What is Pure Polyglutamic Acid CAS 25513-46-6?

Pure Polyglutamic Acid CAS 25513-46-6 is a water-soluble gamma-poly(L-glutamic acid) biopolymer used mainly as a cosmetic humectant and film former. It is supplied in cosmetic grade powder form for serums, masks, creams, lotions, and other water-based skin care formulas.

What is the difference between high molecular weight and low molecular weight Polyglutamic Acid?

High molecular weight PGA stays closer to the skin surface and forms a breathable moisture-retaining film, helping reduce transepidermal water loss. Low molecular weight PGA can penetrate more easily and is used to improve skin hydration and conditioning within deeper layers of the stratum corneum.

How does Polyglutamic Acid compare with Hyaluronic Acid?

Polyglutamic Acid is often compared with Hyaluronic Acid as a moisturizer because both are high-water-binding polymers. PGA may hold several times more moisture than HA by weight in some tests, and it can also help inhibit hyaluronidase, an enzyme that degrades natural hyaluronic acid in skin.

Does Pure Polyglutamic Acid support brightening or anti-aging skin care claims?

PGA can support moisturization-led anti-aging and brightening positioning by improving skin hydration, barrier comfort, and appearance. Some cosmetic studies also report that PGA inhibits tyrosinase activity, which is relevant to skin-brightening formulations, but final product claims depend on the full formula and local regulatory requirements.

What are typical specifications for the standard Cosmetic Grade powder?

The standard cosmetic grade is typically a white to off-white powder with almost no odor, PGA content around 92.0% or higher, pH about 5.0-7.0 in a 1% solution, and loss on drying not more than 10.0%. It is water-soluble and generally insoluble in ethanol.

Pure Polyglutamic Acid CAS 25513-46-6

Pure Polyglutamic Acid, CAS 25513-46-6, also known as gamma-PGA, is a water-soluble cosmetic-grade biopolymer supplied as a humectant and film former for skin-care and hair-care formulations. Confirm the required grade and specification, then request a quotation with COA/TDS/SDS for bulk supply.

CAS: 25513-46-6
Synonyms: Gamma-Polyglutamic Acid, γ-PGA, Poly-L-glutamic acid, Gamma-PGA
Molecular Formula: (C₅H₇NO₃)ₙ
Grade: Cosmetic Grade
Package: 100g/Bottle, 1kg/Aluminum Foil Bag, or 25kg/Fiber Drum.

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Product Description

Pure Polyglutamic Acid, CAS 25513-46-6, also called gamma-PGA, is a water-soluble anionic polypeptide of D- and L-glutamic acid.

Synonyms: Gamma-Polyglutamic Acid; γ-PGA; Poly-L-glutamic acid; Gamma-PGA.

CAS: 25513-46-6.

It has the molecular formula (C5H7NO3)n and is supplied as a white to off-white powder.

It has a polyglutamic acid content of at least 92.0% in the standard cosmetic grade.

It can hold several times more moisture than hyaluronic acid by weight.

High molecular weight PGA forms a breathable film on the skin and reduces water loss.

Low molecular weight PGA penetrates more easily to hydrate deeper layers.

It inhibits tyrosinase activity, relevant to skin-brightening formulations.

It inhibits hyaluronidase and helps protect natural hyaluronic acid in the skin.

It is used as a primary active ingredient in hydrating and anti-aging serums and essences.

It is used in facial masks for a smooth feel and a large hydration boost.

It acts as a humectant and texture enhancer in creams and lotions, and is non-sticky.

It is used in hair conditioners to increase strength and reduce friction.

Confirm appearance, odor, assay, pH, loss on drying, molecular weight, heavy metals, arsenic, bacteria count and solubility.

Store sealed in a cool, dry place, away from moisture and direct sunlight.

Confirm packaging with the requested quantity and destination requirements.

The page is an RFQ entry point and does not state stock, price, MOQ or fixed lead time.

For an RFQ, state the intended use, required grade and specification, quantity, packaging, destination and document needs.

FAQ - Technical & Supply Chain

Q:
What is Pure Polyglutamic Acid CAS 25513-46-6?

A: Pure Polyglutamic Acid CAS 25513-46-6 is a water-soluble gamma-poly(L-glutamic acid) biopolymer used mainly as a cosmetic humectant and film former. It is supplied in cosmetic grade powder form for serums, masks, creams, lotions, and other water-based skin care formulas.
Q:
What is the difference between high molecular weight and low molecular weight Polyglutamic Acid?

A: High molecular weight PGA stays closer to the skin surface and forms a breathable moisture-retaining film, helping reduce transepidermal water loss. Low molecular weight PGA can penetrate more easily and is used to improve skin hydration and conditioning within deeper layers of the stratum corneum.
Q:
How does Polyglutamic Acid compare with Hyaluronic Acid?

A: Polyglutamic Acid is often compared with Hyaluronic Acid as a moisturizer because both are high-water-binding polymers. PGA may hold several times more moisture than HA by weight in some tests, and it can also help inhibit hyaluronidase, an enzyme that degrades natural hyaluronic acid in skin.
Q:
Does Pure Polyglutamic Acid support brightening or anti-aging skin care claims?

A: PGA can support moisturization-led anti-aging and brightening positioning by improving skin hydration, barrier comfort, and appearance. Some cosmetic studies also report that PGA inhibits tyrosinase activity, which is relevant to skin-brightening formulations, but final product claims depend on the full formula and local regulatory requirements.
Q:
What are typical specifications for the standard Cosmetic Grade powder?

A: The standard cosmetic grade is typically a white to off-white powder with almost no odor, PGA content around 92.0% or higher, pH about 5.0-7.0 in a 1% solution, and loss on drying not more than 10.0%. It is water-soluble and generally insoluble in ethanol.

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