What is L-Hydroxyproline CAS 51-35-4?

L-Hydroxyproline is a chiral amino acid derivative with CAS 51-35-4, EC 200-091-9, and molecular formula C5H9NO3. It is commonly listed as trans-4-Hydroxy-L-proline or (2S,4R)-4-hydroxypyrrolidine-2-carboxylic acid, and is supplied as a white to almost white crystalline powder or crystals.

What is L-Hydroxyproline mainly used for?

It is mainly used as a chiral building block and intermediate in pharmaceutical synthesis, peptide chemistry, biochemical research, and specialty organic synthesis. It is also relevant to collagen synthesis and metabolism studies because hydroxyproline helps stabilize the collagen triple helix.

Is L-Hydroxyproline the same as trans-4-Hydroxy-L-proline?

In standard commercial and catalog use for CAS 51-35-4, L-Hydroxyproline is commonly identified as trans-4-Hydroxy-L-proline. Because stereochemistry is important for this chiral amino acid derivative, the identity and specific rotation should be confirmed against the supplied batch specification.

Which specifications should be checked before ordering?

Confirm appearance, assay or purity, specific rotation, melting range, water content, residue on ignition, heavy metals, and related amino acid or stereoisomer impurities. Also confirm whether pharmaceutical, biochemical, or technical grade is required, and verify packaging and storage compatibility with the intended use.

How should L-Hydroxyproline be stored and handled?

Store it in a cool, dry, well-ventilated area in tightly closed containers away from moisture, heat, and strong oxidizers. Use appropriate PPE and controlled dispensing to limit dust exposure during weighing and transfer, and follow the supplied batch specification for storage.

L-Hydroxyproline CAS 51-35-4

L-Hydroxyproline is supplied as an amino acid derivative used mainly in pharmaceutical, biochemical and synthesis-oriented applications. This material is typically handled as an intermediate or specialty raw material rather than a consumer-facing ingredient. It is commonly provided as a white crystalline powder with grade-dependent documentation for technical evaluation and sourcing.

CAS: 51-35-4
Synonyms: trans-4-Hydroxy-L-proline; (2S,4R)-4-Hydroxypyrrolidine-2-carboxylic acid; Hyp
Einecs: 200-091-9
Molecular Formula: C5H9NO3
Grade: Industrial / Technical / Biochemical grade, according to supplied specification
Package: Standard export packaging, according to supplied grade and order quantity

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Product Description

Product Information / Specifications

Product Name	L-Hydroxyproline
CAS Number	51-35-4
Synonyms	trans-4-Hydroxy-L-proline; (2S,4R)-4-Hydroxypyrrolidine-2-carboxylic acid; Hyp
EC Number	200-091-9
Molecular Formula	C5H9NO3
Molecular Weight	131.13
Product Identity	Amino acid derivative / specialty chemical / intermediate-use raw material
Supply Form	Solid powder or crystalline material, depending on supplied grade

Physical & Chemical Properties

Appearance	White to almost white crystalline powder or crystals
Physical State	Solid
Water Solubility	Soluble in water; actual solubility may be reported according to grade or test condition
Melting Point	Typically reported around 273–274°C
Recommended Handling Position	Technical-grade evaluation should follow the supplied specification and batch documentation

Applications

Pharmaceutical intermediate use where hydroxyproline functionality is required in synthesis routes.
Biochemical and laboratory use as an amino acid derivative for controlled technical work.
Specialty synthesis applications involving chiral or structure-specific raw material selection.
Research and process development programs that require defined hydroxyproline identity and batch documentation.

Packaging

Packaging format may vary according to grade, batch size, and supply arrangement. This product is generally supplied in sealed inner packaging with suitable outer protection for routine storage and transport. Packaging details may be confirmed according to the ordered grade and quantity.

Storage Conditions

Store in a cool, dry, and well-closed container away from moisture, direct heat, and prolonged air exposure. Storage recommendations may differ by grade and manufacturer specification, so batch-level technical documents should be followed where applicable.

Safety Precautions

Handle with appropriate industrial hygiene practice and use suitable personal protective equipment during weighing, transfer, and processing. Avoid unnecessary dust generation and direct contact with eyes, skin, or clothing. Refer to the latest SDS for product-specific handling, storage, and disposal guidance before use.

For related amino acid raw material pages, compare Casein Hydrolysate, Taurine, and DL-Methionine.

FAQ - Technical & Supply Chain

Q:
What is L-Hydroxyproline CAS 51-35-4?

A: L-Hydroxyproline is a chiral amino acid derivative with CAS 51-35-4, EC 200-091-9, and molecular formula C5H9NO3. It is commonly listed as trans-4-Hydroxy-L-proline or (2S,4R)-4-hydroxypyrrolidine-2-carboxylic acid, and is supplied as a white to almost white crystalline powder or crystals.
Q:
What is L-Hydroxyproline mainly used for?

A: It is mainly used as a chiral building block and intermediate in pharmaceutical synthesis, peptide chemistry, biochemical research, and specialty organic synthesis. It is also relevant to collagen synthesis and metabolism studies because hydroxyproline helps stabilize the collagen triple helix.
Q:
Is L-Hydroxyproline the same as trans-4-Hydroxy-L-proline?

A: In standard commercial and catalog use for CAS 51-35-4, L-Hydroxyproline is commonly identified as trans-4-Hydroxy-L-proline. Because stereochemistry is important for this chiral amino acid derivative, the identity and specific rotation should be confirmed against the supplied batch specification.
Q:
Which specifications should be checked before ordering?

A: Confirm appearance, assay or purity, specific rotation, melting range, water content, residue on ignition, heavy metals, and related amino acid or stereoisomer impurities. Also confirm whether pharmaceutical, biochemical, or technical grade is required, and verify packaging and storage compatibility with the intended use.
Q:
How should L-Hydroxyproline be stored and handled?

A: Store it in a cool, dry, well-ventilated area in tightly closed containers away from moisture, heat, and strong oxidizers. Use appropriate PPE and controlled dispensing to limit dust exposure during weighing and transfer, and follow the supplied batch specification for storage.

Ordering & Documentation

Key information for document requests, quotations, and supply planning.

Documents

COA, TDS, SDS/MSDS and packing details are available on request.

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Send the CAS number, grade, quantity, packing preference and destination.

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Storage & Shipping

Product-specific conditions are confirmed before order.

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