Squalane CAS 111-01-3

Squalene / squalane (CAS111-01-3) is a highly hydrophobic triterpene used as an emollient, active ingredient, and intermediate in cosmetics, pharmaceuticals, vaccines and nutritional formulations. With very high purity and low odor, it is suitable for high-end skin care, health products and synthesis of hydrogenated squalane.

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Physicochemical Properties

Applications

1. Cosmetics & Personal Care

• Used as an emollient and skin-conditioning agent in serums, facial oils, creams, lotions and hair-care products.
• Enhances spreadability, smooth feel and gloss, and helps reduce transepidermal water loss when combined with other emollients.
• Serves as a raw material for hydrogenated squalane, which offers even higher oxidative stability for long-shelf-life formulations.

2. Pharmaceuticals & Vaccine Adjuvants

• Acts as a biosynthetic precursor to cholesterol and steroid hormones, and is widely used in biochemical and pharmaceutical research.
• Used as an oil-phase component in certain vaccine adjuvant systems and injectable formulations (after meeting pharmacopeial and regulatory requirements).

3. Nutraceuticals & Health Products

• Incorporated into dietary supplements and functional foods as a lipid-soluble ingredient, especially in products marketed for skin, immune and cardiovascular support.

4. Chemical Intermediate & Industrial Use

• Starting material for hydrogenated squalane (C₃₀H₆₂) and specialty hydrocarbons used in cosmetics, lubricants and specialty coatings.
• Can be used as a high-boiling, low-volatility base fluid in certain high-end formulations where low odor and high hydrophobicity are required.

For specific end-use compliance (cosmetics, food, pharma, vaccine), please confirm regulatory status and required grade when you send your inquiry.

Storage Conditions

To maintain quality and minimize oxidation:

• Store in tightly closed, nitrogen-blanketed drums or totes where possible.
• Keep in a cool, dry and well-ventilated warehouse, away from direct sunlight and heat sources.
• Recommended long-term storage temperature: 2–8 °C or in a cool room below 25 °C, protected from light.
• Avoid contact with strong oxidizing agents and sources of ignition (combustible liquid).
• Use up opened containers as soon as possible to minimize peroxide formation and quality degradation.

Safety Precautions

According to typical Safety Data Sheets for squalene:

• Hazard classification: Generally considered of low acute toxicity, but handled as a combustible liquid.
• Personal protection:
  • Avoid inhalation of mists and prolonged skin contact.
  • Use appropriate gloves, safety glasses and protective clothing during bulk handling.
• Handling:
  • Handle in well-ventilated areas.
  • Keep away from sparks, hot surfaces and open flame.
  • Prevent formation of aerosols or fine mists.
• Spill response:
  • Contain spillage with inert absorbent (sand, diatomite, etc.).
  • Collect into suitable containers for disposal according to local regulations.
• First-aid (general guidance):
  • Skin contact: Wash with soap and water.
  • Eye contact: Rinse cautiously with water; seek medical advice if irritation persists.
  • Ingestion: Rinse mouth and seek medical advice if large quantities are swallowed.