Is Alpha Lipoic Acid CAS 1077-28-7 the racemic form?

Yes. CAS 1077-28-7 is the racemic DL-alpha-lipoic acid, also called thioctic acid. The single-isomer R-alpha-lipoic acid is CAS 1200-22-2, so the required stereoisomer should be confirmed before ordering.

What are the main applications of Alpha Lipoic Acid?

Alpha Lipoic Acid is used in nutritional supplement capsules and tablets, functional foods, antioxidant-focused cosmetic formulations, and nutraceutical research. It is chosen for formulations where a sulfur-containing antioxidant is required.

Is Alpha Lipoic Acid suitable for liquid formulations?

It is more practical in solid dosage forms such as capsules and tablets because water solubility is low, typically around 0.25-1 g/L. Aqueous liquids may require solubilizers, co-solvents, pH adjustment, or a suitable salt.

What specifications should be checked before ordering?

Confirm assay, appearance, melting range, enantiomeric or optical purity if the single R-isomer is required, related substances, residual solvents, heavy metals, and microbial limits. The typical melting range is about 60-62 °C.

Alpha Lipoic Acid CAS 1077-28-7

Alpha Lipoic Acid (thioctic acid), CAS 1077-28-7, is a sulfur-containing antioxidant supplied for nutraceutical, pharmaceutical and cosmetic applications. Confirm the required grade, then request a quotation with COA/TDS/SDS for bulk supply.

CAS: 1077-28-7
Synonyms: thioctic acid, 1,2-dithiolane-3-pentanoic acid, 1,2-dithiolane-3-valeric acid, 6,8-thioctic acid, dl-alpha-lipoic acid
Einecs: 214-071-2
Molecular Formula: C₈H₁₄O₂S₂
Grade: Pharma / Nutraceutical grade
Package: 25 kg fiber drum with double PE liner, or 1 kg aluminum foil bag inside carton (custom packaging available)

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Product Description

Alpha Lipoic Acid, CAS 1077-28-7, also known as thioctic acid, is a sulfur-containing antioxidant; the EC/EINECS number is 214-071-2.

Synonyms: thioctic acid; 1,2-dithiolane-3-pentanoic acid; 1,2-dithiolane-3-valeric acid; 6,8-thioctic acid; dl-alpha-lipoic acid.

CAS: 1077-28-7.

Molecular formula: C₈H₁₄O₂S₂.

Molecular weight: 206.33.

EC number: 214-071-2.

It is a slightly yellow crystalline powder with a melting point of about 60.0–62.0 °C and an assay typically ≥99.0% by HPLC on a dried basis.

It has a low water solubility of about 0.9 g/L at 20 °C and is soluble in ethanol, methanol, chloroform and diethyl ether; the predicted pKa of the carboxyl group is about 4.75.

The density is about 1.28 g/cm³; heavy metals are typically ≤10 ppm (Pb ≤3 ppm, As ≤1 ppm), and it is stable under recommended storage but sensitive to strong oxidizers and prolonged light or heat.

It is used as an antioxidant ingredient in dietary-supplement capsules, tablets and softgels, often combined with B vitamins, vitamin C and vitamin E.

It is used in functional foods and nutraceutical formulations for blood-sugar management support, neuropathy support and general wellness.

It is used in antioxidant cosmetic formulations; as CAS 1077-28-7 is the racemic DL form, confirm whether the single R-isomer (CAS 1200-22-2) is required.

Confirm assay, appearance, melting range, optical purity, related substances, residual solvents, heavy metals and microbial limits; it is more practical in solid dosage forms due to low water solubility.

Store in tightly closed, light-protected containers in a cool, dry place, away from strong oxidizers and excessive heat; use powder-handling controls and suitable PPE.

Confirm the current product-specific specification.

Confirm packaging with the requested quantity and destination requirements.

Document requirements should be confirmed from the current specification, SDS, COA or other product-specific files.

The page is an RFQ entry point and does not state stock, price, MOQ or fixed lead time.

For an RFQ, state the intended use, required specification, quantity, packaging, destination and document needs.

FAQ - Technical & Supply Chain

Q:
Is Alpha Lipoic Acid CAS 1077-28-7 the racemic form?

A: Yes. CAS 1077-28-7 is the racemic DL-alpha-lipoic acid, also called thioctic acid. The single-isomer R-alpha-lipoic acid is CAS 1200-22-2, so the required stereoisomer should be confirmed before ordering.
Q:
What are the main applications of Alpha Lipoic Acid?

A: Alpha Lipoic Acid is used in nutritional supplement capsules and tablets, functional foods, antioxidant-focused cosmetic formulations, and nutraceutical research. It is chosen for formulations where a sulfur-containing antioxidant is required.
Q:
Is Alpha Lipoic Acid suitable for liquid formulations?

A: It is more practical in solid dosage forms such as capsules and tablets because water solubility is low, typically around 0.25-1 g/L. Aqueous liquids may require solubilizers, co-solvents, pH adjustment, or a suitable salt.
Q:
What specifications should be checked before ordering?

A: Confirm assay, appearance, melting range, enantiomeric or optical purity if the single R-isomer is required, related substances, residual solvents, heavy metals, and microbial limits. The typical melting range is about 60-62 °C.
Q:
How should Alpha Lipoic Acid be stored and handled?

A: Store Alpha Lipoic Acid in tightly closed, light-protected containers in a cool, dry place, away from strong oxidizers and excessive heat. Use appropriate powder-handling controls to limit dust and skin or eye contact.

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