What is Trichloroacetyl Chloride?

Trichloroacetyl chloride is the acyl chloride of trichloroacetic acid, with CAS 76-02-8 and molecular formula C₂Cl₄O. It is a reactive, moisture-sensitive liquid used mainly as an acylating intermediate.

What is Trichloroacetyl Chloride used for?

It introduces the trichloroacetyl group into amines, alcohols and other nucleophiles. Major uses include agrochemical intermediates such as chlorpyrifos and methylchlorpyrifos, plus pharmaceutical and specialty organic synthesis.

How does it compare with trichloroacetic acid?

Trichloroacetyl chloride is the acid chloride derivative, while trichloroacetic acid is the corresponding carboxylic acid. The chloride is much more electrophilic and must be kept away from water, alcohols and bases to prevent hydrolysis.

How should Trichloroacetyl Chloride be stored and handled?

Keep it in tightly sealed, corrosion-resistant packaging under dry, inert conditions, away from water, alcohols, bases and heat. Use adequate ventilation and appropriate PPE, and avoid moisture ingress during transfer.

Why is moisture control critical for Trichloroacetyl Chloride?

Trichloroacetyl chloride hydrolyzes rapidly in the presence of water, forming trichloroacetic acid and hydrogen chloride. Low moisture in the product and dry transfer procedures preserve acylating activity and reduce corrosive side reactions.

Trichloroacetyl Chloride CAS 76-02-8

Trichloroacetyl Chloride (TCAC), CAS 76-02-8, is a reactive acylating agent used to introduce the trichloroacetyl group into amines, alcohols and other nucleophiles, mainly in agrochemical and pharmaceutical synthesis. Confirm the required grade, then request a quotation with COA/TDS/SDS for bulk supply.

CAS: 76-02-8
Synonyms: Trichloroacetic acid chloride, TCAC, Trichloroacetochloride, 2,2,2-Trichloroacetyl chloride
Einecs: 200-926-7
Molecular Formula: C₂Cl₄O
Grade: Industrial grade 99%
Package: 200kg iron drum or 50kg plastic drum packing

Request a quote

Share:

Product Description

Trichloroacetyl Chloride (TCAC), CAS 76-02-8, is the acyl chloride of trichloroacetic acid, a reactive acylating agent; the EC/EINECS number is 200-926-7.

Synonyms: Trichloroacetic acid chloride; TCAC; Trichloroacetochloride; 2,2,2-Trichloroacetyl chloride.

CAS: 76-02-8.

Molecular formula: C₂Cl₄O.

Molecular weight: 181.83.

EC number: 200-926-7.

It is a colorless to light-yellow fuming liquid with a pungent odor; the melting point is about -57 °C, the boiling point about 114-116 °C and the density about 1.629 g/cm³.

It reacts rapidly with water and alcohols, releasing hydrogen chloride and forming trichloroacetic acid or its esters; it is moisture-sensitive and corrosive.

It is produced by chlorination of acetyl chloride.

It is used as an acylating agent to introduce the trichloroacetyl group into amines, alcohols and other nucleophiles.

It is used as an intermediate for agrochemicals such as chlorpyrifos and methyl chlorpyrifos, via the 3,5,6-trichloro-2-pyridinol sodium salt.

It is used in pharmaceutical intermediates and specialty organic synthesis.

Confirm assay, color, chlorinated impurities, acid content and distillation range.

Store in tightly sealed, corrosion-resistant packaging under dry inert conditions, away from water, alcohols, amines, bases and heat; use ventilation and suitable PPE.

Confirm the current product-specific specification.

Confirm packaging with the requested quantity and destination requirements.

Document requirements should be confirmed from the current specification, SDS, COA, or other product-specific files.

The page is an RFQ entry point and does not state stock, price, MOQ, or fixed lead time.

For an RFQ, state the intended use, required specification, quantity, packaging, destination, and document needs.

FAQ - Technical & Supply Chain

Q:
What is Trichloroacetyl Chloride?

A: Trichloroacetyl chloride is the acyl chloride of trichloroacetic acid, with CAS 76-02-8 and molecular formula C₂Cl₄O. It is a reactive, moisture-sensitive liquid used mainly as an acylating intermediate.
Q:
What is Trichloroacetyl Chloride used for?

A: It introduces the trichloroacetyl group into amines, alcohols and other nucleophiles. Major uses include agrochemical intermediates such as chlorpyrifos and methylchlorpyrifos, plus pharmaceutical and specialty organic synthesis.
Q:
How does it compare with trichloroacetic acid?

A: Trichloroacetyl chloride is the acid chloride derivative, while trichloroacetic acid is the corresponding carboxylic acid. The chloride is much more electrophilic and must be kept away from water, alcohols and bases to prevent hydrolysis.
Q:
How should Trichloroacetyl Chloride be stored and handled?

A: Keep it in tightly sealed, corrosion-resistant packaging under dry, inert conditions, away from water, alcohols, bases and heat. Use adequate ventilation and appropriate PPE, and avoid moisture ingress during transfer.
Q:
Why is moisture control critical for Trichloroacetyl Chloride?

A: Trichloroacetyl chloride hydrolyzes rapidly in the presence of water, forming trichloroacetic acid and hydrogen chloride. Low moisture in the product and dry transfer procedures preserve acylating activity and reduce corrosive side reactions.

Ordering & Documentation

Key information for document requests, quotations, and supply planning.

Documents

COA, TDS, SDS/MSDS and packing details are available on request.

Quotation

Send the CAS number, grade, quantity, packing preference and destination.

Sample & Supply

Support is available for samples, trial orders, bulk and repeat supply.

Storage & Shipping

Product-specific conditions are confirmed before order.

Current Language

Change Language