Guanidine Hydrochloride (CAS 50-01-1), chemically known as guanidinium chloride, is a white crystalline powder and strong chaotropic agent primarily utilized as a powerful protein denaturant in biopharmaceutical purification and as a key intermediate in the synthesis of sulfonamide drugs. This Aminoformamidine hydrochloride compound functions as a bond-breaking agent that disrupts the hydrogen bonds in Guanidinium chloride treated systems, facilitating the solubilization of inclusion bodies and the extraction of nucleic acids (RNA/DNA) in diagnostic kits. To support industrial-scale requirements, we provide bulk supply with competitive factory pricing and ensure rigorous quality control through customized specifications alongside standard technical documentation, including MSDS, TDS, COA.
Guanidine Hydrochloride CAS 50-01-1
- CAS: 50-01-1
- Synonyms: Guanidinium chloride, Aminoformamidine hydrochloride, Guanidine monohydrochloride, Carbamimidic hydrazide monohydrochloride, Guanidinium HCl
- Einecs: 200-002-3
- Molecular Formula: CH5N3⋅HCl
- Grade: Industrial grade 99%
- Package: 200kg iron drum or 50kg plastic drum packing
Product Description
Guanidine hydrochloride, also known as aminocarbamidine hydrochloride or guanidine chloride, chemical formula CH6ClN3, CAS number 50-01-1, is a harmful compound. It is a white to slightly yellow lumpy organic matter with a melting point of 181-183°C, a density of 1.354g/cm³, and a pH value of 6.4 in 4% aqueous solution, easily soluble in water and methanol, and insoluble in acetone, benzene and other solvents
The compound is mainly used in the synthesis of pharmaceutical, pesticide and dye intermediates, and is a key raw material for the production of sulfonamides, folic acid and synthetic fiber antistatic agents, and can also be used as a protein denaturant 。 Its production is mainly based on the melting reaction of dicyanamine and ammonium chloride at 170-230 °C。 Guanidine hydrochloride is irritating to the eyes and skin, swallowing or touching may harm health, use protective equipment and avoid inhaling dust, keep dry and equipped with fire protection measures
Alias：Aminomemidine hydrochloride
chemical formula：CH6ClN3
molecular weight：95.53
CAS login number：50-01-1
EINECS login number：200-002-3
Melting point：181 ℃
water solubility：It can be dissolved in water at 20°C
Density：1.354 g/cm³
Appearance：White or yellowish lumps
application：It can be used as a pharmaceutical, pesticide, dye and other organic synthesis intermediates
Danger symbol：harmful
Description of hazards：R22； R36/38
FAQ - Technical & Supply Chain
-
Q:
What is the primary function of Guanidine Hydrochloride (CAS 50-01-1) in biotechnology?
A: It acts as a potent chaotrope (CH5N3⋅HCl) that unfolds proteins and inhibits enzymatic activity (such as RNase), making it essential for the lysis of cells and the purification of nucleic acids in diagnostic applications like COVID-19 testing kits. -
Q:
Is this material suitable for pharmaceutical synthesis?
A: Yes, industrial-grade Guanidine Hydrochloride serves as a critical raw material for synthesizing active pharmaceutical ingredients (APIs), including sulfadiazine and folic acid, due to its high nitrogen content and reactivity.
Documents and Product Support
For product review and sourcing evaluation, supporting documents can be coordinated according to the product type, inquiry stage, and order requirements.
- COA for batch-based quality reference
- TDS for key physical and chemical information
- SDS / MSDS for handling, storage, and safety reference
- Packing information for sample, trial, and bulk orders
- Technical communication based on application and specification requirements
Information to Confirm Before Quotation
Clear sourcing information helps reduce specification mismatch and allows a more accurate quotation before sample or bulk order discussion.
- Product name and CAS number
- Application or intended end use
- Required purity, grade, or specification
- Sample quantity, trial order, or bulk demand
- Preferred packing form or net weight
- Destination country or port
- Required documents or compliance expectations
Packaging, Storage, and Handling Notes
Packaging form, storage conditions, shelf life, and shipment arrangements should be confirmed according to the product characteristics, package size, and destination requirements.
Before order confirmation, buyers are advised to review the corresponding product documents and confirm whether any special storage, labeling, or handling requirements apply.
Sample, Bulk Order and Repeat Supply Support
Support can be arranged for sample discussion, bulk supply planning, packaging confirmation, and routine sourcing communication based on the actual product and order requirements.
For repeat-use formulations or long-term procurement plans, buyers may discuss specification consistency, packaging preferences, delivery expectations, and document coordination in advance.
