Why is Chlorhexidine Gluconate usually supplied as a 20% aqueous solution?

The pure digluconate salt is difficult to handle and dissolve, while the 20% aqueous solution is stable and easy to formulate. Finished products are normally diluted from this concentrate to lower active levels such as 0.5%, 2%, or 4%, depending on the application.

How is Chlorhexidine Gluconate Solution used in skin antisepsis and surgical preparation?

It is used as a cationic antimicrobial active in surgical hand scrubs, preoperative skin preparations, wound-area cleansers, and related biocidal products. Chlorhexidine can bind to skin proteins and provide persistent antimicrobial activity after application.

What oral-care and preservative applications use Chlorhexidine Gluconate Solution?

It is formulated into mouthwashes, oral rinses, and dental antiseptic products, usually at controlled low concentrations. It is also used as a broad-spectrum preservative or active in selected personal-care and healthcare products.

Why should Chlorhexidine Gluconate Solution not be mixed with anionic surfactants?

Chlorhexidine gluconate is cationic, so anionic surfactants such as common soaps or sodium lauryl sulfate can form insoluble complexes that reduce or inactivate its antimicrobial effect. Formulations should use compatible nonionic, cationic, or amphoteric ingredients and maintain the intended pH range.

Chlorhexidine Gluconate Solution CAS 18472-51-0

Chlorhexidine Gluconate Solution, also called chlorhexidine digluconate or CHG, CAS 18472-51-0, is a 20% aqueous cationic antimicrobial raw material supplied for biocidal and healthcare formulations. Confirm the required grade and specification, then request a quotation with COA/TDS/SDS for bulk supply.

CAS: 18472-51-0
Synonyms: Chlorhexidine digluconate, CHG, 1,1'-Hexamethylenebis[5-(4-chlorophenyl)biguanide] digluconate, Chlorhexidine di-D-gluconate, Hibitane gluconate
Einecs: 242-354-0
Molecular Formula: C₃₄H₅₄Cl₂N₁₀O₁₄
Grade: Antimicrobial / Biocidal Raw Material
Package: 200 kg drum / 1000 kg IBC (customizable)

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Product Description

Chlorhexidine Gluconate Solution CAS 18472-51-0 is the digluconate salt of chlorhexidine, also known as CHG, with molecular formula C34H54Cl2N10O14, molecular weight about 897.76 and EINECS 242-354-0.

Synonyms: Chlorhexidine digluconate; CHG; 1,1’-Hexamethylenebis[5-(4-chlorophenyl)biguanide] digluconate; Chlorhexidine di-D-gluconate; Hibitane gluconate.

CAS: 18472-51-0.

It has the molecular formula C34H54Cl2N10O14 and a molecular weight of about 897.76 g/mol.

It is commonly supplied as a colorless to pale yellowish 20% aqueous solution that is miscible with water and soluble in alcohol.

The product is cationic with a typical pH of 5.5–7.0 and is sensitive to light and high temperatures.

It is a raw-material concentrate normally diluted to lower active levels such as 0.5%, 2%, 4%, 0.12% or 0.2% for finished products.

In surgical hand scrubs and preoperative skin preparation, it binds to skin proteins and provides persistent antimicrobial activity.

It is used in mouthwashes, oral rinses and dental antiseptic products to reduce plaque and treat gingivitis.

It is also used for medical-device disinfection, veterinary wound care, hand sanitizers and antibacterial wet wipes.

Because it is cationic, it is incompatible with anionic surfactants such as soaps or sodium lauryl sulfate.

Concentrated CHG is an eye hazard and must not enter the middle ear; professional handling protocols are required.

High-quality material is controlled for p-chloroaniline (PCA) and other impurities by HPLC.

Store in opaque containers or dark areas at controlled room temperature; do not freeze and avoid temperatures above 40 °C.

Confirm appearance, active content, pH, p-chloroaniline, heavy metals, microbial limits and related impurities as required.

Use HDPE or plastic pharmaceutical-grade containers and avoid prolonged contact with metals.

Confirm packaging with the requested quantity and destination requirements.

The page is an RFQ entry point and does not state stock, price, MOQ or fixed lead time.

For an RFQ, state the intended use, required grade and specification, quantity, packaging, destination and document needs.

FAQ - Technical & Supply Chain

Q:
What is Chlorhexidine Gluconate Solution CAS 18472-51-0?

A: Chlorhexidine Gluconate Solution CAS 18472-51-0 is the digluconate salt of chlorhexidine, with molecular formula C34H54Cl2N10O14, molecular weight about 897.76, and EINECS 242-354-0. It is commonly supplied as a 20% aqueous solution.
Q:
Why is Chlorhexidine Gluconate usually supplied as a 20% aqueous solution?

A: The pure digluconate salt is difficult to handle and dissolve, while the 20% aqueous solution is stable and easy to formulate. Finished products are normally diluted from this concentrate to lower active levels such as 0.5%, 2%, or 4%, depending on the application.
Q:
How is Chlorhexidine Gluconate Solution used in skin antisepsis and surgical preparation?

A: It is used as a cationic antimicrobial active in surgical hand scrubs, preoperative skin preparations, wound-area cleansers, and related biocidal products. Chlorhexidine can bind to skin proteins and provide persistent antimicrobial activity after application.
Q:
What oral-care and preservative applications use Chlorhexidine Gluconate Solution?

A: It is formulated into mouthwashes, oral rinses, and dental antiseptic products, usually at controlled low concentrations. It is also used as a broad-spectrum preservative or active in selected personal-care and healthcare products.
Q:
Why should Chlorhexidine Gluconate Solution not be mixed with anionic surfactants?

A: Chlorhexidine gluconate is cationic, so anionic surfactants such as common soaps or sodium lauryl sulfate can form insoluble complexes that reduce or inactivate its antimicrobial effect. Formulations should use compatible nonionic, cationic, or amphoteric ingredients and maintain the intended pH range.

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