What is Palmitoylethanolamide CAS 544-31-0?

Palmitoylethanolamide, usually called PEA or Palmidrol, is an endogenous fatty acid amide from the N-acylethanolamine family. Its molecular formula is C18H37NO2, molecular weight is about 299.49 g/mol, and it is identified by CAS 544-31-0 and EINECS 208-867-9.

Why is PEA often offered in a micronized grade?

PEA is a lipophilic material with very low water solubility, so ordinary powder can be difficult to wet and absorb in oral formulations. Micronized PEA, typically with D90 below 10-20 um, improves dispersibility, dissolution and absorption in capsules and powders.

What are the main uses of Palmitoylethanolamide?

PEA is mainly used as a dietary supplement and nutraceutical ingredient for capsules, powders and functional food formulations. It is also offered as a food-grade or pharmaceutical-intermediate raw material where a high-purity fatty acid amide is required.

What is the difference between standard and micronized PEA?

Both grades share the same chemical identity, CAS 544-31-0 and molecular formula. The main difference is particle size: standard PEA is a fine white to off-white powder or flakes, while micronized PEA has a controlled small particle size for better dispersion and formulation performance.

How should Palmitoylethanolamide be stored and handled?

Store PEA tightly closed in a cool, dry, ventilated area away from sunlight, moisture, heat and oxidizers. Bulk handling should control dust, and the package should be resealed after each use; the current offer is typically 1 kg aluminum bags or 25 kg fiber drums depending on grade and quantity.

Palmitoylethanolamide CAS 544-31-0

Palmitoylethanolamide CAS 544-31-0 is a saturated endogenous fatty acid amide categorized as a lipid signaling molecule and N-palmitoylethanolamine, functioning primarily as a stabilizing agent in specialized chemical matrices and a physiological lipid intermediate within industrial bioactive formulations. This compound, also recognized as Palmidrol or Hydroxyethylpalmitamide, is utilized in controlled chemical synthesis and the production of advanced lipid-based systems to modulate formulation consistency and structural integrity. We provide professional access to this material with competitive factory pricing and the ability to meet customized specifications for various manufacturing requirements. Our commitment to technical transparency ensures that every shipment is accompanied by comprehensive MSDS, TDS, COA documentation to support your quality assurance protocols, and we maintain capacity for consistent bulk supply to facilitate large-scale industrial operations.

CAS: 544-31-0
Synonyms: Palmidrol, N-Palmitoylethanolamine, N-(2-Hydroxyethyl)palmitamide, Hydroxyethylpalmitamide, Palmitoyl Monoethanolamide
Einecs: 208-867-9
Molecular Formula: C18H37NO2
Grade: Dietary Supplement Grade / Pharmaceutical Intermediate / Food Grade
Package: 1kg/Alu-bag, 25kg/Fiber Drum.

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Product Description

Palmitoylethanolamide (PEA) is a lipid mediator that belongs to the N-acylethanolamine family. It acts primarily by binding to the peroxisome proliferator-activated receptor alpha (PPAR-α) in the cell nucleus, which plays a key role in regulating pain and inflammation.

Why is our PEA popular?

Natural Mechanism: It mimics the body’s own defense mechanism against inflammation. It is naturally found in foods like egg yolks, peanuts, and soy lecithin, but only in trace amounts, making supplementation necessary.
Micronization Technology: Since PEA is a lipid and naturally hard to absorb, we offer micronized options (particle size D90 < 10-20μm) to drastically improve dissolution and absorption rates in the human body.
Safety Profile: It is often marketed as a safe, non-addictive alternative to CBD or NSAIDs for chronic pain relief.

1 Physicochemical Properties

2 Applications

3 Storage Conditions

4 Safety Precautions

Physicochemical Properties

The table below represents the typical Certificate of Analysis (COA) for our Export Grade PEA (99%+).

Parameter	Specification (Standard)
Appearance	White to off-white crystalline powder/flakes
Identification	Consistent with IR / HPLC
Assay (on dried basis)	≥ 99.0%
Melting Point	97.0°C – 99.0°C
Loss on Drying	≤ 1.0% (Typically <0.5%)
Residue on Ignition	≤ 0.1%
Particle Size	100% pass 80 mesh (Standard) OR D90 ≤ 20μm (Micronized)
Heavy Metals	≤ 10 ppm
Lead (Pb)	≤ 3.0 ppm
Arsenic (As)	≤ 1.0 ppm
Solvent Residue (Ethanol)	≤ 5000 ppm (Complies with USP)
Microbiological	Total Plate Count < 1000 cfu/g

Applications

Dietary Supplements (Human Health):
- Pain Management: Used in formulations for chronic pain, sciatic pain, and neuropathic pain.
- Joint Health: Often combined with Glucosamine or Chondroitin for arthritis support.
- Immune Support: PEA has been shown to have anti-inflammatory properties that support immune health (often used during flu season).
Animal Nutrition (Pet Health):
- Extremely popular in the pet industry for dogs and cats suffering from atopic dermatitis (skin allergies) and osteoarthritis.
Sports Nutrition:
- Used for post-workout recovery to reduce muscle inflammation.

Storage Conditions

Temperature: Store in a cool place, preferably below 25°C. Avoid high temperatures as it is a fatty acid derivative and can melt or degrade.
Environment: Keep container tightly closed in a dry and well-ventilated place.
Light: Protect from direct sunlight.
Shelf Life: 24 months (2 years) when stored properly in original unopened packaging.

Safety Precautions

General: PEA is considered a safe dietary ingredient with a very low toxicity profile. It is non-psychoactive.
Handling: As with any fine chemical powder, wear a dust mask and protective gloves during handling to avoid dust inhalation or skin contact.
Dust Hazard: Fine powder can form explosive dust-air mixtures. Prevent dust accumulation and keep away from open flames or sparks.
First Aid:
- Eye Contact: Rinse with plenty of water.
- Skin: Wash with soap and water.

FAQ - Technical & Supply Chain

Q:
What is Palmitoylethanolamide CAS 544-31-0?

A: Palmitoylethanolamide, usually called PEA or Palmidrol, is an endogenous fatty acid amide from the N-acylethanolamine family. Its molecular formula is C18H37NO2, molecular weight is about 299.49 g/mol, and it is identified by CAS 544-31-0 and EINECS 208-867-9.
Q:
Why is PEA often offered in a micronized grade?

A: PEA is a lipophilic material with very low water solubility, so ordinary powder can be difficult to wet and absorb in oral formulations. Micronized PEA, typically with D90 below 10-20 um, improves dispersibility, dissolution and absorption in capsules and powders.
Q:
What are the main uses of Palmitoylethanolamide?

A: PEA is mainly used as a dietary supplement and nutraceutical ingredient for capsules, powders and functional food formulations. It is also offered as a food-grade or pharmaceutical-intermediate raw material where a high-purity fatty acid amide is required.
Q:
What is the difference between standard and micronized PEA?

A: Both grades share the same chemical identity, CAS 544-31-0 and molecular formula. The main difference is particle size: standard PEA is a fine white to off-white powder or flakes, while micronized PEA has a controlled small particle size for better dispersion and formulation performance.
Q:
How should Palmitoylethanolamide be stored and handled?

A: Store PEA tightly closed in a cool, dry, ventilated area away from sunlight, moisture, heat and oxidizers. Bulk handling should control dust, and the package should be resealed after each use; the current offer is typically 1 kg aluminum bags or 25 kg fiber drums depending on grade and quantity.

Ordering & Documentation

Key information for document requests, quotations, and supply planning.

Documents

COA, TDS, SDS/MSDS and packing details are available on request.

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Sample & Supply

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Storage & Shipping

Product-specific conditions are confirmed before order.

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