What is Hydroxyapatite CAS 1306-06-5?

Hydroxyapatite CAS 1306-06-5 is a calcium phosphate mineral with the formula Ca10(PO4)6(OH)2 and EC number 215-145-7. It is the main mineral component of human teeth and bone, and synthetic grades are supplied as a white powder for oral care, food, and biomedical applications.

What is the difference between nano-hydroxyapatite and standard hydroxyapatite?

Nano-hydroxyapatite consists of particles typically smaller than 100 nm, giving it a much higher surface area and better penetration into microscopic dentinal tubules. Standard or micron-grade hydroxyapatite has larger particles and is often used where controlled particle size, mechanical properties, or bulk calcium phosphate content are more important.

How does hydroxyapatite help reduce tooth sensitivity and support enamel?

It can block open dentinal tubules, deposit mineral onto enamel, and support remineralization in the oral environment. Its performance depends on particle size, morphology, stability, and how it is formulated into toothpaste, gel, or mouthwash.

Is Hydroxyapatite CAS 1306-06-5 safe for oral care products?

Hydroxyapatite is considered biocompatible because it is chemically similar to the mineral portion of teeth and bone. Evaluations of nano-hydroxyapatite in oral care, including an SCCS review, found it safe within defined parameters, with no evidence of genotoxicity and minimal systemic exposure.

What applications are available beyond toothpaste and mouthwash?

Food-grade hydroxyapatite can provide bioavailable calcium and phosphorus for bone-support supplements, while biomedical grades are used in bone-repair materials, dental applications, coatings, and chromatography media. The appropriate grade depends on particle size, purity, calcium-to-phosphorus ratio, and regulatory requirements.

Hydroxyapatite CAS 1306-06-5

Hydroxyapatite (CAS 1306-06-5), frequently abbreviated as HAP or HAp, is a bioactive calcium phosphate ceramic utilizing its chemical similarity to natural bone and tooth enamel to provide superior remineralization and biocompatibility. Chemically identified as Calcium hydroxyapatite, this white powder functions as a biomimetic material that can bond directly to bone tissue and seal dentinal tubules. As the primary mineral component of human teeth, it is extensively integrated into desensitizing toothpastes and enamel repair serums to replace lost minerals and whiten teeth naturally without abrasion. In the biomedical field, it serves as a critical synthetic bone graft substitute and coating for orthopedic implants. We ensure bulk supply capabilities for this material, providing access to competitive factory pricing and customized specifications to meet specific particle sizes (e.g., Nano-grade <100nm for high reactivity or Micron-grade for fillers) and shapes (Spherical/Needle-like). Full technical documentation, including MSDS, TDS, COA, is available to support compliance and safety protocols.

CAS: 1306-06-5
Synonyms: Calcium hydroxyapatite, Hydroxylapatite, HAP, Calcium phosphate tribasic (Hydroxy form), Durapatite
Einecs: 215-145-7
Molecular Formula: Ca10(PO4)6(OH)2
Grade: Oral Care Grade / Food Grade / Medical Grade
Package: 25kg/Fiber Drum with inner plastic bag (or customized).

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Product Description

Hydroxyapatite (HAP) is the main mineral component of vertebrate bones and teeth. Due to its excellent biocompatibility and bioactivity, it is non-toxic and non-irritating to human tissue.

Our synthetic Hydroxyapatite is produced via a precise precipitation method, resulting in high purity and controlled morphology.

In Oral Care: It is known as “artificial enamel.” Nano-sized or micro-sized HAP can repair damaged tooth enamel, reduce tooth sensitivity by blocking dentinal tubules, and whiten teeth naturally.
In Supplements: It provides a highly bioavailable source of Calcium and Phosphorus, supporting bone density health.

1 Physicochemical Properties

2 Applications

3 Storage Conditions

4 Safety Precautions

Physicochemical Properties

Standard specifications for Oral/Cosmetic Grade HAP:

Parameter	Specification (Standard)
Appearance	White fine powder
Assay (Hydroxyapatite content)	≥ 98.0%
Calcium (Ca)	39.0% – 39.9%
Phosphorus (P)	18.0% – 18.5%
Ca/P Molar Ratio	1.66 – 1.68 (Theoretical 1.67)
pH Value (10% suspension)	7.0 – 9.0
Loss on Drying	≤ 1.0%
Ignition Loss (800°C)	≤ 3.0%
Heavy Metals (Pb)	≤ 10 ppm
Arsenic (As)	≤ 3 ppm
Particle Size (D50)	Customizable (e.g., 5-10 µm or Nano-grade <100nm)
Whiteness	≥ 96%

Applications

Oral Care Products (Toothpaste & Mouthwash):
- Desensitizing: Blocks exposed dentin tubules to stop sensitivity pain.
- Remineralization: Repairs microscopic surface lesions on enamel.
- Whitening: Acts as a gentle polishing agent and fills micro-cracks for a smoother surface.
Nutritional Supplements:
- Used in calcium tablets and capsules for bone health (osteoporosis prevention). Better absorption compared to calcium carbonate.
Medical Materials (Bone Repair):
- Used as a bone filler, coating for orthopedic implants, and scaffold material for tissue engineering due to its ability to bond directly to bone.
Cosmetics:
- Used in skin care as a filler or soft-focus agent.

Storage Conditions

Storage: Store in a cool, dry, and well-ventilated warehouse.
Packaging: Keep the container tightly sealed. The powder can absorb moisture, which may cause clumping, though it is chemically stable.
Environment: Keep away from toxic or strong-smelling substances to prevent contamination.
Shelf Life: 24 months when stored properly.

Safety Precautions

Handling: Hydroxyapatite is generally recognized as safe (GRAS). However, fine powder handling requires care. Do not breathe dust.
PPE: Wear a dust mask (N95) and safety goggles during handling to prevent mechanical irritation of the respiratory tract or eyes.
First Aid:
- Eye Contact: Flush eyes with water as a precaution.
- Inhalation: Move to fresh air.
Toxicity: Non-toxic, non-inflammatory, and non-immunogenic.

FAQ - Technical & Supply Chain

Q:
What is Hydroxyapatite CAS 1306-06-5?

A: Hydroxyapatite CAS 1306-06-5 is a calcium phosphate mineral with the formula Ca10(PO4)6(OH)2 and EC number 215-145-7. It is the main mineral component of human teeth and bone, and synthetic grades are supplied as a white powder for oral care, food, and biomedical applications.
Q:
What is the difference between nano-hydroxyapatite and standard hydroxyapatite?

A: Nano-hydroxyapatite consists of particles typically smaller than 100 nm, giving it a much higher surface area and better penetration into microscopic dentinal tubules. Standard or micron-grade hydroxyapatite has larger particles and is often used where controlled particle size, mechanical properties, or bulk calcium phosphate content are more important.
Q:
How does hydroxyapatite help reduce tooth sensitivity and support enamel?

A: It can block open dentinal tubules, deposit mineral onto enamel, and support remineralization in the oral environment. Its performance depends on particle size, morphology, stability, and how it is formulated into toothpaste, gel, or mouthwash.
Q:
Is Hydroxyapatite CAS 1306-06-5 safe for oral care products?

A: Hydroxyapatite is considered biocompatible because it is chemically similar to the mineral portion of teeth and bone. Evaluations of nano-hydroxyapatite in oral care, including an SCCS review, found it safe within defined parameters, with no evidence of genotoxicity and minimal systemic exposure.
Q:
What applications are available beyond toothpaste and mouthwash?

A: Food-grade hydroxyapatite can provide bioavailable calcium and phosphorus for bone-support supplements, while biomedical grades are used in bone-repair materials, dental applications, coatings, and chromatography media. The appropriate grade depends on particle size, purity, calcium-to-phosphorus ratio, and regulatory requirements.

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