What is Glutathione Reduced CAS 70-18-8?

Glutathione Reduced CAS 70-18-8, also called L-glutathione or GSH, is a tripeptide made from glutamic acid, cysteine, and glycine. It has the molecular formula C10H17N3O6S, EC number 200-725-4, and molecular weight 307.33 g/mol.

What is the difference between Glutathione Reduced (GSH) and Oxidized Glutathione (GSSG)?

GSH is the active reduced form containing a free thiol group, so it can donate electrons to neutralize free radicals and support antioxidant activity. GSSG is the oxidized disulfide form produced after GSH reacts; cells can convert GSSG back to GSH through glutathione reductase.

Why is Glutathione Reduced used in skin-brightening cosmetics?

It can affect melanin synthesis by inhibiting tyrosinase and shifting pigment production away from darker eumelanin toward lighter pheomelanin. It also acts as an antioxidant and helps regenerate other antioxidants such as vitamin C and vitamin E.

Is Glutathione Reduced stable in aqueous cosmetic formulations?

Pure reduced glutathione can be sensitive to oxidation in water-based products. Formulators often use fresh powder-liquid mixing, anhydrous or low-water bases, protective packaging, pH control, and stabilizers or chelating agents to maintain potency.

What are the typical grades and storage conditions for Glutathione Reduced?

Common commercial grades include pharmaceutical, food, and cosmetic grade, with USP/EP/JP-style assay often in the 98.0-101.0% range. It is normally stored in tightly sealed containers under cool, dry conditions and protected from light, moisture, and heat.

Glutathione Reduced CAS 70-18-8

Glutathione Reduced (CAS 70-18-8), commonly referred to as GSH, is a bioactive tripeptide utilizing its active sulfhydryl (-SH) group to function as the body's "Master Antioxidant" and a premier skin whitening agent.Chemically identified as γ-L-Glutamyl-L-cysteinyl-glycine, this white crystalline powder acts to directly scavenge free radicals and inhibit tyrosinase activity, thereby blocking the melanin production pathway and shifting synthesis from dark eumelanin to light pheomelanin. As a naturally occurring Pharmaceutical and Cosmetic active, it is extensively integrated into high-end brightening injections, oral capsules for liver detoxification, and topical creams to promote a luminous, even skin tone. We ensure bulk supply capabilities for this material, providing access to competitive factory pricing and customized specifications to meet specific bulk density and purity requirements (e.g., USP/EP/JP Grades). Full technical documentation, including MSDS, TDS, COA, is available to support compliance and safety protocols.

CAS: 70-18-8
Synonyms: L-Glutathione Reduced, GSH, Gamma-L-glutamyl-L-cysteinyl-glycine, Glutathione SH, N-(N-L-gamma-Glutamyl-L-cysteinyl)glycine
Einecs: 200-725-4
Molecular Formula: C10H17N3O6S
Grade: Cosmetic Grade / Food Grade / Pharmaceutical Grade
Package: 1kg/Aluminum Foil Bag, 5kg/Carton, or 25kg/Drum.

Request a quote

Share:

Product Description

L-Glutathione Reduced is an active tripeptide consisting of Glutamic acid, Cysteine, and Glycine. It is naturally present in almost every cell of the body and plays a vital role in detoxification and defense against oxidative stress.

Why choose our Glutathione?

Skin Whitening: It effectively interferes with melanin synthesis by inhibiting the enzyme tyrosinase and switching eumelanin (dark pigment) production to pheomelanin (light pigment).
Antioxidant Power: It neutralizes free radicals and regenerates other antioxidants like Vitamin C and E.
Detoxification: It binds to toxins and heavy metals in the liver, facilitating their excretion.
Fermentation Source: Non-animal origin, suitable for vegetarian and clean-label products.

1 Physicochemical Properties

2 Applications

3 Storage Conditions

4 Safety Precautions

Physicochemical Properties

Based on USP/EP/JP standards common for Chinese export.

Parameter	Specification (Standard)
Appearance	White to off-white crystalline powder
Identification (IR/HPLC)	Conforms to standard
Assay (on dried basis)	98.0% – 101.0%
Solubility	Freely soluble in water
Specific Rotation [α]20/D	-15.5° to -17.5°
Melting Point	182°C – 192°C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (Pb)	≤ 10 ppm
Arsenic (As)	≤ 2 ppm
Bulk Density	0.2 – 0.4 g/ml (Tapped)
Clarity & Color of Solution	Clear and Colorless

Applications

Cosmetics & Skincare:
- Whitening Creams & Serums: Key active ingredient for brightening skin tone and reducing dark spots.
- Anti-aging: Reduces oxidative damage to collagen.
- Dosage: Typically 0.5% – 5% in formulations.
Nutraceuticals (Dietary Supplements):
- Capsules and tablets for full-body skin lightening.
- Liver support supplements (alcohol detoxification).
- Immune system boosters.
Food Industry:
- Used as a dough conditioner in baking.
- Anti-browning agent for fruits and yogurt.

Storage Conditions

Sensitivity: Glutathione is sensitive to moisture and oxidation. It can easily oxidize into GSSG if exposed to air and humidity.
Storage: Store in a cool, dry place (2-8°C is recommended for long-term storage).
Packaging: Must be kept in tightly sealed, light-resistant containers (aluminum foil bags are preferred).
Shelf Life: 24 months under proper storage conditions.

Safety Precautions

Handling: Generally considered safe and non-toxic. Minimize dust generation.
Skin/Eye Contact: May cause mild irritation in sensitive individuals. Rinse with water if contact occurs.
Inhalation: Use in a well-ventilated area; wear a dust mask if handling large quantities.
Ingestion: Safe for consumption in dietary supplement dosages.

FAQ - Technical & Supply Chain

Q:
What is Glutathione Reduced CAS 70-18-8?

A: Glutathione Reduced CAS 70-18-8, also called L-glutathione or GSH, is a tripeptide made from glutamic acid, cysteine, and glycine. It has the molecular formula C10H17N3O6S, EC number 200-725-4, and molecular weight 307.33 g/mol.
Q:
What is the difference between Glutathione Reduced (GSH) and Oxidized Glutathione (GSSG)?

A: GSH is the active reduced form containing a free thiol group, so it can donate electrons to neutralize free radicals and support antioxidant activity. GSSG is the oxidized disulfide form produced after GSH reacts; cells can convert GSSG back to GSH through glutathione reductase.
Q:
Why is Glutathione Reduced used in skin-brightening cosmetics?

A: It can affect melanin synthesis by inhibiting tyrosinase and shifting pigment production away from darker eumelanin toward lighter pheomelanin. It also acts as an antioxidant and helps regenerate other antioxidants such as vitamin C and vitamin E.
Q:
Is Glutathione Reduced stable in aqueous cosmetic formulations?

A: Pure reduced glutathione can be sensitive to oxidation in water-based products. Formulators often use fresh powder-liquid mixing, anhydrous or low-water bases, protective packaging, pH control, and stabilizers or chelating agents to maintain potency.
Q:
What are the typical grades and storage conditions for Glutathione Reduced?

A: Common commercial grades include pharmaceutical, food, and cosmetic grade, with USP/EP/JP-style assay often in the 98.0-101.0% range. It is normally stored in tightly sealed containers under cool, dry conditions and protected from light, moisture, and heat.

Ordering & Documentation

Key information for document requests, quotations, and supply planning.

Documents

COA, TDS, SDS/MSDS and packing details are available on request.

Quotation

Send the CAS number, grade, quantity, packing preference and destination.

Sample & Supply

Support is available for samples, trial orders, bulk and repeat supply.

Storage & Shipping

Product-specific conditions are confirmed before order.

Current Language

Change Language