4 Butylresorcinol CAS 18979-61-8

4-Butylresorcinol (4-butylbenzene-1,3-diol) is a high-value cosmetic active widely used in advanced skin-brightening formulas. As a substituted resorcinol, it shows strong inhibitory activity on tyrosinase and related enzymes involved in melanin formation, making it a key ingredient for even-tone and spot-correcting products.

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Physicochemical Properties

Applications

1. Cosmetic skin-brightening active

• Core active ingredient in whitening and brightening creams, lotions and serums aimed at reducing the appearance of dark spots, uneven tone and age-related hyperpigmentation.
• Often combined with niacinamide, vitamin C derivatives, arbutin, tranexamic acid, etc., to create multi-pathway brightening complexes.
• Suitable for face, neck, hand and body spot-correction cosmetic products at appropriately controlled use levels, following local cosmetic regulations.

2. Advanced derma-cosmetics & clinic-inspired lines

• Used in premium depigmenting serums and dermatology-inspired formulations where fast visible brightening and good tolerance are required.
• Frequently selected as an alternative or complement to traditional actives in products designed for sensitive or long-term cosmetic use.

3. R&D and pharmaceutical intermediate use

• Employed as a reference standard and research tool in studies of tyrosinase inhibition and melanogenesis.
• Can serve as an intermediate or building block in the synthesis of other specialty molecules (e.g. cannabinoid derivatives) in laboratory-scale work.

Typical customer groups:

• Cosmetic brands and OEM/ODM factories
• Derma-cosmetic and clinical skin-care developers
• Raw-material distributors and traders
• R&D laboratories focusing on pigmentation and skin biology

Storage Conditions

To maintain the stability and activity of 4-Butylresorcinol, we recommend:

1. Temperature
   • Store in a cool environment, 2–8 °C for long-term storage. Short-term handling at room temperature is acceptable.
2. Container & atmosphere
   • Keep in the original, tightly closed container (aluminum foil inner bag + fiber drum or HDPE container).
   • Protect from moisture, direct sunlight and high temperature.
   • Avoid prolonged exposure to air to minimize oxidation and color change.
3. Handling
   • Open containers in a dry, well-ventilated area.
   • Reseal promptly after sampling or weighing.

Safety Precautions

This information is for general industrial and laboratory handling only. Always follow your local regulations and the Safety Data Sheet (SDS) for your purchased batch.

• GHS classification: Typically supplied with GHS “Warning” signal word. May be harmful if swallowed and may cause skin and eye irritation.

Personal protection

• Wear appropriate protective gloves, safety goggles and lab coat when handling powders.
• Avoid generating and breathing dust; use local exhaust ventilation or dust extraction where necessary.
• Avoid direct contact with skin and eyes. In case of contact, rinse immediately with plenty of water and seek medical attention if irritation persists.

Operational safety

• Do not eat, drink or smoke in areas where the product is handled.
• Wash hands thoroughly after handling.
• Prevent release to the environment; collect spills mechanically and dispose of according to local regulations.

First aid (general guidance)

• Inhalation: Move to fresh air; seek medical advice if symptoms occur.
• Skin contact: Wash with soap and water; remove contaminated clothing.
• Eye contact: Rinse cautiously with water for several minutes; remove contact lenses if present and easy to do; continue rinsing and seek medical advice if irritation persists.
• Ingestion: Rinse mouth, do not induce vomiting; seek medical attention immediately.