What is Chlorhexidine Digluconate CAS 18472-51-0?

Chlorhexidine Digluconate, also called chlorhexidine gluconate or CHG, is the digluconate salt of chlorhexidine. It has CAS 18472-51-0, EC 242-354-0, molecular formula C34H54Cl2N10O14, and molecular weight about 897.76 g/mol, and is normally supplied as an aqueous solution.

Is Chlorhexidine Digluconate the same as chlorhexidine base?

No. Chlorhexidine base is the unformulated biguanide compound and has a different identity from the soluble digluconate salt. Chlorhexidine Digluconate CAS 18472-51-0 is the commercially useful salt form that is dissolved in water for antiseptic, disinfectant, oral-care, and preservative-related formulations.

Why is the 20% solution commonly supplied?

A 20% aqueous chlorhexidine digluconate solution is a widely used commercial strength for formulation and industrial handling. Typical 20% material has an active content of about 19.0-21.0%, a pH of about 5.5-7.0, and a density of about 1.06-1.07 g/mL, though the exact range should be confirmed with the supplier.

What are the main formulation uses of Chlorhexidine Digluconate?

It is used as a cationic broad-spectrum antimicrobial active in topical antiseptics, disinfectants, skin cleansers, medical and institutional hygiene products, and oral-care systems where permitted. In cosmetic or preservative-related applications it is normally used at low, controlled concentrations and must be assessed against the target market regulations.

Which compatibility issues should be checked before formulation?

Because chlorhexidine digluconate is cationic, it can be incompatible with anionic surfactants, soaps, and certain complex anions, which may reduce activity or cause precipitation. Formulators should check pH, surfactant charge, and final-system compatibility before combining it with other ingredients.

Chlorhexidine Digluconate CAS 18472-51-0

Chlorhexidine Digluconate is a broad-spectrum antimicrobial ingredient widely used in disinfectant, antiseptic, hygiene, and related formulation systems. In commercial supply, it is commonly handled as an aqueous solution rather than a dry bulk pure substance, with 20% solution being a frequently listed market form. This product is generally positioned as an antimicrobial active for disinfectant and personal care formulations where controlled bacteriostatic or antimicrobial performance is required. Standard export supply can be arranged, and COA, TDS, and SDS can be provided according to customer requirements. Benzalkonium Chloride is a related antimicrobial formulation active to compare when the required chemistry is quaternary ammonium rather than chlorhexidine salt.

CAS: 18472-51-0
Synonyms: Chlorhexidine Digluconate; Chlorhexidine Gluconate; Chlorhexidine Digluconate Solution
Einecs: 242-354-0
Grade: Disinfectant Grade / Cosmetic Grade / Industrial Grade
Package: Standard export packaging can be arranged according to solution concentration, order quantity, and logistics requirements.

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Product Description

1 Physicochemical Properties

2 Typical Applications

3 Functional Role

4 Typical Supply Form

5 Packaging

6 Storage

Physicochemical Properties

Item	Typical Description
Appearance	Colorless to pale yellow transparent liquid, depending on concentration and supply specification
Product Form	Aqueous solution
Common Commercial Strength	20% solution is a commonly listed supply form
Active Nature	Cationic broad-spectrum antimicrobial ingredient
Odor	Mild characteristic odor
Water Compatibility	Supplied in water-based solution form for formulation use
Molecular Formula	C34H54Cl2N10O14
Molecular Weight	897.76
Hazard Profile	Commercial sources commonly list aquatic hazard statements; handling should follow SDS guidance

Typical Applications

Disinfectant and antiseptic formulation
Skin cleansing and hygiene products
Medical and institutional cleaning formulations
Personal care antimicrobial systems
Oral care and related specialty hygiene applications where permitted by local regulations

Actual end-use suitability should be evaluated according to local regulatory requirements, formulation design, and target market compliance.

Functional Role

Chlorhexidine Digluconate is typically used as an antimicrobial active in formulations requiring broad-spectrum hygiene support. In supplier practice, it is commonly positioned as a functional disinfectant or preservative-related active depending on the application scenario and regulatory framework.

Typical Supply Form

This product is commonly supplied as aqueous solution, with 20% solution being one of the most frequently referenced commercial forms. Supply concentration, packaging, and documentation can be arranged according to the agreed specification.

For related antimicrobial active pages, compare PHMB, Benzalkonium Chloride, and Piroctone Olamine.

Packaging

Chlorhexidine Digluconate can be supplied in sealed industrial packaging suitable for liquid chemical transport and export handling. Packaging arrangement can be made according to concentration, order volume, and shipping requirements.

Storage

Store in a cool, dry, and well-ventilated place in tightly closed original containers. Protect from direct sunlight, excessive heat, and contamination. Follow the applicable SDS and local handling requirements during storage and transportation.

FAQ - Technical & Supply Chain

Q:
What is Chlorhexidine Digluconate CAS 18472-51-0?

A: Chlorhexidine Digluconate, also called chlorhexidine gluconate or CHG, is the digluconate salt of chlorhexidine. It has CAS 18472-51-0, EC 242-354-0, molecular formula C34H54Cl2N10O14, and molecular weight about 897.76 g/mol, and is normally supplied as an aqueous solution.
Q:
Is Chlorhexidine Digluconate the same as chlorhexidine base?

A: No. Chlorhexidine base is the unformulated biguanide compound and has a different identity from the soluble digluconate salt. Chlorhexidine Digluconate CAS 18472-51-0 is the commercially useful salt form that is dissolved in water for antiseptic, disinfectant, oral-care, and preservative-related formulations.
Q:
Why is the 20% solution commonly supplied?

A: A 20% aqueous chlorhexidine digluconate solution is a widely used commercial strength for formulation and industrial handling. Typical 20% material has an active content of about 19.0-21.0%, a pH of about 5.5-7.0, and a density of about 1.06-1.07 g/mL, though the exact range should be confirmed with the supplier.
Q:
What are the main formulation uses of Chlorhexidine Digluconate?

A: It is used as a cationic broad-spectrum antimicrobial active in topical antiseptics, disinfectants, skin cleansers, medical and institutional hygiene products, and oral-care systems where permitted. In cosmetic or preservative-related applications it is normally used at low, controlled concentrations and must be assessed against the target market regulations.
Q:
Which compatibility issues should be checked before formulation?

A: Because chlorhexidine digluconate is cationic, it can be incompatible with anionic surfactants, soaps, and certain complex anions, which may reduce activity or cause precipitation. Formulators should check pH, surfactant charge, and final-system compatibility before combining it with other ingredients.

Ordering & Documentation

Key information for document requests, quotations, and supply planning.

Documents

COA, TDS, SDS/MSDS and packing details are available on request.

Quotation

Send the CAS number, grade, quantity, packing preference and destination.

Sample & Supply

Support is available for samples, trial orders, bulk and repeat supply.

Storage & Shipping

Product-specific conditions are confirmed before order.

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