Language

Current Language
    Change Language
    Chemical products
    Related: Cosmetic Humectant HA HA
    • Pure Polyglutamic Acid CAS 25513-46-6

    Pure Polyglutamic Acid CAS 25513-46-6

    Pure Polyglutamic Acid, identified by CAS 25513-46-6, is a water-soluble, biodegradable biopolymer composed of glutamic acid monomers linked by gamma-amide bonds. As a versatile pure polyglutamic acid, this technical-grade gamma-polyglutamic acid functions as a high-efficiency flocculant and heavy metal sequestrant in various industrial water treatment processes. This anionic polypeptide is valued for its superior hygroscopic properties and its ability to enhance the structural stability of aqueous formulations without environmental toxicity. Our facility provides competitive factory pricing and customized specifications regarding molecular weight—ranging from low to ultra-high daltons—to ensure optimal performance in specific filtration or stabilization systems. For technical validation and regulatory compliance, we offer comprehensive MSDS, TDS, COA documentation and maintain consistent bulk supply for industrial-scale utility.

    • CAS: 25513-46-6
    • Synonyms: Gamma-Polyglutamic Acid, γ-PGA, Poly-L-glutamic acid, Gamma-PGA
    • Molecular Formula: (C5H7NO3)n
    • Grade: Cosmetic Grade
    • Package: 100g/Bottle, 1kg/Aluminum Foil Bag, or 25kg/Fiber Drum.
    Request a quote
    Share:

    Product Description

    Polyglutamic Acid is an anionic polypeptide consisting of D- and L-glutamic acid. Unlike collagen or hyaluronic acid, PGA does not just sit on the skin; it functions through a unique mechanism.

    Core Benefits:

    1. Superior Moisturization: Studies suggest PGA can hold 4-5 times more moisture than Hyaluronic Acid.
    2. Dual Action:
      • High Molecular Weight (HMW): Forms a breathable, smooth film on the skin surface to prevent water loss (TEWL).
      • Low Molecular Weight (LMW): Penetrates deeper layers to hydrate and nourish the skin.
    3. Whitening Effect: It inhibits the production of melanin by blocking tyrosinase activity.
    4. Long-lasting: It inhibits the activity of Hyaluronidase, thereby protecting the natural Hyaluronic Acid in the skin from breaking down.
    1 Physicochemical Properties
    2 Applications
    3 Storage Conditions
    4 Safety Precautions

    Physicochemical Properties

    The data below represents the standard Cosmetic Grade Powder.

    ParameterSpecification (Standard)
    AppearanceWhite to off-white powder
    OdorAlmost odorless
    Assay (Polyglutamic Acid)≥ 92.0%
    pH Value (1% Solution)5.0 – 7.0
    Loss on Drying≤ 10.0%
    Molecular Weight700 kDa – 2000 kDa (Standard HMW)
    Heavy Metals (Pb)≤ 10 ppm
    Arsenic (As)≤ 2 ppm
    Bacteria Count≤ 100 CFU/g
    SolubilitySoluble in water, insoluble in ethanol

    Applications

    1. Serums & Essences:
      • Used as the primary active ingredient for deep hydration and anti-aging serums.
    2. Facial Masks:
      • Provides a slippery, luxurious feel and immense hydration boost in sheet masks.
    3. Creams & Lotions:
      • Acts as a humectant and texture enhancer. It is non-sticky compared to glycerin.
    4. Hair Care:
      • Used in conditioners to increase hair strength, reduce friction, and repair damage caused by bleaching.
    5. Makeup:
      • Added to foundations to prevent caking and improve spreadability.

    For related humectant raw materials used in hydration-focused formulations, see Sodium Hyaluronate and Saccharide Isomerate.

    Storage Conditions

    • Hygroscopic: The powder is highly hygroscopic (absorbs moisture from air).
    • Temperature: Store in a cool, dry place. For long-term storage, keeping it at low temperatures (2-8°C) is recommended to maintain molecular weight stability, though room temperature is acceptable for shorter periods.
    • Sealing: Keep packaging tightly sealed immediately after use.
    • Shelf Life: 24 months in original unopened packaging.

    Safety Precautions

    • Origin: Derived from natto (fermented soybeans), generally considered safe and non-toxic.
    • Handling: Avoid breathing dust. Use in a well-ventilated area.
    • Skin/Eye Contact: Non-irritating in normal use concentrations. If powder enters eyes, rinse with water.
    • Biodegradability: Fully biodegradable and eco-friendly.

    FAQ - Technical & Supply Chain

    • Q:

      What is Pure Polyglutamic Acid CAS 25513-46-6?

      A: Pure Polyglutamic Acid CAS 25513-46-6 is a water-soluble gamma-poly(L-glutamic acid) biopolymer used mainly as a cosmetic humectant and film former. It is supplied in cosmetic grade powder form for serums, masks, creams, lotions, and other water-based skin care formulas.
    • Q:

      What is the difference between high molecular weight and low molecular weight Polyglutamic Acid?

      A: High molecular weight PGA stays closer to the skin surface and forms a breathable moisture-retaining film, helping reduce transepidermal water loss. Low molecular weight PGA can penetrate more easily and is used to improve skin hydration and conditioning within deeper layers of the stratum corneum.
    • Q:

      How does Polyglutamic Acid compare with Hyaluronic Acid?

      A: Polyglutamic Acid is often compared with Hyaluronic Acid as a moisturizer because both are high-water-binding polymers. PGA may hold several times more moisture than HA by weight in some tests, and it can also help inhibit hyaluronidase, an enzyme that degrades natural hyaluronic acid in skin.
    • Q:

      Does Pure Polyglutamic Acid support brightening or anti-aging skin care claims?

      A: PGA can support moisturization-led anti-aging and brightening positioning by improving skin hydration, barrier comfort, and appearance. Some cosmetic studies also report that PGA inhibits tyrosinase activity, which is relevant to skin-brightening formulations, but final product claims depend on the full formula and local regulatory requirements.
    • Q:

      What are typical specifications for the standard Cosmetic Grade powder?

      A: The standard cosmetic grade is typically a white to off-white powder with almost no odor, PGA content around 92.0% or higher, pH about 5.0-7.0 in a 1% solution, and loss on drying not more than 10.0%. It is water-soluble and generally insoluble in ethanol.

    Ordering & Documentation

    Key information for document requests, quotations, and supply planning.

    Documents

    COA, TDS, SDS/MSDS and packing details are available on request.

    Quotation

    Send the CAS number, grade, quantity, packing preference and destination.

    Sample & Supply

    Support is available for samples, trial orders, bulk and repeat supply.

    Storage & Shipping

    Product-specific conditions are confirmed before order.

    Contact Form

    Use our contact form to send us your questions, suggestions or comments. We will respond as soon as possible.

    Product Categories

    Related Products