What is the difference between Trometamol (Tris Base) and Tris-HCl?

Tris Base (CAS 77-86-1) is the alkaline component , whereas Tris-HCl is the pre-acidified salt; Tris Base is typically used to adjust the pH of acidic solutions or is mixed with Tris-HCl to achieve a specific buffer pH.

Why is Trometamol preferred in pharmaceutical injections?

It acts as an organic amine counterion that forms stable, soluble salts with acidic active pharmaceutical ingredients (APIs), significantly improving their solubility and bioavailability in the bloodstream.

Trometamol CAS 77-86-1

Trometamol (CAS 77-86-1), universally recognized as Tris Base or THAM, is a white crystalline substance and organic amine primarily utilized as the gold-standard biological buffer in electrophoresis, molecular biology, and pharmaceutical formulations. This Tris(hydroxymethyl)aminomethane compound functions as a highly stable buffering agent in 2-Amino-2-(hydroxymethyl)propane-1,3-diol prepared solutions, maintaining a physiological pH range (7.0–9.0) essential for enzyme stability and DNA integrity, while also serving as an alkalizing excipient to solubilize acidic drugs in injectable medications. To support industrial-scale requirements, we provide bulk supply with competitive factory pricing and ensure rigorous quality control through customized specifications alongside standard technical documentation, including MSDS, TDS, COA.

CAS: 77-86-1
Synonyms: THAM; riladyl; Talatrol; 1,3-Propanediol, 2-amino-2-(hydroxymethyl)-; Trizma; TRISMAT; TRIS; Tromethamine; Pehanorm;
Einecs: 201-064-4
Molecular Formula: C4H11NO3
Grade: Industrial grade 99%
Package: 200kg iron drum or 50kg plastic drum packing

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Product Description

Trometamol

alias: 1,3-Propanediol, 2-amino-2-(hydroxymethyl)-; Trizma; TRISMAT; TRIS; Tromethamine; Pehanorm;

CAS Number: 77-86-1

MDL number: MFCD00004679

EINECS Number: 201-064-4

RTECS number: TY2900000

BRN number: 741883

PubChem number: 24899961

Formula: C4H11NO3

Structural formula:

Molecular weight: 121.13500

Exact mass: 121.07400

PSA：86.71000

Physical and chemical properties

Appearance and properties: white crystalline powder

Density: 1.3±0.1 g/cm3^[5]

Melting point: 167-172°C(lit.)

Boiling point: 219-220°C 10mm Hg(lit.)

Flash point: 219-220°C/10mm

Refractive index: 1.531

Water solubility: 550 g/L (25 ºC)

Stability: Stable. Incompatible with bases, strong oxidizing agents. Protect from moisture.

Storage conditions: 2-8ºC

use

1. The intermediate of fosfomycin can also be used as a vulcanization accelerator, cosmetics (cream, lotion), mineral oil, paraffin emulsifier, and biological buffer.

2. Used as an acid gas absorber, preparing buffers, surfactants, emulsifiers and accelerators. Also used in organic synthesis.

FAQ - Technical & Supply Chain

Q:
What is the difference between Trometamol (Tris Base) and Tris-HCl?

A: Tris Base (CAS 77-86-1) is the alkaline component , whereas Tris-HCl is the pre-acidified salt; Tris Base is typically used to adjust the pH of acidic solutions or is mixed with Tris-HCl to achieve a specific buffer pH.
Q:
Why is Trometamol preferred in pharmaceutical injections?

A: It acts as an organic amine counterion that forms stable, soluble salts with acidic active pharmaceutical ingredients (APIs), significantly improving their solubility and bioavailability in the bloodstream.

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