What is L-Hydroxyproline CAS 51-35-4?

L-Hydroxyproline is a chiral amino acid derivative with CAS 51-35-4, EC 200-091-9, and molecular formula C5H9NO3. It is commonly listed as trans-4-Hydroxy-L-proline or (2S,4R)-4-hydroxypyrrolidine-2-carboxylic acid, and is supplied as a white to almost white crystalline powder or crystals.

What is L-Hydroxyproline mainly used for?

It is mainly used as a chiral building block and intermediate in pharmaceutical synthesis, peptide chemistry, biochemical research, and specialty organic synthesis. It is also relevant to collagen synthesis and metabolism studies because hydroxyproline helps stabilize the collagen triple helix.

Is L-Hydroxyproline the same as trans-4-Hydroxy-L-proline?

In standard commercial and catalog use for CAS 51-35-4, L-Hydroxyproline is commonly identified as trans-4-Hydroxy-L-proline. Because stereochemistry is important for this chiral amino acid derivative, the identity and specific rotation should be confirmed against the supplied batch specification.

Which specifications should be checked before ordering?

Confirm appearance, assay or purity, specific rotation, melting range, water content, residue on ignition, heavy metals, and related amino acid or stereoisomer impurities. Also confirm whether pharmaceutical, biochemical, or technical grade is required, and verify packaging and storage compatibility with the intended use.

L-Hydroxyproline (Hyp) CAS 51-35-4

L-Hydroxyproline (Hyp), also called trans-4-hydroxy-L-proline or (2S,4R)-4-hydroxypyrrolidine-2-carboxylic acid, CAS 51-35-4, is a chiral amino acid derivative supplied for pharmaceutical synthesis and specialty organic chemistry. Confirm the required grade and specification, then request a quotation with COA/TDS/SDS for bulk supply.

CAS: 51-35-4
Synonyms: trans-4-Hydroxy-L-proline; (2S,4R)-4-Hydroxypyrrolidine-2-carboxylic acid; Hyp
Einecs: 200-091-9
Molecular Formula: C5H9NO3
Grade: Industrial / Technical / Biochemical grade
Package: Standard export packaging

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Product Description

L-Hydroxyproline (Hyp) CAS 51-35-4 is a chiral amino acid derivative with EINECS 200-091-9 and molecular formula C5H9NO3.

Synonyms: trans-4-Hydroxy-L-proline; (2S,4R)-4-Hydroxypyrrolidine-2-carboxylic acid; Hyp.

CAS: 51-35-4.

Molecular formula: C5H9NO3.

It is supplied as a white to almost white crystalline powder or crystals.

It is also called trans-4-hydroxy-L-proline or (2S,4R)-4-hydroxypyrrolidine-2-carboxylic acid.

It is mainly used as a chiral building block and intermediate in pharmaceutical synthesis and peptide chemistry.

It is also used in biochemical research and specialty organic synthesis.

Hydroxyproline helps stabilize the collagen triple helix, so it is also relevant to collagen synthesis and metabolism studies.

As a chiral amino acid derivative, its stereochemical identity and specific rotation are important batch properties.

Confirm appearance, assay or purity, specific rotation, melting range, water content, residue on ignition, heavy metals, and related amino acid or stereoisomer impurities.

Confirm whether pharmaceutical, biochemical, or technical grade is required for the intended use.

Store in tightly closed containers in a cool, dry, well-ventilated area away from moisture, heat, and strong oxidizers.

Use appropriate PPE and controlled dispensing to limit dust exposure during weighing and transfer.

Confirm packaging suitable for the supplied grade and order quantity, and follow the current SDS.

Every batch is checked for appearance, assay or purity, specific rotation, melting range, water content, residue on ignition, heavy metals, and related impurities, with COA/TDS/SDS supplied per grade.

Confirm assay, specific rotation, melting range, water content, packaging, and grade as required.

The page is an RFQ entry point and does not state stock, price, MOQ, or fixed lead time.

For an RFQ, state the intended application, required grade, quantity, packaging, destination, and document needs.

FAQ - Technical & Supply Chain

Q:
What is L-Hydroxyproline CAS 51-35-4?

A: L-Hydroxyproline is a chiral amino acid derivative with CAS 51-35-4, EC 200-091-9, and molecular formula C5H9NO3. It is commonly listed as trans-4-Hydroxy-L-proline or (2S,4R)-4-hydroxypyrrolidine-2-carboxylic acid, and is supplied as a white to almost white crystalline powder or crystals.
Q:
What is L-Hydroxyproline mainly used for?

A: It is mainly used as a chiral building block and intermediate in pharmaceutical synthesis, peptide chemistry, biochemical research, and specialty organic synthesis. It is also relevant to collagen synthesis and metabolism studies because hydroxyproline helps stabilize the collagen triple helix.
Q:
Is L-Hydroxyproline the same as trans-4-Hydroxy-L-proline?

A: In standard commercial and catalog use for CAS 51-35-4, L-Hydroxyproline is commonly identified as trans-4-Hydroxy-L-proline. Because stereochemistry is important for this chiral amino acid derivative, the identity and specific rotation should be confirmed against the supplied batch specification.
Q:
Which specifications should be checked before ordering?

A: Confirm appearance, assay or purity, specific rotation, melting range, water content, residue on ignition, heavy metals, and related amino acid or stereoisomer impurities. Also confirm whether pharmaceutical, biochemical, or technical grade is required, and verify packaging and storage compatibility with the intended use.
Q:
How should L-Hydroxyproline be stored and handled?

A: Store it in a cool, dry, well-ventilated area in tightly closed containers away from moisture, heat, and strong oxidizers. Use appropriate PPE and controlled dispensing to limit dust exposure during weighing and transfer, and follow the supplied batch specification for storage.

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