What is Hydroxyphenyl Propamidobenzoic Acid CAS 697235-49-7?

Hydroxyphenyl Propamidobenzoic Acid, also called Dihydroavenanthramide D or HPPBA, is a synthetic bioactive amide with the molecular formula C16H15NO4 and a molecular weight of 285.29 g/mol. It is modeled after the soothing compounds found in oats.

How does HPPBA work in sensitive-skin and anti-redness products?

It is used for its antihistamine-like, anti-inflammatory and anti-irritant activity. Cosmetic formulas use it to help reduce chemically induced redness, itching and discomfort in serums, lotions, creams and scalp-care products.

What is the difference between HPPBA and a natural oat extract?

Natural oat extract contains a mixture of avenanthramides and other plant components, while Hydroxyphenyl Propamidobenzoic Acid is a standardized single molecule. The synthetic form provides more consistent assay, identity and formulation behavior.

Which specifications should be checked for cosmetic formulation?

Check HPLC assay, appearance, melting point, water content, residual solvents, heavy metals and microbial limits. The cosmetic grade shown here specifies an assay of at least 99.0%.

How should Hydroxyphenyl Propamidobenzoic Acid be stored, and what use level is typical?

Store it in tightly closed containers in a cool, dry, light-protected area and use powder-handling controls. Supplier guidance commonly recommends low use levels, often around 2% or lower in leave-on cosmetic products, depending on the formulation.

Hydroxyphenyl Propamidobenzoic Acid CAS 697235-49-7

Hydroxyphenyl Propamidobenzoic Acid (CAS 697235-49-7) is a synthetic bioactive amide, chemically modeled after natural oat avenanthramides, utilized primarily as a high-performance soothing agent in cosmetic skincare formulations and sensitive skin products. This pure Dihydroavenanthramide D powder functions as a potent antihistamine-like active, significantly reducing itching and erythema by inhibiting the release of inflammatory mediators in the skin. Unlike complex natural extracts, this synthetic avenanthramide offers standardized purity and stability, serving as a critical HED ingredient for neuro-cosmetic lotions, anti-irritant serums, and scalp care applications. We provide this cosmetic active with competitive factory pricing to support personal care manufacturing and ensure bulk supply availability for formulation scale-up. Our facility accommodates customized specifications for assay and solubility profiles, while every shipment is fully documented with MSDS, TDS, COA files to ensure global regulatory compliance.

CAS: 697235-49-7
Synonyms: Dihydroavenanthramide D, HED, synthetic avenanthramide
Einecs: 470-130-4
Molecular Formula: C₁₆H₁₅NO₄
Grade: Cosmetic / personal care grade, assay ≥99.0%
Package: 1 kg aluminum foil bag, 25 kg fiber drum or as required (inner double PE bag, outer drum/carton)

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Product Description

Hydroxyphenyl Propamidobenzoic Acid (also known as Dihydroavenanthramide D or HPPBA) is a high-purity cosmetic active used as a skin-soothing, anti-itch and anti-redness ingredient in personal care and dermatological formulations. It is derived from oat-related structures and provides strong anti-irritant and antioxidant benefits for sensitive and stressed skin.

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1 Physicochemical Properties

2 Applications

3 Storage Conditions

4 Safety Precautions

Physicochemical Properties

Property	Specification / Typical Value
Chemical Name	2-(3-(4-Hydroxyphenyl)propanamido)benzoic acid
CAS No.	697235-49-7
EC / EINECS No.	470-130-4
Molecular Formula	C₁₆H₁₅NO₄
Molecular Weight	285.29 g/mol
Appearance	White to off-white crystalline or fine powder
Purity (Assay)	≥99.0% (HPLC)
Melting Point	188–200 °C
Boiling Point (predicted)	~590 ± 40 °C
Density (predicted, 20 °C)	~1.35 g/cm³
pKa (20 °C, predicted)	~3.47
LogP (20 °C)	~3.0 (moderately lipophilic)
Water Solubility (20 °C)	~86.5 mg/L (sparingly soluble)
Solubility in Organic Solvents	Soluble in ethanol and other common cosmetic solvents; often used in hydroalcoholic or solvent-based premixes
Volatility / Vapor Pressure	Very low; ~0 Pa at 20 °C
Flammability	Non-flammable solid under normal conditions

Applications

1. Skin Care (Face & Body)

Rapid soothing of acute and chronic irritation (itching, burning, tightness).
Reduces visible redness and helps even out skin tone in sensitive or reactive skin.
Supports barrier recovery in dry, atopic-prone or over-exfoliated skin.

2. Scalp & Hair Care

Anti-itch and anti-redness active for sensitive scalp shampoos, scalp essences and leave-on treatments.
Helps reduce discomfort caused by surfactants, styling products or environmental factors.

3. Body Wash, Shower & Bath Products

Adds a “dermatologist-style soothing” positioning to shower gels, syndet bars and bath oils.
Suitable for daily cleansing of dry, itchy or easily irritated skin.

4. After-Sun & Post-Procedure Care

Ideal for after-sun gels, masks and creams to calm UV-induced redness and heat sensation.
Can be combined with panthenol, bisabolol, madecassoside and ceramides for advanced repair concepts.

5. Medical & Dermocosmetic Creams

Used as a non-steroidal soothing component in creams targeting contact dermatitis, eczema and other itch-related conditions, often as an alternative or complement to glucocorticoids (regulatory status depends on local regulations and final product positioning).

Storage Conditions

Temperature: Store in a cool place, typically 2–8 °C (refrigerated storage recommended for long-term stability).
Environment: Keep in a dry, well-ventilated area away from moisture and direct sunlight.
Packaging: Keep container tightly closed (inner double PE bag + sealed drum or carton) to avoid exposure to air and humidity.
Shelf Life: Under recommended storage conditions, typical shelf life is 24 months from production date; always refer to the COA/label of your specific batch.

Safety Precautions

The following information is for industrial / laboratory handling of the raw material, not for end-user cosmetic products.

Classified as Skin Sensitizer (H317: May cause an allergic skin reaction) in some regulatory databases – avoid direct skin contact with the powder.
Avoid inhalation of dust. Handle in a well-ventilated area or under local exhaust.
Wear suitable PPE: protective gloves, safety glasses and lab coat when handling bulk powder.
Prevent contamination of food, drinks and animal feed; keep out of reach of unauthorized personnel.
In case of skin contact with the raw powder, wash with plenty of water and remove contaminated clothing.
In case of eye contact, rinse cautiously with clean water for several minutes and seek medical advice if irritation persists.
Dispose of and/or incinerate waste material and packaging in accordance with local environmental regulations.

FAQ - Technical & Supply Chain

Q:
What is Hydroxyphenyl Propamidobenzoic Acid CAS 697235-49-7?

A: Hydroxyphenyl Propamidobenzoic Acid, also called Dihydroavenanthramide D or HPPBA, is a synthetic bioactive amide with the molecular formula C16H15NO4 and a molecular weight of 285.29 g/mol. It is modeled after the soothing compounds found in oats.
Q:
How does HPPBA work in sensitive-skin and anti-redness products?

A: It is used for its antihistamine-like, anti-inflammatory and anti-irritant activity. Cosmetic formulas use it to help reduce chemically induced redness, itching and discomfort in serums, lotions, creams and scalp-care products.
Q:
What is the difference between HPPBA and a natural oat extract?

A: Natural oat extract contains a mixture of avenanthramides and other plant components, while Hydroxyphenyl Propamidobenzoic Acid is a standardized single molecule. The synthetic form provides more consistent assay, identity and formulation behavior.
Q:
Which specifications should be checked for cosmetic formulation?

A: Check HPLC assay, appearance, melting point, water content, residual solvents, heavy metals and microbial limits. The cosmetic grade shown here specifies an assay of at least 99.0%.
Q:
How should Hydroxyphenyl Propamidobenzoic Acid be stored, and what use level is typical?

A: Store it in tightly closed containers in a cool, dry, light-protected area and use powder-handling controls. Supplier guidance commonly recommends low use levels, often around 2% or lower in leave-on cosmetic products, depending on the formulation.

Ordering & Documentation

Key information for document requests, quotations, and supply planning.

Documents

COA, TDS, SDS/MSDS and packing details are available on request.

Quotation

Send the CAS number, grade, quantity, packing preference and destination.

Sample & Supply

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Storage & Shipping

Product-specific conditions are confirmed before order.

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