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    • Hydroxypropyl Methylcellulose (HPMC) CAS 9004-65-3

    Hydroxypropyl Methylcellulose (HPMC) CAS 9004-65-3

    Hydroxypropyl Methylcellulose (HPMC, Hypromellose), CAS 9004-65-3, is a nonionic water-soluble cellulose ether supplied for construction, pharmaceutical, food and personal-care applications. Confirm the required viscosity grade, then request a quotation with COA/TDS/SDS for bulk supply.

    • CAS: 9004-65-3
    • Synonyms: HPMC, Hypromellose, Hydroxypropyl methyl cellulose ether
    • Einecs: 618-389-6
    • Grade: Construction / Pharmaceutical / Food / Personal Care (customizable)
    • Package: 25 kg multi-layer kraft bag with inner PE liner (500 kg / 600 kg jumbo bags available)
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    Product Description

    Hydroxypropyl Methylcellulose, CAS 9004-65-3, commonly abbreviated HPMC, is a nonionic water-soluble cellulose ether; the EC/EINECS number is 618-389-6.

    Synonyms: HPMC; Hypromellose; Hydroxypropyl methyl cellulose ether.

    CAS: 9004-65-3.

    EC number: 618-389-6.

    It is a white to off-white, odorless and tasteless powder; the bulk density is about 0.35–0.55 g/cm³.

    It disperses in cold water and dissolves to a clear or opaline solution; it is insoluble in hot water and most organic solvents.

    It is produced from refined cellulose by methylation and hydroxypropylation; the methoxy content is about 19–30% and the hydroxypropoxy content about 4–12%.

    A 1% aqueous solution has a pH of about 6.0–8.5; the 2% solution viscosity range is about 3,000–200,000 mPa·s depending on grade.

    It provides thickening, water retention, film formation and thermal gelation; the gel temperature depends on the grade.

    It is used as a thickener, water-retention agent, binder, film former and stabilizer in dry-mix mortars, coatings, pharmaceuticals, food and personal care.

    Construction, pharmaceutical and food grades differ mainly in viscosity range, substitution content, purity, residual impurities and applicable standards.

    Confirm the required viscosity grade, methoxy and hydroxypropoxy content, particle size, moisture and the applicable construction, pharmaceutical or food standard.

    Store in tightly closed bags or containers in a cool, dry, ventilated area away from moisture and strong oxidizers.

    Use appropriate dust controls and personal protective equipment when transferring bulk powder; keep away from open flames because fine powder can present a dust-combustion risk.

    Confirm the current product-specific specification.

    Confirm packaging with the requested quantity and destination requirements.

    Document requirements should be confirmed from the current specification, SDS, COA or other product-specific files.

    The page is an RFQ entry point and does not state stock, price, MOQ or fixed lead time.

    For an RFQ, state the intended use, required specification, quantity, packaging, destination and document needs.

    FAQ - Technical & Supply Chain

    • Q:

      What is Hydroxypropyl Methylcellulose CAS 9004-65-3?

      A: Hydroxypropyl methylcellulose, or HPMC, is a nonionic water-soluble cellulose ether produced from refined cellulose by methylation and hydroxypropylation. CAS 9004-65-3 identifies this polymer type, while commercial products are further defined by viscosity, substitution content and particle size.
    • Q:

      Why is HPMC supplied in different viscosity grades?

      A: HPMC performance depends on molecular weight, methoxy and hydroxypropoxy content, and the measurement method. Different viscosity grades provide different thickening, water retention, gelation and film-forming behavior for each end use.
    • Q:

      What is Hydroxypropyl Methylcellulose used for?

      A: HPMC is used as a thickener, water-retention agent, binder, film former and stabilizer in dry-mix mortars, coatings, pharmaceuticals, food and personal-care products. The specific grade is selected according to the required viscosity, solubility and thermal gelation profile.
    • Q:

      What is the difference between construction, pharmaceutical and food grade HPMC?

      A: The grades are differentiated mainly by viscosity range, substitution content, purity, residual impurities and applicable standards. Construction grade is optimized for mortar workability and water retention, while pharmaceutical and food grades are selected to meet stricter purity and regulatory requirements.
    • Q:

      How should HPMC powder be stored and handled?

      A: Store HPMC in tightly closed bags or containers in a cool, dry, ventilated area away from moisture and strong oxidizers. Use appropriate dust controls and personal protective equipment when transferring bulk powder.

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