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    Related: Cosmetic Preservative Chlorphenesin CHA
    • p-Hydroxyacetophenone CAS 99-93-4

    p-Hydroxyacetophenone CAS 99-93-4

    p-Hydroxyacetophenone (CAS 99-93-4) is a multifunctional nature-identical phenolic compound functioning as a safe preservative booster and anti-irritant in modern cosmetic formulations. Chemically identified as 4'-Hydroxyacetophenone or P-HAP, this white crystalline powder acts to inhibit the enzyme COX-2 to soothe skin irritation while simultaneously enhancing the efficacy of traditional preservatives like Phenoxyethanol and Ethylhexylglycerin. As a stable Phenyl ketone derivative found naturally in Alpine cloudberries, it is extensively integrated into sensitive skin lotions, facial masks, and paraben-free systems to provide antioxidant protection and ensure broad-spectrum microbial stability. We ensure bulk supply capabilities for this material, providing access to competitive factory pricing and customized specifications to meet specific purity standards (typically >99% Cosmetic Grade). Full technical documentation, including MSDS, TDS, COA, is available to support compliance and safety protocols.

    • CAS: 99-93-4
    • Synonyms: 4'-Hydroxyacetophenone, 1-(4-Hydroxyphenyl)ethanone, p-Acetylphenol, P-HAP, 4-Acetylphenol
    • Einecs: 202-802-8
    • Molecular Formula: C8H8O2
    • Grade: Cosmetic Grade / Pharma Intermediates
    • Package: 25kg/Cardboard Drum with double PE inner lining
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    Product Description

    p-Hydroxyacetophenone is a multifunctional cosmetic ingredient and a vital pharmaceutical intermediate. It appears as white needle-like crystals or powder with excellent thermal stability. In the cosmetic industry, it is widely recognized as a safe, antioxidant, and skin-soothing agent.

    Crucially, Hydroxyacetophenone acts as a potent preservative booster. It has weak antimicrobial activity on its own but significantly enhances the efficacy of traditional preservatives (such as Phenoxyethanol or Ethylhexylglycerin), allowing formulators to reduce the total preservative load in products. It also inhibits the COX-2 enzyme, providing anti-irritant properties to soothe sensitive skin. It is compatible with a wide range of cosmetic formulations, including emulsions, serums, and masks.

    1 Physicochemical Properties
    2 Applications
    3 Storage Conditions
    4 Safety Precautions

    Physicochemical Properties

    The following specifications represent our high-purity Cosmetic Grade standard:

    Test ItemSpecification
    AppearanceWhite crystalline powder
    Assay (GC/HPLC)≥ 99.0%
    Melting Point107.0°C – 111.0°C
    Loss on Drying≤ 0.50%
    Residue on Ignition (Ash)≤ 0.10%
    Heavy Metals (Pb)≤ 10 ppm
    Iron (Fe)≤ 10 ppm
    Color (Hazen/APHA)≤ 30 (Solution in Ethanol)
    SolubilitySoluble in ethanol, propylene glycol, and warm water; Slightly soluble in cold water
    Clarity of SolutionClear and Transparent

    Applications

    Hydroxyacetophenone is versatile and used across multiple high-value industries:

    1. Cosmetics & Personal Care (Primary Application):
      • Preservative Booster: Used in “Preservative-Free” or “Clean Label” concepts. It enhances the antimicrobial efficacy of other ingredients.
      • Soothing Agent: Reduces skin irritation and redness effectively.
      • Antioxidant: Scavenges free radicals to protect skin quality.
      • Applications: Facial masks, sensitive skin lotions, anti-aging creams, shampoos, and wet wipes. Recommended dosage: 0.5% – 1.0%.
    2. Pharmaceutical Industry:
      • Key intermediate in the synthesis of Atenolol (a beta-blocker used for heart conditions).
      • Used in the synthesis of choleretic drugs.
    3. Chemical Synthesis:
      • Used as an intermediate for flavors, fragrances, and agrochemicals.

    For a related preservation-supporting formulation raw material, see 1,2-Hexanediol.

    Storage Conditions

    • Environment: Store in a cool, dry, and well-ventilated warehouse.
    • Temperature: Stable at room temperature. Keep away from high heat sources.
    • Container: Keep the container tightly sealed to prevent oxidation and moisture absorption.
    • Light: Protect from direct sunlight to maintain whiteness.

    Safety Precautions

    • Handling: Wear protective gloves, safety goggles, and a dust mask. Avoid breathing dust.
    • Eye Contact: Causes serious eye irritation. If in eyes, rinse cautiously with water for several minutes and remove contact lenses if present.
    • Skin Contact: Generally safe for skin at cosmetic concentrations, but wash with soap and water if handling pure raw powder.
    • Ingestion: Harmful if swallowed in large quantities.
    • Environmental: Do not discharge pure powder directly into the environment. Dispose of contents in accordance with local regulations.

    FAQ - Technical & Supply Chain

    • Q:

      What is p-Hydroxyacetophenone CAS 99-93-4?

      A: p-Hydroxyacetophenone CAS 99-93-4 is an aromatic ketone with the molecular formula C8H8O2 and molecular weight 136.15 g/mol. It is also called 4'-hydroxyacetophenone or P-HAP and is used in cosmetics and organic synthesis.
    • Q:

      How is Hydroxyacetophenone used in cosmetic preservation?

      A: It is used as a multifunctional cosmetic ingredient and preservation booster. It has weak antimicrobial activity on its own, so it is normally combined with a suitable preservative system rather than used as the sole preservative.
    • Q:

      Why is p-Hydroxyacetophenone described as an antioxidant?

      A: The material can function as an antioxidant ingredient in cosmetic formulations, helping protect oil-soluble components from oxidative degradation. It is also compatible with many emulsion, serum and mask systems.
    • Q:

      What are typical physical specifications for this product?

      A: It is generally a white to off-white crystalline powder with a melting point around 108-111 C, HPLC purity of about 99% or higher, low loss on drying and controlled ash and heavy-metal content. It is soluble in ethanol and some other organic solvents.
    • Q:

      What other applications are relevant to CAS 99-93-4?

      A: p-Hydroxyacetophenone is also used as an intermediate in pharmaceutical and fine-chemical synthesis and can be used in fragrance compositions. The appropriate grade depends on whether the final use is cosmetic, pharmaceutical, or industrial.

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