Chlorotrimethylsilane (CAS 75-77-4), chemically designated as Trimethylchlorosilane or TMCS, is an organosilicon compound belonging to the silyl halide class. Commonly recognized in synthesis as Trimethylsilyl chloride, this fuming liquid functions as a potent silylating agent and protecting group for hydroxyl, carboxyl, and amine functionalities. It is extensively utilized in the industrial production of pharmaceutical intermediates, silicone fluids, and hydrophobic coatings. We provide this industrial material with competitive factory pricing to support continuous manufacturing operations, alongside options for customized specifications. Essential technical documentation, including MSDS, TDS, COA, is readily available for all bulk supply orders.
Chlorotrimethylsilane CAS 75-77-4
- CAS: 75-77-4
- Synonyms: TMCS, Trimethylchlorosilane, Trimethylsilyl chloride, Monochlorotrimethylsilicon
- Einecs: 200-900-5
- Molecular Formula: C3H9ClSi
- Grade: Industrial grade 99%
- Package: 200kg iron drum or 50kg plastic drum packing
Product Description
Trimethylchlorosilane is a colorless transparent liquid with a pungent odor, exposed to air, and easily reacts with moisture to produce hydrogen chloride. Silicon-halogen bonding compounds. In industry, large-scale production capacity has been formed, generally using chloromethane and silica powder to be directly synthesized under the action of catalysts, and pure products are obtained by fractionation
Chemical formula: C3H9ClSi
Molecular weight: 108.64
CAS Accession Number: 75-77-4
Melting point: -40°C
Boiling point: 57.3°C
Density: 0.857g/cm3
Appearance: Colorless solution
Flash point: -18°C
Uses of trimethylchlorosilane:
1. Due to the special activity of silicon-halogen bonds, a series of silicon compounds containing silicon-functional group structures can be synthesized from trimethylchlorosilane, such as trimethylalkoxysilane, hexamethyldisisiloxane, hexamethyldisiazane, trimethylcyanosilane, etc.
2. Trimethylchlorosilane is an excellent reagent for introducing trimethylsilyl groups into organic molecules, which can be used as protective groups for functional groups such as hydroxyl groups, carboxyl groups, and amino groups. The reaction of joining and removing trimethylsilica groups has high yield, mild conditions, and a wide range of applications, and is used in organic synthesis.
3. Some biochemical samples are reacted with trimethylchlorosilane to obtain silanated derivatives, which have large volatility, so that the gas chromatography analysis of biochemical samples can be realized.
4. Trimethylchlorosilane is used as a heading agent for silicone polymers, which plays a role in regulating the molecular weight of polymers, especially in the production of silicone oil.

FAQ - Technical & Supply Chain
-
Q:
Is CAS 75-77-4 the unique identifier for Trimethylchlorosilane?
A: Yes, CAS 75-77-4 specifically identifies Chlorotrimethylsilane (TMCS), distinguishing it from other organosilanes like Dimethyldichlorosilane. -
Q:
Is this product intended for use as a silylating agent in organic synthesis?
A: Yes, this grade is typically applied to introduce trimethylsilyl groups for the protection of functional groups during complex chemical synthesis or antibiotic production.
Documents and Product Support
For product review and sourcing evaluation, supporting documents can be coordinated according to the product type, inquiry stage, and order requirements.
- COA for batch-based quality reference
- TDS for key physical and chemical information
- SDS / MSDS for handling, storage, and safety reference
- Packing information for sample, trial, and bulk orders
- Technical communication based on application and specification requirements
Information to Confirm Before Quotation
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- Product name and CAS number
- Application or intended end use
- Required purity, grade, or specification
- Sample quantity, trial order, or bulk demand
- Preferred packing form or net weight
- Destination country or port
- Required documents or compliance expectations
Packaging, Storage, and Handling Notes
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Before order confirmation, buyers are advised to review the corresponding product documents and confirm whether any special storage, labeling, or handling requirements apply.
Sample, Bulk Order and Repeat Supply Support
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For repeat-use formulations or long-term procurement plans, buyers may discuss specification consistency, packaging preferences, delivery expectations, and document coordination in advance.




