What is Chloromethyl Pivalate CAS 18997-19-8?

Chloromethyl pivalate, also called pivaloyloxymethyl chloride or POM-Cl, is an organic ester intermediate with CAS 18997-19-8, molecular formula C₆H₁₁ClO₂ and molecular weight about 150.60. It is normally a colorless liquid with low water solubility.

What is Chloromethyl Pivalate used for?

Chloromethyl pivalate is mainly used as a pharmaceutical intermediate in prodrug synthesis and pivaloyloxymethyl ester formation. It is used in beta-lactam antibiotic synthesis, including certain oral cephalosporins, and in antiviral and related fine-chemical intermediate manufacture.

Which specifications should be checked when buying Chloromethyl Pivalate?

Confirm assay, appearance, color, water or residual solvent and related impurities. Pharmaceutical use may require a defined GC or HPLC purity and controlled moisture or acid value, while the required specification should be matched to the intended reaction and downstream purification.

How should Chloromethyl Pivalate be stored and handled?

Store Chloromethyl pivalate in tightly closed containers in a cool, ventilated area away from ignition sources and incompatible materials. It can irritate the eyes, respiratory system and skin, so use chemical-resistant PPE, adequate ventilation and applicable spill or first-aid procedures.

Chloromethyl Pivalate CAS 18997-19-8

Chloromethyl Pivalate (POM-Cl), CAS 18997-19-8, is a pharmaceutical intermediate used in prodrug synthesis and pivaloyloxymethyl ester formation. Confirm the required purity and handling requirements for the intended synthesis.

CAS: 18997-19-8
Synonyms: Pivaloyloxymethyl chloride, POM-Cl, Chloromethyl 2,2-dimethylpropanoate, Pivalic acid chloromethyl ester, Chloromethyl trimethylacetate
Einecs: 242-735-1
Molecular Formula: C₆H₁₁ClO₂
Grade: Industrial grade 99%
Package: 200kg iron drum or 50kg plastic drum packing

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Product Description

Chloromethyl Pivalate (POM-Cl) is an organic ester intermediate identified by CAS 18997-19-8 and EC/EINECS 242-735-1.

Synonyms: Pivaloyloxymethyl chloride; POM-Cl; Chloromethyl 2,2-dimethylpropanoate; Pivalic acid chloromethyl ester; Chloromethyl trimethylacetate.

CAS: 18997-19-8.

Molecular formula: C₆H₁₁ClO₂.

Molecular weight: 150.60.

EC number: 242-735-1.

It is normally a colorless transparent liquid with low water solubility.

Typical properties include density about 1.045 g/mL at 25 °C and boiling point about 146-148 °C.

It is mainly used as a pharmaceutical intermediate in prodrug synthesis and pivaloyloxymethyl ester formation, including beta-lactam antibiotic intermediates.

It is also used in antiviral and related fine-chemical intermediate manufacture.

Confirm assay, appearance, color, water or residual solvent and related impurities.

Store in tightly closed containers away from ignition sources and incompatible materials; it can irritate eyes, respiratory system and skin, so use appropriate PPE.

Confirm the current product-specific specification.

Confirm packaging with the requested quantity and destination requirements.

Document requirements should be confirmed from the current specification, SDS, COA, or other product-specific files.

Regulated-use suitability must be confirmed separately with current product-specific documentation.

The page is an RFQ entry point and does not state stock, price, MOQ, or fixed lead time.

For an RFQ, state the intended use, required specification, quantity, packaging, destination, and document needs.

FAQ - Technical & Supply Chain

Q:
What is Chloromethyl Pivalate CAS 18997-19-8?

A: Chloromethyl pivalate, also called pivaloyloxymethyl chloride or POM-Cl, is an organic ester intermediate with CAS 18997-19-8, molecular formula C₆H₁₁ClO₂ and molecular weight about 150.60. It is normally a colorless liquid with low water solubility.
Q:
What is Chloromethyl Pivalate used for?

A: Chloromethyl pivalate is mainly used as a pharmaceutical intermediate in prodrug synthesis and pivaloyloxymethyl ester formation. It is used in beta-lactam antibiotic synthesis, including certain oral cephalosporins, and in antiviral and related fine-chemical intermediate manufacture.
Q:
Which specifications should be checked when buying Chloromethyl Pivalate?

A: Confirm assay, appearance, color, water or residual solvent and related impurities. Pharmaceutical use may require a defined GC or HPLC purity and controlled moisture or acid value, while the required specification should be matched to the intended reaction and downstream purification.
Q:
How should Chloromethyl Pivalate be stored and handled?

A: Store Chloromethyl pivalate in tightly closed containers in a cool, ventilated area away from ignition sources and incompatible materials. It can irritate the eyes, respiratory system and skin, so use chemical-resistant PPE, adequate ventilation and applicable spill or first-aid procedures.

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