What is Methylparaben?

Methylparaben, CAS 99-76-3, is the methyl ester of p-hydroxybenzoic acid. It is used as a preservative in cosmetics, pharmaceuticals and some food applications.

How is Methylparaben different from Propylparaben?

Methylparaben has a methyl ester group and is more water-soluble than propylparaben. Propylparaben is more lipophilic, so the two are often combined to broaden antimicrobial activity across different product matrices.

What is its effective pH range?

Methylparaben is generally stable and active over a broad pH range, commonly around pH 4-8. Efficacy still depends on the full formulation, temperature, solubility and other ingredients.

What is a typical use level for Methylparaben?

Typical preservative use levels are commonly about 0.01% to 0.3%, depending on the product type and regulatory limits. Methylparaben is slightly soluble in water and freely soluble in ethanol, so formulation pH and phase distribution should be considered when setting the dose.

What specifications should be checked before ordering?

Confirm assay, appearance, melting range, water, residue on ignition, related substances, heavy metals and microbial limits. Specify whether pharmaceutical, cosmetic or food grade is required so the supplier can match the correct monograph.

Methylparaben CAS 99-76-3

Methylparaben (methyl 4-hydroxybenzoate), CAS 99-76-3, is a broad-spectrum preservative supplied for pharmaceuticals, personal care and food. Confirm the required grade, then request a quotation with COA/TDS/SDS for bulk supply.

CAS: 99-76-3
Synonyms: methyl 4-hydroxybenzoate, methyl p-hydroxybenzoate, 4-hydroxybenzoic acid methyl ester, p-carbomethoxyphenol, methyl parahydroxybenzoate
Einecs: 202-785-7
Molecular Formula: C₈H₈O₃
Grade: Pharmaceutical / Cosmetic / Food Grade
Package: 25 kg fiber drum or carton with inner PE bag; other packaging available on request

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Product Description

Methylparaben, CAS 99-76-3, also known as methyl 4-hydroxybenzoate, is the methyl ester of 4-hydroxybenzoic acid; the EC/EINECS number is 202-785-7.

Synonyms: methyl 4-hydroxybenzoate; methyl p-hydroxybenzoate; 4-hydroxybenzoic acid methyl ester; p-carbomethoxyphenol; methyl parahydroxybenzoate.

CAS: 99-76-3.

Molecular formula: C₈H₈O₃.

Molecular weight: about 152.15 g/mol.

EC number: 202-785-7.

It is a white or almost white crystalline powder, odorless or with a faint characteristic odor and a slightly burning taste.

The assay (on dry basis) is 99.0–100.5%; the melting point is 125–128 °C.

It is slightly soluble in water (about 0.25–0.30% w/w at 25 °C) and freely soluble in ethanol; a saturated solution has a pH of about 5.7–5.8.

It is used as a broad-spectrum preservative in cosmetics and personal care products.

It is used in pharmaceuticals and, where permitted, in some food applications.

It is generally stable and active over a broad pH range, commonly around pH 4–8.

Typical preservative use levels are about 0.01–0.3%, depending on product type and regulatory limits.

Confirm assay, appearance, melting range, water, residue on ignition, related substances, heavy metals and microbial limits; select the required grade.

Store in tightly closed, light-protected containers in a cool, dry place away from strong oxidizers and incompatible materials.

Confirm packaging with the requested quantity and destination requirements.

Document requirements should be confirmed from the current specification, SDS, COA or other product-specific files.

The page is an RFQ entry point and does not state stock, price, MOQ or fixed lead time.

For an RFQ, state the intended use, required grade, quantity, packaging, destination and document needs.

FAQ - Technical & Supply Chain

Q:
What is Methylparaben?

A: Methylparaben, CAS 99-76-3, is the methyl ester of p-hydroxybenzoic acid. It is used as a preservative in cosmetics, pharmaceuticals and some food applications.
Q:
How is Methylparaben different from Propylparaben?

A: Methylparaben has a methyl ester group and is more water-soluble than propylparaben. Propylparaben is more lipophilic, so the two are often combined to broaden antimicrobial activity across different product matrices.
Q:
What is its effective pH range?

A: Methylparaben is generally stable and active over a broad pH range, commonly around pH 4-8. Efficacy still depends on the full formulation, temperature, solubility and other ingredients.
Q:
What is a typical use level for Methylparaben?

A: Typical preservative use levels are commonly about 0.01% to 0.3%, depending on the product type and regulatory limits. Methylparaben is slightly soluble in water and freely soluble in ethanol, so formulation pH and phase distribution should be considered when setting the dose.
Q:
What specifications should be checked before ordering?

A: Confirm assay, appearance, melting range, water, residue on ignition, related substances, heavy metals and microbial limits. Specify whether pharmaceutical, cosmetic or food grade is required so the supplier can match the correct monograph.
Q:
How should Methylparaben be stored and handled?

A: Store in tightly closed, light-protected containers in a cool, dry place, away from strong oxidizers and incompatible materials. Use dust-control measures and suitable PPE, and follow the safety information.

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