What is Ascorbyl Glucoside CAS 129499-78-1?

It is a stable vitamin C derivative, also known as AA2G or L-ascorbic acid 2-glucoside. Its molecular formula is C12H18O11 and its molecular weight is about 338.26 g/mol. The product is commonly supplied as a white to off-white crystalline powder.

Why is Ascorbyl Glucoside described as a stable vitamin C derivative?

A glucose group is attached at the C-2 position of ascorbic acid, protecting the site that is most vulnerable to oxidation. This structure makes AA2G more stable than ascorbic acid in water-based cosmetic systems and allows it to tolerate a practical formulation pH range of about 5-7.

How does AA2G work in skin care?

AA2G acts as a prodrug. After application, skin enzymes gradually release ascorbic acid, which supports antioxidant activity, skin brightening, and collagen-related benefits. This gradual conversion is why it is used in serums, creams, and lotions.

What is the difference between Ascorbyl Glucoside and ascorbic acid?

Ascorbic acid is active directly but is more prone to oxidation and usually requires a low-pH formula. Ascorbyl Glucoside is more stable around neutral pH and is converted to ascorbic acid in the skin, making it a gentler option for many water-based cosmetic formulations.

What pH and formulation conditions suit Ascorbyl Glucoside?

The practical cosmetic formulation range is usually pH 5-7, with published stability data indicating an optimum near pH 6.4. It is freely water soluble and can normally be added to the water phase during processing, with typical use levels in finished formulas commonly around 1-3%.

How should Ascorbyl Glucoside powder be stored and handled?

Store the powder in tightly sealed containers in a cool, dry, well-ventilated area, away from direct sunlight, heat, and high humidity. Protect the material from moisture uptake and check that it remains white to off-white, since yellowing can indicate oxidation or degradation.

Ascorbyl Glucoside CAS 129499-78-1

Ascorbyl Glucoside is supplied as a glucoside-stabilized derivative of ascorbic acid, positioned as a functional ingredient in cosmetic and personal care formulations. It is designed for improved stability compared to pure vitamin C, allowing its incorporation into aqueous systems where gradual conversion to active ascorbic acid is desired.

In commercial supply, this material is typically provided as a water-soluble powder, suitable for use in skin care formulations such as serums, creams, and lotions. It supports formulation processes requiring stable antioxidant ingredients. Standard packaging, batch documentation (COA, TDS, SDS), and supply support are available for development and bulk applications.

CAS: 129499-78-1
Synonyms: AA2G; L-Ascorbic Acid 2-Glucoside
Molecular Formula: C12H18O11
Grade: Typically supplied for cosmetic formulation use
Package: Available in sealed bags, fiber drums, or lined containers; packaging arranged according to order volume and handling requirements

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Product Description

1 Physicochemical Properties

2 Typical Applications

3 Packaging

4 Storage

Physicochemical Properties

Item	Description
Appearance	White to off-white crystalline powder
Odor	Odorless or faint characteristic odor
Solubility	Freely soluble in water
pH (aqueous solution)	Typically mildly acidic
Melting Point	Approx. 158–163°C (decomposition)
Stability	More stable than ascorbic acid under light and heat conditions
Moisture Sensitivity	Hygroscopic to slight extent

Typical Applications

Skin care formulations such as serums, creams, and lotions
Formulations requiring stable vitamin C derivatives
Cosmetic systems targeting skin tone improvement and antioxidant support
Water-based formulations requiring improved ingredient stability

Use in final products should be evaluated in accordance with formulation requirements and local regulatory frameworks.

Packaging

Ascorbyl Glucoside is supplied as a solid powder and packed in sealed, moisture-resistant containers such as fiber drums or lined bags. Inner packaging is designed to protect the product from humidity and contamination during storage and transport. Packaging configurations can be arranged based on order quantity and export requirements, ensuring suitability for bulk handling and formulation use.

Storage

Store in a cool, dry, and well-ventilated area. Keep containers tightly closed to prevent moisture uptake. Avoid exposure to direct sunlight, heat, and high humidity, which may affect product stability over time. Maintain proper sealing during storage and transport to preserve product quality.

For related vitamin C derivative pages, compare Ascorbyl Tetraisopalmitate, Ascorbyl Palmitate, and Ethyl Ascorbic Acid.

FAQ - Technical & Supply Chain

Q:
What is Ascorbyl Glucoside CAS 129499-78-1?

A: It is a stable vitamin C derivative, also known as AA2G or L-ascorbic acid 2-glucoside. Its molecular formula is C12H18O11 and its molecular weight is about 338.26 g/mol. The product is commonly supplied as a white to off-white crystalline powder.
Q:
Why is Ascorbyl Glucoside described as a stable vitamin C derivative?

A: A glucose group is attached at the C-2 position of ascorbic acid, protecting the site that is most vulnerable to oxidation. This structure makes AA2G more stable than ascorbic acid in water-based cosmetic systems and allows it to tolerate a practical formulation pH range of about 5-7.
Q:
How does AA2G work in skin care?

A: AA2G acts as a prodrug. After application, skin enzymes gradually release ascorbic acid, which supports antioxidant activity, skin brightening, and collagen-related benefits. This gradual conversion is why it is used in serums, creams, and lotions.
Q:
What is the difference between Ascorbyl Glucoside and ascorbic acid?

A: Ascorbic acid is active directly but is more prone to oxidation and usually requires a low-pH formula. Ascorbyl Glucoside is more stable around neutral pH and is converted to ascorbic acid in the skin, making it a gentler option for many water-based cosmetic formulations.
Q:
What pH and formulation conditions suit Ascorbyl Glucoside?

A: The practical cosmetic formulation range is usually pH 5-7, with published stability data indicating an optimum near pH 6.4. It is freely water soluble and can normally be added to the water phase during processing, with typical use levels in finished formulas commonly around 1-3%.
Q:
How should Ascorbyl Glucoside powder be stored and handled?

A: Store the powder in tightly sealed containers in a cool, dry, well-ventilated area, away from direct sunlight, heat, and high humidity. Protect the material from moisture uptake and check that it remains white to off-white, since yellowing can indicate oxidation or degradation.

Ordering & Documentation

Key information for document requests, quotations, and supply planning.

Documents

COA, TDS, SDS/MSDS and packing details are available on request.

Quotation

Send the CAS number, grade, quantity, packing preference and destination.

Sample & Supply

Support is available for samples, trial orders, bulk and repeat supply.

Storage & Shipping

Product-specific conditions are confirmed before order.

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