefits:

    1. Non-Hygroscopic: unlike Sorbitol, Mannitol does not absorb moisture from the air, making it the ideal dusting powder for chewing gum to prevent sticking.
    2. Cooling Effect: It has a significant negative heat of solution, creating a strong cooling sensation, perfect for mints and chewable tablets.
    3. Health Benefits: It is non-cariogenic (does not cause tooth decay), low in calories (1.6 kcal/g), and has a low glycemic response, making it suitable for diabetic formulations.
    4. Chemical Stability: It does not undergo Maillard browning reactions and is stable against heat and acids.
    1 Physicochemical Properties
    2 Applications
    3 Storage Conditions
    4 Safety Precautions

    Physicochemical Properties

    The following parameters represent our standard specification which meets USP (United States Pharmacopeia) and Food Grade (FCC) standards.

    Test ItemSpecification (Standard)
    AppearanceWhite crystalline powder or granules
    Assay (on dry basis)98.0% – 102.0%
    Melting Point165.0°C – 170.0°C
    Loss on Drying≤ 0.30%
    Specific Rotation+23.0° to +25.0°
    Reducing SugarsPasses Test (Conforms)
    Acidity or AlkalinityPasses Test
    Chloride (Cl)≤ 0.007%
    Sulfate (SO4)≤ 0.01%
    Heavy Metals (as Pb)≤ 5 ppm
    Nickel (Ni)≤ 1 ppm
    Arsenic (As)≤ 1 ppm
    SolubilitySoluble in water (approx 18% at 20°C); slightly soluble in ethanol

    Applications

    1. Food & Confectionery:
      • Chewing Gum: Used as a dusting agent/anti-caking agent to prevent gum from sticking to wrappers or machinery.
      • Mints & Lozenges: Used as the primary sweetener base for its cooling effect.
      • Functional Foods: Used in diabetic candies and low-calorie bakery products.
    2. Pharmaceuticals:
      • Tablet Excipient: An excellent diluent and binder for chewable and sublingual tablets due to its moisture stability and pleasant taste.
      • Lyophilization: Used as a bulking agent (cryoprotectant) in freeze-dried injectable drugs.
    3. Personal Care:
      • Used in toothpaste and mouthwash as a humectant and flavoring agent.

    For other bulk carbohydrate-based sweetener or carrier raw materials, see Erythritol and Maltodextrin.

    Storage Conditions

    • Environment: Store in a cool, dry, and well-ventilated area.
    • Temperature: Recommended storage temperature is 15°C – 30°C.
    • Packaging: Keep containers tightly closed. Although non-hygroscopic, keeping it sealed ensures purity and prevents dust contamination.
    • Shelf Life: 24 – 36 months in original unopened packaging.

    Safety Precautions

    • Ingestion: Mannitol is Generally Recognized As Safe (GRAS). However, excessive consumption (typically >20g per day) may cause a laxative effect (osmotic diarrhea).
    • Inhalation: Dust may cause mild respiratory irritation. Use dust extraction or wear a mask if handling large volumes of powder.
    • Skin/Eye Contact: Non-irritating. Rinse with water if contact occurs.
    • Flammability: Combustible dust hazard (like all fine organic powders). Keep away from open flames and ignition sources.

    FAQ - Technical & Supply Chain

    • Q:

      What is Mannitol CAS 69-65-8?

      A: Mannitol CAS 69-65-8 is D-mannitol, a six-carbon sugar alcohol with the formula C6H14O6 and molecular weight 182.17 g/mol. It is supplied as a white crystalline powder or granules for food and pharmaceutical use.
    • Q:

      Why is Mannitol described as non-hygroscopic and cooling?

      A: Mannitol absorbs very little moisture from the air, which helps prevent sticking in chewing gum and protects moisture-sensitive formulations. Its negative heat of solution also creates a noticeable cooling effect in mints and chewable products.
    • Q:

      What is the difference between food grade and pharmaceutical grade Mannitol?

      A: Food grade Mannitol is commonly used as E421 with a focus on sweetness, anti-caking, and stability, while pharmaceutical grade is controlled to USP, BP, or EP standards for excipient use. Pharmaceutical grade has stricter identity, purity, and microbial requirements.
    • Q:

      What pharmaceutical and analytical roles does Mannitol serve?

      A: In pharmaceuticals it is used as a tablet diluent, dusting powder, and osmotic agent in approved formulations. It is also used in analytical chemistry, for example in boron determinations, because of its predictable reactivity and solubility.
    • Q:

      What stability and solubility properties matter in formulation?

      A: Mannitol is chemically stable, does not readily undergo Maillard browning, and dissolves in water with a cooling effect. Typical USP-grade material has a melting range around 164-170 C and controlled moisture, reducing sugars, and rotation values.

    Ordering & Documentation

    Key information for document requests, quotations, and supply planning.

    Documents

    COA, TDS, SDS/MSDS and packing details are available on request.

    Quotation

    Send the CAS number, grade, quantity, packing preference and destination.

    Sample & Supply

    Support is available for samples, trial orders, bulk and repeat supply.

    Storage & Shipping

    Product-specific conditions are confirmed before order.

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