What is Pure Allantoin CAS 97-59-6?

Pure Allantoin CAS 97-59-6 is a white crystalline powder with the molecular formula C4H6N4O3 and molecular weight 158.12 g/mol. It is used as a skin-soothing and mild keratolytic ingredient in cosmetics and topical formulations.

How does Allantoin function in skin care products?

Allantoin helps soften the outer skin layer and is widely used as a soothing agent in leave-on and rinse-off products. It is compatible with many cosmetic systems and is often included in sensitive-skin, baby-care and after-sun formulations.

What are the solubility and pH properties of Allantoin?

Allantoin is slightly soluble in cold water and more soluble in hot water or dilute alkali. It is amphoteric and generally stable over a broad pH range, making it easy to incorporate into different cosmetic bases.

What are common applications for Allantoin?

It is used in creams, lotions, serums, cleansers, shaving products, after-sun care, baby products and some oral care formulations. Typical cosmetic use levels are low, often around 0.2-0.5% in leave-on skin care.

What quality specifications apply to high-purity Allantoin?

USP/EP and cosmetic grades are commonly controlled for assay, melting point, loss on drying, residue on ignition, acidity or alkalinity, heavy metals and solution appearance. Store it sealed in a cool, dry place.

Pure Allantoin CAS 97-59-6

Pure Allantoin (CAS 97-59-6) is a highly effective skin-protecting active ingredient utilizing its keratolytic and moisturizing properties to promote cell regeneration and soothe irritated tissue. Chemically identified as 5-Ureidohydantoin or Glyoxyldiureide, this odorless white crystalline powder functions to stimulate healthy tissue growth (granulation) and accelerate the shedding of dead skin cells, making the skin softer and more radiant. As a nature-identical Imidazolidine derivative (historically found in the Comfrey plant), it is extensively integrated into sensitive skin lotions, acne treatments, oral care products (toothpaste for gum health), and pharmaceutical dermatological creams to treat burns and ulcers. We ensure bulk supply capabilities for this material, providing access to competitive factory pricing and customized specifications to meet specific particle size needs (e.g., Micronized for better dispersion) and purity standards (USP/EP/BP Grade). Full technical documentation, including MSDS, TDS, COA, is available to support compliance and safety protocols.

CAS: 97-59-6
Synonyms: 5-Ureidohydantoin, Glyoxyldiureide, (2,5-Dioxo-4-imidazolidinyl)urea, Cordianine, Allantol
Einecs: 202-592-8
Molecular Formula: C4H6N4O3
Grade: USP (United States Pharmacopeia) / EP (European Pharmacopoeia) / Cosmetic Grade
Package: 25kg/Fiber Drum or 25kg/Cardboard Box with PE inner bag

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Product Description

Allantoin is a white, odorless, non-toxic crystalline powder widely used as an active ingredient in the cosmetic and pharmaceutical industries. It is produced through a high-purity synthetic process to ensure stability and safety.

Our Allantoin functions as an excellent skin-soothing agent and keratolytic. It promotes cell proliferation and wound healing, helping to shed the outer layer of the epidermis and promoting healthy tissue formation. It is non-irritating and compatible with a vast range of cosmetic ingredients, making it ideal for sensitive skin formulations, baby products, and high-end repair creams. It is amphoteric and has weak acidity, offering good stability in pH ranges of 4-9.

1 Physicochemical Properties

2 Applications

3 Storage Conditions

4 Safety Precautions

Physicochemical Properties

The following specifications are based on our standard export quality (USP/EP Standards):

Test Item	Specification
Appearance	White Crystalline Powder
Assay (Purity)	98.5% – 101.0%
Melting Point	225°C – 236°C (Decomposition)
Loss on Drying	≤ 0.20%
Residue on Ignition (Ash)	≤ 0.10%
Acidity / Alkalinity	Passes Test (Neutral)
Heavy Metals (Pb)	≤ 10 ppm
Readily Carbonizable Substances	Passes Test
Solubility	Slightly soluble in cold water; Soluble in hot water
pH Value (0.5% Solution)	4.5 – 6.0
Glycoluril	≤ 0.1%

Applications

Allantoin CAS 97-59-6 is a versatile additive used in various sectors:

Skin Care & Cosmetics:
- Repair Creams: Used in anti-acne products, scar reduction creams, and sun-repair lotions (typical dosage 0.1% – 0.5%).
- Moisturizers: Improves the moisture retention capacity of the skin matrix.
- Sensitive Skin: Reduces irritation in products for baby care and sensitive skin.
Hair Care:
- Used in shampoos and conditioners to soften keratin, improve scalp health, and reduce dandruff.
Oral Care:
- Added to toothpaste and mouthwash to protect mucous membranes and assist in healing oral tissues.
Pharmaceuticals:
- Used in dermatological ointments to treat psoriasis, eczema, and skin ulcers.

For a related personal-care formulation raw material, see D-Panthenol.

Storage Conditions

Environment: Store in a cool, dry, and well-ventilated area.
Temperature: Store at room temperature.
Packaging: Keep containers tightly sealed. The powder is stable, but exposure to excessive moisture should be avoided to prevent caking.
Shelf Life: 24 months from the date of manufacture when stored properly.

Safety Precautions

Toxicity: Allantoin is non-toxic, non-irritating, and non-allergenic. It is considered safe for cosmetic use.
Handling: Wear standard dust masks and safety glasses when handling bulk powder to avoid inhaling dust.
Skin/Eye Contact:
- Skin: Wash off with water (though it is beneficial to skin, high concentrations should be rinsed).
- Eyes: Rinse thoroughly with water.
Fire: Not flammable under normal conditions.

FAQ - Technical & Supply Chain

Q:
What is Pure Allantoin CAS 97-59-6?

A: Pure Allantoin CAS 97-59-6 is a white crystalline powder with the molecular formula C4H6N4O3 and molecular weight 158.12 g/mol. It is used as a skin-soothing and mild keratolytic ingredient in cosmetics and topical formulations.
Q:
How does Allantoin function in skin care products?

A: Allantoin helps soften the outer skin layer and is widely used as a soothing agent in leave-on and rinse-off products. It is compatible with many cosmetic systems and is often included in sensitive-skin, baby-care and after-sun formulations.
Q:
What are the solubility and pH properties of Allantoin?

A: Allantoin is slightly soluble in cold water and more soluble in hot water or dilute alkali. It is amphoteric and generally stable over a broad pH range, making it easy to incorporate into different cosmetic bases.
Q:
What are common applications for Allantoin?

A: It is used in creams, lotions, serums, cleansers, shaving products, after-sun care, baby products and some oral care formulations. Typical cosmetic use levels are low, often around 0.2-0.5% in leave-on skin care.
Q:
What quality specifications apply to high-purity Allantoin?

A: USP/EP and cosmetic grades are commonly controlled for assay, melting point, loss on drying, residue on ignition, acidity or alkalinity, heavy metals and solution appearance. Store it sealed in a cool, dry place.

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