Is fumaryl chloride interchangeable with maleoyl chloride?

No. Fumaryl chloride, CAS 627-63-4, is the E or trans butenedioyl dichloride. Maleoyl chloride is the Z or cis geometric isomer and has a different CAS number. If double-bond geometry affects the downstream reaction, confirm the isomer, CAS number and an agreed GC or NMR identity method.

What should be fixed in a purchase specification for fumaryl chloride?

Confirm fumaryl chloride identity and E-isomer content, assay method, limits for maleoyl chloride and hydrolysis products, color or appearance, water where the method is suitable, packaging and storage conditions. Because it is a moisture-reactive acid chloride, qualify the delivered container, sampling method and downstream reaction performance.

Fumaryl Chloride CAS 627-63-4

Fumaryl Chloride (CAS 627-63-4), also called Fumaroyl Chloride or (E)-2-Butenedioyl dichloride, is a moisture-reactive bifunctional diacyl chloride used for acylation, esterification, amidation and polycondensation. Confirm identity, assay, water or hydrolysis indicators, color, impurity profile and packaging against the current COA and SDS.

CAS: 627-63-4
Synonyms: Fumaryl Chloride, Fumaroyl Chloride, Fumaroyl Dichloride, (E)-2-Butenedioyl dichloride, Fumaric acid dichloride
Einecs: 211-005-4
Molecular Formula: C₄H₂Cl₂O₂
Grade: Specified by identity, assay, water or hydrolysis indicators, color, impurity profile and packaging integrity; see the current COA.
Package: Confirm approved container, inerting or stabilizer needs, fill quantity, temperature controls and dangerous-goods requirements against the SDS.

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Product Description

1 Identity and physicochemical profile

2 Applications and grade selection

3 Storage and handling

4 Safety, documentation and procurement

Identity and physicochemical profile

Item	Technical guidance
Correct identity	Fumaryl chloride; fumaroyl dichloride; (E)-2-butenedioyl dichloride
CAS / EC	627-63-4 / 211-005-4
Formula / molecular weight	C₄H₂Cl₂O₂ / 152.96 g/mol
Functional character	Bifunctional unsaturated diacyl chloride with two moisture-reactive acyl chloride groups
Key purchase controls	Identity, assay, water or hydrolysis indicators, color, impurity profile and packaging integrity
Data boundary	Properties for formyl chloride, CHClO, are not applicable to Fumaryl Chloride

Applications and grade selection

Fumaryl Chloride is evaluated for acylation, esterification, amidation and polycondensation routes used to prepare fumarate derivatives, unsaturated polyesters, polyamides and other specialty intermediates.

State the required assay method, water limit, color and impurity profile, including any route-critical hydrolysis products.
Run a small-scale reaction to compare conversion, selectivity, filtration, work-up and final-product quality with the approved source.
Agree compatible moisture-tight packaging, headspace, sampling and transport conditions before supply.

Storage and handling

Store tightly closed in compatible packaging under dry conditions and away from water, alcohols, bases and other incompatible materials. Follow the current SDS and supplier instructions for atmosphere and temperature; do not transfer the product into an unqualified container.

Safety, documentation and procurement

Fumaryl Chloride is corrosive and moisture-reactive. Use closed handling where practicable, suitable gloves, face and eye protection, ventilation and an approved emergency plan. Procurement should confirm the current SDS, classification, package, destination restrictions and shipping arrangement.

FAQ - Technical & Supply Chain

Q:
Is fumaryl chloride interchangeable with maleoyl chloride?

A: No. Fumaryl chloride, CAS 627-63-4, is the E or trans butenedioyl dichloride. Maleoyl chloride is the Z or cis geometric isomer and has a different CAS number. If double-bond geometry affects the downstream reaction, confirm the isomer, CAS number and an agreed GC or NMR identity method.
Q:
What should be fixed in a purchase specification for fumaryl chloride?

A: Confirm fumaryl chloride identity and E-isomer content, assay method, limits for maleoyl chloride and hydrolysis products, color or appearance, water where the method is suitable, packaging and storage conditions. Because it is a moisture-reactive acid chloride, qualify the delivered container, sampling method and downstream reaction performance.

Ordering & Documentation

Key information for document requests, quotations, and supply planning.

Documents

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Quotation

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Sample & Supply

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Storage & Shipping

Product-specific conditions are confirmed before order.

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