What is Palmitoylethanolamide CAS 544-31-0?

Palmitoylethanolamide, usually called PEA or Palmidrol, is an endogenous fatty acid amide from the N-acylethanolamine family. Its molecular formula is C18H37NO2, molecular weight is about 299.49 g/mol, and it is identified by CAS 544-31-0 and EINECS 208-867-9.

Why is PEA often offered in a micronized grade?

PEA is a lipophilic material with very low water solubility, so ordinary powder can be difficult to wet and absorb in oral formulations. Micronized PEA, typically with D90 below 10-20 um, improves dispersibility, dissolution and absorption in capsules and powders.

What are the main uses of Palmitoylethanolamide?

PEA is mainly used as a dietary supplement and nutraceutical ingredient for capsules, powders and functional food formulations. It is also offered as a food-grade or pharmaceutical-intermediate raw material where a high-purity fatty acid amide is required.

How should Palmitoylethanolamide be stored and handled?

Store PEA tightly closed in a cool, dry, ventilated area away from sunlight, moisture, heat and oxidizers. Bulk handling should control dust, and the package should be resealed after each use; the current offer is typically 1 kg aluminum bags or 25 kg fiber drums depending on grade and quantity.

Palmitoylethanolamide PEA CAS 544-31-0

Palmitoylethanolamide, usually called PEA, CAS 544-31-0, is a fatty acid amide supplied as a dietary supplement and nutraceutical ingredient. Confirm the required grade and specification, then request a quotation with COA/TDS/SDS for bulk supply.

CAS: 544-31-0
Synonyms: Palmidrol, N-Palmitoylethanolamine, N-(2-Hydroxyethyl)palmitamide, Hydroxyethylpalmitamide, Palmitoyl Monoethanolamide
Einecs: 208-867-9
Molecular Formula: C₁₈H₃₇NO₂
Grade: Dietary Supplement Grade / Pharmaceutical Intermediate / Food Grade
Package: 1kg/Alu-bag, 25kg/Fiber Drum.

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Product Description

Palmitoylethanolamide, usually called PEA or Palmidrol, CAS 544-31-0, is an endogenous fatty acid amide from the N-acylethanolamine family with the molecular formula C18H37NO2.

Synonyms: Palmidrol; N-Palmitoylethanolamine; N-(2-Hydroxyethyl)palmitamide; Hydroxyethylpalmitamide; Palmitoyl Monoethanolamide.

CAS: 544-31-0.

It has the molecular formula C18H37NO2 and a molecular weight of 299.49 g/mol.

It is a white to off-white crystalline powder or flakes.

It has a melting point of about 97–99 °C and is lipophilic with very low water solubility.

It acts by binding to the peroxisome proliferator-activated receptor alpha (PPAR-alpha), which is involved in regulating pain and inflammation.

Micronized grades, typically with D90 below 10–20 µm, improve dispersibility, dissolution and absorption in oral formulations.

It is used as a dietary supplement and nutraceutical ingredient in capsules, powders and functional foods.

It is also offered as a food-grade or pharmaceutical-intermediate raw material.

Standard PEA is a fine white to off-white powder or flakes; micronized PEA has a controlled small particle size.

Both grades share the same chemical identity, CAS and molecular formula.

A typical specification includes assay of at least 99.0%, melting point 97–99 °C, loss on drying of at most 1.0% and residue on ignition of at most 0.1%.

Heavy metals, lead, arsenic and solvent residue limits are controlled to meet typical pharmacopoeial requirements.

Confirm appearance, assay, particle size, moisture, residue, heavy metals and microbiological limits.

Store tightly closed in a cool, dry, ventilated area away from sunlight, moisture, heat and oxidizers; control dust and reseal after use.

Confirm packaging with the requested quantity and destination requirements.

The page is an RFQ entry point and does not state stock, price, MOQ or fixed lead time.

For an RFQ, state the intended use, required grade and specification, quantity, packaging, destination and document needs.

FAQ - Technical & Supply Chain

Q:
What is Palmitoylethanolamide CAS 544-31-0?

A: Palmitoylethanolamide, usually called PEA or Palmidrol, is an endogenous fatty acid amide from the N-acylethanolamine family. Its molecular formula is C18H37NO2, molecular weight is about 299.49 g/mol, and it is identified by CAS 544-31-0 and EINECS 208-867-9.
Q:
Why is PEA often offered in a micronized grade?

A: PEA is a lipophilic material with very low water solubility, so ordinary powder can be difficult to wet and absorb in oral formulations. Micronized PEA, typically with D90 below 10-20 um, improves dispersibility, dissolution and absorption in capsules and powders.
Q:
What are the main uses of Palmitoylethanolamide?

A: PEA is mainly used as a dietary supplement and nutraceutical ingredient for capsules, powders and functional food formulations. It is also offered as a food-grade or pharmaceutical-intermediate raw material where a high-purity fatty acid amide is required.
Q:
What is the difference between standard and micronized PEA?

A: Both grades share the same chemical identity, CAS 544-31-0 and molecular formula. The main difference is particle size: standard PEA is a fine white to off-white powder or flakes, while micronized PEA has a controlled small particle size for better dispersion and formulation performance.
Q:
How should Palmitoylethanolamide be stored and handled?

A: Store PEA tightly closed in a cool, dry, ventilated area away from sunlight, moisture, heat and oxidizers. Bulk handling should control dust, and the package should be resealed after each use; the current offer is typically 1 kg aluminum bags or 25 kg fiber drums depending on grade and quantity.

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