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    Related: Cosmetic Preservative P-HAP CHA
    • Chlorphenesin CAS 104-29-0
    • Chlorphenesin CAS 104-29-0

    Chlorphenesin CAS 104-29-0

    Chlorphenesin CAS 104-29-0 is a glycerol ether derivative chemically defined as 3-(4-chlorophenoxy)-1,2-propanediol , functioning primarily as a broad-spectrum antimicrobial preservative in cosmetic formulations and a fungistatic agent in personal care systems. Also known as p-Chlorophenyl glyceryl ether, this white crystalline powder is utilized to inhibit the growth of bacteria and fungi in leave-on and rinse-off products, often working synergistically with phenoxyethanol to optimize the preservation system of emulsions and serums. We provide professional access to this material with competitive factory pricing and the ability to meet customized specifications for various manufacturing requirements. Our commitment to technical transparency ensures that every shipment is accompanied by comprehensive MSDS, TDS, COA documentation to support your quality assurance protocols, and we maintain capacity for consistent bulk supply to facilitate large-scale industrial operations.

    • CAS: 104-29-0
    • Synonyms: 3-(4-Chlorophenoxy)-1,2-propanediol, p-Chlorophenyl glyceryl ether, Chlorphenesin alcohol, Glycerol alpha-p-chlorophenyl ether, CPC
    • Einecs: 203-192-6
    • Molecular Formula: C9H11ClO3
    • Grade: Cosmetic / Personal Care Preservative Grade
    • Package: 25kg/bag (Plastic woven bag with PE liner) or 500kg/1000kg Jumbo Bag.
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    Product Description

    1 1. Physical and Chemical Properties
    2 2. Applications: The “Booster” Effect
    3 3. A Formulator’s Guide: Overcoming Solubility
    4 4. Regulatory & Safety Profile
    5 5. Safety Precautions for Handling
    6 6. Storage Conditions

    1. Physical and Chemical Properties

    Chlorphenesin appears as a white crystalline powder. For a formulator, understanding its solubility profile is key to using it successfully.

    PropertySpecification / Description
    CAS Number104-29-0
    Chemical Name3-(4-Chlorophenoxy)-1,2-propanediol
    AppearanceWhite to off-white crystalline powder
    OdorCharacteristic, faint (High purity is odorless)
    Melting Point77.0°C – 81.0°C
    Solubility (Water)Low (< 1% at room temperature)
    Solubility (Solvents)Soluble in alcohol, propylene glycol, and glycerol
    StabilityStable in wide pH ranges; heat stable up to 80°C

    2. Applications: The “Booster” Effect

    Chlorphenesin is rarely a solo act. Its strength lies in its ability to boost the efficacy of other preservatives.

    • Skincare (Creams, Lotions, Serums): It is a favorite in facial moisturizers because it is non-irritating and provides excellent protection against fungi and yeast, which are common spoilers in water-heavy formulas.
    • Color Cosmetics: Widely used in mascara and liquid foundations where preventing mold growth is critical.
    • Facial Masks: In wet sheet masks, where the water activity is very high, Chlorphenesin is often paired with Phenoxyethanol to ensure broad-spectrum protection without stinging the user’s face.
    • Deodorants: Due to its antimicrobial properties, it helps control odor-causing bacteria.

    3. A Formulator’s Guide: Overcoming Solubility

    If there is one complaint about Chlorphenesin, it is that it can be “finicky” to dissolve. Here is how seasoned chemists handle it:

    1. Heat is your friend: While it has low solubility in cold water, it dissolves readily in water heated to 50°C – 60°C.
    2. Pre-mix in Glycols: The best practice is to pre-dissolve Chlorphenesin in a solvent like Butylene Glycol or Propylene Glycol before adding it to the water phase. This ensures a crystal-clear solution and prevents the powder from precipitating out later.
    3. The “Synergy” Blend: It works exceptionally well when combined with Ethylhexylglycerin or Phenoxyethanol. This combination allows you to lower the total preservative load while maintaining a “Class A” preservation challenge test result.

    4. Regulatory & Safety Profile

    Chlorphenesin is valued because it has a long history of safe use.

    • Global Compliance: It is approved for use in the USA, EU, China, and Japan.
    • Concentration Limits:
      • EU & China: Maximum authorized concentration is 0.3%.
      • Japan: Maximum authorized concentration is 0.3%.
    • Safety: It is considered non-sensitizing and non-toxic at approved levels. It does not contain formaldehyde and is not a paraben.

    5. Safety Precautions for Handling

    While safe in the finished cream, the raw powder requires standard chemical hygiene:

    • Dust Hazard: The fine powder can irritate the respiratory tract. Workers should wear N95 dust masks during weighing and mixing.
    • Eye Contact: Can cause irritation. Safety goggles are mandatory.
    • Ingestion: Harmful if swallowed in large quantities (due to its muscle relaxant history).

    6. Storage Conditions

    Proper storage is essential to prevent caking and maintain flowability.

    • Moisture Control: Chlorphenesin is stable, but high humidity can cause the powder to clump. Keep containers tightly sealed.
    • Packaging: typically shipped in 25kg fiber drums with double PE inner liners.
    • Temperature: Store in a cool, dry place away from direct sunlight and strong oxidizing agents.

    FAQ - Technical & Supply Chain

    • Q:

      What is Chlorphenesin CAS 104-29-0?

      A: Chlorphenesin CAS 104-29-0 is 3-(4-chlorophenoxy)-1,2-propanediol, with molecular formula C9H11ClO3, molecular weight about 202.63, and EINECS 203-192-6. It is also known as p-chlorophenyl glyceryl ether and is commonly used as a cosmetic preservative.
    • Q:

      How does Chlorphenesin differ from Chlorphenesin Carbamate?

      A: Chlorphenesin is the alcohol form and is used mainly as a cosmetic preservative/biocide. Chlorphenesin carbamate is a different compound with a carbamate group and is associated with pharmaceutical muscle-relaxant use, so the two should not be confused.
    • Q:

      Why is Chlorphenesin often combined with Phenoxyethanol?

      A: Chlorphenesin provides useful antibacterial and antifungal activity, especially against molds and yeasts, while phenoxyethanol contributes broader preservative coverage. The combination is widely used in water-rich cosmetics such as sheet masks, creams, and lotions.
    • Q:

      How should Chlorphenesin be incorporated into a formulation?

      A: It has low cold-water solubility and is more soluble in alcohol, propylene glycol, and glycerol. In manufacturing, it is usually pre-dissolved in a compatible solvent or added to a warmed aqueous phase, then incorporated before final pH and viscosity adjustment.
    • Q:

      What cosmetic products commonly use Chlorphenesin?

      A: It is used in facial creams, lotions, serums, mascara, liquid foundations, and wet sheet masks where water activity is high and protection against fungi or yeast is important. It is typically used as part of a preservative system rather than as the only preservative.

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