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    • Acetylacetone CAS 123-54-6

    Acetylacetone CAS 123-54-6

    Acetylacetone (2,4-pentanedione), CAS 123-54-6, is a β-diketone intermediate and chelating agent that exists as keto and enol tautomers. It is used in heterocyclic synthesis and as a precursor for metal acetylacetonates. For bulk quotations, specify the GC assay, water, colour and application requirements, quantity and destination, and request COA/TDS/SDS and GC data.

    • CAS: 123-54-6
    • Synonyms: Acetylacetone; 2,4-Pentanedione; Pentane-2,4-dione; Acac
    • Einecs: 204-634-0
    • Molecular Formula: C₅H₈O₂
    • Grade: Industrial grade, purity ≥99.5%
    • Package: Confirm packaging compatible with the offered form and destination requirements.
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    Product Description

    1 Physicochemical Properties
    2 Applications
    2.1 Pharmaceutical & Agrochem Synthesis
    2.2 Metal Acetylacetonate Production
    2.3 Research & Development (R&D)
    3 Quality Assurance (QA/QC)
    4 Storage & Safety
    4.1 Storage Guidelines
    4.2 Safety & PPE Recommendations

    Physicochemical Properties

    ParameterSpecificationTest Method
    AppearanceColorless to light yellow liquidVisual Inspection
    Purity (GC)≥ 99.5%Gas Chromatography
    Color (Hazen)≤ 15ASTM D1209
    Density (20°C)0.972 – 0.977 g/cm³ASTM D1298
    Water Content≤ 0.10%Karl Fischer, ketone-compatible method
    Refractive Index (20°C, sodium D line)1.450 – 1.453Refractometer
    Boiling Point (reference)Approximately 140°C at atmospheric pressureAgree a separate distillation-range method for lot acceptance

    Applications

    Pharmaceutical & Agrochem Synthesis

    • Heterocyclic Compounds: A primary building block for the synthesis of pyridines, pyrimidines, and isoxazoles used in active pharmaceutical ingredients (APIs).
    • Chemical Intermediates: Employed in the production of sulfonamide-based drugs and various veterinary medicines.

    Metal Acetylacetonate Production

    • Chelating Agent: Acetylacetone forms metal acetylacetonate complexes, including those of cobalt, aluminium, iron and nickel. Selected complexes are used in catalysis; their function depends on the metal, oxidation state and formulation.
    • Materials Applications: Acetylacetone is a precursor for metal acetylacetonates used in applications such as PVC stabilization. The parent liquid and its metal complexes are different products and must not be treated as interchangeable additives.

    Research & Development (R&D)

    • Organometallic Chemistry: Extensively used in laboratories as a ligand for studying transition metal coordination and as a solvent for specialized chemical reactions.

    Quality Assurance (QA/QC)

    For bulk purchasing, agree GC assay, water, colour, acidity, nonvolatile residue, density and refractive index with their test conditions. Request COA/TDS/SDS and a GC chromatogram with the method and reporting basis. GC area percentage is not automatically a mass-fraction assay and does not replace separate water or nonvolatile-residue tests.

    Determine water using a validated Karl Fischer method suitable for ketones. Acetylacetone can react with alcohol-containing reagents and generate water, so reagent compatibility and side reactions matter. Compare the COA results with the agreed purchasing specification; reference physical properties are not a substitute for lot-specific analytical results.

    Storage & Safety

    Storage Guidelines

    • Environment: Store in a cool, dry, and well-ventilated dedicated flammable storage area.
    • Temperature: Keep away from heat, sparks, open flames, and direct sunlight.
    • Compatibility: Keep containers tightly closed. Store separately from strong oxidizers and reducing agents.

    Safety & PPE Recommendations

    • Respiratory Protection: Use effective ventilation and select respiratory protection through an exposure assessment and the grade-specific SDS. An organic-vapour filter is not suitable for every concentration or emergency.
    • Skin & Eye Protection: Use splash goggles and chemical-resistant gloves selected from the SDS and the glove manufacturer’s permeation data for the actual concentration, contact time and task.
    • Body Protection: Wear anti-static protective clothing.
    • First Aid: After inhalation, move the affected person to fresh air without exposing rescuers. After skin contact, remove contaminated clothing and wash the skin thoroughly with water. Follow the SDS first-aid instructions and seek medical advice.

    FAQ - Technical & Supply Chain

    • Q:

      Are Acetylacetone, 2,4-Pentanedione and ACAC the same compound?

      A: Yes. These names identify pentane-2,4-dione, CAS 123-54-6. It is a beta-diketone that exists in keto and enol forms, not a mixture of acetone and acetic acid.
    • Q:

      What is Acetylacetone used for?

      A: Acetylacetone is a building block for heterocyclic intermediates used in pharmaceutical and agrochemical synthesis. It is also a precursor for metal acetylacetonates used in selected catalyst and materials applications, including PVC stabilization. The function depends on the specific metal complex and formulation; the parent liquid is not interchangeable with its metal salts.
    • Q:

      What are the key specifications and physical properties of Acetylacetone?

      A: Agree GC assay and its reporting basis, appearance, APHA colour, water, acidity, nonvolatile residue, refractive index and density with the test conditions. Water analysis needs a validated Karl Fischer method suitable for ketones. Request COA/TDS/SDS and a GC chromatogram; confirm drum net weight, seals, sampling and transport classification.
    • Q:

      What storage and handling points apply to Acetylacetone?

      A: Store in closed flammable-liquid containers away from ignition sources and oxidizing agents. Acetylacetone is flammable with a flash point around 34-35 C and should be handled with ventilation and chemical-resistant PPE.

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