What is Hydroxyphenyl Propamidobenzoic Acid CAS 697235-49-7?

Hydroxyphenyl Propamidobenzoic Acid, also called Dihydroavenanthramide D or HPPBA, is a synthetic bioactive amide with the molecular formula C₁₆H₁₅NO₄ and a molecular weight of 285.29 g/mol. It is modeled after the soothing compounds found in oats.

How does HPPBA work in sensitive-skin and anti-redness products?

It is used for its antihistamine-like, anti-inflammatory and anti-irritant activity. Cosmetic formulas use it to help reduce chemically induced redness, itching and discomfort in serums, lotions, creams and scalp-care products.

What is the difference between HPPBA and a natural oat extract?

Natural oat extract contains a mixture of avenanthramides and other plant components, while Hydroxyphenyl Propamidobenzoic Acid is a standardized single molecule. The synthetic form provides more consistent assay, identity and formulation behavior.

How should Hydroxyphenyl Propamidobenzoic Acid be stored, and what use level is typical?

Store it in tightly closed containers in a cool, dry, light-protected area and use powder-handling controls. Supplier guidance commonly recommends low use levels, often around 2% or lower in leave-on cosmetic products, depending on the formulation.

Hydroxyphenyl Propamidobenzoic Acid CAS 697235-49-7

Hydroxyphenyl Propamidobenzoic Acid (Dihydroavenanthramide D, HPPBA), CAS 697235-49-7, is a standardized synthetic soothing active for cosmetic and personal-care applications. Confirm the required assay, then request a quotation with COA/TDS/SDS for bulk supply.

CAS: 697235-49-7
Synonyms: Dihydroavenanthramide D, HED, synthetic avenanthramide
Einecs: 470-130-4
Molecular Formula: C₁₆H₁₅NO₄
Grade: Cosmetic / personal care grade, assay ≥99.0%
Package: 1 kg aluminum foil bag, 25 kg fiber drum or as required (inner double PE bag, outer drum/carton)

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Product Description

Hydroxyphenyl Propamidobenzoic Acid, CAS 697235-49-7, also called Dihydroavenanthramide D or HPPBA, is a synthetic bioactive amide modeled after natural oat avenanthramides; the EC/EINECS number is 470-130-4.

Synonyms: Dihydroavenanthramide D; HED; synthetic avenanthramide.

CAS: 697235-49-7.

Molecular formula: C₁₆H₁₅NO₄.

Molecular weight: 285.29.

EC number: 470-130-4.

It is a white to off-white crystalline or fine powder with a melting point of about 188–200 °C.

The predicted density at 20 °C is about 1.35 g/cm³; the pKa is about 3.47 and the log P about 3.0.

It is sparingly soluble in water (about 86.5 mg/L at 20 °C) and soluble in ethanol and other common cosmetic solvents.

It is used for its antihistamine-like, anti-inflammatory and anti-irritant activity in serums, lotions, creams and scalp-care products.

It helps reduce chemically induced redness, itching and discomfort and is suited to sensitive or reactive skin.

It differs from natural oat extract by being a standardized single molecule, giving more consistent assay, identity and formulation behavior.

Confirm HPLC assay, appearance, melting point, water content, residual solvents, heavy metals and microbial limits; the cosmetic grade typically specifies assay at least 99.0%.

Store in tightly closed containers in a cool, dry, light-protected area; supplier guidance commonly recommends low use levels, often around 2% or lower in leave-on products.

Confirm the current product-specific specification.

Confirm packaging with the requested quantity and destination requirements.

Document requirements should be confirmed from the current specification, SDS, COA or other product-specific files.

The page is an RFQ entry point and does not state stock, price, MOQ or fixed lead time.

For an RFQ, state the intended use, required specification, quantity, packaging, destination and document needs.

FAQ - Technical & Supply Chain

Q:
What is Hydroxyphenyl Propamidobenzoic Acid CAS 697235-49-7?

A: Hydroxyphenyl Propamidobenzoic Acid, also called Dihydroavenanthramide D or HPPBA, is a synthetic bioactive amide with the molecular formula C₁₆H₁₅NO₄ and a molecular weight of 285.29 g/mol. It is modeled after the soothing compounds found in oats.
Q:
How does HPPBA work in sensitive-skin and anti-redness products?

A: It is used for its antihistamine-like, anti-inflammatory and anti-irritant activity. Cosmetic formulas use it to help reduce chemically induced redness, itching and discomfort in serums, lotions, creams and scalp-care products.
Q:
What is the difference between HPPBA and a natural oat extract?

A: Natural oat extract contains a mixture of avenanthramides and other plant components, while Hydroxyphenyl Propamidobenzoic Acid is a standardized single molecule. The synthetic form provides more consistent assay, identity and formulation behavior.
Q:
Which specifications should be checked for cosmetic formulation?

A: Check HPLC assay, appearance, melting point, water content, residual solvents, heavy metals and microbial limits. The cosmetic grade shown here specifies an assay of at least 99.0%.
Q:
How should Hydroxyphenyl Propamidobenzoic Acid be stored, and what use level is typical?

A: Store it in tightly closed containers in a cool, dry, light-protected area and use powder-handling controls. Supplier guidance commonly recommends low use levels, often around 2% or lower in leave-on cosmetic products, depending on the formulation.

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