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    • Glutathione Reduced CAS 70-18-8

    Glutathione Reduced CAS 70-18-8

    Glutathione Reduced (CAS 70-18-8), commonly referred to as GSH, is a bioactive tripeptide utilizing its active sulfhydryl (-SH) group to function as the body's "Master Antioxidant" and a premier skin whitening agent.Chemically identified as γ-L-Glutamyl-L-cysteinyl-glycine, this white crystalline powder acts to directly scavenge free radicals and inhibit tyrosinase activity, thereby blocking the melanin production pathway and shifting synthesis from dark eumelanin to light pheomelanin. As a naturally occurring Pharmaceutical and Cosmetic active, it is extensively integrated into high-end brightening injections, oral capsules for liver detoxification, and topical creams to promote a luminous, even skin tone. We ensure bulk supply capabilities for this material, providing access to competitive factory pricing and customized specifications to meet specific bulk density and purity requirements (e.g., USP/EP/JP Grades). Full technical documentation, including MSDS, TDS, COA, is available to support compliance and safety protocols.

    • CAS: 70-18-8
    • Synonyms: L-Glutathione Reduced, GSH, Gamma-L-glutamyl-L-cysteinyl-glycine, Glutathione SH, N-(N-L-gamma-Glutamyl-L-cysteinyl)glycine
    • Einecs: 200-725-4
    • Molecular Formula: C10H17N3O6S
    • Grade: Cosmetic Grade / Food Grade / Pharmaceutical Grade
    • Package: 1kg/Aluminum Foil Bag, 5kg/Carton, or 25kg/Drum.
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    Product Description

    L-Glutathione Reduced is an active tripeptide consisting of Glutamic acid, Cysteine, and Glycine. It is naturally present in almost every cell of the body and plays a vital role in detoxification and defense against oxidative stress.

    Why choose our Glutathione?

    1. Skin Whitening: It effectively interferes with melanin synthesis by inhibiting the enzyme tyrosinase and switching eumelanin (dark pigment) production to pheomelanin (light pigment).
    2. Antioxidant Power: It neutralizes free radicals and regenerates other antioxidants like Vitamin C and E.
    3. Detoxification: It binds to toxins and heavy metals in the liver, facilitating their excretion.
    4. Fermentation Source: Non-animal origin, suitable for vegetarian and clean-label products.
    1 Physicochemical Properties
    2 Applications
    3 Storage Conditions
    4 Safety Precautions

    Physicochemical Properties

    Based on USP/EP/JP standards common for Chinese export.

    ParameterSpecification (Standard)
    AppearanceWhite to off-white crystalline powder
    Identification (IR/HPLC)Conforms to standard
    Assay (on dried basis)98.0% – 101.0%
    SolubilityFreely soluble in water
    Specific Rotation [α]20/D-15.5° to -17.5°
    Melting Point182°C – 192°C
    Loss on Drying≤ 0.5%
    Residue on Ignition≤ 0.1%
    Heavy Metals (Pb)≤ 10 ppm
    Arsenic (As)≤ 2 ppm
    Bulk Density0.2 – 0.4 g/ml (Tapped)
    Clarity & Color of SolutionClear and Colorless

    Applications

    1. Cosmetics & Skincare:
      • Whitening Creams & Serums: Key active ingredient for brightening skin tone and reducing dark spots.
      • Anti-aging: Reduces oxidative damage to collagen.
      • Dosage: Typically 0.5% – 5% in formulations.
    2. Nutraceuticals (Dietary Supplements):
      • Capsules and tablets for full-body skin lightening.
      • Liver support supplements (alcohol detoxification).
      • Immune system boosters.
    3. Food Industry:
      • Used as a dough conditioner in baking.
      • Anti-browning agent for fruits and yogurt.

    Storage Conditions

    • Sensitivity: Glutathione is sensitive to moisture and oxidation. It can easily oxidize into GSSG if exposed to air and humidity.
    • Storage: Store in a cool, dry place (2-8°C is recommended for long-term storage).
    • Packaging: Must be kept in tightly sealed, light-resistant containers (aluminum foil bags are preferred).
    • Shelf Life: 24 months under proper storage conditions.

    Safety Precautions

    • Handling: Generally considered safe and non-toxic. Minimize dust generation.
    • Skin/Eye Contact: May cause mild irritation in sensitive individuals. Rinse with water if contact occurs.
    • Inhalation: Use in a well-ventilated area; wear a dust mask if handling large quantities.
    • Ingestion: Safe for consumption in dietary supplement dosages.

    FAQ - Technical & Supply Chain

    • Q:

      What is the difference between Glutathione Reduced (GSH) and Oxidized Glutathione (GSSG)?

      A: Glutathione Reduced (CAS 70-18-8) is the active antioxidant form containing a free thiol group, capable of donating electrons to neutralize free radicals. Oxidized Glutathione (GSSG) is the form that results after GSH has done its work; in supplements and cosmetics, the Reduced form is the industry standard for efficacy.
    • Q:

      Is this ingredient stable in topical cosmetic formulations?

      A: Pure Glutathione Reduced can be sensitive to oxidation in aqueous solutions. Formulators often use it in powder-liquid mix kits, anhydrous bases, or pair it with stabilizers like Vitamin C and specific chelating agents to maintain its potency in lotions and serums.
    Documents

    Documents and Product Support

    For product review and sourcing evaluation, supporting documents can be coordinated according to the product type, inquiry stage, and order requirements.

    • COA for batch-based quality reference
    • TDS for key physical and chemical information
    • SDS / MSDS for handling, storage, and safety reference
    • Packing information for sample, trial, and bulk orders
    • Technical communication based on application and specification requirements
    Quotation

    Information to Confirm Before Quotation

    Clear sourcing information helps reduce specification mismatch and allows a more accurate quotation before sample or bulk order discussion.

    • Product name and CAS number
    • Application or intended end use
    • Required purity, grade, or specification
    • Sample quantity, trial order, or bulk demand
    • Preferred packing form or net weight
    • Destination country or port
    • Required documents or compliance expectations
    Storage & Handling

    Packaging, Storage, and Handling Notes

    Packaging form, storage conditions, shelf life, and shipment arrangements should be confirmed according to the product characteristics, package size, and destination requirements.

    Before order confirmation, buyers are advised to review the corresponding product documents and confirm whether any special storage, labeling, or handling requirements apply.

    Supply Support

    Sample, Bulk Order and Repeat Supply Support

    Support can be arranged for sample discussion, bulk supply planning, packaging confirmation, and routine sourcing communication based on the actual product and order requirements.

    For repeat-use formulations or long-term procurement plans, buyers may discuss specification consistency, packaging preferences, delivery expectations, and document coordination in advance.

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    Antioxidant Ingredient Cosmetic Active Ingredient Life Science Chemical Peptide Ingredient

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