What is Ammonium Formate CAS 540-69-2?

Ammonium Formate, also known as formic acid ammonium salt or ammonium methanoate, is a white crystalline solid with the molecular formula CH5NO2 and molecular weight 63.06 g/mol. Its EC number is 208-753-9, and it is commonly used in analytical chemistry and chemical synthesis.

Why is Ammonium Formate widely used in LC-MS mobile phases?

Both the ammonium ion and formate ion are volatile, so Ammonium Formate can control mobile-phase pH and ionic strength without leaving the heavy nonvolatile salt deposits associated with sodium or potassium buffers. This makes it especially suitable for LC-MS, HPLC-MS, and other detection methods where low residue and good ionization compatibility matter.

What is the role of Ammonium Formate in catalytic transfer hydrogenation?

Ammonium Formate acts as a convenient hydrogen donor in transfer hydrogenation and reduction systems. With catalysts such as palladium on carbon, nickel, or copper, it can reduce nitro groups, carbonyl compounds, alkenes, and other reducible substrates without requiring pressurized molecular hydrogen.

What happens when Ammonium Formate is heated?

Ammonium Formate decomposes on heating, initially forming formamide and water, and further heating can release ammonia and other decomposition products. For this reason it should not be exposed to high heat for prolonged periods, and storage should be cool, dry, and sealed.

What is the difference between Ammonium Formate and Ammonium Acetate?

Both are volatile ammonium salt buffers, but Ammonium Formate is based on formic acid and is generally selected for lower-pH mobile phases or applications where formate is the preferred anion. Ammonium Acetate is based on acetic acid and is often used at somewhat higher pH; the best choice depends on the target pH range, analyte chemistry, and detection method.

Ammonium Formate CAS 540-69-2

Ammonium Formate, also called formic acid ammonium salt or ammonium methanoate, CAS 540-69-2, is a white crystalline solid positioned as a buffering component, reducing agent and intermediate for analytical and chemical processes. Confirm the required grade, then request a quotation with COA/TDS/SDS for bulk supply.

CAS: 540-69-2
Synonyms: Formic acid ammonium salt; Ammonium methanoate
Einecs: 208-753-9
Molecular Formula: CH5NO2
Grade: Industrial / analytical grade
Package: Standard moisture-protected packaging

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Product Description

Ammonium Formate CAS 540-69-2 is a low-molecular-weight ammonium salt with EC 208-753-9 and molecular formula CH5NO2.

Synonyms: Formic acid ammonium salt; Ammonium methanoate.

CAS: 540-69-2.

Molecular formula: CH5NO2.

It is supplied as a white crystalline solid.

It has a molecular weight of about 63.06 g/mol.

It is positioned as a buffering component, reducing agent and intermediate for analytical and chemical processes.

It is used as a buffering agent in analytical chemistry, including LC-MS and HPLC-MS mobile phase preparation.

It is used as a convenient hydrogen donor in catalytic transfer hydrogenation and reduction systems.

It is used as a precursor or intermediate in chemical synthesis.

It decomposes on heating, initially forming formamide and water, and further heating can release ammonia and other decomposition products.

Confirm the required industrial or analytical grade, assay, appearance, and related specifications for the chosen grade.

Check compatibility with the target mobile phase, reaction system, or synthesis conditions.

Store in a cool, dry, well-ventilated area, away from heat sources.

Keep containers tightly sealed to prevent moisture absorption and decomposition during handling and storage.

Confirm packaging suitable for the crystalline solid form and order quantity, and follow the current SDS.

Confirm grade, packaging, and specification as required.

The page is an RFQ entry point and does not state stock, price, MOQ, or fixed lead time.

For an RFQ, state the intended application, required grade, quantity, packaging, destination, and document needs.

FAQ - Technical & Supply Chain

Q:
What is Ammonium Formate CAS 540-69-2?

A: Ammonium Formate, also known as formic acid ammonium salt or ammonium methanoate, is a white crystalline solid with the molecular formula CH5NO2 and molecular weight 63.06 g/mol. Its EC number is 208-753-9, and it is commonly used in analytical chemistry and chemical synthesis.
Q:
Why is Ammonium Formate widely used in LC-MS mobile phases?

A: Both the ammonium ion and formate ion are volatile, so Ammonium Formate can control mobile-phase pH and ionic strength without leaving the heavy nonvolatile salt deposits associated with sodium or potassium buffers. This makes it especially suitable for LC-MS, HPLC-MS, and other detection methods where low residue and good ionization compatibility matter.
Q:
What is the role of Ammonium Formate in catalytic transfer hydrogenation?

A: Ammonium Formate acts as a convenient hydrogen donor in transfer hydrogenation and reduction systems. With catalysts such as palladium on carbon, nickel, or copper, it can reduce nitro groups, carbonyl compounds, alkenes, and other reducible substrates without requiring pressurized molecular hydrogen.
Q:
What happens when Ammonium Formate is heated?

A: Ammonium Formate decomposes on heating, initially forming formamide and water, and further heating can release ammonia and other decomposition products. For this reason it should not be exposed to high heat for prolonged periods, and storage should be cool, dry, and sealed.
Q:
What is the difference between Ammonium Formate and Ammonium Acetate?

A: Both are volatile ammonium salt buffers, but Ammonium Formate is based on formic acid and is generally selected for lower-pH mobile phases or applications where formate is the preferred anion. Ammonium Acetate is based on acetic acid and is often used at somewhat higher pH; the best choice depends on the target pH range, analyte chemistry, and detection method.

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