p-Hydroxyacetophenone CAS 99-93-4

p-Hydroxyacetophenone is a multifunctional cosmetic ingredient and a vital pharmaceutical intermediate. It appears as white needle-like crystals or powder with excellent thermal stability. In the cosmetic industry, it is widely recognized as a safe, antioxidant, and skin-soothing agent.

Crucially, Hydroxyacetophenone acts as a potent preservative booster. It has weak antimicrobial activity on its own but significantly enhances the efficacy of traditional preservatives (such as Phenoxyethanol or Ethylhexylglycerin), allowing formulators to reduce the total preservative load in products. It also inhibits the COX-2 enzyme, providing anti-irritant properties to soothe sensitive skin. It is compatible with a wide range of cosmetic formulations, including emulsions, serums, and masks.

Physicochemical Properties

The following specifications represent our high-purity Cosmetic Grade standard:

Applications

Hydroxyacetophenone is versatile and used across multiple high-value industries:

1. Cosmetics & Personal Care (Primary Application):
   • Preservative Booster: Used in “Preservative-Free” or “Clean Label” concepts. It enhances the antimicrobial efficacy of other ingredients.
   • Soothing Agent: Reduces skin irritation and redness effectively.
   • Antioxidant: Scavenges free radicals to protect skin quality.
   • Applications: Facial masks, sensitive skin lotions, anti-aging creams, shampoos, and wet wipes. Recommended dosage: 0.5% – 1.0%.
2. Pharmaceutical Industry:
   • Key intermediate in the synthesis of Atenolol (a beta-blocker used for heart conditions).
   • Used in the synthesis of choleretic drugs.
3. Chemical Synthesis:
   • Used as an intermediate for flavors, fragrances, and agrochemicals.

Storage Conditions

• Environment: Store in a cool, dry, and well-ventilated warehouse.
• Temperature: Stable at room temperature. Keep away from high heat sources.
• Container: Keep the container tightly sealed to prevent oxidation and moisture absorption.
• Light: Protect from direct sunlight to maintain whiteness.

Safety Precautions

• Handling: Wear protective gloves, safety goggles, and a dust mask. Avoid breathing dust.
• Eye Contact: Causes serious eye irritation. If in eyes, rinse cautiously with water for several minutes and remove contact lenses if present.
• Skin Contact: Generally safe for skin at cosmetic concentrations, but wash with soap and water if handling pure raw powder.
• Ingestion: Harmful if swallowed in large quantities.
• Environmental: Do not discharge pure powder directly into the environment. Dispose of contents in accordance with local regulations.