What is Ascorbyl Glucoside CAS 129499-78-1?

It is a stable vitamin C derivative, also known as AA2G or L-ascorbic acid 2-glucoside. Its molecular formula is C12H18O11 and its molecular weight is about 338.26 g/mol. The product is commonly supplied as a white to off-white crystalline powder.

Why is Ascorbyl Glucoside described as a stable vitamin C derivative?

A glucose group is attached at the C-2 position of ascorbic acid, protecting the site that is most vulnerable to oxidation. This structure makes AA2G more stable than ascorbic acid in water-based cosmetic systems and allows it to tolerate a practical formulation pH range of about 5-7.

How does AA2G work in skin care?

AA2G acts as a prodrug. After application, skin enzymes gradually release ascorbic acid, which supports antioxidant activity, skin brightening, and collagen-related benefits. This gradual conversion is why it is used in serums, creams, and lotions.

What is the difference between Ascorbyl Glucoside and ascorbic acid?

Ascorbic acid is active directly but is more prone to oxidation and usually requires a low-pH formula. Ascorbyl Glucoside is more stable around neutral pH and is converted to ascorbic acid in the skin, making it a gentler option for many water-based cosmetic formulations.

What pH and formulation conditions suit Ascorbyl Glucoside?

The practical cosmetic formulation range is usually pH 5-7, with published stability data indicating an optimum near pH 6.4. It is freely water soluble and can normally be added to the water phase during processing, with typical use levels in finished formulas commonly around 1-3%.

How should Ascorbyl Glucoside powder be stored and handled?

Store the powder in tightly sealed containers in a cool, dry, well-ventilated area, away from direct sunlight, heat, and high humidity. Protect the material from moisture uptake and check that it remains white to off-white, since yellowing can indicate oxidation or degradation.

Ascorbyl Glucoside (AA2G) CAS 129499-78-1

Ascorbyl Glucoside, also called AA2G or L-ascorbic acid 2-glucoside, CAS 129499-78-1, is a glucoside-stabilized derivative of ascorbic acid supplied as a water-soluble powder and positioned for cosmetic and personal care formulations. Confirm the required grade, then request a quotation with COA/TDS/SDS for bulk supply.

CAS: 129499-78-1
Synonyms: AA2G; L-Ascorbic Acid 2-Glucoside
Molecular Formula: C12H18O11
Grade: Cosmetic formulation grade
Package: Sealed bags, fiber drums, or lined containers

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Product Description

Ascorbyl Glucoside (AA2G) CAS 129499-78-1 is a glucoside-stabilized derivative of ascorbic acid with molecular formula C12H18O11.

Synonyms: AA2G; L-Ascorbic Acid 2-Glucoside.

CAS: 129499-78-1.

Molecular formula: C12H18O11.

It is supplied as a white to off-white crystalline powder.

It has a molecular weight of about 338.26 g/mol.

It is positioned as a stable, water-soluble vitamin C derivative for skin care.

It is used in serums, creams, and lotions.

It acts as a prodrug: skin enzymes gradually release ascorbic acid for antioxidant and brightening benefits.

A glucose group at the C-2 position protects the oxidation-prone site, making it more stable than ascorbic acid.

The practical cosmetic formulation pH range is usually 5-7, with an optimum near pH 6.4.

Confirm the required cosmetic grade, assay, appearance, and related specifications for the chosen grade.

Check compatibility with the target water-based formulation and confirm the typical use level.

Store in tightly sealed containers in a cool, dry, well-ventilated area, away from direct sunlight, heat, and high humidity.

Protect from moisture uptake and check that the powder remains white to off-white, since yellowing can indicate degradation.

Confirm packaging suitable for the powder form and order quantity, and follow the current SDS.

Confirm grade, packaging, and specification as required.

The page is an RFQ entry point and does not state stock, price, MOQ, or fixed lead time.

For an RFQ, state the intended application, required grade, quantity, packaging, destination, and document needs.

FAQ - Technical & Supply Chain

Q:
What is Ascorbyl Glucoside CAS 129499-78-1?

A: It is a stable vitamin C derivative, also known as AA2G or L-ascorbic acid 2-glucoside. Its molecular formula is C12H18O11 and its molecular weight is about 338.26 g/mol. The product is commonly supplied as a white to off-white crystalline powder.
Q:
Why is Ascorbyl Glucoside described as a stable vitamin C derivative?

A: A glucose group is attached at the C-2 position of ascorbic acid, protecting the site that is most vulnerable to oxidation. This structure makes AA2G more stable than ascorbic acid in water-based cosmetic systems and allows it to tolerate a practical formulation pH range of about 5-7.
Q:
How does AA2G work in skin care?

A: AA2G acts as a prodrug. After application, skin enzymes gradually release ascorbic acid, which supports antioxidant activity, skin brightening, and collagen-related benefits. This gradual conversion is why it is used in serums, creams, and lotions.
Q:
What is the difference between Ascorbyl Glucoside and ascorbic acid?

A: Ascorbic acid is active directly but is more prone to oxidation and usually requires a low-pH formula. Ascorbyl Glucoside is more stable around neutral pH and is converted to ascorbic acid in the skin, making it a gentler option for many water-based cosmetic formulations.
Q:
What pH and formulation conditions suit Ascorbyl Glucoside?

A: The practical cosmetic formulation range is usually pH 5-7, with published stability data indicating an optimum near pH 6.4. It is freely water soluble and can normally be added to the water phase during processing, with typical use levels in finished formulas commonly around 1-3%.
Q:
How should Ascorbyl Glucoside powder be stored and handled?

A: Store the powder in tightly sealed containers in a cool, dry, well-ventilated area, away from direct sunlight, heat, and high humidity. Protect the material from moisture uptake and check that it remains white to off-white, since yellowing can indicate oxidation or degradation.

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